PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus DSP UBAC1 17353931 intact exp G G G G G G G GP G G G G G G G G G G P G GP G GP G G G GP G G RTBDN UBAC1 26186194 biogrid exp P G P P P G P CPSF6 UBAC1 16189514 hprd,biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G PRSS45 UBAC1 26186194 biogrid exp P P P P P P P P UBAC1 EID1 17353931 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G PSMD7 UBAC1 16227581 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G PNPLA1 UBAC1 26186194 biogrid exp P P G GP P P P P P P P P P P P P P P INSL3 UBAC1 26186194 biogrid exp G G G P G G P P GP G HTT UBAC1 23275563,17500595 biogrid,intact exp GP GP G G GP GP G G GP G P GP P GP G GP GP GP P G GP GP GP G GP GP GP GP NEDD4L UBAC1 19953087 biogrid exp GP GP G GP G GP GP G GP G GP P G GP GP GP P G GP GP G G GP G GP G IQGAP2 UBAC1 17353931 biogrid,intact exp GP GP G GP P G GP GP GP GP GP G G GP P GP P G GP GP GP GP G GP GP G PSMD4 UBAC1 16227581 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP G GP GP G RAD23A UBAC1 19013454 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G RDH12 UBAC1 26186194 biogrid exp G G G G G G G G EIF4EBP1 UBAC1 17353931 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G DVL2 UBAC1 21516116 biogrid,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G MED7 UBAC1 17353931 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G BVES UBAC1 26186194 biogrid exp G G G G G G G GP G G GP P G G G G G G P G G G G GP G G G G G MAB21L1 UBAC1 26186194 biogrid exp G G G G G G G G G G G VPS25 UBAC1 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBAC1 TRIM39 25416956 biogrid,intact exp P P P P P P P P P P P P P AIRE UBAC1 16310047 biogrid exp P P P P P GP P P P P P P P P P P P P P EIF1B UBAC1 17353931 intact exp G G G G G GP G G GP G G G G G G G GP G G GP G G G G G G G G ZDHHC17 UBAC1 24705354 biogrid,intact exp G GP G G GP GP G G GP G GP GP GP GP G GP GP G P G GP GP GP G GP GP GP GP G TCEA1 UBAC1 22939629 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP P G GP GP GP G GP GP GP GP G LAPTM5 UBAC1 15231748 hprd exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G G GP GP G GP GP GP GP G UBAC1 RPS6KA6 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP P GP G GP GP GP P G GP P GP GP GP GP GP GP G RDH11 UBAC1 26186194 biogrid exp G G G G G GP G G G G GP G G G G G GP G G G GP G G G G G GP G USP7 UBAC1 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBAC1 CHIA 26186194 biogrid exp P P G G P G GP P P GP GP P G GP GP GP G P P P G P P GP P G UBAC1 MCTS1 17353931 intact exp G G G G G GP G G G G GP G GP G G G GP G G GP G G G G G G G G DAZAP2 UBAC1 25416956,16189514 hprd,biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G APP UBAC1 21832049 biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G P G GP GP G G GP G G GP G UBAC1 TRIM2 25416956,21516116 biogrid,mint,intact exp GP G G GP G G GP G G G G G G G GP G G G G G G G G G MAP3K1 UBAC1 25260751 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBAC1 RNF11 15231748 hprd exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UNC119B UBAC1 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBAC1 MYH2 17353931 biogrid,intact exp G GP G G GP G G G CDKN1B UBAC1 15531880 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G TWF2 UBAC1 22939629 biogrid exp G G G G G G G G G G G G GP GP G G G G G G G G G G GP GP GP G RSAD2 UBAC1 26186194 biogrid exp G GP G G GP GP G GP GP G GP GP GP G G P GP GP P G GP G G GP GP GP GP P G SMRP1 UBAC1 26186194 biogrid exp P G GP G G GP GP P G GP G G P G UBAC1 UTP6 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP G GP GP G RNF123 UBAC1 15746103,15531880,16227581,17353931 hprd,biogrid,intact exp, ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMD6 