PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus GCH1 PRKAR2B 19294699 biogrid exp G GP G G G G GP G GP P GP G G G G P GP G GP G GP G G G GP GP G GCH1 RPH3A 7802677 hprd,biogrid exp G G G G G G G G G G GP G G G G G G G G G G G G G PPM1B GCH1 19294699 biogrid exp GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 MAPK12 19294699 innatedb,biogrid exp G GP G G G GP GP G GP G GP GP G GP G P G G GP GP G GP GP G GCH1 CALML6 19294699 biogrid exp P P G GP P P P P P P P GP P P GP GP P P GCH1 MAP2K5 19294699 biogrid exp GP GP G GP G GP GP G GP P GP GP G GP G P P G P G GP GP GP G GP GP G GCH1 SH3GL2 21900206 biogrid,mint,intact exp G G G G GP G G GCH1 OSBPL9 19615732 biogrid,intact exp GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 CSNK2A1 19294699 innatedb,biogrid exp GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 GIT2 21988832 biogrid,intact exp GP GP G GP G G GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 CSNK1G1 19294699 biogrid exp GP GP G G G GP GP G GP GP GP GP G GP G GP G GP G GP GP GP G GP GP G GCH1 PACSIN3 19294699 biogrid exp GP GP G GP P P GP P G G GP G P GP GP G GP GP GP GP P G GCH1 CSNK2B 19294699 biogrid exp GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 MAPK10 19294699 innatedb,biogrid exp G G G G G G GP G G G G G G G G GP G G G G G G G GP G G PRKAR2A GCH1 19294699 biogrid exp GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 CAMKK1 19294699 biogrid exp GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 CALML5 19294699 biogrid exp GP G GP G GCH1 MAP2K4 19294699 biogrid exp GP GP G GP G G GP G GP G GP G G G G G G GP G G G G G GP GP G GCH1 RGS19 19294699 biogrid exp GP GP G GP G G GP G GP GP GP GP G G G GP G GP G GP GP G G GP GP G GCH1 CDC37 21900206 biogrid,mint,intact exp GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G ATP1B1 GCH1 16696853 hprd,biogrid exp GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 YWHAZ 21988832 innatedb,biogrid,intact exp GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 GCH1 16696853,2463916,11087827, 23023127 hprd,biogrid,i2d,intact exp, ortho, pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G TH GCH1 21836163 bci exp, ortho, pred G P G P G G GCHFR GCH1 8702680,16696853, 25402006, 23023127, 21836163 hprd,biogrid,intact,bci exp, ortho, pred GP GP G G G G GP G GP GP GP GP G GP G GP G GP G GP GP GP G GP GP G AHSA1 GCH1 16696853, 25402006, 21836163 hprd,biogrid,intact,bci exp, pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G G G GP G GP GP G HSPA8 GCH1 16696853, 25402006 hprd,biogrid,intact,bci exp, pred P P P P P P P P P P P P GCH1 RAB26 16696853, 25402006 hprd,biogrid,intact exp, pred P G G GP G GP GP G GP G GP G G GP G G G GP G GP GP GP GP GP G GCH1 CNRIP1 16696853, 25402006 biogrid,intact exp, pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 RLF 16696853, 25402006 hprd,biogrid,intact,bci exp, pred G GP G G G GP GP G GP G GP G G GP G G G G G G GP GP G G GP G GCH1 SP3 16696853, 25402006 biogrid,intact,bci exp, pred GP G G GP G GP GP G GP GP GP GP G GP G P G G GP G GP GP GP G GP GP G UBC GCH1 ortho GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G KPNA5 GCH1 ortho GP GP G GP G GP GP G GP G G G G GP G G G GP GP GP G GP GP GCH1 HSPA4 ortho GP GP G GP G G GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 CCT7 ortho GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 FPGS ortho GP G G G G G GP G GP GP G G G GP G GP G GP G GP GP GP G GP G G GCH1 ATL2 ortho G GP G G G GP GP G GP G GP G G GP G GP G GP G G GP GP G GP GP G GCH1 PDSS1 ortho GP GP G GP G GP GP G GP GP GP GP G GP G GP G GP G GP GP GP G GP GP G GCH1 NTMT1 ortho GP GP G GP G GP GP G GP G GP GP G GP G P GP G GP G GP G GP G GP GP G GCH1 FBXL20 ortho GP GP G GP G G GP G GP GP GP GP G GP