PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus BLM TEP1 19329795 biogrid exp GP GP G G P G GP GP G GP GP GP GP G GP P GP P G GP G GP G GP G GP P MVP TEP1 10551828 biogrid exp GP GP G G P G G GP G GP GP GP GP G GP P GP P G GP G GP G GP G GP P ATN1 TEP1 16713569 hprd,biogrid,mint,intact exp GP GP G G P G GP GP G GP GP G G G GP P GP P G GP G GP G GP G GP P TROVE2 TEP1 22939629 biogrid exp G GP G G P G GP G G GP GP GP G G GP P G P G GP G GP G GP G GP P TEP1 PARP4 15169895 biogrid exp GP GP G G P G GP GP G GP GP GP GP G GP P GP P G GP G GP G GP G GP P PRKCA TEP1 9837921 hprd,bci exp G GP G G P G GP GP G GP G G GP G GP P G P G GP G G G GP G GP P TIRAP TEP1 26186194 biogrid exp G GP G G P G GP GP G GP G G G G GP P GP P G GP G GP G GP G GP P TERT TEP1 9389643,11029039, 25402006, 21836163 hprd,biogrid,bci exp, pred G G G G G G G TERF2 TEP1 19329795, 21836163 biogrid exp, pred GP GP G G P G GP GP G GP GP GP GP G GP P GP P G GP G GP G GP G GP P TP53 TEP1 10597287, 21836163 hprd,biogrid,bci exp, pred G G G G G G G G G G G G G GP G G GP G G G GP G G P YWHAE TEP1 ortho GP GP G G P G GP GP G GP GP GP GP G GP P GP P G GP G GP G GP G GP P BCL10 TEP1 16082366 pred GP GP G G P G GP GP G GP GP GP GP G GP P GP P G GP G GP G GP G GP P TEP1 TERF2IP 21836163 pred GP GP G G P G G GP G GP GP GP GP G GP P GP P G GP G GP G GP G GP P NBN TEP1 21836163 pred GP GP G G P G GP GP G GP GP GP GP G GP P GP P G GP G GP G GP G GP P TEP1 TNKS2 21836163 pred G G G G G G G G GP G G G G G G P G G G G G G G G TRAF2 TEP1 21836163 pred P P P P P P P P P P P P P P P P G GP P MED6 TEP1 21836163 pred GP GP P P GP GP GP GP GP G GP P GP P G GP G P G P G GP P TEP1 NOP10 21836163 pred GP GP G G P G GP GP G GP GP GP GP G GP P GP P G G G GP G GP G GP P TEP1 SMG5 21836163 pred G G G G G G G G G G G G G G G G G G G G G TEP1 POT1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G TEP1 TINF2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G TEP1 SWAP70 23023127 pred GP GP G G P G G GP G GP GP GP GP G GP P G G GP G G G GP G GP P KRIT1 TEP1 21836163 pred G G G G G G GP G G G G G G GP G G G G G G GP G GP P SP100 TEP1 21836163 pred GP GP G G P G GP GP GP GP GP GP G GP P GP P G GP G GP G GP G GP P SCYL1 TEP1 21836163 pred G G G G P G G GP G G G GP G G G P GP P G GP G G G G G GP P TEP1 RAD54B 23023127 pred P G G P G GP P P P P G P P GP P G P P P GP P BIRC3 TEP1 16082366 pred GP G G G G GP P GP G GP G GP G P P G GP GP G GP P TEP1 NHP2 21836163 pred GP GP G G P G G GP G GP G GP G G GP P GP P G GP G GP G GP G GP P TEP1 MED13 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G TEP1 TFIP11 21836163 pred GP GP G G P G GP GP G GP GP GP GP G GP P GP P G GP G GP G GP G GP P TEP1 PYCARD 16082366 pred GP GP G G P G G GP G P GP GP GP G GP P GP P G GP G GP GP G GP P AKT1 TEP1 25402006 pred GP GP G G P G GP GP G GP GP GP GP G GP P GP P G GP G GP G GP G GP P TNKS TEP1 21836163 pred GP GP G G P G GP GP G GP GP GP GP G GP P GP P G GP G GP G GP G GP P MRE11A TEP1 21836163 pred GP P G G P P GP P P GP GP G GP P GP P GP G P P G GP P ACD TEP1 21836163 pred GP GP G G P G GP GP G GP GP GP GP G GP P GP P G P G GP G GP G GP P MED12 TEP1 21836163 pred GP GP G G P G GP GP G GP GP GP GP G GP P GP P G GP G GP G GP G GP P DKC1 TEP1 21836163 pred P P P P P P P P P P P P P P P P P P RIF1 TEP1 21836163 pred GP GP G G P G GP GP G GP GP GP GP G P P GP P G GP G GP G GP G GP P TEP1 MED23 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G RAD50 TEP1 21836163 pred GP GP G G P G GP GP G GP GP GP GP G GP P GP P G GP G GP G GP G GP P ERCC1 TEP1 23023127 pred GP GP G G P G GP GP G GP GP GP GP G GP P GP P G GP G GP G GP G GP P SIRT1 TEP1 21836163 pred GP GP G G P G GP GP G GP GP GP GP G GP P GP P G GP G GP G GP G GP P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q99973 Q14764 biochemical 10551828 colocalization X 2 Q99973 Q14764 affinity chromatography technology 10551828 physical association X 2 Q99973 Q86V38 two hybrid 16713569 direct interaction X 2 Q99973 Q9UKK3 affinity chromatography technology 15169895 