PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus USP6 ANKRD44 16555005 hprd,biogrid,intact exp G GP G G G GP G GP GP G G G G G G G GP G GP G G G G G G GP P G USP6 EXOSC8 25416956 biogrid exp G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 ATXN7L3 16713569 hprd,biogrid,mint,intact exp G G G G G GP G G GP G GP GP G G G GP GP G G G G G GP G GP G GP G G USP6 MDFI 19060904 biogrid,intact exp G G G P G P G G P G GP G G G GP P G USP6 CALM1, CALM2, CALM3 16127172 biogrid exp G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 RAC1 12612085 biogrid exp G GP G G G G G G GP G G G G G G GP G G GP G G GP G G GP G GP GP G MYL2 USP6 16555005 hprd,biogrid,intact exp G G G G GP G G G G G G G G G G USP6 ARF6 15509780 biogrid exp G GP G G G GP G G GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G APP USP6 21832049 biogrid exp G GP G G G GP G G GP G G G G G G GP GP G GP G G GP G G GP G G GP G USP6 CDC42 12612085 biogrid exp G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 RAB33B 16923123 biogrid exp G GP G G G G G GP GP G G G G G G G G G G G G G GP G G G GP GP G USP6 USP32 19615732 biogrid,intact exp G GP G G G GP G GP GP G GP GP G G G GP GP G GP G G GP G G GP G GP GP G USP6 AQP5 25402006 pred G G P GP P GP GP GP GP PGLS USP6 25402006 pred G GP G G G GP G GP GP G GP GP G G G GP GP G GP G G GP GP G GP G GP GP G USP6 TBC1D3C 23023127 pred USP6 TIE1 25402006 pred G G G G G G G G G G G G G G G G G G G G USP6 B3GNT9 25402006 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 ENKD1 25402006 pred G GP G P GP GP G GP GP G G G GP P GP GP G G GP GP GP G GP GP G USP6 GRTP1 23023127 pred GP P P GP GP GP G GP P GP P G GP GP G GP G GP GP OTX1 USP6 25402006 pred P G G GP G G G GP G G G P NDUFA7 USP6 25402006 pred G GP G G G GP G GP GP G GP G G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 ZNF707 25402006 pred G GP G G G GP GP P G GP P G G GP GP P P G G P GP G GP GP P G EVI5 USP6 23023127 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 CCDC120 25402006 pred P P P P P P P P G G P P P P P G USP6 CNTN2 21836163 pred P G GP G P G P GP P G P USP6 SLC25A10 25402006 pred G GP P P GP GP GP GP P P GP G GP GP GP GP GP G USP6 RABGAP1L 23023127 pred G GP G G G G GP G GP G G G G GP G GP G G G GP GP G GP GP G USP6 ZNF136 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP6 APLN 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP6 NEU4 25402006 pred P P GP G P G G G P G G G P G P G USP6 TBC1D10C 23023127 pred G G G G G G G G G G G G G USP6 CNNM3 25402006 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 C19orf60 25402006 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP G G G GP GP G GP G GP GP G USP6 IQUB 25402006 pred P P P P GP P P P P P P P P P GP USP6 TBC1D5 23023127 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 SGSM1 23023127 pred GP G GP G GP GP G GP P G G GP GP GP GP G GP P GP GP GP G USP6 C10orf62 25402006 pred GP G G GP GP GP G GP GP GP GP GP G P GP G GP GP GP USP6 TBC1D1 23023127 pred G GP G G G GP G GP GP G GP GP G G G GP GP G GP G G G G G GP G GP GP G ZBTB24 USP6 25402006 pred G GP G G G G G GP GP G GP GP G G G GP G G GP G G GP GP G GP G GP GP USP6 TBCK 23023127 pred G GP G G G GP G G GP G GP G G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 CLPB 25402006 pred P P P P GP GP GP P P P P GP P GP USP6 TBC1D17 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP6 TBC1D24 23023127 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G GP GP G GP G GP P G LRCH4 USP6 25402006 pred G GP G G G G G GP GP G GP G G G G GP G G GP G G GP GP G GP G GP GP G USP6 TBC1D20 23023127 pred G GP G G G GP G GP GP G GP GP G G G GP GP G GP G G GP GP G GP G GP GP G DKK1 USP6 25402006 pred G P G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP P G USP6 EVI5L 23023127 pred G GP G GP G GP GP G GP GP G G G GP GP GP P G G GP GP G GP G GP GP G USP6 DCAF8 25402006 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 CDC16 21836163 pred G GP G G G GP G GP GP G GP GP G G G GP GP G GP G G GP GP G GP G GP GP G USP6 TBC1D8B 23023127 pred G GP G G G GP G GP GP G GP GP G G G GP GP G GP G GP GP G GP G GP GP G USP6 TBC1D3G 23023127 pred USP6 DIDO1 21836163 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 TBC1D16 23023127 pred G GP G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP GP GP G USP6 C5orf30 25402006 pred G GP G G G GP G G GP G GP G G G GP GP G GP G G GP G G GP G GP G G USP6 TBC1D3 23023127 pred USP6 FAM124B 25402006 pred P G G USP6 C8orf48 25402006 pred P P