G GP G GP G GP G GP G GP GP G FDPS GCH1 ortho G GP G GP G GP GP G GP GP GP GP G GP G GP G G G G GP GP G GP GP G GCH1 RIOK2 ortho GP GP P G G GP G GP G GP GP G GP G P GP G GP G GP GP GP G GP GP MPPED1 GCH1 ortho G G G G G G G G G G G G G G G G G G G G G G G GCH1 FUT8 ortho G GP G GP G G GP G GP P GP GP G GP G GP G GP G GP P GP G GP GP G IPO5 GCH1 ortho GP GP G GP G G GP G GP G GP GP G GP G P GP G GP G GP G GP G GP GP G GGPS1 GCH1 ortho G GP G G G G G G GP GP GP G G GP G GP G GP G GP G GP G GP GP G PRKACB GCH1 ortho GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 KPNB1 16082366 ortho, pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G DNAJB1 GCH1 25402006 ortho, pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G UBA1 GCH1 16082366 ortho, pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 EIF2B2 21836163 ortho, pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 MAPK7 16082366 ortho, pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP P GP G GP GP G PIAS1 GCH1 25402006 pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCSH GCH1 16082366 pred P P P P P P P P P P P P P P P P ARG1 GCH1 16082366 pred G G GP G G GP G G G G G G GCH1 SPR 16082366 pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 RAB14 16082366 pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 STAT1 25402006 pred G G G GP G G GP G GP G GP GP G GP G GP G GP G G G GP G G GP G GCH1 HIF1A 23023127 pred GP GP G GP G G GP G GP G GP GP G GP G GP G GP G GP G GP G GP GP G GCH1 HDAC1 25402006 pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP G GP G GP GP G GCH1 SHMT1 16082366 pred GP GP G GP G GP GP G GP GP GP GP G GP G P P G GP G GP G GP G GP GP G MOCS3 GCH1 16082366 pred P GP G GP G GP G G GP GP GP P G GP G GP G GP G G GP GP GP GP G CXCL10 GCH1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GCH1 AMDHD1 16082366 pred P GP P P GP GP P GP P GP P P P P P COMT GCH1 16082366 pred GP GP G GP G G GP G GP GP GP GP G GP G P GP G GP G GP G GP G GP GP G MOCS2 GCH1 16082366 pred GP GP P G GP GP G GP GP GP GP G GP G GP G GP G GP GP GP G GP GP G GCH1 RIT1 25402006 pred GP GP G GP G GP GP G GP GP GP G G GP G P GP G GP G GP GP GP G GP GP G IDO1 GCH1 16082366 pred GP GP G G G GP P G GP GP G GP G G G GP G G G GP GP G GCH1 EGLN3 21836163 pred P P G GP G G G G G G G G G G G G G G G GCH1 TSC22D3 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GCH1 PSAT1 21836163 pred G GP G GP G G G G GP GP G G G G GP G G G GP G G GP GP G GCH1 ATP7A 23023127 pred GP GP G GP G G GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G PSMB9 GCH1 25402006 pred GP GP G GP G G GP G GP GP GP GP G GP G GP G GP G GP G GP G GP GP G GCH1 HAL 16082366 pred GP P G GP P P P GP P P GP G P P G P GP GP P G GP P G PAH GCH1 16082366 pred GP P GP GP G P P G P GP HRAS GCH1 25402006 pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G TNFAIP8 GCH1 25402006 pred GP G G GP G G GP G G GP GP G GP G G G G G G GP G GP G G GCH1 HPD 16082366 pred GP GP FAH GCH1 16082366 pred G GP G G G G GP G GP GP G G G GP G G G G G G G GP G GP GP G GCH1 RNF4 21836163 pred GP G G G G GP GP G GP G G G G G G P G G GP G GP GP G G GP GP G GCH1 SLC6A8 16082366 pred GP GP G GP G GP GP G GP P P GP G GP G P P G GP G GP GP GP G GP GP G GCH1 RIT2 25402006 pred G G G GCH1 PSME2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GCH1 NIT2 16082366 pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G G G GP GP GP G GP GP G SP100 GCH1 23023127 pred GP GP G GP G GP GP GP GP GP GP G GP P P G GP G GP GP GP G GP P G GSTZ1 GCH1 16082366 pred GP GP P P P G GP GP P GP G GP P GP P G GP GP GP P GP G GCH1 ALDH5A1 16082366 pred GP GP G GP G GP GP G GP GP GP GP G GP G P G P G GP GP GP G GP GP G CXCL11 GCH1 25402006 pred P P P P P P P P P P P GP P P P P P P GCH1 NMI 