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GP G G G G G G G G GP GP G G ARRDC3 WWP1 21191027 biogrid exp G G G G G GP G G G G GP GP G G G GP GP G G G G G G GP GP G GP GP G SMAD6 WWP1 15221015,15359284,24850914 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G HSPB1 WWP1 25277244 biogrid,intact exp GP GP G G GP G G GP GP G GP GP GP G G GP G GP GP G GP GP GP GP GP G GP GP G SCNN1A WWP1 14556380 biogrid exp GP GP P P P GP GP P GP GP G GP P P GP G P GP GP P GP P GP GP G DAG1 WWP1 9169421 hprd,bci exp G G G G G GP G GP GP G GP G GP G G G GP GP GP G GP GP G GP G G GP GP G HIVEP3 WWP1 16728642 biogrid exp P GP G P GP G P P G P P GP GP G P GP P P G P GP GP P P GP P P ESR2 WWP1 21487105 biogrid exp GP GP G GP GP G GP GP GP GP GP GP G P GP GP GP G GP P GP GP GP GP GP GP PHF20L1 WWP1 21988832 biogrid,intact exp G GP G G G GP G GP GP G GP G G G G GP GP G GP G GP G G GP GP G GP GP G DVL2 WWP1 20007894 i2d exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G EZR WWP1 22629406 biogrid exp GP GP G G GP GP 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G G G G GP G G G GP G G G G G GP G G TMEM255A WWP1 26186194 biogrid exp, ortho G P G P GP G P GP G P P G P GP G P G P P P P GP P SMAD4 WWP1 15359284,15946939, 25402006 innatedb,biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP GP GP GP G CPSF6 WWP1 16189514,19447967, 25402006 innatedb,hprd,biogrid,mint,intact exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SMAD7 WWP1 15221015,15359284,22773947, 25402006 biogrid exp, ortho, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G SMAD1 WWP1 15221015,15359284, 25402006 biogrid,bci exp, ortho, pred G G G G G G G G GP G G G G G G G G G G G G G G G G G G GP G WWP1 KLF2 11375995,15003522, 21836163 hprd,biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G SMAD2 WWP1 15221015,15359284,15946939, 25402006 innatedb,biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SKIL WWP1 15221015, 25402006 biogrid exp, pred GP GP G G GP GP G G GP G GP GP GP G G GP GP G G G GP GP GP GP GP G GP GP G SMAD5 WWP1 15221015,15231748, 25402006, 21836163 hprd,biogrid,i2d,mint,intact exp, pred GP GP G G G GP G G GP G GP GP GP G G G GP GP G G GP GP G G G G G GP G TGIF1 WWP1 18511908, 25402006 hprd exp, pred GP G G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G XRCC5 WWP1 26496610, 23023127 biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KLF5 WWP1 20694673,22045023,16223724,21487105, 21836163 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G ATN1 WWP1 9647693,16713569, 25402006, 21836163 hprd,biogrid,i2d,mint,intact,bci exp, pred GP GP G G GP GP G GP GP G GP GP G G G GP GP GP GP G GP GP GP GP GP GP GP GP G WWP1 RNF11 18724389,15231748, 25402006, 21836163 hprd,biogrid,i2d,mint,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WWP1 TP63 18806757,20951678, 25402006 biogrid exp, pred GP G G G G G G G G G G G G G G G G G G GP GP G G G G G SMAD3 WWP1 15221015,25416956,15359284,15946939, 25402006 innatedb,biogrid,intact exp, pred GP GP G G G GP G G G G G G GP GP G G GP G GP G GP G G G G G G G G LCK WWP1 23023127 bci exp, pred G G GP G G G G G G GP G G G G G GP G UBE2L3 WWP1 17996703,20951678, 16082366 biogrid exp, pred GP G G G G GP G GP GP G GP G G G G GP GP G GP G G G GP GP GP G GP GP G KATNB1 WWP1 ortho GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G HID1 WWP1 ortho G GP G G G GP G GP GP G GP GP GP G G G GP G GP G GP GP G GP G G GP GP G WWP1 SUCLA2 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G NUDT6 WWP1 ortho GP GP G P GP G GP GP G GP GP P GP G GP GP GP P G P GP GP GP GP GP GP GP DDX3Y WWP1 ortho G GP G G GP GP G G GP G GP GP GP GP GP GP GP G P GP GP G GP GP GP GP LDB2 WWP1 ortho GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DNM1 WWP1 ortho G G G G GP G G GP G G GP GP G G G GP G G G G G G G G G LAPTM4A WWP1 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MLYCD WWP1 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G WWP1 COG4 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G EPS8L1 WWP1 ortho GP GP G G G G GP GP GP G G GP G G GP G GP G G GP GP GP G G CDC37 WWP1 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SGTA WWP1 ortho GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G WWP1 MAP1LC3A ortho G GP G G G GP G G GP G G GP G G G GP GP G GP G G G G G GP G G GP G PDPK1 WWP1 ortho GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ITSN1 WWP1 ortho G GP G G G GP G GP GP G GP GP GP GP G GP GP G G G GP G GP GP GP G GP GP G PAX6 WWP1 16082366 ortho, pred G 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GP GP GP GP GP G PSMA3 WWP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G ACVR1 WWP1 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G WWP1 HIPK2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G FBLN1 WWP1 25402006 pred GP G G GP G GP GP G GP P G G G G GP GP G G GP G G G G G G G CCL1 WWP1 16082366 pred P P P P P P P P P P P WWP1 FBXO7 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G ZEB2 WWP1 25402006 pred G G G G GP GP G GP G G GP GP GP GP G G GP G G G G G G GP G G G UBE2D2 WWP1 16082366 pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G PLSCR1 WWP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2F WWP1 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G WWP1 CLEC4M 23023127 pred G G G G G G G G G G G G GP G G G G G 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GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP G GP GP GP GP GP G UBE2E3 WWP1 16082366 pred GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G ERBB2IP WWP1 25402006 pred G GP G G GP GP G GP GP G GP GP G GP G GP GP GP GP G GP G G GP GP GP GP G G MECOM WWP1 25402006 pred GP P P P G GP GP G GP P GP P G GP P GP GP G GP GP GP GP GP GP GP GP G NUDT21 WWP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G MAGI1 WWP1 25402006 pred G G G G G G G G GP G GP GP GP G G GP G G GP G G G GP G GP G GP G G CALCOCO2 WWP1 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G HS3ST5 WWP1 23023127 pred G G GP GP G GP G P P P GP P G G G GP GP P G UBE2E2 WWP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G YY1 WWP1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CTSG WWP1 23023127 pred G G G GP G G G G G GP G G G G G G G G G P G G G SH3GL2 WWP1 23023127 pred G GP G G G GP GP G G FBXW4 WWP1 21836163 pred G G G G GP G G G G G G G GP G G GP G G GP G GP G G G GP GP G G G MAGI2 WWP1 25402006 pred G GP G P GP G GP GP G GP GP GP G G G GP G GP G P G GP GP G GP G GP G WWP1 BIRC6 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SNW1 WWP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP9X WWP1 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CD4 WWP1 23023127, 16082366 pred G G G G GP G G G G G G G G GP G G G G G G G G G G G GP G G G SOCS5 WWP1 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G AP1G2 WWP1 23023127 pred GP GP G G GP GP GP GP G