PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus WDR44 ATP6V1H 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G TMEM52B WDR44 26186194 biogrid exp P P P P P P GP P P P P P P P P P P P P CSNK2A1 WDR44 22113938 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G WDR44 PRPF39 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G HEPACAM2 WDR44 26186194 biogrid exp P G GP P P GP GP P P P G GP P GP G P GP GP GP GRB2 WDR44 20936779,21706016 biogrid,i2d,intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G OR5F1 WDR44 26186194 biogrid exp P P P P TRIP10 WDR44 22863883 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDR44 FBXL19 24035498 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G WDR44 LSM4 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G POLD1 WDR44 22863883 biogrid exp GP P G GP P G GP GP GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G WDR44 LSM7 22939629 biogrid exp G GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP G GP GP GP GP G WDR44 OSBPL11 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G WDR44 VAPA 24885147 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G WDR44 USP47 22863883 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G DLK1 WDR44 26186194 biogrid exp G GP G G G G G G G G G G G G G GP G G G G G G G G G ELAVL1 WDR44 19322201 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G WDR44 VSIG4 26186194 biogrid exp G G G G G GP G G G G G G GP GP G G GP G G G GP G G G G G GP GP G DHX16 WDR44 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G WDR44 PDXDC1 22863883 biogrid exp GP GP G G GP G G G GP G GP G GP G G GP G G GP G GP GP GP G GP G GP GP G WDR44 MREG 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G ILF2 WDR44 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G SPINT2 WDR44 26186194 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP G RAB11B WDR44 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TGFBR2 WDR44 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G VAPB WDR44 24885147,26186194 biogrid exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G SEC13 WDR44 10747849, 21836163 hprd exp, pred GP GP G G GP GP G GP GP G G G G G G GP GP G GP G GP GP GP G GP GP GP G G RAB11A WDR44 10464283,26496610,10077598, 21836163 hprd,biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G SNX3 WDR44 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G PAFAH1B1 WDR44 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G WDR44 RAB11FIP4 25402006 pred G G G P P G G G GP G GP GP G GP P WDR44 LRSAM1 21836163 pred P GP G P GP G P GP G GP GP P GP P GP G GP G P GP P P GP P P G RABEP1 WDR44 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ITGB3 WDR44 23023127 pred GP G G G GP GP G GP G G GP G GP G G G GP G G G G G G G G G GP G RAB11FIP3 WDR44 25402006 pred GP GP G G GP G G G GP G GP GP G G G GP G G G G G GP G G GP G G GP G RAB4A WDR44 21836163 pred P P P P P P P P P P P P P P P P P P P P WDR44 RAB11FIP5 25402006 pred G GP G G G GP G G G G GP G G G G GP GP G GP G GP G GP G GP G GP GP G WDR44 SNX13 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDR44 RAB11FIP2 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G WDR44 RAB11FIP1 25402006 pred GP GP G GP P G GP GP GP GP GP GP G GP P G GP G GP GP GP G GP GP GP GP G WDR44 MYO5B 25402006 pred GP GP G GP G GP GP G GP GP GP G G GP GP GP G GP GP GP GP G GP GP G WDR44 PDCD6IP 21836163 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q5JSH3 in vivo 10747849 - X 2 Q5JSH3 two hybrid 10747849 - X 2 Q5JSH3 in vitro 10747849 - X 2 Q5JSH3 