UBAC1 16227581, 25402006 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP GP GP GP G CSNK2A1 UBAC1 10857748, 21836163 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G PPP5C UBAC1 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G PPM1B UBAC1 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G SLC12A8 UBAC1 ortho P P G G G P P P GP P G GP P GP P GP P GP P GP GP GP UBAC1 UBQLN4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBAC1 FAF1 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBXN11 UBAC1 23023127 pred G GP G G G GP G GP P G GP GP GP G G GP GP GP P G GP GP GP GP GP G GP GP G UBXN7 UBAC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G PSMD14 UBAC1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP P G GP G G GP GP G GP GP G SUMO4 UBAC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G G GP GP P G GP GP GP GP G GP GP GP G UBAC1 CUEDC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP P G RGS14 UBAC1 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP GP GP GP G UBAC1 NXF2, NXF2B 23023127 pred HERPUD2 UBAC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G RALGDS UBAC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G ATXN3 UBAC1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G P GP GP P G GP GP GP GP GP GP GP GP G UBL7 UBAC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP G GP GP GP GP G UBAC1 UBQLN3 23023127 pred G G G G G G GP G PSMC6 UBAC1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBXN2B UBAC1 23023127 pred G GP G G G G G G GP G GP G GP G G GP G GP G G GP G G GP G GP GP G UBAC1 NXF1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBQLNL UBAC1 23023127 pred P P P P P P P P P P P P GP CBLB UBAC1 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP P G GP GP G G GP GP GP GP G SF3A1 UBAC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G HERPUD1 UBAC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBAC1 TMUB1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP G GP GP G UBAC1 TAB2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBFD1 UBAC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBL4B UBAC1 23023127 pred P P P P P P P P P P P P P P P P P P P P TCEB2 UBAC1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G PSMC4 UBAC1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G ARAF UBAC1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBAC1 AUP1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBC UBAC1 23023127 pred UBAC1 ASPSCR1 23023127 pred GP GP G P GP G GP P G GP GP GP GP G GP GP P P G GP GP GP GP GP G GP GP CSNK2A2 UBAC1 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBAC1 UBL5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBAC1 TDRD3 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP UHRF2 UBAC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBAC1 UBTD1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G G GP GP P G P G GP G G G GP G UBAC1 AMFR 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G CIDEA UBAC1 23023127 pred G G G G G G G PSMC5 UBAC1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G PSMC3 UBAC1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBAC1 ASCC2 23023127 pred GP GP G G P GP GP GP GP GP GP G GP P GP P G GP GP GP GP GP GP GP GP G TMUB2 UBAC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G UBAC1 PSMD13 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G P G GP GP GP GP GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P05067-7 Q9BSL1 pull down 21832049 direct interaction X 2 Q13576 Q9BSL1 affinity chromatography technology 17353931 physical association X 2 Q6IBS0 Q9BSL1 biochemical 22939629 colocalization X 2 Q5XPI4 Q9BSL1 affinity chromatography technology 17353931 physical association X 2 Q5XPI4 Q9BSL1 