GP GP GP GP G GP GP GP GP G GP GP GP P GP GP GP GP G WWP1 FBXL4 21836163 pred GP GP G GP GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP GP GP GP P G WWP1 CHMP4B 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP G GP GP GP GP GP G TRAF7 WWP1 21836163 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G G G G G GP GP GP G GP GP G TRIP12 WWP1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G NEDD9 WWP1 25402006 pred GP GP G G GP GP G GP GP GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SP100 WWP1 23023127 pred GP GP G GP P G GP GP GP GP GP GP G GP P GP P G GP GP GP GP GP GP GP P G CD2 WWP1 16082366 pred G G G G G G G G G G G G G GP G G G G G G G G G G G GP G G G WWP1 SMURF1 25402006 pred G GP G G GP GP G G GP G GP G GP G G G GP GP G G GP G G G G GP G GP G RCHY1 WWP1 23023127 pred G GP G G G GP G GP GP G GP G GP G G GP GP G GP G G G GP G GP G GP G G PVRL1 WWP1 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP G G GP G GP GP G PIAS4 WWP1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G EID2 WWP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G WWP1 HECW2 25402006 pred GP GP G G GP GP G GP GP G GP G GP G G P GP P GP G GP GP GP GP GP G GP GP VIM WWP1 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G G GP GP GP G G G G G G GP G GP G TGFBR1 WWP1 25402006 pred GP G G G GP GP G GP GP G GP GP GP G G GP GP G G G G G G G GP G GP G G WWP1 PLEKHA5 25402006 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G G GP G CD28 WWP1 16082366 pred G G G G G UBR5 WWP1 25402006 pred GP G G G G GP G G GP G GP GP GP GP G G GP G G G GP G G G G G GP GP G CCL5 WWP1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO11 WWP1 21836163 pred G G G G G GP G G G G G GP GP G G GP GP G G G GP G G G GP G G G G WWP1 LEF1 25402006 pred G G G G GP GP G GP G GP GP GP G G GP G G G G G G GP G G G IL27 WWP1 16082366 pred P P P P P G P P P P P G P P WWP1 UBE2Z 16082366 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G WWP1 FBXL3 21836163 pred G G G G GP G G G G G G G G G G G G G G G G G G G G GP G G G TSG101 WWP1 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF111 WWP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IL12B WWP1 16082366 pred P P P P P P P P P P P P P CCL4 WWP1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G IL2 WWP1 16082366 pred P P P P P P P P P P P P P P P P P P P WWP1 CPVL 21836163 pred G G G G GP G G GP G G GP G GP G G G G G GP G GP G G G G GP G GP G UBE2D1 WWP1 16082366 pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G WWP1 UBE2D4 16082366 pred GP G G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G GP GP GP G SPRY1 WWP1 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G FOXH1 WWP1 25402006 pred G G G G G G G G G G G G G G G WWP1 FBXL7 21836163 pred G G G G G G G G GP G GP G G G G GP G G G G G G GP G GP G GP G G ZFYVE9 WWP1 25402006 pred G GP G G G GP G G GP G GP G G G G GP GP GP GP G GP GP G G GP GP GP GP G WWP1 UFC1 16082366 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G UBE2H WWP1 16082366 pred GP GP G G GP GP G GP G G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WWP1 ANAPC10 25402006 pred GP G G G GP GP G GP GP G GP GP GP GP G GP GP G GP G G GP GP GP GP GP GP GP G UBE2N WWP1 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PPIA WWP1 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ANKRD46 WWP1 25402006 pred GP G G G G GP G GP GP G GP GP G G G GP GP GP GP G GP GP GP GP GP G GP GP G SMAD9 WWP1 25402006 pred GP GP G P GP G GP GP G GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G ICAM1 WWP1 23023127 pred G G G G GP GP G G GP G GP G GP GP G G GP G G G G G G G G GP G GP G GTF2A2 WWP1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2V2 WWP1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NFIA WWP1 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ATF2 WWP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G SYK WWP1 23023127 pred GP G G G GP GP G GP G GP G GP GP G GP GP GP G G G G G GP GP GP GP G UBE2A WWP1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WWP1 LEMD3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G DOCK9 WWP1 25402006 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP GP GP GP G CAND1 WWP1 21836163 pred G GP G G G G G G GP G GP GP G G G GP G GP G G G G GP GP GP G G GP G UBE2I WWP1 16082366 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G JUNB WWP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G THOC5 WWP1 23023127 pred G GP G G G GP G G GP G GP G GP G G GP GP G G G GP GP G GP GP G GP G G RPS27A WWP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WWP2 WWP1 25402006, 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G PIN1 WWP1 25402006 pred G GP G G GP GP G G GP G G G G GP G G GP G P G P GP G G G G GP GP G IRF7 WWP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WWP1 UBE2T 16082366 pred G G G GP G GP P P P GP GP P GP P G GP P GP G WWP1 ALG2 21836163 pred G GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP GP GP G GP GP G UBE2R2 WWP1 16082366 pred G G G G GP G G G G G G G G GP G G G G G G G G G G G GP GP G G NEFM WWP1 25402006 pred G G GP G GP G G GP G G G G NCF1B WWP1 23023127 pred WWP1 FBXO8 21836163 pred GP G G G G GP G G GP G G GP G G G GP GP G GP G GP GP GP G GP G GP GP G CXCL8 WWP1 16082366 pred G GP G G GP GP G GP G GP G G GP G G GP GP G G G G G P G GP GP P G MYC WWP1 25402006 pred GP GP G GP P G GP GP GP GP GP GP G GP P GP GP GP GP GP GP GP GP GP GP G DVL1 WWP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G YWHAZ WWP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MYLIP WWP1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G INSR WWP1 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WWP1 TRIM33 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G UBE2C WWP1 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2L6 WWP1 25402006, 16082366 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G WWP1 ARIH1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IL4 WWP1 16082366 pred G HUWE1 WWP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CBFA2T2 WWP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ARL6IP1 WWP1 21836163 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G WWP1 FBXL5 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZFR WWP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NEDD4 WWP1 25402006, 23023127, 21836163 pred GP GP G GP P G GP GP GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G WWP1 RERE 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G IFNB1 WWP1 16082366 pred P P P P P P P P P P P P P P P P P P P P P P WWP1 JAG2 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ACTB WWP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RELB WWP1 25402006 pred GP GP G G GP GP GP G GP GP GP GP G GP GP G G G G G G G GP GP GP GP G JUN WWP1 25402006 pred GP GP G G G GP G G GP G GP G GP G G GP GP G