PTM - CPLM Gene Name UniProt ID Type Position Code TRAF2; TRAP3 Q12933 Ubiquitination 21 K TRAF2; TRAP3 Q12933 Ubiquitination 140 K TRAF2; TRAP3 Q12933 Ubiquitination 255 K TRAF2; TRAP3 Q12933 Ubiquitination 313 K TRAF2; TRAP3 Q12933 Ubiquitination 320 K TRAF2; TRAP3 Q12933 Ubiquitination 331 K TRAF2; TRAP3 Q12933 Ubiquitination 481 K TRAF2; TRAP3 Q12933 Ubiquitination 119 K TRAF2; TRAP3 Q12933 Ubiquitination 27 K TRAF2; TRAP3 Q12933 Ubiquitination 176 K TRAF2; TRAP3 Q12933 Ubiquitination 231 K TRAF2; TRAP3 Q12933 Ubiquitination 201 K TRAF2; TRAP3 Q12933 Ubiquitination 207 K TRAF2; TRAP3 Q12933 Ubiquitination 278 K TRAF2; TRAP3 Q12933 Ubiquitination 31 K

PTM - dbPAF Gene Name UniProt ID Position Type Species TRAF2; TRAP3 Q12933 102 S Homo sapiens(Human) TRAF2; TRAP3 Q12933 11 S Homo sapiens(Human) TRAF2; TRAP3 Q12933 117 T Homo sapiens(Human) TRAF2; TRAP3 Q12933 121 Y Homo sapiens(Human) TRAF2; TRAP3 Q12933 20 S Homo sapiens(Human) TRAF2; TRAP3 Q12933 22 T Homo sapiens(Human) TRAF2; TRAP3 Q12933 26 T Homo sapiens(Human) TRAF2; TRAP3 Q12933 274 S Homo sapiens(Human) TRAF2; TRAP3 Q12933 401 T Homo sapiens(Human) TRAF2; TRAP3 Q12933 431 T Homo sapiens(Human) TRAF2; TRAP3 Q12933 5 S Homo sapiens(Human) TRAF2; TRAP3 Q12933 55 S Homo sapiens(Human) TRAF2; TRAP3 Q12933 7 T Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q12933 S5-p Phosphorylation ___MAAAsVtPPGsL Q12933 T7-p Phosphorylation _MAAAsVtPPGsLEL Q12933 S11-p Phosphorylation AsVtPPGsLELLQPG Q12933 T22-p Phosphorylation LQPGFSKtLLGtkLE Q12933 T26-p Phosphorylation FSKtLLGtkLEAKYL Q12933 S55-p Phosphorylation QCGHRYCsFCLASIL Q12933 S102-p Phosphorylation AARREVEsLPAVCPS Q12933 T117-p Phosphorylation DGCTWKGtLKEyEsC Q12933 Y121-p Phosphorylation WKGtLKEyEsCHEGR Q12933 S123-p Phosphorylation GtLKEyEsCHEGRCP Q12933 S160-p Phosphorylation EHECPERsLSCRHCR Q12933 S274-p Phosphorylation ELLQRCEsLEKKTAT Q12933 T401-p Phosphorylation IYLNGDGtGRGTHLS Q12933 T431-p Phosphorylation WPFNQKVtLMLLDQN Q12933 K27-ub Ubiquitination SKtLLGtkLEAKYLC Q12933 K140-ub Ubiquitination LTECPACkGLVRLGE Q12933 K176-ub Ubiquitination PCCGADVkAHHEVCP Q12933 K255-ub Ubiquitination LSSVLEAkPLLGDQS Q12933 K313-ub Ubiquitination QHRLDQDkIEALSSk Q12933 K320-ub Ubiquitination kIEALSSkVQQLERS Q12933 K331-ub Ubiquitination LERSIGLkDLAMADL Q12933 K481-ub Ubiquitination PVSKMEAkNSYVRDD