P P P P P P P P P P P GP USP6 TBC1D22A 23023127 pred G GP G G G GP G GP GP G GP G G G G G GP G GP G G G GP G G G G GP G TBC1D8 USP6 23023127 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 DBF4B 25402006 pred P G G G G GP G P G G G G P P P G G USP6 TBC1D9 23023127 pred G GP G G G GP G GP GP G GP G G G G G GP GP GP G G GP GP G G G GP GP G TBC1D12 USP6 23023127 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 PBXIP1 25402006 pred G GP G G G GP G G GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 TBC1D21 23023127 pred G GP G G G GP GP GP G GP GP G G GP GP GP GP G G P GP G GP G GP GP G USP6 CBX2 25402006 pred GP G P G P GP G G TBC1D3F USP6 23023127 pred MYF5 USP6 25402006 pred P P P P P P P P P P P P G P P P TBC1D3H USP6 23023127 pred USP6 TBC1D14 23023127 pred G GP G G G GP G GP GP G GP G G G G GP GP G GP G G GP GP G GP G GP GP G USP6 RABGAP1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP6 TBC1D10A 23023127 pred G GP G G G GP G GP GP G GP GP G G G GP GP G GP G G GP GP GP G GP GP G FOS USP6 21836163 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 SIX1 25402006 pred G G G P G GP GP G G GP TBC1D4 USP6 23023127 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 ZNF670 25402006 pred P P P P P P P P P P P P P P USP6 TBC1D15 23023127 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 USP6NL 23023127 pred G GP P G P G G P GP G GP GP GP P G G GP GP GP G GP GP G TBC1D3B USP6 23023127 pred USP6 C8orf33 25402006 pred G GP G G G GP G GP GP G GP G G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 TBC1D19 23023127 pred P P G P P P P P P P P P P P P P TBC1D3H USP6 23023127 pred USP6 TBC1D25 23023127 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 CDC42EP1 25402006 pred G GP G GP G G GP G GP GP G G G GP GP GP GP G G G GP GP G GP GP G USP6 RABL6 25402006 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 TBC1D7 23023127 pred G GP G G G GP G G G G GP GP G G G GP GP G GP G G GP G G GP G G GP G USP6 TBC1D2 23023127 pred P P G G G G GP P P G P P P USP6 TBC1D22B 23023127 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP GP G USP6 THEG 25402006 pred P P P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P0CG48 P35125 affinity chromatography technology 16127172 physical association X 2 P35125 A4D2P0 pull down 12612085 direct interaction X 2 P35125 A0A024RAE4 pull down 12612085 direct interaction X 2 P35125 Q9H082 two hybrid 16923123 direct interaction X 2 P35125 P62330 affinity chromatography technology 15509780 physical association X 2 P35125 P62330 imaging technique 15509780 colocalization X 2 P35125 P10916 two hybrid 16555005 direct interaction X 2 P35125 two hybrid 16555005 direct interaction X 2 P35125 P10916 pull down 16555005 direct interaction X 2 P35125 pull down 16555005 direct interaction X 2 P35125 P10916 affinity chromatography technology 16555005 physical association X 2 P35125 affinity chromatography technology 16555005 physical association X 2 P35125 Q14CW9 two hybrid 16713569 direct interaction X 2 P35125 A0A024RCY2 two hybrid 19060904 direct interaction X 2 P35125 B4DJ51 affinity chromatography technology 16127172 physical association X 2 P35125 Q96B26 two hybrid 25416956 direct interaction X 2 P35125 B4DJ51 affinity chromatography technology 16127172 physical association X 2 Q8NFA0 P35125 affinity chromatography technology 19615732 physical association X 2 P35125 P05067-7 pull down 21832049 direct interaction X 2 P35125 P10916 in vitro 16555005 - X 2 P35125 P10916 two hybrid 16555005 - X 2 P35125 P10916 in vivo 16555005 - X 2 P35125 P10916 two hybrid 16555005 - X 2 P35125 P10916 in vivo 16555005 - X 2 P35125 P10916 in vitro 16555005 - X 2 P35125 in vivo 16555005 - X 2 P35125 two hybrid 16555005 - X 2 P35125 in vitro 16555005 - X 2 P35125 Q14CW9 two hybrid 16713569 - X 2 P35125 Q14CW9 two hybrid 16713569 - X 2 P35125 in vivo 16555005 - X 2 P35125 in vitro 16555005 - X 2 P35125 two hybrid 16555005 - X 2 P35125 Q8N8A2 two hybrid 16555005 physical association X 2 P35125 Q14CW9 two hybrid array 16713569 physical association X 2 P35125 A0A024RCY2 two hybrid array 19060904 physical association X 2 P35125 A0A024RCY2 two hybrid pooling approach 19060904 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B USP6 USP32 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120009|UniProt_100693 prey|prey bait|bait USP6 ANKRD44 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid) 16555005 