G G GP G GP G GP G GP G G UBE2K WWP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2B WWP1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RHOA WWP1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WWP1 CD209 23023127 pred G G G G GP G G G G G G G GP GP G G G G G G G G G G G G G G G SKI WWP1 25402006 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G ITCH WWP1 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G EP300 WWP1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WWP1 HCFC2 16082366 pred GP GP G G GP GP G GP G G GP GP GP GP G P GP G GP G GP G G G GP GP GP GP GFI1 WWP1 16082366 pred P P G GP P P P P P P P GP P P P P P P P P GP P P UBE4A WWP1 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9Y3C5 Q9H0M0 - 15231748 - X 2 Q9H0M0 - 9647693 - X 2 Q9H0M0 Q13571 - 15231748 - X 2 Q9H0M0 - 15231748 - X 2 A0A024RDV9 Q9H0M0 two hybrid 19307600 direct interaction X 2 A0A024RDV9 Q9H0M0 imaging technique 19307600 colocalization X 2 A0A024RDV9 Q9H0M0 affinity chromatography technology 19307600 physical association X 2 A0A024RDV9 Q9H0M0 affinity chromatography technology 19307600 physical association X 2 A0A024RDV9 Q9H0M0 affinity chromatography technology 19765186 physical association X 2 A0A024RDV9 Q9H0M0 affinity chromatography technology 19580544 physical association X 2 P27348 Q9H0M0 pull down 15161933 direct interaction X 2 Q9H0M0 far western blotting 22379092 direct interaction X 2 Q15884 Q9H0M0 two hybrid 25416956 direct interaction X 2 Q9Y3C5 Q9H0M0 two hybrid 15231748 direct interaction X 2 Q9Y3C5 Q9H0M0 affinity chromatography technology 18724389 physical association X 2 Q9Y3C5 Q9H0M0 affinity chromatography technology 18724389 physical association X 2 Q9Y3C5 Q9H0M0 pull down 18724389 direct interaction X 2 Q9Y3C5 Q9H0M0 imaging technique 18724389 colocalization X 2 Q9Y3C5 Q9H0M0 pull down 18724389 direct interaction X 2 Q9H0M0 P15311 affinity chromatography technology 22629406 physical association X 2 Q9H0M0 Q15038-2 two hybrid 16189514 direct interaction X 2 Q9H0M0 Q16630 affinity chromatography technology 16189514 physical association X 2 Q9H0M0 affinity chromatography technology 16728642 physical association X 2 Q9H0M0 affinity chromatography technology 16728642 physical association X 2 Q9H0M0 affinity chromatography technology 15359284 physical association X 2 Q9H0M0 A0A024R274 affinity chromatography technology 15359284 physical association X 2 Q9H0M0 O43541-2 affinity chromatography technology 15359284 physical association X 2 Q9H0M0 Q15797 affinity chromatography technology 15359284 physical association X 2 Q9H0M0 E9QMJ8 two hybrid 12223491 direct interaction X 2 Q9H0M0 E9QMJ8 affinity chromatography technology 12223491 physical association X 2 Q9H0M0 Q15678 affinity chromatography technology 22948661 physical association X 2 Q9H0M0 Q9H469 affinity chromatography technology 21572392 physical association X 2 Q9H0M0 Q16630 two hybrid 19447967 direct interaction X 2 Q9H0M0 Q9Y4K3 affinity chromatography technology 23799152 physical association X 2 Q9H0M0 Q9P0M6 two hybrid 21988832 direct interaction X 2 Q9H0M0 P46531 pull down 16785210 direct interaction X 2 Q9H0M0 P46531 imaging technique 16785210 colocalization X 2 Q9H0M0 O43541-2 affinity chromatography technology 24850914 physical association X 2 Q9H0M0 two hybrid 25416956 direct interaction X 2 Q9H0M0 Q9BTC0 two hybrid 16189514 direct interaction X 2 Q9H0M0 Q9Y5W3 two hybrid 11375995 direct interaction X 2 Q9H0M0 Q9Y5W3 affinity chromatography technology 11375995 physical association X 2 Q9H0M0 P37088-2 two hybrid 14556380 direct interaction X 2 Q9H0M0 Q9NQC3 pull down 19035836 direct interaction X 2 Q9H0M0 Q9NQC3 affinity chromatography technology 19035836 physical association X 2 Q9H0M0 B4DQB3 two hybrid 20211142 direct interaction X 2 Q9H0M0 Q8N653 two hybrid 20211142 direct interaction X 2 Q9H0M0 two hybrid 20211142 direct interaction X 2 Q9H0M0 affinity chromatography technology 15221015 physical association X 2 Q9H0M0 Q15797 affinity chromatography technology 15221015 physical association X 2 Q9H0M0 O43541-2 affinity chromatography technology 15221015 physical association X 2 Q9H0M0 P12757-5 affinity chromatography technology 15221015 physical association X 2 Q9H0M0 Q9Y5W3 affinity chromatography technology 15003522 physical association X 2 Q9H0M0 Q7LCB3 affinity chromatography technology 21487105 physical association X 2 Q9H0M0 Q7LCB3 affinity chromatography technology 21487105 physical association X 2 Q9H0M0 pull down 21191027 direct interaction X 2 Q9H0M0 A8K583 two hybrid 16189514 direct interaction X 2 Q9H0M0 Q16630 two hybrid 16189514 direct interaction X 2 Q9H0M0 Q01844-6 two hybrid 16189514 direct interaction X 2 F6KD01 Q9H0M0 affinity chromatography technology 21532586 physical association X 2 F6KD01 Q9H0M0 pull down 21532586 direct interaction X 2 Q68DB7 Q9H0M0 two hybrid 15231748 direct interaction X 2 Q68DB7 Q9H0M0 affinity chromatography technology 15221015 physical association X 2 Q96B67 Q9H0M0 pull down 21191027 direct interaction X 2 A0A024R1A4 Q9H0M0 pull down 20951678 direct interaction X 2 A0A024R1A4 Q9H0M0 pull down 17996703 direct interaction X 2 P61457 Q9H0M0 two hybrid 20211142 direct interaction X 2 P54646 Q9H0M0 affinity chromatography technology 23293026 physical association X 2 P54646 Q9H0M0 affinity chromatography technology 23293026 physical association X 2 P54646 Q9H0M0 pull down 23293026 direct interaction X 2 P54646 Q9H0M0 two hybrid 23293026 direct interaction X 2 A0A024R857 Q9H0M0 two hybrid 25416956 direct interaction X 2 A0A024QZ59 Q9H0M0 two hybrid 25416956 direct interaction X 2 Q96G27 Q9H0M0 unspecified method 9169421 direct interaction X 2 O95835 Q9H0M0 unspecified method 24107629 direct interaction X 2 Q86V38 Q9H0M0 two hybrid 16713569 direct interaction X 2 Q86V38 Q9H0M0 two hybrid 9647693 direct interaction X 2 P0CG48 Q9H0M0 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q9H0M0 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q9H0M0 affinity chromatography technology 25147182 physical association X 2 P0CG48 Q9H0M0 affinity chromatography technology 17013377 physical association X 2 P0CG48 Q9H0M0 affinity chromatography technology 19343052 physical association X 2 P0CG48 Q9H0M0 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q9H0M0 affinity chromatography technology 21906983 physical association X 2 O15105-2 Q9H0M0 affinity chromatography technology 15359284 physical association X 2 O15105-2 Q9H0M0 affinity chromatography technology 15359284 physical association X 2 O15105-2 Q9H0M0 affinity chromatography technology 22773947 physical association X 2 O15105-2 Q9H0M0 affinity chromatography technology 15221015 physical association X 2 A8K3E0 Q9H0M0 pull down 9753456 direct interaction X 2 Q9H0M0 two hybrid 15163754 direct interaction X 2 Q9H0M0 Q5T1R4-2 