25402006 pred GP GP G G G GP GP G GP GP GP GP G GP G GP G GP G GP GP GP G GP GP G GCH1 TAP1 25402006 pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 HDAC2 25402006 pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 MOCS1 16082366 pred GP GP G GP G GP GP G GP GP GP GP G GP G GP GP G GP GP GP GP P G QDPR GCH1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G WARS GCH1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GOT2 GCH1 21836163 pred GP GP G G G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 SRP54 25402006 pred GP GP G GP G GP G G GP GP GP GP G GP G P GP G GP G GP G GP G GP GP G HSP90AA1 GCH1 25402006 pred GP GP G G G G GP G G G G G G G G G G GP G G G G G G GP G GCH1 DEFA3 23023127 pred P P P P P P ALDH4A1 GCH1 16082366 pred GP GP P G GP P G GP GP P P G P G P P GP G P GP GP G P P GCH1 PCBD1 16082366 pred G GP G G G GP GP G GP GP G G G GP G GP G G G GP G GP G GP GP G ISG15 GCH1 25402006 pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 MCCC2 16082366 pred GP GP G GP G GP GP G GP GP GP GP G GP G GP G GP G GP G GP G GP GP G SRM GCH1 21836163 pred GP GP G G G GP GP G GP GP GP GP G GP G GP G GP G GP GP GP G GP GP G SOD2 GCH1 25402006 pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 KYNU 16082366 pred GP P G G P P GP GP GP GP G P P GP P P P G GP GP PSMB8 GCH1 25402006 pred GP GP G GP G G GP GP GP GP GP G GP GP GP G GP GP G GP P G GCH1 STK19 25402006 pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 PTS 23023127, 21836163, 16082366 pred GP GP G GP G GP G G GP GP G GP G G G GP G GP G G G G G GP GP G IFNG GCH1 21836163 pred P GP G G G GP P P G GP G P G G G P GP GP P G GP P G LAP3 GCH1 25402006 pred GP GP G GP G G GP G GP GP GP GP G GP G GP G GP G GP G GP G GP GP G GOT1 GCH1 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G GCH1 RBBP4 25402006 pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 SLC1A3 16082366 pred G G G G G G G G G G G G G G G G G G G GCH1 ISG20 25402006 pred G G G G G G G G G G G G G G G G G G G G GCH1 SP110 25402006 pred GP GP G GP G GP GP G GP GP GP GP G GP G P GP G GP G GP GP GP G GP GP G GCH1 DNAJA1 25402006 pred GP GP G GP G G GP G GP GP GP GP G GP G P GP G GP G GP G GP G GP GP G GCH1 SLC7A2 16082366 pred GP GP G GP GP GP GP GP GP G GP G P GP G GP G P GP GP G GP GP G GCH1 MOCOS 23023127 pred GP GP G GP P GP GP GP P GP G GP P GP G GP G GP GP GP GP GP GCH1 DEFA1, DEFA1B 23023127 pred P P P P P P GCH1 GBP1 25402006 pred G G G G G G GP G GP G GP G G GP G G G G G G GP G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B AHSA1 GCH1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16696853 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid)|MI:0468(hprd)|(intact)|(biogrid) UniProt_84172|UniProt_84178|BIOGRID_227076|HPRD_27157|UniProt_84186|BIOGRID_227069 prey|prey|prey|-|prey|prey bait|bait|bait|-|bait|bait GCH1 CALML6 MI:0004(affinity chromatography technology) 19294699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273764 bait prey GCH1 CSNK2B MI:0004(affinity chromatography technology) 19294699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273774 bait prey GCH1 RLF MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16696853 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|- (intact)|(biogrid)|(intact)|MI:0468(hprd) UniProt_84182|BIOGRID_227070|UniProt_84176|HPRD_27161 bait|bait|bait|- prey|prey|prey|- GCH1 MAP2K5 MI:0004(affinity chromatography technology) 19294699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273768 bait prey GCH1 CSNK2A1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19294699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_273778|BIOGRID_273773 prey|bait bait|prey GCH1 RGS19 MI:0004(affinity chromatography technology) 