PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SRPK2 DAW1 23602568 biogrid,intact exp P P P P P G P GP DAW1 SRPK1 23602568 biogrid,intact exp P P P P P P GP P P P P P GP CTNNB1 DAW1 ortho P P P P P P GP P P P P P GP FLOT2 DAW1 ortho P P P P P P GP P P P P P GP DAW1 FTMT ortho P P P P P P P P P P P P ITGA6 DAW1 ortho P P P P P P GP P P P P P GP ADRBK1 DAW1 23023127 pred P P P P P P GP P P P P P GP GNG2 DAW1 23023127 pred P P P P GP P P P GP GNGT1 DAW1 23023127 pred P P P P GNB5 DAW1 23023127 pred P P P P P P GP P P P P GP RGS9 DAW1 23023127 pred G PAFAH1B1 DAW1 23023127 pred P P P P P P GP P P P P P GP ARPC4 DAW1 23023127 pred G G WDR5B DAW1 23023127 pred P P P P P P GP P P P GP PDC DAW1 23023127 pred P P P P P P P P P P P GNA14 DAW1 23023127 pred P P P P P P GP P P P GP GNAT1 DAW1 23023127 pred GNAL DAW1 23023127 pred P P P P P P P P P P P P GP GNAI1 DAW1 23023127 pred P P P P P P GP P P P P P GP GNB1 DAW1 23023127 pred P P P P P GP P P P GP GNAZ DAW1 23023127 pred P P P P P GP P P P GP GNAI3 DAW1 23023127 pred P P P P GP P P GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8N136 P78362-2 enzymatic study 23602568 direct interaction X 2 Q8N136 A0A024R3Z2 affinity chromatography technology 17549794 physical association X 2 Q8N136 Q92630-2 affinity chromatography technology 19287380 physical association X 2 Q8N136 Q96SB4 enzymatic study 23602568 direct interaction X 2 Q8N136 A0A024R704 protein kinase assay 23602568 phosphorylation reaction X 2 Q8N136 Q96SB4 protein kinase assay 23602568 phosphorylation reaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SUMO1 WDR69 MI:0004(affinity chromatography technology) 17549794 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_134436 bait prey WDR69 DYRK2 MI:0004(affinity chromatography technology) 19287380 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_149578 prey bait NRF1 WDR69 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295447 bait prey SRPK2 WDR69 MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 23602568 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0217(phosphorylation reaction)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_128948|BIOGRID_291425 neutral component|bait neutral component|prey WDR69 SRPK1 MI:0676(tandem affinity purification)|MI:0004(affinity chromatography technology) 23602568 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0217(phosphorylation reaction)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_129136|BIOGRID_291589 neutral component|prey neutral component|bait

PPI - HINT Gene A Gene B PMID Method Quality SRPK2 DAW1 23602568,23602568 0415,0424 LC DAW1 SRPK1 23602568,23602568 0415,0424 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96SB4 Q8N136 SRPK1 DAW1 0.21 23602568 Q8N136 P78362 DAW1 SRPK2 0.21 23602568

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 CTNNB1 DAW1 MI:0362 inference MI:0461 interaction database SUMO1 DAW1 MI:0045 experimental interaction detection MI:0461 interaction database SRPK2 DAW1 MI:0045 experimental interaction detection MI:0461 interaction database DAW1 DYRK2 MI:0045 experimental interaction detection MI:0461 interaction database DAW1 SRPK1 MI:0045 experimental interaction detection MI:0461 interaction database