PTM - dbPTM UniProt ID Position Code Type Resources References Q12933 2 A Acetylation Swiss-Prot 1010711 19413330 Q12933 7 T Phosphorylation Swiss-Prot 1010711 19369195 Q12933 11 S Phosphorylation Swiss-Prot 1010711 18981220;19369195 Q12933 31 K Ubiquitylation Swiss-Prot 1010711 19150425 Q12933 117 T Phosphorylation Swiss-Prot 1010711 19150425 Q12933 140 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q12933 255 K Ubiquitylation Phosphositeplus.1010730 20972266;21890473;21906983 Q12933 27 K Ubiquitylation Phosphositeplus.1010730 20972266;21906983 Q12933 313 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q12933 320 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q12933 331 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q12933 481 K Ubiquitylation Phosphositeplus.1010730 20972266;21890473;21906983 Q12933 11 S Phosphorylation Phosphositeplus.1010730 18981220;19336568;19369195;20058876;21406692;22115753 Q12933 5 S Phosphorylation Phosphositeplus.1010730 20058876 Q12933 55 S Phosphorylation Phosphositeplus.1010730 19336568 Q12933 117 T Phosphorylation Phosphositeplus.1010730 17188031 Q12933 22 T Phosphorylation Phosphositeplus.1010730 21406692 Q12933 26 T Phosphorylation Phosphositeplus.1010730 21406692 Q12933 7 T Phosphorylation Phosphositeplus.1010730 19369195;21406692;22115753 Q12933 5 S Phosphorylation HPRD 9.0 20058876 Q12933 11 S Phosphorylation HPRD 9.0 17081983,19651622,20068231,20058876 Q12933 20 S Phosphorylation HPRD 9.0 20068231 Q12933 7 T Phosphorylation HPRD 9.0 17081983,19651622,20068231 Q12933 22 T Phosphorylation HPRD 9.0 20068231 Q12933 21 K Ubiquitylation HPRD 9.0 11907583,11909853 Q12933 31 K Ubiquitylation HPRD 9.0 11909853 Q12933 11 S Phosphorylation SysPTM 1.1 17081983 Q12933 7 T Phosphorylation SysPTM 1.1 17081983

PTM - HPRD Symbol Position Code Type References TRAF2 11 S Phosphorylation 17081983,19651622,20068231,20058876 TRAF2 20 S Phosphorylation 20068231 TRAF2 21 K Ubiquitination 11907583,11909853 TRAF2 22 T Phosphorylation 20068231 TRAF2 31 K Ubiquitination 11909853 TRAF2 5 S Phosphorylation 20058876 TRAF2 7 T Phosphorylation 17081983,19651622,20068231

PTM - UniProt UniProt ID Position Type PMIDs Q12933 2 N-acetylalanine 19413330;20068231;21406692 Q12933 5 Phosphoserine 23186163 Q12933 7 Phosphothreonine 21406692;23186163 Q12933 11 Phosphoserine 21406692;23186163;18981220 Q12933 22 Phosphothreonine 21406692 Q12933 117 Phosphothreonine; by PKC 19150425

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type TRAF2 IPI00030278 S 11 SVTPPGpSLELLQP phosphorylation TRAF2 IPI00030278 S 20 LLQPGFpSKTLLGT phosphorylation TRAF2 IPI00030278 T 26 SKTLLGpTKLEAKY phosphorylation TRAF2 IPI00030278 T 7 MAAASVpTPPGSLE phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 7186 113038 - K Ubiquitination 17923499 7186 113038 - K Ubiquitination 16936264 7186 113038 - K Ubiquitination 15861135 7186 113038 - K Ubiquitination 12917690 7186 113038 - K Ubiquitination 12917689 7186 113038 - K Ubiquitination 12591926 7186 113038 - K Ubiquitination 11909853 7186 113038 - K Ubiquitination 17314283 7186 113038 - K Ubiquitination 20577214 7186 113038 - K Ubiquitination 22029577 7186 113038 - K Ubiquitination 19815509 7186 113038 - K Ubiquitination 22179575 7186 113038 - K Ubiquitination 22184250 7186 113038 - K Ubiquitination 22212761 7186 113038 - K Ubiquitination 17851586 7186 113038 - K Ubiquitination 21987572 7186 113038 - K Ubiquitination 20972266 7186 113038 - K Ubiquitination 21078302 7186 113038 - K Ubiquitination 21139048 7186 113038 - K Ubiquitination 21890473 7186 113038 - K Ubiquitination 21906983 7186 113038 - K Ubiquitination 21793045 7186 113038 - K Ubiquitination 19584093 7186 113038 - K Ubiquitination 22550173 7186 113038 - K Ubiquitination 22863753 7186 113038 - K Ubiquitination 23007157 7186 113038 - K Ubiquitination 22505724 7186 113038 - K Ubiquitination 22732732 7186 113038 - K Ubiquitination 23357418 7186 113038 - K Ubiquitination 21963094 7186 113038 - K Ubiquitination 23000965 7186 113038 - K Ubiquitination 23690480 7186 113038 - K Ubiquitination 23319823 7186 113038 - K Ubiquitination 24841215 7186 113038 - K Ubiquitination 25029497 7186 113038 - K Ubiquitination 11907583 7186 113038 - K Ubiquitination 24586810 7186 113038 - K Ubiquitination 21115689 7186 113038 - K Ubiquitination 16378096 7186 113038 - K Ubiquitination 20348096 7186 113038 - K Neddylation 18247557