affinity chromatography technology 16728642 physical association X 2 Q9H0M0 Q15796-2 affinity chromatography technology 15359284 physical association X 2 Q9H0M0 Q8TBB1 two hybrid 22087225 direct interaction X 2 Q9H0M0 affinity chromatography technology 19047365 physical association X 2 Q9H0M0 affinity chromatography technology 19047365 physical association X 2 Q9H0M0 Q9H3D4-7 affinity chromatography technology 18806757 physical association X 2 Q9H0M0 P07900-2 affinity chromatography technology 22939624 physical association X 2 Q9H0M0 Q13571 two hybrid 15231748 direct interaction X 2 Q9H0M0 two hybrid 21988832 direct interaction X 2 Q9H0M0 B4DPT1 two hybrid 21988832 direct interaction X 2 Q9H0M0 Q13635 affinity chromatography technology 25092867 physical association X 2 Q9H0M0 Q9H0M0 enzymatic study 17996703 direct interaction X 2 Q9H0M0 affinity chromatography technology 24457600 physical association X 2 Q9H0M0 Q13887 affinity chromatography technology 16223724 physical association X 2 Q9H0M0 Q13887 pull down 16223724 direct interaction X 2 Q9H0M0 Q13887 enzymatic study 16223724 direct interaction X 2 Q9H0M0 Q15796-2 affinity chromatography technology 15221015 physical association X 2 Q9H0M0 affinity chromatography technology 19561640 physical association X 2 Q9H0M0 pull down 19561640 direct interaction X 2 Q9H0M0 enzymatic study 19561640 direct interaction X 2 Q9H0M0 Q13887 affinity chromatography technology 21487105 physical association X 2 Q9H0M0 pull down 19366705 direct interaction X 2 Q9H0M0 Q9H3D4-7 affinity chromatography technology 20951678 physical association X 2 Q9H0M0 Q9H3D4-7 enzymatic study 20951678 direct interaction X 2 Q9H0M0 Q13887 affinity chromatography technology 22045023 physical association X 2 Q9H0M0 Q13887 enzymatic study 20694673 direct interaction X 2 A0A024R8L1 Q9H0M0 unspecified method 9169421 direct interaction X 2 Q8N5I2 Q9H0M0 pull down 21191027 direct interaction X 2 Q8N5I2 Q9H0M0 two hybrid 21191027 direct interaction X 2 Q15038-3 Q9H0M0 two hybrid 16189514 - X 2 Q15038-3 Q9H0M0 two hybrid 16189514 - X 2 Q01844 Q9H0M0 two hybrid 16189514 - X 2 Q01844 Q9H0M0 two hybrid 16189514 - X 2 P08887-2 Q9H0M0 in vitro 9169421 - X 2 P08887-2 Q9H0M0 in vitro 9169421 - X 2 Q9Y3C5 Q9H0M0 two hybrid 15231748 - X 2 Q9Y3C5 Q9H0M0 two hybrid 15231748 - X 2 Q9H0M0 P51795 in vitro 9169421 - X 2 Q9H0M0 Q9Y5W3 in vitro 11375995 - X 2 Q9H0M0 Q9Y5W3 in vivo 11375995 - X 2 Q9H0M0 Q9Y5W3 two hybrid 11375995 - X 2 Q9H0M0 Q9Y5W3 in vitro 11375995 - X 2 Q9H0M0 Q9Y5W3 in vivo 11375995 - X 2 Q9H0M0 Q9Y5W3 two hybrid 11375995 - X 2 Q9H0M0 Q13625-2 in vitro 9169421 - X 2 Q9H0M0 Q16630 two hybrid 16189514 - X 2 Q9H0M0 Q9BTC0 two hybrid 16189514 - X 2 Q9H0M0 P51795 in vitro 9169421 - X 2 Q9H0M0 Q16630 two hybrid 16189514 - X 2 Q9H0M0 Q13625-2 in vitro 9169421 - X 2 Q9H0M0 Q9BTC0 two hybrid 16189514 - X 2 P31785 Q9H0M0 in vitro 9169421 - X 2 P31785 Q9H0M0 in vitro 9169421 - X 2 Q68DB7 Q9H0M0 two hybrid 15231748 - X 2 Q68DB7 Q9H0M0 two hybrid 15231748 - X 2 P20936 Q9H0M0 in vitro 9169421 - X 2 P20936 Q9H0M0 in vitro 9169421 - X 2 Q15583-4 Q9H0M0 in vivo 18511908 - X 2 Q15583-4 Q9H0M0 in vivo 18511908 - X 2 Q96G27 Q9H0M0 in vitro 9169421 - X 2 Q96G27 Q9H0M0 in vivo 9169421 - X 2 Q96G27 Q9H0M0 in vivo 9169421 - X 2 Q96G27 Q9H0M0 in vitro 9169421 - X 2 P54259 Q9H0M0 two hybrid 16713569,9647693 - X 2 P54259 Q9H0M0 two hybrid 16713569,9647693 - X 2 Q14966 Q9H0M0 two hybrid 16189514 - X 2 Q14966 Q9H0M0 two hybrid 16189514 - X 2 A8K3E0 Q9H0M0 in vitro 9753456 - X 2 A8K3E0 Q9H0M0 in vitro 9753456 - X 2 Q9H0M0 P05549-5 in vitro 9169421 - X 2 Q9H0M0 A0A024R2W4 in vitro 9169421 - X 2 Q9H0M0 Q13571 two hybrid 15231748 - X 2 Q9H0M0 P05549-5 in vitro 9169421 - X 2 Q9H0M0 A0A024R2W4 in vitro 9169421 - X 2 Q9H0M0 Q13571 two hybrid 15231748 - X 2 Q9H0M0 tandem affinity purification 19765186 association C 20 Q9H0M0 tandem affinity purification 23455153 association C 185 O00401 Q9H0M0 two hybrid fragment pooling approach 23414517 physical association X 2 O00401 Q9H0M0 two hybrid fragment pooling approach 23414517 physical association X 2 Q96D16 Q9H0M0 two hybrid prey pooling approach 25416956 physical association X 2 Q96D16 Q9H0M0 two hybrid array 25416956 physical association X 2 Q96D16 Q9H0M0 validated two hybrid 25416956 physical association X 2 A0A024R110 Q9H0M0 two hybrid pooling approach 16189514 physical association X 2 A0A024R5Z3 Q9H0M0 two hybrid prey pooling approach 25416956 physical association X 2 A0A024R5Z3 Q9H0M0 two hybrid array 25416956 physical association X 2 A0A024R5Z3 Q9H0M0 validated two hybrid 25416956 physical association X 2 Q01844 Q9H0M0 two hybrid pooling approach 16189514 physical association X 2 Q8ZD41 Q9H0M0 two hybrid pooling approach 20711500 physical association X 2 Q9Y3C5 Q9H0M0 two hybrid 15231748 physical association X 2 Q9H0M0 Q16630 pull down 16189514 physical association X 2 Q9H0M0 Q16630 two hybrid pooling approach 16189514 physical association X 2 Q9H0M0 Q9BTC0 two hybrid pooling approach 16189514 physical association X 2 Q9H0M0 Q16630 two hybrid pooling approach 19447967 physical association X 2 Q9H0M0 Q81RS1 two hybrid pooling approach 20711500 physical association X 2 Q9H0M0 Q9H469 anti tag coimmunoprecipitation 21572392 physical association X 2 Q9H0M0 A8MW92 two hybrid array 21988832 physical association X 2 Q9H0M0 Q9P0M6 two hybrid array 21988832 physical association X 2 Q9H0M0 P04792 reverse ras recruitment system 25277244 physical association X 2 Q9H0M0 Q8WU02 two hybrid prey pooling approach 25416956 physical association X 2 Q9H0M0 Q8WU02 two hybrid array 25416956 physical association X 2 Q9H0M0 Q8WU02 validated two hybrid 25416956 physical association X 2 P11217 Q9H0M0 two hybrid fragment pooling approach 23414517 physical association X 2 Q9UBL3 Q9H0M0 two hybrid array 21988832 physical association X 2 Q81SZ0 Q9H0M0 two hybrid pooling approach 20711500 physical association X 2 Q68DB7 Q9H0M0 two hybrid 15231748 physical association X 2 A0A024QZ59 Q9H0M0 two hybrid prey pooling approach 25416956 physical association X 2 A0A024QZ59 Q9H0M0 two hybrid array 25416956 physical association X 2 A0A024QZ59 Q9H0M0 validated two hybrid 25416956 physical association X 2 P54259 Q9H0M0 two hybrid 16713569 physical association X 2 Q14966 Q9H0M0 two hybrid pooling approach 16189514 physical association X 2 P0CG48 Q9H0M0 pull down 19343052 association X 2 Q9H0M0 Q13571 two hybrid 15231748 physical association X 2 Q9H0M0 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B DIDO1 WWP1 MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_21960 - - IL2RG WWP1 MI:0492(in vitro) 9169421 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_5798 - - RUNX2 WWP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16728642 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_196851|BIOGRID_196852 