in vivo 10747849 - X 2 Q5JSH3 two hybrid 10747849 - X 2 Q5JSH3 in vitro 10747849 - X 2 A0A024R5Z8 Q5JSH3 in vivo 10077598,10464283 - X 2 A0A024R5Z8 Q5JSH3 in vitro 10077598,10464283 - X 2 A0A024R5Z8 Q5JSH3 in vivo 10077598,10464283 - X 2 A0A024R5Z8 Q5JSH3 in vitro 10077598,10464283 - X 2 P68400 Q5JSH3 protein kinase assay 22113938 phosphorylation reaction X 2 Q5JSH3 B0LPF3 two hybrid pooling approach 20936779 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBC WDR44 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_176935|BIOGRID_174254|BIOGRID_167486|BIOGRID_269401 bait|bait|bait|bait prey|prey|prey|prey SEC13 WDR44 MI:0493(in vivo) 10747849 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_6423 - - NRF1 WDR44 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_294630 bait prey WDR44 ATP6V1H MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_298695 bait prey GRB2 WDR44 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0096(pull down)|MI:0004(affinity chromatography technology) 20936779,21706016 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(intact)|(biogrid) UniProt_113996|BIOGRID_127116|UniProt_110502|BIOGRID_257687 bait|bait|bait|bait prey|prey|prey|prey ELAVL1 WDR44 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_186701 bait prey WDR44 LSM7 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240362 prey bait WDR44 OSBPL11 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_301615 bait prey CSNK2A1 WDR44 MI:0424(protein kinase assay)|MI:0415(enzymatic study) 22113938 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0217(phosphorylation reaction)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_121013|BIOGRID_255789 neutral component|bait null|prey DHX16 WDR44 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240506 bait prey WDR44 LSM4 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236556 prey bait TRIP10 WDR44 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304992 bait prey ILF2 WDR44 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241714 bait prey WDR44 PRPF39 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_302306 bait prey WDR44 PDXDC1 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304990 prey bait WDR44 FBXL19 MI:0004(affinity chromatography technology) 24035498 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_289817 prey bait POLD1 WDR44 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304991 bait prey RAB11A WDR44 MI:0493(in vivo) 10464283 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_13800 - - WDR44 USP47 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304993 prey bait

PPI - HINT Gene A Gene B PMID Method Quality HEPACAM2 WDR44 26186194 0004 HT SPINT2 WDR44 26186194 0004 HT DHX16 WDR44 22939629 0401 HT OR5F1 WDR44 26186194 0004 HT VAPB WDR44 24885147,26186194 0004,0004 LC,HT TGFBR2 WDR44 26186194 0004 HT RAB11A WDR44 26496610,26496610 0004,0007 HT DLK1 WDR44 26186194 0004 HT TRIP10 WDR44 22863883 0401 HT RAB11B WDR44 26186194 0004 HT TMEM52B WDR44 26186194 0004 HT Q53FG3 WDR44 22939629 0401 HT Q59FA0 WDR44 22863883 0401 HT WDR44 PDXDC1 22863883 0401 HT WDR44 PRPF39 22863883 0401 HT WDR44 MREG 26186194 0004 HT WDR44 USP47 22863883 0401 HT WDR44 OSBPL11 22863883 0401 HT WDR44 ATP6V1H 22863883 0401 HT WDR44 LSM7 22939629 0401 HT WDR44 VSIG4 26186194 0004 HT WDR44 LSM4 22939629 0401 HT HEPACAM2 WDR44 26186194 0004 HT SPINT2 WDR44 26186194 0004 HT DHX16 WDR44 22939629 0401 HT OR5F1 WDR44 26186194 0004 HT VAPB WDR44 26186194 0004 HT TGFBR2 WDR44 26186194 0004 HT RAB11A