affinity chromatography technology 16227581 physical association X 2 Q5XPI4 Q9BSL1 biochemical 16227581 colocalization X 2 Q5XPI4 Q9BSL1 affinity chromatography technology 16227581 physical association X 2 Q5XPI4 Q9BSL1 affinity chromatography technology 15746103 physical association X 2 Q5XPI4 Q9BSL1 affinity chromatography technology 15746103 physical association X 2 Q5XPI4 Q9BSL1 pull down 15531880 direct interaction X 2 Q15038-2 Q9BSL1 two hybrid 25416956 direct interaction X 2 Q15038-2 Q9BSL1 two hybrid 16189514 direct interaction X 2 P68400-2 Q9BSL1 enzymatic study 10857748 direct interaction X 2 P55036 Q9BSL1 affinity chromatography technology 16227581 physical association X 2 Q16630 Q9BSL1 two hybrid 16189514 direct interaction X 2 Q8IUH5 Q9BSL1 two hybrid 24705354 direct interaction X 2 Q9C040 Q9BSL1 two hybrid 25416956 direct interaction X 2 P46527 Q9BSL1 pull down 15531880 direct interaction X 2 Q9UK32 Q9BSL1 biochemical 22939629 colocalization X 2 Q93009 Q9BSL1 biochemical 22939629 colocalization X 2 A0A024R7G8 Q9BSL1 affinity chromatography technology 19013454 physical association X 2 Q9NYH9 Q9BSL1 biochemical 22939629 colocalization X 2 Q9BSL1 biochemical 22939629 colocalization X 2 P42858 Q9BSL1 two hybrid 23275563 direct interaction X 2 Q9BSL1 A6NIH7 biochemical 22939629 colocalization X 2 Q9BSL1 B7Z2P9 enzymatic study 19953087 direct interaction X 2 Q9BSL1 B7Z2P9 pull down 19953087 direct interaction X 2 Q13541 Q9BSL1 affinity chromatography technology 17353931 physical association X 2 P51665 Q9BSL1 affinity chromatography technology 16227581 physical association X 2 P51665 Q9BSL1 affinity chromatography technology 16227581 physical association X 2 O43918 Q9BSL1 two hybrid 16310047 direct interaction X 2 Q9UKX2 Q9BSL1 affinity chromatography technology 17353931 physical association X 2 Q15008 Q9BSL1 affinity chromatography technology 16227581 physical association X 2 A0A024R1X3 Q9BSL1 biochemical 22939629 colocalization X 2 O43513 Q9BSL1 affinity chromatography technology 17353931 physical association X 2 P0CG48 Q9BSL1 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q9BSL1 affinity chromatography technology 22053931 physical association X 2 P0CG48 Q9BSL1 affinity chromatography technology 20639865 physical association X 2 P0CG48 Q9BSL1 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q9BSL1 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q9BSL1 affinity chromatography technology 21906983 physical association X 2 A0A024RCP5 Q9BSL1 two hybrid 25416956 direct interaction X 2 Q5XPI4 Q9BSL1 anti tag coimmunoprecipitation 15531880 association X 2 P88993 Q9BSL1 two hybrid 22028648 direct interaction X 2 Q5XPI4 Q9BSL1 in vitro 15531880 - X 2 Q5XPI4 Q9BSL1 in vivo 15531880 - X 2 Q5XPI4 Q9BSL1 in vivo 15531880 - X 2 Q5XPI4 Q9BSL1 in vitro 15531880 - X 2 Q15038-3 Q9BSL1 two hybrid 16189514 - X 2 Q15038-3 Q9BSL1 two hybrid 16189514 - X 2 Q16630 Q9BSL1 two hybrid 16189514 - X 2 Q16630 Q9BSL1 two hybrid 16189514 - X 2 Q13571 Q9BSL1 two hybrid 15231748 - X 2 Q13571 Q9BSL1 two hybrid 15231748 - X 2 Q9Y3C5 Q9BSL1 two hybrid 15231748 - X 2 Q9Y3C5 Q9BSL1 two hybrid 15231748 - X 2 Q13576 Q9BSL1 anti bait coimmunoprecipitation 17353931 physical association X 2 O14641 Q9BSL1 two hybrid 21516116 physical association X 2 Q5XPI4 Q9BSL1 anti bait coimmunoprecipitation 17353931 physical association X 2 A0A024R110 Q9BSL1 two hybrid pooling approach 16189514 physical association X 2 A0A024R110 Q9BSL1 two hybrid prey pooling approach 25416956 physical association X 2 A0A024R110 Q9BSL1 two hybrid array 25416956 physical association X 2 A0A024R110 Q9BSL1 validated two hybrid 25416956 physical association X 2 P15924 Q9BSL1 anti bait coimmunoprecipitation 17353931 physical