bait|prey prey|bait SMAD3 WWP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15221015,15359284 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_197548|BIOGRID_130312 prey|bait bait|prey CPSF6 WWP1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514,19447967 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(intact)|MI:0471(mint)|(intact)|MI:0468(hprd)|(intact)|MI:0471(mint)|(biogrid) BIOGRID_81316|BIOGRID_78947|UniProt_82459|MINT_37174|UniProt_151799|HPRD_21957|UniProt_101608|MINT_66355|BIOGRID_261574 bait|bait|prey|bait|unspecified role|-|bait|bait|bait prey|prey|bait|prey|unspecified role|-|prey|prey|prey SKIL WWP1 MI:0004(affinity chromatography technology) 15221015 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_130333 prey bait HSP90AA1 WWP1 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255428 bait prey SFTPC WWP1 MI:0096(pull down) 19366705 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_148322 prey bait RASA1 WWP1 MI:0492(in vitro) 9169421 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_34970 - - LZTR1 WWP1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128766 bait prey WWP1 TP63 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18806757,20951678 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_148787|BIOGRID_209469|BIOGRID_148786 bait|bait|bait prey|prey|prey LNX1 WWP1 MI:0096(pull down) 22087225 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_200604 bait prey WWP1 FBXL15 MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 21572392 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_115329|BIOGRID_258627 bait|bait prey|prey TFAP2A WWP1 MI:0492(in vitro) 9169421 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_1053 - - NFE2 WWP1 MI:0492(in vitro)|MI:0096(pull down) 9753456 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_10619|BIOGRID_199041 -|bait -|prey NRF1 WWP1 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_294576 bait prey WWP1 IKBKG MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128790 prey bait WWP1 KLF2 MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid) 11375995,15003522 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) HPRD_10186|BIOGRID_131130|BIOGRID_107621|BIOGRID_107622 -|prey|bait|prey -|bait|prey|bait WWP1 TRAF6 MI:0004(affinity chromatography technology) 23799152 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_283261 prey bait WWP1 RNF11 MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748,18724389 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|MI:0471(mint)|(biogrid)|MI:0471(mint) BIOGRID_146840|UniProt_78546|BIOGRID_146839|BIOGRID_146838|BIOGRID_146837|HPRD_37816|BIOGRID_146836|MINT_31457|BIOGRID_259435|MINT_60222 bait|prey|prey|prey|bait|-|prey|prey|prey|prey prey|bait|bait|bait|prey|-|bait|bait|bait|bait EZH2 WWP1 MI:0004(affinity chromatography technology) 24457600 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_305714 bait prey ERBB4 WWP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19047365,19561640 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_209339|BIOGRID_209338|BIOGRID_141226|BIOGRID_141225|BIOGRID_141224 bait|prey|prey|prey|prey prey|bait|bait|bait|bait PTPN14 WWP1 MI:0004(affinity chromatography technology) 22948661 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_208819 bait prey IL6R WWP1 MI:0492(in vitro) 9169421 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_36734 - - ZNF638 WWP1 MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0468(hprd)|(biogrid)|MI:0471(mint)|MI:0471(mint) UniProt_151679|HPRD_21959|BIOGRID_78827|MINT_66043|MINT_36883 unspecified role|-|prey|prey|prey unspecified role|-|bait|bait|bait YWHAQ WWP1 MI:0096(pull down) 15161933 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_291778 bait prey WWP1 H2AFY2 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_118249|BIOGRID_285911 unspecified role|prey unspecified role|bait UBE2L3 WWP1 MI:0004(affinity chromatography technology) 20951678 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226088 prey bait SPG20 WWP1 MI:0676(tandem affinity purification)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid) 19307600,19580544,19765186 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_103074|BIOGRID_197102|BIOGRID_197101|BIOGRID_148351|BIOGRID_153181|BIOGRID_197105|BIOGRID_197095 bait|bait|bait|bait|bait|prey|bait prey|prey|prey|prey|prey|bait|prey TP53BP2 WWP1 MI:0492(in vitro) 9169421 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_10621 - - KLF5 WWP1 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down) 16223724,20694673,21487105,22045023 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_164722|BIOGRID_126317|BIOGRID_156130|BIOGRID_126314|BIOGRID_126315|BIOGRID_142635 prey|prey|bait|prey|prey|prey bait|bait|prey|bait|bait|bait PYGM WWP1 MI:0663(confocal microscopy) 23414517 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_127335 bait prey EWSR1 WWP1 MI:0096(pull down)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_152032|BIOGRID_79187 unspecified role|bait unspecified role|prey SMAD1 WWP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15221015,15359284 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_130313|BIOGRID_197551 bait|prey prey|bait HIVEP3 WWP1 MI:0004(affinity chromatography technology) 16728642 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_196850 bait prey DAG1 WWP1 MI:0492(in vitro) 9169421 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_31360 - - WWP1 RTN4 MI:0096(pull down)|MI:0096(pull down) 19035836 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_116241|BIOGRID_116242 bait|bait prey|prey EWSR1 WWP1 MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_66574|MINT_37393 bait|bait prey|prey WBP2 WWP1 MI:0686(unspecified method) 9169421 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_99485 bait prey DIDO1 WWP1 MI:0096(pull down)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_153810|BIOGRID_81445 unspecified role|prey unspecified role|bait UBC WWP1 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10,16728642,17013377,19343052,21890473,21906983,21963094,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0914(association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|MI:0471(mint)|(intact)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|(biogrid)|(biogrid)|(biogrid) UniProt_183939|MINT_71093|UniProt_99929|BIOGRID_141983|BIOGRID_196854|BIOGRID_268757|MINT_41483|BIOGRID_153305|BIOGRID_172985|BIOGRID_178366|BIOGRID_264972 bait|bait|bait|prey|bait|bait|bait|bait|bait|bait|bait prey|prey|prey|bait|prey|prey|prey|prey|prey|prey|prey ESR2 WWP1 MI:0096(pull down)|MI:0096(pull down) 21487105 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_142634|BIOGRID_142633 prey|bait bait|prey ATN1 WWP1 MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0096(pull