WDR44 26496610,26496610 0004,0007 HT DLK1 WDR44 26186194 0004 HT TRIP10 WDR44 22863883 0401 HT RAB11B WDR44 26186194 0004 HT TMEM52B WDR44 26186194 0004 HT Q53FG3 WDR44 22939629 0401 HT Q59FA0 WDR44 22863883 0401 HT WDR44 PDXDC1 22863883 0401 HT WDR44 PRPF39 22863883 0401 HT WDR44 MREG 26186194 0004 HT WDR44 USP47 22863883 0401 HT WDR44 OSBPL11 22863883 0401 HT WDR44 ATP6V1H 22863883 0401 HT WDR44 LSM7 22939629 0401 HT WDR44 VSIG4 26186194 0004 HT WDR44 LSM4 22939629 0401 HT VAPB WDR44 24885147 0004 LC DHX16 WDR44 22939629 0401 LC SEC13 WDR44 10747849 0018 LC GRB2 WDR44 20936779,20936779 0398,0018 HT CSNK2A1 WDR44 22113938,22113938 0424,0415 LC TRIP10 WDR44 22863883 0401 LC Q53FG3 WDR44 22939629 0401 LC Q59FA0 WDR44 22863883 0401 LC WDR44 PDXDC1 22863883 0401 LC WDR44 PRPF39 22863883 0401 LC WDR44 USP47 22863883 0401 LC WDR44 OSBPL11 22863883 0401 LC WDR44 ATP6V1H 22863883 0401 LC WDR44 LSM7 22939629 0401 LC WDR44 LSM4 22939629 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5JSH3 O95292 WDR44 VAPB 0.454 24885147,26186194 Q5JSH3 P62993 WDR44 GRB2 0.454 21706016,20936779 Q9BXB4 Q5JSH3 OSBPL11 WDR44 0.081 22863883 Q9UI12 Q5JSH3 ATP6V1H WDR44 0.081 22863883 Q5JSH3 O43291 WDR44 SPINT2 0.126 26186194 Q8N565 Q5JSH3 MREG WDR44 0.126 26186194 Q5JSH3 O60231 WDR44 DHX16 0.081 22939629 Q9P0L0 Q5JSH3 VAPA WDR44 0.21 24885147 Q9Y4Z0 Q5JSH3 LSM4 WDR44 0.081 22939629 Q9Y279 Q5JSH3 VSIG4 WDR44 0.126 26186194 Q6P996 Q5JSH3 PDXDC1 WDR44 0.081 22863883 Q6PCT2 Q5JSH3 FBXL19 WDR44 0.21 24035498 Q5JSH3 O95221 WDR44 OR5F1 0.126 26186194 Q5JSH3 P68400 WDR44 CSNK2A1 0.21 22113938 Q5JSH3 P62491 WDR44 RAB11A 0.236 26496610 Q5JSH3 P62492 WDR44 RAB11A 0.236 26496610 Q96K76 Q5JSH3 USP47 WDR44 0.081 22863883 Q5JSH3 P28340 WDR44 POLD1 0.081 22863883 Q9UK45 Q5JSH3 LSM7 WDR44 0.081 22939629 Q5JSH3 P80370 WDR44 DLK1 0.126 26186194 Q5JSH3 Q12905 WDR44 ILF2 0.081 22939629 Q5JSH3 Q15642 WDR44 TRIP10 0.081 22863883 Q5JSH3 Q15717 WDR44 ELAVL1 0.126 19322201 Q5JSH3 Q15907 WDR44 RAB11B 0.126 26186194 Q5JSH3 A8MVW5 WDR44 HEPACAM2 0.126 26186194 Q5JSH3 Q4KMG9 WDR44 TMEM52B 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 HEPACAM2 WDR44 MI:0045 experimental interaction detection MI:0461 interaction database SPINT2 WDR44 MI:0045 experimental interaction detection MI:0461 interaction database OR5F1 WDR44 MI:0045 experimental interaction detection MI:0461 interaction database VAPB WDR44 MI:0045 experimental interaction detection MI:0461 interaction database UBC WDR44 MI:0045 experimental interaction detection MI:0461 interaction database TGFBR2 WDR44 MI:0045 experimental interaction detection MI:0461 interaction database RAB11A WDR44 MI:0045 experimental interaction detection MI:0461 interaction database GRB2 WDR44 MI:0045 experimental interaction detection MI:0461 interaction database CSNK2A1 WDR44 MI:0045 experimental interaction detection MI:0461 interaction database DLK1 WDR44 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 WDR44 MI:0045 experimental interaction detection MI:0461 interaction database RAB11B WDR44 MI:0045 experimental interaction detection MI:0461 interaction database TMEM52B WDR44 MI:0045 experimental interaction detection MI:0461 interaction database WDR44 FBXL19 MI:0045 experimental interaction detection MI:0461 interaction database WDR44 MREG MI:0045 experimental interaction detection MI:0461 interaction database WDR44 VAPA MI:0045 experimental interaction detection MI:0461 interaction database WDR44 VSIG4 MI:0045 experimental interaction detection MI:0461 interaction database