19294699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273765 bait prey GCH1 MAPK12 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19294699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_273769|BIOGRID_273779 bait|prey prey|bait GCH1 MAPK10 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19294699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_273777|BIOGRID_273770 prey|bait bait|prey HSPA8 GCH1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16696853 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|- (intact)|(intact)|(biogrid)|MI:0468(hprd) UniProt_84173|UniProt_84180|BIOGRID_227071|HPRD_27158 prey|prey|prey|- bait|bait|bait|- GCH1 SP3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16696853 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_84177|BIOGRID_227072|UniProt_84183 bait|bait|bait prey|prey|prey ATP1B1 GCH1 MI:0018(two hybrid)|MI:0018(two hybrid) 16696853 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_227075|HPRD_27160 prey|- bait|- GCHFR GCH1 MI:0492(in vitro)|MI:0018(two hybrid)|MI:0018(two hybrid) 16696853,8702680 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|(intact)|(biogrid) HPRD_6583|UniProt_84185|BIOGRID_227068 -|prey|prey -|bait|bait GCH1 CDC37 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_158145|BIOGRID_157845|UniProt_178743 prey|prey|prey bait|bait|bait GCH1 PRKAR2B MI:0004(affinity chromatography technology) 19294699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273776 bait prey GCH1 PACSIN3 MI:0004(affinity chromatography technology) 19294699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273762 bait prey GCH1 YWHAZ MI:0004(affinity chromatography technology)|MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(intact)|(intact)|(intact)|(intact)|(biogrid) BIOGRID_285291|UniProt_118895|UniProt_120318|UniProt_120366|UniProt_120251|BIOGRID_287363 bait|unspecified role|unspecified role|neutral component|unspecified role|bait prey|unspecified role|unspecified role|neutral component|unspecified role|prey GCH1 RAB26 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16696853 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|- (intact)|(intact)|(biogrid)|MI:0468(hprd) UniProt_84181|UniProt_84174|BIOGRID_227074|HPRD_27159 bait|bait|bait|- prey|prey|prey|- GCH1 SH3GL2 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_177839|BIOGRID_156728|UniProt_157241 prey|prey|prey bait|bait|bait GCH1 CALML5 MI:0004(affinity chromatography technology) 19294699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273763 bait prey GCH1 CSNK1G1 MI:0004(affinity chromatography technology) 19294699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273772 bait prey GCH1 GIT2 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_287364|UniProt_117116 bait|unspecified role prey|unspecified role PRKAR2A GCH1 MI:0004(affinity chromatography technology) 19294699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273775 prey bait GCH1 CAMKK1 MI:0004(affinity chromatography technology) 19294699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273771 bait prey p53 GCH1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18162465 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_139384|BIOGRID_333898 prey|prey bait|bait GCH1 MAP2K4 MI:0004(affinity chromatography technology) 19294699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273767 bait prey GCH1 CNRIP1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16696853 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_84175|UniProt_84179|BIOGRID_227073 bait|bait|bait prey|prey|prey GCH1 OSBPL9 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100713|BIOGRID_119494 prey|prey bait|bait PPM1B GCH1 MI:0004(affinity chromatography technology) 19294699 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273766 prey bait GCH1 RPH3A MI:0004(affinity chromatography technology)|MI:0493(in vivo) 7802677 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_109057|HPRD_6584 prey|- bait|-