down) 16713569,9647693 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0468(hprd)|(biogrid)|(biogrid)|(intact)|MI:0471(mint) MINT_50555|HPRD_10618|BIOGRID_215543|BIOGRID_114709|UniProt_86086|MINT_82843 bait|-|bait|bait|bait|bait prey|-|prey|prey|prey|prey WASL WWP1 MI:0663(confocal microscopy)|MI:0663(confocal microscopy) 23414517 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_127577|UniProt_127578 bait|bait prey|prey WWP1 ASH2L MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_117664|BIOGRID_288060 unspecified role|prey unspecified role|bait ARRDC2 WWP1 MI:0096(pull down) 21191027 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_160728 bait prey WWP1 PHF20L1 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_118248|BIOGRID_286314 unspecified role|prey unspecified role|bait SMAD5 WWP1 MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15221015,15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association) MI:0471(mint)|(biogrid)|(biogrid)|MI:0471(mint)|MI:0468(hprd)|(intact) MINT_32333|BIOGRID_130314|BIOGRID_259348|MINT_61181|HPRD_615|UniProt_78855 bait|bait|bait|bait|-|bait prey|prey|prey|prey|-|prey WWP1 EWSR1 MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_20506 - - SMAD4 WWP1 MI:0004(affinity chromatography technology) 15359284 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_197549 prey bait HSP90AB1 WWP1 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125120 prey bait ARRDC3 WWP1 MI:0096(pull down) 21191027 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_160729 bait prey DAZAP2 WWP1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) MI:0471(mint)|MI:0468(hprd)|MI:0471(mint)|(intact)|(biogrid) MINT_40050|HPRD_21958|MINT_69345|UniProt_153813|BIOGRID_80987 bait|-|bait|unspecified role|bait prey|-|prey|unspecified role|prey NOTCH1 WWP1 MI:0096(pull down)|MI:0096(pull down) 16785210 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_309283|BIOGRID_309282 bait|prey prey|bait ARRDC1 WWP1 MI:0096(pull down)|MI:0096(pull down) 21191027 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_160734|BIOGRID_160727 bait|bait prey|prey STAT6 WWP1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128679 bait prey TGIF1 WWP1 MI:0493(in vivo) 18511908 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_33280 - - LAPTM5 WWP1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|(intact)|MI:0471(mint)|(biogrid)|MI:0471(mint) HPRD_2809|UniProt_79184|MINT_61518|BIOGRID_259140|MINT_32670 -|bait|bait|bait|bait -|prey|prey|prey|prey SMAD2 WWP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15221015,15359284 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_197547|BIOGRID_130311 prey|bait bait|prey SMAD7 WWP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15221015,15359284,22773947 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_130316|BIOGRID_197543|BIOGRID_197542|BIOGRID_197929 bait|bait|prey|bait prey|prey|bait|prey PCBD1 WWP1 MI:0018(two hybrid) 20211142 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_128597 bait prey WBP1 WWP1 MI:0686(unspecified method)|MI:0492(in vitro) 9169421 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_99482|HPRD_10620 bait|- prey|- SMAD6 WWP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15221015,15359284 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_130315|BIOGRID_197550 bait|prey prey|bait EZR WWP1 MI:0004(affinity chromatography technology) 22629406 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187945 bait prey CLCN5 WWP1 MI:0492(in vitro) 9169421 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_5090 - - AMPKa2 WWP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23293026 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_247913|BIOGRID_247915|BIOGRID_247914|BIOGRID_247916 bait|bait|prey|bait prey|prey|bait|prey PTEN WWP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21532586 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_149758|BIOGRID_149759 bait|bait prey|prey SCNN1A WWP1 MI:0018(two hybrid) 14556380 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_110004 bait prey

PPI - HINT Gene A Gene B PMID Method Quality SMAD7 WWP1 15359284,15221015,22773947 0004,0004,0004 LC LDLRAD4 WWP1 26186194 0004 HT SMAD6 WWP1 15359284,15221015,24850914 0004,0004,0004 LC UBC WWP1 19343052,17013377,19343052,16728642 0096,0004,0004,0004 LC XRCC5 WWP1 26496610,26496610 0007,0004 HT CDK8 WWP1 26496610,26496610 0007,0004 HT PTEN WWP1 21532586,25547115,21532586 0096,0004,0004 LC UBE2L3 WWP1 26152726,25723849,26949039,20951678,17996703,26949039 0096,0096,0114,0096,0096,0096 LC SMAD3 WWP1 15946939,15221015,15359284 0007,0004,0004 LC SMAD4 WWP1 15359284,15946939 0004,0007 LC KLF5 WWP1 22045023,16223724,21487105,16223724,16223724 0004,0004,0004,0415,0096 LC ERBB4 WWP1 19561640,19561640,19047365,19561640 0004,0415,0004,0096 LC SMAD2 WWP1 15359284,15221015,15946939 0004,0004,0007 LC SMAD1 WWP1 15359284,15221015 0004,0004 LC Q7Z4S8 WWP1 26186194 0004 HT SPG20 WWP1 19765186,19765186,19307600,19307600,19580544,19307600 0676,0004,0428,0018,0004,0004 LC Q8WU02 WWP1 26186194 0004 HT TMEM255B WWP1 26186194 0004 HT WBP1 WWP1 26186194 0004 HT WWP1 TP63 18806757,20951678,20951678 0004,0415,0004 LC WWP1 SETD4 26496610,26496610 0007,0004 HT WWP1 TMEM51 26186194 0004 HT WWP1 Q9P0T0 15359284,15221015 0004,0004 LC WWP1 KLF2 15003522,11375995,11375995 0004,0018,0004 LC WWP1 Q9Y6J7 26186194 0004 HT LDLRAD4 WWP1 26186194 0004 HT XRCC5 WWP1 26496610,26496610 0007,0004 HT CDK8 WWP1 26496610,26496610 0007,0004 HT Q7Z4S8 WWP1 26186194 0004 HT Q8WU02 WWP1 26186194 0004 HT TMEM255B WWP1 26186194 0004 HT WBP1 WWP1 26186194 0004 HT WWP1 SETD4 26496610,26496610 0007,0004 HT WWP1 TMEM51 26186194 0004 HT WWP1 Q9Y6J7 26186194 0004 HT SMAD7 WWP1 15359284,15221015,22773947 0004,0004,0004 LC SMAD6 WWP1 15359284,15221015,24850914 0004,0004,0004 LC UBC WWP1 19343052,17013377,19343052,16728642 0096,0004,0004,0004 LC PTEN WWP1 21532586,25547115,21532586 0096,0004,0004 LC UBE2L3 WWP1 26152726,25723849,26949039,20951678,17996703,26949039 0096,0096,0114,0096,0096,0096 LC SMAD3 WWP1 15946939,15221015,15359284 0007,0004,0004 LC SMAD4 WWP1 15359284,15946939 0004,0007 LC KLF5 WWP1 22045023,16223724,21487105,16223724,16223724 0004,0004,0004,0415,0096 LC ERBB4 WWP1 19561640,19561640,19047365,19561640 0004,0415,0004,0096 LC SMAD2 WWP1 15359284,15221015,15946939 0004,0004,0007 LC SMAD1 WWP1 15359284,15221015 0004,0004 LC SPG20 WWP1 19765186,19765186,19307600,19307600,19580544,19307600 0676,0004,0428,0018,0004,0004 LC WWP1 TP63 18806757,20951678,20951678 0004,0415,0004 LC WWP1 Q9P0T0 15359284,15221015 0004,0004 LC WWP1 KLF2 15003522,11375995,11375995 0004,0018,0004 LC PHF20L1 WWP1 21988832 0397 HT WASL WWP1 23414517 0399 HT HSPB1 WWP1 25277244 0097 LC HSP90AB1 WWP1 22939624 0729 HT UBC WWP1 25723849 0415 LC PYGM WWP1 23414517 