PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus EML2 EXD1 25416956 biogrid,intact exp P P P P P P P P P P P P P P P P GP EML2 TUBB2A 26186194 biogrid exp GP GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP G G GP GP GP G G EML2 NHP2L1 26344197 biogrid exp GP GP G G G GP G GP GP G GP GP G G G GP GP G GP G GP GP GP G GP G GP GP G EML2 TTC38 26344197 biogrid exp G GP P P GP GP GP GP G GP G GP P G GP G P GP GP GP GP GP GP P EML2 GNAS 26344197 biogrid exp G G G G G G G G GP G G G G G G GP G G GP G G G G G GP G G G G EML2 NEK6 17353931 biogrid,intact exp GP G G G GP GP G GP G G GP G GP G G GP GP G GP G GP GP GP GP G GP GP G EML2 ELAVL1 19322201 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G EML2 TUBA1C 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G EML2 REL 25416956 biogrid,intact exp GP G G G GP GP G G GP G GP G GP GP G GP GP G GP G P GP GP G GP GP GP GP G EML2 TUBB2B 26186194 biogrid exp P P G P GP G GP G GP P P P G GP GP GP G GP GP GP P GP P G EML2 YWHAE ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G GRID2 EML2 25402006 ortho, pred G G G GP G GP P P P GP G GP G P P G P P GP G EML2 GRID1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G EML2 COL2A1 23023127 pred G G G P P P G G P GP G G EML2 PDC 23023127 pred P P P P P P P P P P P P P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants O95834 A0A024R8A6 anti bait coimmunoprecipitation 17353931 physical association X 2 O95834 Q04864 two hybrid prey pooling approach 25416956 physical association X 2 O95834 Q04864 two hybrid array 25416956 physical association X 2 O95834 Q04864 validated two hybrid 25416956 physical association X 2 Q8NHP7 O95834 two hybrid prey pooling approach 25416956 physical association X 2 Q8NHP7 O95834 two hybrid array 25416956 physical association X 2 Q8NHP7 O95834 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B EML2 NEK6 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_149619|BIOGRID_82848 prey|prey bait|bait EML2 UBC MI:0004(affinity chromatography technology) 21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_180900 prey bait EML2 ELAVL1 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187607 prey bait EML2 SUMO2 MI:0004(affinity chromatography technology) 21693764 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_165918 prey bait

PPI - HINT Gene A Gene B PMID Method Quality EML2 TUBB2A 26186194 0004 HT EML2 GNAS 26344197 0401 HT EML2 TTC38 26344197 0401 HT EML2 NHP2L1 26344197 0401 HT EML2 TUBA1C 26496610,26496610 0007,0004 HT EML2 TUBB2B 26186194 0004 HT EML2 NEK6 17353931,17353931 0006,0004 HT EML2 TUBB2A 26186194 0004 HT EML2 GNAS 26344197 0401 HT EML2 TTC38 26344197 0401 HT EML2 NHP2L1 26344197 0401 HT EML2 TUBA1C 26496610,26496610 0007,0004 HT EML2 TUBB2B 26186194 0004 HT EML2 NEK6 17353931,17353931 0006,0004 HT EML2 EML2 25740311 0114 LC EML2 REL 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT EML2 GNAS 26344197 0401 LC EML2 TTC38 26344197 0401 LC EML2 NHP2L1 26344197 0401 LC EML2 EXD1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5JWF2 O95834 GNAS EML2 0.081 26344197 Q04864 O95834 REL EML2 0.454 25416956 Q9HC98 O95834 NEK6 EML2 0.236 17353931 Q8NHP7 O95834 EXD1 EML2 0.454 25416956 O95834 O95467 EML2 GNAS 0.081 26344197 Q5R3I4 O95834 TTC38 EML2 0.081 26344197 Q32P44 O95834 EML3 EML2 0.21 25740311 Q8K1R7 O95834 NEK9 EML2 0.236 26496610 Q9BQE3 O95834 TUBA1C EML2 0.126 26496610 Q9BVA1 O95834 TUBB2B EML2 0.126 26186194 Q13885 O95834 TUBB2A EML2 0.126 26186194 P84996 O95834 GNAS EML2 0.081 26344197 P63092 O95834 GNAS EML2 0.081 26344197 Q15717 O95834 ELAVL1 EML2 0.126 19322201 P55769 O95834 NHP2L1 EML2 0.081 26344197

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 GRID2 EML2 MI:0362 inference MI:0461 interaction database EML2 UBC MI:0045 experimental interaction detection MI:0461 interaction database EML2 SUMO2 MI:0045 experimental interaction detection MI:0461 interaction database EML2 REL MI:0045 experimental interaction detection MI:0461 interaction database EML2 TUBB2A MI:0045 experimental interaction detection MI:0461 interaction database EML2 ELAVL1 MI:0045 experimental interaction detection MI:0461 interaction database EML2 EML3 MI:0045 experimental interaction detection MI:0461 interaction database EML2 EXD1 MI:0045 experimental interaction detection MI:0461 interaction database EML2 NEK9 MI:0362 inference MI:0461 interaction database EML2 TUBA1C MI:0045 experimental interaction detection MI:0461 interaction database EML2 TUBB2B MI:0045 experimental interaction detection MI:0461 interaction database EML2 NEK6 MI:0045 experimental interaction detection MI:0461 interaction database