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0403(colocalization) (intact)|(biogrid)|(intact)|(biogrid)|(intact)|(biogrid)|MI:0468(hprd)|(intact)|(intact) UniProt_83972|BIOGRID_210023|UniProt_83974|BIOGRID_210025|UniProt_83976|BIOGRID_210027|HPRD_31608|UniProt_83977|UniProt_83980 bait|bait|null|prey|null|prey|-|null|null prey|prey|bait|bait|bait|bait|-|prey|neutral component USP6 CALM1 MI:0096(pull down)|MI:0096(pull down) 16127172 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_126477|BIOGRID_126478 bait|bait prey|prey USP6 ARF6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 15509780 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid) BIOGRID_209950|BIOGRID_209951 bait|prey prey|bait USP6 MDFI MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0018(two hybrid) 19060904 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_99437|UniProt_97262|BIOGRID_262404 bait|bait|bait prey|prey|prey USP6 RAC1 MI:0096(pull down) 12612085 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_189079 prey bait USP6 CDC42 MI:0096(pull down) 12612085 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_189080 prey bait APP USP6 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_228869 prey bait USP6 RAB33B MI:0018(two hybrid) 16923123 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_209803 bait prey MYL2 USP6 MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16555005 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|MI:0468(hprd)|(intact)|(biogrid)|(intact)|(biogrid)|(intact)|(intact)|(intact) BIOGRID_210022|HPRD_31607|UniProt_83971|BIOGRID_210024|UniProt_83973|BIOGRID_210026|UniProt_83975|UniProt_83978|UniProt_83979 prey|-|prey|bait|bait|bait|prey|bait|neutral component bait|-|null|prey|null|prey|null|null|null UBC USP6 MI:0096(pull down) 16127172 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_126479 prey bait USP6 ATXN7L3 MI:0018(two hybrid)|MI:0397(two hybrid array)|MI:0096(pull down)|MI:0096(pull down)|MI:0018(two hybrid) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|- (biogrid)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0468(hprd) BIOGRID_215320|UniProt_85885|MINT_82708|MINT_50420|HPRD_34026 prey|prey|prey|prey|- bait|bait|bait|bait|-

PPI - HINT Gene A Gene B PMID Method Quality USP6 USP32 19615732,19615732 0004,0007 HT USP6 USP32 19615732,19615732 0004,0007 HT MYL2 USP6 16555005,16555005,16555005,16555005,16555005 0018,0007,0096,0663,0004 LC USP6 ATXN7L3 16713569,16713569 0397,0018 HT USP6 ANKRD44 16555005,16555005,16555005,16555005,16555005 0018,0007,0096,0663,0004 LC USP6 EXOSC8 25416956 0018 HT USP6 MDFI 19060904,19060904,19060904 0018,0397,0398 HT USP6 RAB33B 16923123 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P60953 P35125 CDC42 USP6 0.309 12612085 Q8N8A2 P35125 ANKRD44 USP6 0.876 16555005 Q8NFA0 P35125 USP32 USP6 0.236 19615732 Q99750 P35125 MDFI USP6 0.376 19060904 P35125 P10916 USP6 MYL2 0.858 16555005 P35125 P05067 USP6 APP 0.183 21832049 P62158 P35125 CALM3 USP6 0.569 16127172 P62330 P35125 ARF6 USP6 0.309 15509780 Q14CW9 P35125 ATXN7L3 USP6 0.376 16713569 Q96B26 P35125 EXOSC8 USP6 0.183 25416956 Q9H082 P35125 RAB33B USP6 0.309 16923123 P63000 P35125 RAC1 USP6 0.309 12612085

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 APP USP6 MI:0045 experimental interaction detection MI:0461 interaction database UBC USP6 MI:0045 experimental interaction detection MI:0461 interaction database MYL2 USP6 MI:0045 experimental interaction detection MI:0461 interaction database PSMB1 USP6 MI:0362 inference MI:0461 interaction database PSMB4 USP6 MI:0362 inference MI:0461 interaction database USP6 CDC42 MI:0045 experimental interaction detection MI:0461 interaction database USP6 CALM1 MI:0045 experimental interaction detection MI:0461 interaction database USP6 ARF6 MI:0045 experimental interaction detection MI:0461 interaction database USP6 RAC1 MI:0045 experimental interaction detection MI:0461 interaction database USP6 ATXN7L3 MI:0045 experimental interaction detection MI:0461 interaction database USP6 ANKRD44 MI:0045 experimental interaction detection MI:0461 interaction database USP6 USP32 MI:0045 experimental interaction detection MI:0461 interaction database USP6 EXOSC8 MI:0045 experimental interaction detection MI:0461 interaction database USP6 MDFI MI:0045 experimental interaction detection MI:0461 interaction database USP6 RAB33B MI:0045 experimental interaction detection MI:0461 interaction database USP6 RUVBL1 MI:0362 inference MI:0461 interaction database