0399 HT SCNN1A WWP1 14556380 0018 LC STAT6 WWP1 20211142 0018 HT ATN1 WWP1 9647693,16713569 0018,0018 LC,HT PRKAA2 WWP1 23293026,23293026,23293026 0004,0096,0018 LC PCBD1 WWP1 20211142 0018 HT UBE2L3 WWP1 26949039,26949039 0114,0096 LC SMAD3 WWP1 25416956,25416956,25416956 1112,0397,1356 HT EWSR1 WWP1 16189514,16189514 0398,0018 HT LAPTM5 WWP1 15231748 0018 HT KLF5 WWP1 20694673,16223724,16223724,16223724 0415,0004,0415,0096 LC ZNF638 WWP1 16189514,16189514 0398,0018 HT DAZAP2 WWP1 16189514,16189514 0398,0018 HT ERBB4 WWP1 19561640,19561640,19561640 0004,0415,0096 LC CPSF6 WWP1 16189514,16189514,16189514,16189514,19447967,19447967 0398,0096,0018,0004,0018,0398 HT DKFZP781O1323 WWP1 15231748 0018 HT SPG20 WWP1 19307600,19307600,19307600 0428,0018,0004 LC ARRDC1 WWP1 21191027,21191027 0096,0018 LC LZTR1 WWP1 20211142 0018 HT LNX1 WWP1 22087225 0018 LC Q8WU02 WWP1 25416956,25416956,25416956,25416956 0397,1112,0018,1356 HT FBXL18 WWP1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SMAD5 WWP1 15231748 0018 HT DIDO1 WWP1 16189514,16189514 0398,0018 HT TRAF4 WWP1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT WWP1 WWP1 26152726,26949039,17996703,26949039 0415,0415,0415,0114 LC WWP1 TP63 20951678,20951678 0415,0004 LC WWP1 Q9H8G4 21988832 0018 HT WWP1 H2AFY2 21988832,21988832 0397,0018 HT WWP1 Q9P0T0 25416956 0018 HT WWP1 ASH2L 21988832,21988832 0397,0018 HT WWP1 RNF11 15231748 0018 HT WWP1 KLF2 11375995,11375995 0018,0004 LC WWP1 IKBKG 20211142 0018 HT WWP1 HEL-S-102 25277244 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H0M0 Q5JRV8 WWP1 TMEM255A 0.126 26186194 Q9H0M0 Q5T1R4 WWP1 HIVEP3 0.21 16728642 Q9H0M0 P61457 WWP1 PCBD1 0.183 20211142 Q9H0M0 O15165 WWP1 LDLRAD4 0.126 26186194 Q9H0M0 Q8N653 WWP1 LZTR1 0.183 20211142 Q9H0M0 O35182 WWP1 SMAD6 0.126 23455153 Q9H0M0 O14641 WWP1 DVL2 0.454 26701932 Q9H0M0 O15105 WWP1 SMAD7 0.61 15359284,15221015,22773947 Q9H0M0 P12757 WWP1 SKIL 0.21 15221015 Q9H0M0 P11686 WWP1 SFTPC 0.309 19366705 Q9H0M0 O43541 WWP1 SMAD6 0.507 15359284,24850914,15221015 Q9H0M0 P08238 WWP1 HSP90AB1 0.126 22939624 Q9H0M0 P54646 WWP1 PRKAA2 0.702 23293026 Q9H0M0 P54259 WWP1 ATN1 0.539 16713569,9647693 Q9H0M0 P51668 WWP1 UBE2D1 0.309 25723849 Q9H0M0 Q13485 WWP1 SMAD4 0.21 15359284 Q9H0M0 P62837 WWP1 UBE2D2 0.309 25723849 Q9H0M0 P61077 WWP1 UBE2D3 0.309 25723849 Q9H0M0 Q8WU02 WWP1 Q8WU02 0.332 25416956 Q9H0M0 Q81RS1 WWP1 THRC 0.126 20711500 Q9H0M0 Q8N0X7 WWP1 SPG20 0.814 19580544,19307600,19765186 Q9H0M0 Q81SZ0 WWP1 FER 0.126 20711500 Q9H0M0 Q96D16 WWP1 FBXL18 0.332 25416956 Q9H0M0 Q99717 WWP1 SMAD5 0.472 15231748,15221015 Q9H469 Q9H0M0 FBXL15 WWP1 0.376 21572392 Q9Y5W3 Q9H0M0 KLF2 WWP1 0.569 15003522,11375995 Q9P0M6 Q9H0M0 H2AFY2 WWP1 0.286 21988832 Q9H0M0 Q8TBB1 WWP1 LNX1 0.309 22087225 Q9H0M0 Q8TBH0 WWP1 ARRDC2 0.309 21191027 Q9NW97 Q9H0M0 TMEM51 WWP1 0.126 26186194 Q9H0M0 P07900 WWP1 HSP90AA1 0.126 22939624 Q9Y6K9 Q9H0M0 IKBKG WWP1 0.183 20211142 Q9Y4K3 Q9H0M0 TRAF6 WWP1 0.21 23799152 Q9H0M0 P11217 WWP1 PYGM 0.126 23414517 Q9H0M0 P13285 WWP1 LMP2 0.126 22810586 Q9NVD3 Q9H0M0 SETD4 WWP1 0.236 26496610 Q9UBL3 Q9H0M0 ASH2L WWP1 0.286 21988832 Q9H0M0 P04792 WWP1 HSPB1 0.286 25277244 Q9H0M0 Q96G27 WWP1 WBP1 0.396 9169421,26186194 Q9H0M0 P13010 WWP1 XRCC5 0.236 26496610 Q9H0M0 P0CG48 WWP1 UBC 0.454 19343052,25723849 Q9H0M0 Q16630 WWP1 CPSF6 0.61 19447967,16189514 Q9NQC3 Q9H0M0 RTN4 WWP1 0.454 19035836 Q9Y3C5 Q9H0M0 RNF11 WWP1 0.826 15231748,18724389 Q9H0M0 Q9D287 WWP1 BCAS2 0.236 26496610 Q9H0M0 Q15884 WWP1 FAM189A2 0.286 25416956,26186194 Q9H0M0 P49336 WWP1 CDK8 0.236 26496610 Q9H0M0 Q8BUN5 WWP1 SMAD3 0.236 26496610 Q9H0M0 P60484 WWP1 PTEN 0.376 21532586,25547115 Q9H3D4 Q9H0M0 TP63 WWP1 0.569 18806757,20951678 Q9H0M0 Q9H0M0 WWP1 WWP1 0.702 26152726,26949039,17996703 Q9H0M0 Q9BUZ4 WWP1 TRAF4 0.454 25416956 Q9H0M0 Q8N5I2 WWP1 ARRDC1 0.636 21191027,unassigned1304 Q9H0M0 P84022 WWP1 SMAD3 0.826 25416956,unassigned1304,15221015,25910212,15359284 Q9H0M0 P68036 WWP1 UBE2L3 0.843 26152726,26949039,20951678,17996703,25723849 Q9H0M0 Q92731 WWP1 ESR2 0.376 21487105 Q9H0M0 P37088 WWP1 SCNN1A 0.309 14556380 Q9H0M0 Q8WV15 WWP1 TMEM255B 0.126 26186194 Q9H0M0 Q969T9 WWP1 WBP2 0.309 9169421 Q9H0M0 Q96B67 WWP1 ARRDC3 0.472 unassigned1304,21191027 Q9H0M0 Q8ZD41 WWP1 AROC 0.126 20711500 Q9H0M0 Q96J02 WWP1 ITCH 0.126 26508657 Q9H0M0 Q9BTC0 WWP1 DIDO1 0.286 16189514 Q9H0M0 Q99732 WWP1 LITAF 0.21 25963657 Q9H0M0 P27348 WWP1 YWHAQ 0.183 15161933 Q9QR71 Q9H0M0 ORF73 WWP1 0.183 22379092 Q9H0M0 P46531 WWP1 NOTCH1 0.396 16785210 Q9H0M0 Q13571 WWP1 LAPTM5 0.332 15231748 Q9H0M0 Q13635 WWP1 PTCH1 0.21 25092867 Q9H0M0 P81408 WWP1 FAM189B 0.126 26186194 Q9H0M0 Q13887 WWP1 KLF5 0.837 21487105,20694673,16223724,22045023 Q9H0M0 Q13950 WWP1 RUNX2 0.376 16728642 Q9H0M0 F7C846 WWP1 F7C846 0.126 26496610 Q9H0M0 Q14966 WWP1 ZNF638 0.286 16189514 Q9H0M0 Q15038 WWP1 DAZAP2 0.286 16189514 Q9H0M0 P42226 WWP1 STAT6 0.183 20211142 Q9H0M0 Q15303 WWP1 ERBB4 0.765 19561640,19047365 Q9H0M0 Q01844 WWP1 EWSR1 0.286 16189514 Q9H0M0 Q15796 WWP1 SMAD2 0.376 15221015,15359284 Q9H0M0 Q15797 WWP1 SMAD1 0.376 15221015,15359284 Q9H0M0 Q02843 WWP1 GAG 0.309 15163754 Q9H0M0 Q15910 WWP1 EZH2 0.126 24457600 Q9H0M0 O00401 WWP1 WASL 0.236 23414517 Q9H0M0 Q07279 WWP1 NFE2 0.309 9753456 Q9H0M0 P15311 WWP1 EZR 0.21 22629406 Q9H0M0 A8MW92 WWP1 PHF20L1 0.286 21988832

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PHF20L1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database SGK1 WWP1 MI:0362 inference MI:1106 pathways database WASL WWP1 MI:0045 experimental interaction detection MI:0461 interaction database DVL2 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database TCERG1 WWP1 MI:0362 inference MI:0461 interaction database SMAD7 WWP1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database LDLRAD4 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database AXIN1 WWP1 MI:0362 inference MI:0461 interaction database PDPK1 WWP1 MI:0362 inference MI:0461 interaction database SMAD6 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database LDB2 WWP1 MI:0362 inference MI:0461 interaction database SGTA WWP1 MI:0362 inference MI:0461 interaction database BCAS2 WWP1 MI:0362 inference MI:0461 interaction database CCNB2 WWP1 MI:0362 inference MI:0461 interaction database MLYCD WWP1 MI:0362 inference MI:0461 interaction database LATS1 WWP1 MI:0362 inference MI:0461 interaction database RAF1 WWP1 MI:0362 inference MI:1106 pathways database HSPB1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database UBB WWP1 MI:0362 inference MI:1106 pathways database UBC WWP1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PYGM WWP1 MI:0045 experimental interaction detection MI:0461 interaction database SFTPC WWP1 MI:0045 experimental interaction detection MI:0461 interaction database SKIL WWP1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database