association X 2 Q9ULC4 Q9BSL1 anti bait coimmunoprecipitation 17353931 physical association X 2 Q16630 Q9BSL1 two hybrid pooling approach 16189514 physical association X 2 Q8IUH5 Q9BSL1 two hybrid array 24705354 physical association X 2 P88993 Q9BSL1 two hybrid array 22028648 physical association X 2 Q9C040 Q9BSL1 two hybrid 21516116 physical association X 2 Q9C040 Q9BSL1 two hybrid prey pooling approach 25416956 physical association X 2 Q9C040 Q9BSL1 two hybrid array 25416956 physical association X 2 Q9C040 Q9BSL1 validated two hybrid 25416956 physical association X 2 Q9BSL1 ubiquitinase assay 25260751 ubiquitination reaction C 5 P42858 Q9BSL1 two hybrid 17500595 physical association X 2 P42858 Q9BSL1 two hybrid 17500595 physical association X 2 P42858 Q9BSL1 two hybrid 17500595 physical association X 2 P42858 Q9BSL1 two hybrid 17500595 physical association X 2 P42858 Q9BSL1 two hybrid prey pooling approach 23275563 physical association X 2 Q13541 Q9BSL1 anti bait coimmunoprecipitation 17353931 physical association X 2 Q9UKX2 Q9BSL1 anti bait coimmunoprecipitation 17353931 physical association X 2 O60739 Q9BSL1 anti bait coimmunoprecipitation 17353931 physical association X 2 Q9Y6B2 Q9BSL1 anti bait coimmunoprecipitation 17353931 physical association X 2 O43513 Q9BSL1 anti bait coimmunoprecipitation 17353931 physical association X 2 A0A024RCP5 Q9BSL1 two hybrid prey pooling approach 25416956 physical association X 2 A0A024RCP5 Q9BSL1 two hybrid array 25416956 physical association X 2 A0A024RCP5 Q9BSL1 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B DAZAP2 UBAC1 MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|- (intact)|(biogrid)|MI:0468(hprd) UniProt_153048|BIOGRID_80206|HPRD_23169 unspecified role|bait|- unspecified role|prey|- VPS25 UBAC1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239355 prey bait TCEA1 UBAC1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241509 bait prey NEDD4L UBAC1 MI:0415(enzymatic study)|MI:0415(enzymatic study) 19953087 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_162431|BIOGRID_165764 bait|bait prey|prey APP UBAC1 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_228565 prey bait UBAC1 UNC119B MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240361 prey bait UBAC1 MYH2 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_82523|UniProt_149437 bait|bait prey|prey UBAC1 MCTS1 MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_146561 prey bait UBAC1 RPS6KA6 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239629 prey bait CSNK2A1 UBAC1 MI:0415(enzymatic study) 10857748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_195518 bait prey UBC UBAC1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20639865,21139048,21890473,21906983,21963094,22053931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_160123|BIOGRID_178991|BIOGRID_173894|BIOGRID_169703|BIOGRID_265423|BIOGRID_266797 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey USP7 UBAC1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_242611 prey bait LAPTM5 UBAC1 MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_2499 - - UBAC1 EID1 MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_146670 prey bait UBAC1 RNF11 MI:0018(two hybrid) 15231748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_37709 - - IQGAP2 UBAC1 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_82508|UniProt_148880 prey|prey bait|bait EIF1B UBAC1 MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_144816 bait prey RNF123 UBAC1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 15531880,15746103,16227581,17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0403(colocalization)|- (biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_126305|BIOGRID_128968|UniProt_147165|BIOGRID_128967|BIOGRID_81898|BIOGRID_129423|BIOGRID_126311|BIOGRID_126310|HPRD_18093 