Disease associated variation - ClinVar Allele ID Type Name RS#dbSNP Phenotype IDs Chromosome Start Stop Reference Alternate 45854 single nucleotide variant NM_145725.2(TRAF3):c.352C>T (p.Arg118Trp) 143813189 MedGen:C3553868,OMIM:614849 14 103342015 103342015 C T 45854 single nucleotide variant NM_145725.2(TRAF3):c.352C>T (p.Arg118Trp) 143813189 MedGen:C3553868,OMIM:614849 14 102875678 102875678 C T 247093 single nucleotide variant NM_145725.2(TRAF3):c.449G>A (p.Arg150His) 141920055 MedGen:CN169374 14 102876404 102876404 G A 247093 single nucleotide variant NM_145725.2(TRAF3):c.449G>A (p.Arg150His) 141920055 MedGen:CN169374 14 103342741 103342741 G A

Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 14 103304425 rs7143963 C T rs7143963 1.70E-04 ALANINE|PROLINE TNIP1 PROTEIN, HUMAN|HLA-B8 ANTIGEN|DNA-BINDING PROTEINS Myasthenia gravis HPOID:0001290 DOID:437 C intron GWASdb_drug 14 103342049 rs1131877 T C rs1131877 2.10E-04 ALANINE|PROLINE TNIP1 PROTEIN, HUMAN|HLA-B8 ANTIGEN|DNA-BINDING PROTEINS Myasthenia gravis HPOID:0001290 DOID:437 G missense GWASdb_drug 14 103362017 rs4906269 A C rs4906269 2.20E-05 ALANINE|PROLINE TNIP1 PROTEIN, HUMAN|HLA-B8 ANTIGEN|DNA-BINDING PROTEINS Myasthenia gravis HPOID:0001290 DOID:437 A intron GWASdb_drug 14 103377321 rs10133111 G A rs10133111 1.70E-04 ALANINE|PROLINE TNIP1 PROTEIN, HUMAN|HLA-B8 ANTIGEN|DNA-BINDING PROTEINS Myasthenia gravis HPOID:0001290 DOID:437 G UTR-3 GWASdb_drug 1 40531094 rs16826852 A G rs16826852 6.47E-04 Alcohol dependence HPOID:0000707 DOID:0050741 A intron GWASdb_trait 1 40534842 rs16826856 T A rs16826856 8.52E-04 Type 2 diabetes HPOID:0005978 DOID:9352 T intron GWASdb_trait 14 103251003 rs12586226 C T rs12586226 1.92E-04 Self-reported allergy HPOID:0002715 DOID:0060056 C intron GWASdb_trait 14 103293716 rs7152791 C T rs7152791 9.13E-04 Self-reported allergy HPOID:0002715 DOID:0060056 T intron GWASdb_trait 14 103304425 rs7143963 C T rs7143963 7.46E-05 Brain imaging in schizophrenia (interaction) HPOID:0007319|HPOID:0100753 DOID:5419 C intron GWASdb_trait 14 103304425 rs7143963 C T rs7143963 1.70E-04 Myasthenia gravis HPOID:0001290 DOID:437 C intron GWASdb_trait 14 103329430 rs7145509 C A rs7145509 7.71E-04 Alzheimer's disease HPOID:0002511 DOID:10652 A intron GWASdb_trait 14 103331590 rs10144464 A T rs10144464 3.20E-04 Self-reported allergy HPOID:0002715 DOID:0060056 A intron GWASdb_trait 14 103338324 rs2295402 T A rs2295402 5.23E-04 Self-reported allergy HPOID:0002715 DOID:0060056 A intron GWASdb_trait 14 103342049 rs1131877 T C rs1131877 2.10E-04 Myasthenia gravis HPOID:0001290 DOID:437 G missense GWASdb_trait 14 103360000 rs12588538 A G rs12588538 5.30E-04 Self-reported allergy HPOID:0002715 DOID:0060056 A intron GWASdb_trait 14 103361736 rs11160706 G A rs11160706 6.98E-04 Alzheimer's disease HPOID:0002511 DOID:10652 G intron GWASdb_trait 14 103362017 rs4906269 A C rs4906269 2.20E-05 Myasthenia gravis HPOID:0001290 DOID:437 A intron GWASdb_trait 14 103362017 rs4906269 A C rs4906269 6.61E-04 Self-reported allergy HPOID:0002715 DOID:0060056 A intron GWASdb_trait 14 103377321 rs10133111 G A rs10133111 5.00E-06 Brain imaging in schizophrenia (interaction) HPOID:0007319|HPOID:0100753 DOID:5419 G UTR-3 GWASdb_trait 14 103377321 rs10133111 G A rs10133111 1.70E-04 Myasthenia gravis HPOID:0001290 DOID:437 G UTR-3 GWASdb_trait

Disease associated variation - GWAS Central Study Name Source Marker Accession Chromosome Marker Start Marker Stop Alleles Gene Section P-value -log(p-value) GWAS of prostate cancer rs3122413 1 40519523 40519523 intronic 0.36903 0.43293832678170296 GWAS of prostate cancer rs4660378 1 40516396 40516396 intronic 0.365402 0.437229079899226

Disease associated variation - OMIM Ensembl_gene_ID Approved Gene Symbol MIM Number ENSG00000131323.14 TRAF3 601896