XRCC5 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database CCNB1 WWP1 MI:0362 inference MI:0461 interaction database EZR WWP1 MI:0045 experimental interaction detection MI:0461 interaction database CBL WWP1 MI:0362 inference MI:0461 interaction database YWHAQ WWP1 MI:0045 experimental interaction detection MI:0461 interaction database YWHAB WWP1 MI:0362 inference MI:0461 interaction database HOXD12 WWP1 MI:0362 inference MI:0461 interaction database TGFBR1 WWP1 MI:0362 inference MI:1106 pathways database SCNN1A WWP1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TGFBR2 WWP1 MI:0362 inference MI:1106 pathways database STAT6 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database NOTCH1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database NEDD4 WWP1 MI:0362 inference MI:0461 interaction database CDK8 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database DNM2 WWP1 MI:0362 inference MI:0461 interaction database SCNN1B WWP1 MI:0362 inference MI:1106 pathways database SCNN1G WWP1 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database SCNN1D WWP1 MI:0362 inference MI:1106 pathways database UBE2D1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database NUDT6 WWP1 MI:0362 inference MI:0461 interaction database ATN1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database PRKAA2 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database PTEN WWP1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database PCBD1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database RPS27A WWP1 MI:0362 inference MI:1106 pathways database UBA52 WWP1 MI:0362 inference MI:1106 pathways database YWHAZ WWP1 MI:0362 inference MI:0461 interaction database UBE2L3 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database FAM189B WWP1 MI:0045 experimental interaction detection MI:0461 interaction database SMAD3 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database EWSR1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database NOTCH2 WWP1 MI:0362 inference MI:0461 interaction database DNM1 WWP1 MI:0362 inference MI:0461 interaction database SMAD4 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database MTX1 WWP1 MI:0362 inference MI:0461 interaction database LAPTM5 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database PTCH1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database KLF5 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database RUNX2 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database ZNF638 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database LAPTM4A WWP1 MI:0362 inference MI:0461 interaction database DAZAP2 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database ERBB4 WWP1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PTPN14 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database SMAD2 WWP1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SMAD1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database FAM189A2 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database EZH2 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database CDC37 WWP1 MI:0362 inference MI:0461 interaction database NFE2 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database CPSF6 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database TMEM255A WWP1 MI:0045 experimental interaction detection MI:0461 interaction database HIVEP3 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database LARP4 WWP1 MI:0362 inference MI:0461 interaction database LDB1 WWP1 MI:0362 inference MI:0461 interaction database DTX2 WWP1 MI:0362 inference MI:0461 interaction database LAPTM4B WWP1 MI:0362 inference MI:0461 interaction database DTX1 WWP1 MI:0362 inference MI:0461 interaction database HID1 WWP1 MI:0362 inference MI:0461 interaction database SPG20 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database ARRDC1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database LZTR1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database LNX1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database ARRDC2 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database TMEM255B WWP1 MI:0045 experimental interaction detection MI:0461 interaction database ESR2 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database WBP2 WWP1 MI:0362 inference MI:0461 interaction database ARRDC3 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database SGK3 WWP1 MI:0362 inference MI:1106 pathways database SGTB WWP1 MI:0362 inference MI:0461 interaction database WBP1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database SUCLG2 WWP1 MI:0362 inference MI:0461 interaction database ITCH WWP1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FBXL18 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database NEDD4L WWP1 MI:0362 inference MI:0461 interaction database TSC22D3 WWP1 MI:0362 inference MI:1106 pathways database SMAD5 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database LITAF WWP1 MI:0045 experimental interaction detection MI:0461 interaction database DIDO1 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database PI4K2A WWP1 MI:0362 inference MI:0461 interaction database TRAF4 WWP1 MI:0045 experimental interaction detection MI:0461 interaction database KATNB1 WWP1 MI:0362 inference MI:0461 interaction database MAP1LC3B WWP1 MI:0362 inference MI:0461 interaction database WWP1 TP63 MI:0045 experimental interaction detection MI:0461 interaction database WWP1 PTPN23 MI:0362 inference MI:0461 interaction database WWP1 FBXL15 MI:0045 experimental interaction detection MI:0461 interaction database WWP1 MAP1LC3A MI:0362 inference MI:0461 interaction database WWP1 SMURF2 MI:0362 inference MI:1106 pathways database WWP1 SGK2 MI:0362 inference MI:1106 pathways database WWP1 SMURF1 MI:0362 inference MI:1106 pathways database WWP1 RTN4 MI:0045 experimental interaction detection MI:0461 interaction database WWP1 SETD4 MI:0045 experimental interaction detection MI:0461 interaction database WWP1 TMEM51 MI:0045 experimental interaction detection MI:0461 interaction database WWP1 H2AFY2 MI:0045 experimental interaction detection MI:0461 interaction database WWP1 ASH2L MI:0045 experimental interaction detection MI:0461 interaction database WWP1 CBLC MI:0362 inference MI:0461 interaction database WWP1 NOTCH3 MI:0362 inference MI:0461 interaction database WWP1 DNM3 MI:0362 inference MI:0461 interaction database WWP1 DTX4 MI:0362 inference MI:0461 interaction database WWP1 RNF11 MI:0045 experimental interaction detection MI:0461 interaction database WWP1 TRAF6 MI:0045 experimental interaction detection MI:0461 interaction database WWP1 KLF2 MI:0045 experimental interaction detection MI:0461 interaction database WWP1 IKBKG MI:0045 experimental interaction detection MI:0461 interaction database