prey|prey|prey|bait|prey|bait|bait|prey|- bait|bait|bait|prey|bait|prey|prey|bait|- ZDHHC17 UBAC1 MI:0397(two hybrid array)|MI:0397(two hybrid array) 24705354 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_133402|UniProt_176633 bait|bait prey|prey EIF4EBP1 UBAC1 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_81949|UniProt_147538 bait|bait prey|prey PSMD7 UBAC1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16227581 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_126307|BIOGRID_126308 bait|prey prey|bait HTT UBAC1 MI:0018(two hybrid)|-|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 17500595,23275563 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(intact)|(intact)|(intact)|(biogrid) UniProt_90769|UniProt_126500|UniProt_90742|UniProt_90681|UniProt_90910|BIOGRID_251045 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey TWF2 UBAC1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237731 bait prey PSMD4 UBAC1 MI:0004(affinity chromatography technology) 16227581 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_126306 prey bait UBAC1 UTP6 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238452 bait prey RAD23A UBAC1 MI:0415(enzymatic study) 19013454 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_188747 bait prey CDKN1B UBAC1 MI:0096(pull down) 15531880 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_129424 bait prey DVL2 UBAC1 MI:0018(two hybrid) 21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_114702 prey bait DSP UBAC1 MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_148801 prey bait CPSF6 UBAC1 MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0407(direct interaction) (intact)|MI:0468(hprd)|(biogrid) UniProt_153487|HPRD_22518|BIOGRID_80659 unspecified role|-|prey unspecified role|-|bait AIRE UBAC1 MI:0018(two hybrid) 16310047 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_207917 bait prey MED7 UBAC1 MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 17353931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_82052|UniProt_146227 bait|bait prey|prey TRIM2 UBAC1 MI:0018(two hybrid) 21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_114701 prey bait PSMD6 UBAC1 MI:0004(affinity chromatography technology) 16227581 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_126309 prey bait

PPI - HINT Gene A Gene B PMID Method Quality MED7 UBAC1 17353931,17353931 0006,0004 HT EIF1B UBAC1 17353931 0006 HT DSP UBAC1 17353931 0006 HT TCEA1 UBAC1 22939629 0401 HT INSL3 UBAC1 26186194 0004 HT MAB21L1 UBAC1 26186194 0004 HT EIF4EBP1 UBAC1 17353931,17353931,17353931 0006,0007,0004 HT IQGAP2 UBAC1 17353931,17353931 0006,0004 HT Q59HA3 UBAC1 17353931 0004 HT RNF123 UBAC1 15531880,15531880,15531880,15531880,15746103,17353931,16227581,16227581,17353931 0004,0019,0007,0096,0004,0006,0004,0401,0004 LC,HT DKFZP434A0172 UBAC1 22939629 0401 HT CRSP9 UBAC1 17353931 0004 HT TWF2 UBAC1 22939629 0401 HT PRSS45 UBAC1 26186194 0004 HT PNPLA1 UBAC1 26186194 0004 HT SMRP1 UBAC1 26186194 0004 HT BVES UBAC1 26186194 0004 HT RDH11 UBAC1 26186194 0004 HT RSAD2 UBAC1 26186194 0004 HT USP7 UBAC1 22939629 0401 HT RDH12 UBAC1 26186194 0004 HT VPS25 UBAC1 22939629 0401 HT RTBDN UBAC1 26186194 0004 HT UBAC1 CHIA 26186194 0004 HT UBAC1 UTP6 22939629 0401 HT UBAC1 RPS6KA6 22939629 0401 HT UBAC1 MYH2 17353931,17353931 0006,0004 HT UBAC1 MCTS1 17353931 0006 HT UBAC1 EID1 17353931 0006 HT MED7 UBAC1 17353931,17353931 0006,0004 HT EIF1B UBAC1 17353931 0006 HT DSP UBAC1 17353931 0006 HT TCEA1 UBAC1 22939629 0401 HT INSL3 UBAC1 26186194 0004 HT MAB21L1 UBAC1 26186194 0004 HT EIF4EBP1 UBAC1 17353931,17353931,17353931 