PPI - HINT Gene A Gene B PMID Method Quality GCH1 OSBPL9 19615732 0007 HT GCH1 OSBPL9 19615732 0007 HT B7Z9S8 GCH1 16696853 0018 LC AHSA1 GCH1 16696853,16696853 0018,0096 LC ATP1B1 GCH1 16696853 0018 LC HSPA8 GCH1 16696853 0018 LC GCHFR GCH1 16696853 0018 LC GCH1 GCH1 11087827,16696853 0114,0018 LC GCH1 YWHAZ 21988832,21988832,21988832,21988832 0096,0663,0018,0007 HT GCH1 SP3 16696853 0018 LC GCH1 RLF 16696853 0018 LC GCH1 GIT2 21988832 0397 HT GCH1 CDC37 21900206 0018 HT GCH1 CNRIP1 16696853 0018 LC GCH1 SH3GL2 21900206 0018 HT GCH1 RAB26 16696853 0018 LC GCH1 HEL-S-72P 16696853 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Y2J0 P30793 RPH3A GCH1 0.21 7802677 P30793 O95433 GCH1 AHSA1 0.74 16696853 Q9Y5L0 P30793 TNPO3 GCH1 0.236 unassigned1304 Q96SU4 P30793 OSBPL9 GCH1 0.236 19615732 Q99962 P30793 SH3GL2 GCH1 0.332 21900206 Q96F85 P30793 CNRIP1 GCH1 0.523 16696853 Q13129 P30793 RLF GCH1 0.523 16696853 Q9ULW5 P30793 RAB26 GCH1 0.523 16696853 P30793 O14787 GCH1 TNPO2 0.236 unassigned1304 P63104 P30793 YWHAZ GCH1 0.59 21988832 P30793 P30793 GCH1 GCH1 0.772 16696853,11087827,2463916 P30793 P30047 GCH1 GCHFR 0.523 16696853 P30793 O75688 GCH1 PPM1B 0.21 19294699 P30793 P05026 GCH1 ATP1B1 0.309 16696853 P30793 P11142 GCH1 HSPA8 0.523 16696853 P30793 P13861 GCH1 PRKAR2A 0.21 19294699 P31323 P30793 PRKAR2B GCH1 0.21 19294699 P45985 P30793 MAP2K4 GCH1 0.21 19294699 P49795 P30793 RGS19 GCH1 0.21 19294699 P53778 P30793 MAPK12 GCH1 0.376 19294699 P53779 P30793 MAPK10 GCH1 0.376 19294699 P67870 P30793 CSNK2B GCH1 0.21 19294699 P68400 P30793 CSNK2A1 GCH1 0.376 19294699 Q13163 P30793 MAP2K5 GCH1 0.21 19294699 Q14161 P30793 GIT2 GCH1 0.286 21988832 Q16543 P30793 CDC37 GCH1 0.332 21900206 Q8N5S9 P30793 CAMKK1 GCH1 0.21 19294699 Q8TD86 P30793 CALML6 GCH1 0.21 19294699 Q9HCP0 P30793 CSNK1G1 GCH1 0.21 19294699 Q9NZT1 P30793 CALML5 GCH1 0.21 19294699 Q9UKS6 P30793 PACSIN3 GCH1 0.21 19294699 Q02447 P30793 SP3 GCH1 0.671 16696853

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TUBAL3 GCH1 MI:0362 inference MI:0461 interaction database EIF4E1B GCH1 MI:0362 inference MI:0461 interaction database EIF3CL GCH1 MI:0362 inference MI:0461 interaction database PSMD11 GCH1 MI:0362 inference MI:0461 interaction database IPO5 GCH1 MI:0362 inference MI:0461 interaction database AGPAT2 GCH1 MI:0362 inference MI:0461 interaction database KPNA5 GCH1 MI:0362 inference MI:0461 interaction database MPPED1 GCH1 MI:0362 inference MI:0461 interaction database IDH3B GCH1 MI:0362 inference MI:0461 interaction database RANBP6 GCH1 MI:0362 inference MI:0461 interaction database EIF4E2 GCH1 MI:0362 inference MI:0461 interaction database HIST1H2BK GCH1 MI:0362 inference MI:0461 interaction database DNAJA2 GCH1 MI:0362 inference MI:0461 interaction database CS GCH1 MI:0362 inference MI:0461 interaction database PPM1B GCH1 MI:0045 experimental interaction detection MI:0461 interaction database EIF3G GCH1 MI:0362 inference MI:0461 interaction database DNAJB5 GCH1 MI:0362 inference MI:0461 interaction database ALDH1A2 GCH1 MI:0362 inference MI:0461 interaction database IPO7 GCH1 MI:0362 inference MI:0461 interaction database AHSA1 GCH1 MI:0045 experimental interaction detection MI:0461 interaction database NSA2 GCH1 MI:0362 inference MI:0461 interaction database HSPA4L GCH1 MI:0362 inference MI:0461 interaction database ALDH1A1 GCH1 MI:0362 inference MI:0461 interaction database SOD1 GCH1 MI:0362 inference MI:0461 interaction database OTC GCH1 MI:0362 inference MI:0461 interaction database