physical association X 2 Q99973 O14746 affinity chromatography technology 11029039 physical association X 2 Q99973 P54132 affinity chromatography technology 19329795 physical association X 2 Q99973 Q15554 affinity chromatography technology 19329795 physical association X 2 Q99973 Q15554 affinity chromatography technology 19329795 physical association X 2 Q99973 P54132 affinity chromatography technology 19329795 physical association X 2 Q99973 Q15554 affinity chromatography technology 19329795 physical association X 2 Q99973 biochemical 22939629 colocalization X 2 Q99973 P04637-7 pull down 10597287 direct interaction X 2 Q99973 P0CG48 affinity chromatography technology 21139048 physical association X 2 Q99973 in vitro 11029039,9389643 - X 2 Q99973 in vivo 11029039,9389643 - X 2 Q99973 P54259 two hybrid 16713569 - X 2 Q99973 in vitro 11029039,9389643 - X 2 Q99973 in vivo 11029039,9389643 - X 2 Q99973 P54259 two hybrid 16713569 - X 2 Q99973 in vitro 9837921 - X 2 Q99973 in vivo 9837921 - X 2 Q99973 P04637-8 in vitro 10597287 - X 2 Q99973 P04637-8 in vivo 10597287 - X 2 Q99973 in vivo 9837921 - X 2 Q99973 in vitro 9837921 - X 2 Q99973 P04637-8 in vivo 10597287 - X 2 Q99973 P04637-8 in vitro 10597287 - X 2 Q99973 P54259 two hybrid 16713569 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B PRKCA TEP1 MI:0493(in vivo) 9837921 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_1891 - - TERF2 TEP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19329795 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_212195|BIOGRID_212191|BIOGRID_212186 prey|bait|bait bait|prey|prey UBC TEP1 MI:0004(affinity chromatography technology) 21139048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_171337 bait prey BLM TEP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19329795 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_212194|BIOGRID_212181 prey|bait bait|prey TERT TEP1 MI:0004(affinity chromatography technology)|MI:0493(in vivo) 11029039 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_100501|HPRD_3518 prey|- bait|- TEP1 PARP4 MI:0004(affinity chromatography technology) 15169895 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_270568 prey bait TROVE2 TEP1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236570 bait prey ATN1 TEP1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0397(two hybrid array) 16713569 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(intact) HPRD_1575|BIOGRID_215535|UniProt_86059 -|bait|bait -|prey|prey MVP TEP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10551828 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid) BIOGRID_213453|BIOGRID_213452 bait|bait prey|prey p53 TEP1 MI:0096(pull down)|MI:0493(in vivo) 10597287 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_113193|HPRD_4488 prey|- bait|-

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q99973 P58753 TEP1 TIRAP 0.126 26186194 Q99973 P10155 TEP1 TROVE2 0.081 22939629 Q99973 Q14764 TEP1 MVP 0.309 10551828 Q99973 P54132 TEP1 BLM 0.376 19329795 Q99973 P04637 TEP1 TP53 0.309 10597287 Q99973 O14746 TEP1 TERT 0.21 11029039 Q99973 Q15554 TEP1 TERF2 0.376 19329795 Q99973 P54259 TEP1 ATN1 0.454 16713569 Q9UKK3 Q99973 PARP4 TEP1 0.21 15169895

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TERT TEP1 MI:0045 experimental interaction detection MI:0461 interaction database TP53 TEP1 MI:0045 experimental interaction detection MI:0461 interaction database UBC TEP1 MI:0045 experimental interaction detection MI:0461 interaction database BLM TEP1 MI:0045 experimental interaction detection MI:0461 interaction database ATN1 TEP1 MI:0045 experimental interaction detection MI:0461 interaction database TIRAP TEP1 MI:0045 experimental interaction detection MI:0461 interaction database MVP TEP1 MI:0045 experimental interaction detection MI:0461 interaction database TERF2 TEP1 MI:0045 experimental interaction detection MI:0461 interaction database TEP1 PARP4 MI:0045 experimental interaction detection MI:0461 interaction database