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID TRAF2 Homo sapiens (Human) 255; 21; 140; 320; 313; 481; 331 "255,SSVLEAKPLLGDQ; 21,LQPGFSKTLLGTK; 140,TECPACKGLVRLG; 320,IEALSSKVQQLER; 313,HRLDQDKIEALSS; 481,VSKMEAKNSYVRD; 331,ERSIGLKDLAMAD" 255:21890473; 21:21890473; 140:21890473; 320:21890473; 313:21890473; 481:21890473; 331:21890473 TRAF2 Homo sapiens (Human) 21; 140 "21,LQPGFSKTLLGTK; 140,TECPACKGLVRLG" 21:21890473; 140:21890473 TRAF2 Homo sapiens (Human) 255; 21; 140; 320; 313; 27; 481; 331 "255,SSVLEAKPLLGDQ; 21,LQPGFSKTLLGTK; 140,TECPACKGLVRLG; 320,IEALSSKVQQLER; 313,HRLDQDKIEALSS; 27,KTLLGTKLEAKYL; 481,VSKMEAKNSYVRD; 331,ERSIGLKDLAMAD" "255:21890473,21906983; 21:21890473; 140:21890473,21906983; 320:21890473,21906983; 313:21890473,21906983; 27:21906983; 481:21890473,21906983; 331:21890473,21906983" TRAF2 Homo sapiens (Human) 533; 372; 307; 21; 365; 27; 383; 192 "533,VSKMEAKNSYVRD; 372,IEALSSKVQQLER; 307,SSVLEAKPLLGDQ; 21,LQPGFSKTLLGTK; 365,HRLDQDKIEALSS; 27,KTLLGTKLEAKYL; 383,ERSIGLKDLAMAD; 192,TECPACKGLVRLG" "533:21890473,21906983; 372:21890473,21906983; 307:21890473,21906983; 21:21890473; 365:21890473,21906983; 27:21906983; 383:21890473,21906983; 192:21890473,21906983" TRAF2 Homo sapiens (Human) 21 "21,LQPGFSKTLLGTK" 21:21890473 TRAF2 Homo sapiens (Human) 252; 21; 234; 402; 27; 192; 241 "252,ERSIGLKDLAMAD; 21,LQPGFSKTLLGTK; 234,KRLDQDKIEALSS; 402,VSKMEAKNSYVRD; 27,KTLLGTKLEAKYL; 192,TECPACKGLVRLG; 241,IEALSSKVQQLER" "252:21906983,21890473; 21:21890473; 234:21906983; 402:21906983,21890473; 27:21906983; 192:21906983,21890473; 241:21906983,21890473" TRAF2 Homo sapiens (Human) 21; 140; 27 "21,LQPGFSKTLLGTK; 140,TECPACKGLVRLG; 27,KTLLGTKLEAKYL" "21:21890473; 140:21906983,21890473; 27:21906983" TRAF2 Homo sapiens (Human) 21; 140; 27 "21,LQPGFSKTLLGTK; 140,TECPACKGLVRLG; 27,KTLLGTKLEAKYL" 21:21890473; 140:21890473; 27:21906983 TRAF2 Homo sapiens (Human) 255; 21; 140; 320; 313; 481; 331 "255,SSVLEAKPLLGDQ; 21,LQPGFSKTLLGTK; 140,TECPACKGLVRLG; 320,IEALSSKVQQLER; 313,HRLDQDKIEALSS; 481,VSKMEAKNSYVRD; 331,ERSIGLKDLAMAD" 255:21890473; 21:21890473; 140:21890473; 320:21890473; 313:21890473; 481:21890473; 331:21890473 TRAF2 Homo sapiens (Human) 140; 27 "140,TECPACKGLVRLG; 27,KTLLGTKLEAKYL" 140:21906983; 27:21906983