0006,0007,0004 HT IQGAP2 UBAC1 17353931,17353931 0006,0004 HT Q59HA3 UBAC1 17353931 0004 HT RNF123 UBAC1 17353931,17353931 0006,0004 HT DKFZP434A0172 UBAC1 22939629 0401 HT CRSP9 UBAC1 17353931 0004 HT TWF2 UBAC1 22939629 0401 HT PRSS45 UBAC1 26186194 0004 HT PNPLA1 UBAC1 26186194 0004 HT SMRP1 UBAC1 26186194 0004 HT BVES UBAC1 26186194 0004 HT RDH11 UBAC1 26186194 0004 HT RSAD2 UBAC1 26186194 0004 HT USP7 UBAC1 22939629 0401 HT RDH12 UBAC1 26186194 0004 HT VPS25 UBAC1 22939629 0401 HT RTBDN UBAC1 26186194 0004 HT UBAC1 CHIA 26186194 0004 HT UBAC1 UTP6 22939629 0401 HT UBAC1 RPS6KA6 22939629 0401 HT UBAC1 MYH2 17353931,17353931 0006,0004 HT UBAC1 MCTS1 17353931 0006 HT UBAC1 EID1 17353931 0006 HT RNF123 UBAC1 15531880,15531880,15531880,15531880,15746103,16227581,16227581 0004,0019,0007,0096,0004,0004,0401 LC B7Z2P9 UBAC1 19953087,19953087 0415,0096 HT DVL2 UBAC1 21516116 0018 HT AIRE UBAC1 16310047 0018 LC TCEA1 UBAC1 22939629 0401 LC HTT UBAC1 23275563,17500595,23275563 1112,0018,0018 HT,LC CSNK2A1 UBAC1 10857748 0415 LC MAP3K1 UBAC1 25260751 0415 LC LAPTM5 UBAC1 15231748 0018 HT DAZAP2 UBAC1 16189514,25416956,25416956,25416956,16189514,25416956 0398,1112,0397,0018,0018,1356 HT CPSF6 UBAC1 16189514,16189514 0398,0018 HT RNF123 UBAC1 15531880,15531880,15531880,15531880,16227581,16227581 0004,0019,0007,0096,0004,0401 LC DKFZP434A0172 UBAC1 22939629 0401 LC TWF2 UBAC1 22939629 0401 LC ZDHHC17 UBAC1 24705354,24705354 0397,0018 HT USP7 UBAC1 22939629 0401 LC NEDD4L UBAC1 19953087,19953087 0415,0096 HT VPS25 UBAC1 22939629 0401 LC UBAC1 TRIM2 25416956,25416956,25416956,21516116,25416956 1112,0397,0018,0018,1356 HT UBAC1 SMURF1 20804422 0415 LC UBAC1 TRIM39 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT UBAC1 UTP6 22939629 0401 LC UBAC1 RPS6KA6 22939629 0401 LC UBAC1 RNF11 15231748 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9BSL1 P23193 UBAC1 TCEA1 0.081 22939629 Q9BSL1 O43918 UBAC1 AIRE 0.309 16310047 Q9BSL1 Q8N8W4 UBAC1 PNPLA1 0.126 26186194 Q9HCE7 Q9BSL1 SMURF1 UBAC1 0.183 20804422 Q9BSL1 Q8NCR6 UBAC1 SMRP1 0.126 26186194 Q9BSL1 Q8NE79 UBAC1 BVES 0.126 26186194 Q9BSL1 Q8TC12 UBAC1 RDH11 0.126 26186194 Q9BSL1 Q62925 UBAC1 MAP3K1 0.033 25260751 Q9BSL1 Q7RTY3 UBAC1 PRSS45 0.126 26186194 Q9BSL1 Q6IBS0 UBAC1 TWF2 0.081 22939629 Q9UHD9 Q9BSL1 UBQLN2 UBAC1 0.236 unassigned1304 Q9BSL1 P0CG47 UBAC1 UBB 0.236 unassigned1304 Q9BSL1 Q96M89 UBAC1 CCDC138 0.236 unassigned1304 Q9BSL1 Q96PU5 UBAC1 NEDD4L 0.332 19953087 Q9BSL1 Q96C32 UBAC1 UBC 0.236 unassigned1304 Q9BSL1 Q96CS7 UBAC1 PLEKHB2 0.236 unassigned1304 Q9BSL1 P78424 UBAC1 POU6F2 0.236 unassigned1304 Q9BSL1 A0A0C4DGN4 UBAC1 ZG16B {ECO:0000313|ENSEMBL:ENSP00000461740} 0.236 unassigned1304 Q9BSL1 P42858 UBAC1 HTT 0.523 23275563,17500595 Q9BSL1 Q96B67 UBAC1 ARRDC3 0.236 unassigned1304 Q9BSL1 Q92567 UBAC1 FAM168A 0.236 unassigned1304 Q9NWF9 Q9BSL1 RNF216 UBAC1 0.236 unassigned1304 Q9BSL1 Q15038 UBAC1 DAZAP2 0.702 25416956,16189514,unassigned1304 Q9HCM9 Q9BSL1 TRIM39 UBAC1 0.454 25416956 Q9C040 Q9BSL1 TRIM2 UBAC1 0.722 21516116,25416956,unassigned1304 Q9BSL1 Q5XPI4 UBAC1 RNF123 0.82 17353931,16227581,15746103,15531880 Q9BSL1 Q8WXG1 UBAC1 RSAD2 {ECO:0000312|EMBL:EAX01034.1} 0.126 26186194 Q9BSL1 Q96NR8 UBAC1 RDH12 0.126 26186194 Q9BSL1 Q9BSG5 UBAC1 RTBDN 0.126 26186194 Q9BSL1 O14641 UBAC1 DVL2 0.332 21516116 Q9BSL1 O43513 UBAC1 MED7 0.236 17353931 Q9BSL1 O60739 UBAC1 EIF1B 0.126 17353931 Q9BSL1 P05067 UBAC1 APP 0.183 21832049 Q9BSL1 P15924 UBAC1 DSP 0.236 17353931 Q9BSL1 P51665 UBAC1 PSMD7 0.376 16227581 Q9BSL1 P55036 UBAC1 PSMD4 0.21 16227581 Q9BSL1 Q13541 UBAC1 EIF4EBP1 0.236 17353931 Q9BSL1 Q15008 UBAC1 PSMD6 0.21 16227581 Q9BSL1 Q16630 UBAC1 CPSF6 0.286 16189514 Q9BSL1 Q8IUH5 UBAC1 ZDHHC17 0.286 24705354 Q9BSL1 Q93009 UBAC1 USP7 0.081 22939629 Q9BSL1 Q9BRG1 UBAC1 VPS25 0.081 22939629 Q9NYH9 Q9BSL1 UTP6 UBAC1 0.081 22939629 Q9ULC4 Q9BSL1 MCTS1 UBAC1 0.126 17353931 Q9Y6B2 Q9BSL1 EID1 UBAC1 0.126 17353931 Q9BZP6 Q9BSL1 CHIA UBAC1 0.126 26186194 Q9UK32 Q9BSL1 RPS6KA6 UBAC1 0.081 22939629 Q9UKX2 Q9BSL1 MYH2 UBAC1 0.332 17353931 Q9BSL1 P46527 UBAC1 CDKN1B 0.309 15531880 Q9BSL1 Q13576 UBAC1 IQGAP2 0.332 17353931 Q9BSL1 P88993 UBAC1 BKLF1 0.126 22028648 Q9BSL1 P68400 UBAC1 CSNK2A1 0.309 10857748 Q9BSL1 P51460 UBAC1 INSL3 0.126 26186194 Q9BSL1 Q13394 UBAC1 MAB21L1 0.126 26186194 Q9BSL1 A6NIH7 UBAC1 UNC119B 0.081 22939629 Q9BSL1 Q13233 UBAC1 MAP3K1 0.183 25260751 Q9BSL1 P54725 UBAC1 RAD23A 0.126 19013454

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 DVL2 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database MED7 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database AIRE UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database EIF1B UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database MYC UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database APP UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database UBC UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database DSP UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database HTT UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database CDKN1B UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database INSL3 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database PSMD7 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database RAD23A UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database PSMD4 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database MAX UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database CSNK2A1 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K1 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database MAB21L1 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database EIF4EBP1 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database LAPTM5 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database IQGAP2 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database PSMD6 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database DAZAP2 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database CPSF6 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database RNF123 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database PRSS45 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database ZDHHC17 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database PNPLA1 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database SMRP1 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database BVES UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database RDH11 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database RSAD2 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database RDH12 UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database NEDD4L UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database RTBDN UBAC1 MI:0045 experimental interaction detection MI:0461 interaction database UBAC1 CHIA MI:0045 experimental interaction detection MI:0461 interaction database UBAC1 TRIM2 MI:0045 experimental interaction detection MI:0461 interaction database UBAC1 TRIM39 MI:0045 experimental interaction detection MI:0461 interaction database UBAC1 MYH2 MI:0045 experimental interaction detection MI:0461 interaction database UBAC1 MCTS1 MI:0045 experimental interaction detection MI:0461 interaction database UBAC1 RNF11 MI:0045 experimental interaction detection MI:0461 interaction database UBAC1 EID1 MI:0045 experimental interaction detection MI:0461 interaction database