SOD2 GCH1 MI:0362 inference MI:0461 interaction database OAT GCH1 MI:0362 inference MI:0461 interaction database TUBB4A GCH1 MI:0362 inference MI:0461 interaction database ATP1B1 GCH1 MI:0045 experimental interaction detection MI:0461 interaction database ALDH2 GCH1 MI:0362 inference MI:0461 interaction database SLC25A5 GCH1 MI:0362 inference MI:0461 interaction database ATP5B GCH1 MI:0362 inference MI:0461 interaction database EIF4E GCH1 MI:0362 inference MI:0461 interaction database GPI GCH1 MI:0362 inference MI:0461 interaction database HIST1H2BJ GCH1 MI:0362 inference MI:0461 interaction database TUBB GCH1 MI:0362 inference MI:0461 interaction database BPGM GCH1 MI:0362 inference MI:0461 interaction database APRT GCH1 MI:0362 inference MI:0461 interaction database HSP90AA1 GCH1 MI:0362 inference MI:0461 interaction database GALT GCH1 MI:0362 inference MI:0461 interaction database PFKM GCH1 MI:0362 inference MI:0461 interaction database HSP90AB1 GCH1 MI:0362 inference MI:0461 interaction database PDHA1 GCH1 MI:0362 inference MI:0461 interaction database DLD GCH1 MI:0362 inference MI:0461 interaction database UBC GCH1 MI:0362 inference MI:0461 interaction database HSPA1A GCH1 MI:0362 inference MI:0461 interaction database HSPA1B GCH1 MI:0362 inference MI:0461 interaction database DLAT GCH1 MI:0362 inference MI:0461 interaction database PRKAR1A GCH1 MI:0362 inference MI:0461 interaction database HSPD1 GCH1 MI:0362 inference MI:0461 interaction database HSPA8 GCH1 MI:0045 experimental interaction detection MI:0461 interaction database PC GCH1 MI:0362 inference MI:0461 interaction database SLC25A4 GCH1 MI:0362 inference MI:0461 interaction database SLC25A6 GCH1 MI:0362 inference MI:0461 interaction database PRKAR2A GCH1 MI:0045 experimental interaction detection MI:0461 interaction database PGAM2 GCH1 MI:0362 inference MI:0461 interaction database ATP6V1B1 GCH1 MI:0362 inference MI:0461 interaction database HSPA6 GCH1 MI:0362 inference MI:0461 interaction database PRKACA GCH1 MI:0362 inference MI:0461 interaction database PFKL GCH1 MI:0362 inference MI:0461 interaction database PGAM1 GCH1 MI:0362 inference MI:0461 interaction database HK1 GCH1 MI:0362 inference MI:0461 interaction database SRM GCH1 MI:0362 inference MI:0461 interaction database SDS GCH1 MI:0362 inference MI:0461 interaction database RAB5A GCH1 MI:0362 inference MI:0461 interaction database ATP6V1B2 GCH1 MI:0362 inference MI:0461 interaction database VDAC1 GCH1 MI:0362 inference MI:0461 interaction database UBA1 GCH1 MI:0362 inference MI:0461 interaction database PRKACG GCH1 MI:0362 inference MI:0461 interaction database PRKACB GCH1 MI:0362 inference MI:0461 interaction database AHCY GCH1 MI:0362 inference MI:0461 interaction database HIST1H2BO GCH1 MI:0362 inference MI:0461 interaction database CFL1 GCH1 MI:0362 inference MI:0461 interaction database CCNC GCH1 MI:0362 inference MI:0461 interaction database DNAJB1 GCH1 MI:0362 inference MI:0461 interaction database ATP5A1 GCH1 MI:0362 inference MI:0461 interaction database CAD GCH1 MI:0362 inference MI:0461 interaction database PDHA2 GCH1 MI:0362 inference MI:0461 interaction database PRDX5 GCH1 MI:0362 inference MI:0461 interaction database GCHFR GCH1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PRDX3 GCH1 MI:0362 inference MI:0461 interaction database PPP2R1A GCH1 MI:0362 inference MI:0461 interaction database PPP2R1B GCH1 MI:0362 inference MI:0461 interaction database PPIF GCH1 MI:0362 inference MI:0461 interaction database GCH1 ALDH1B1 MI:0362 inference MI:0461 interaction database GCH1 POLR2B MI:0362 inference MI:0461 interaction database GCH1 MAT2A MI:0362 inference MI:0461 interaction database GCH1 PRKAR1B MI:0362 inference MI:0461 interaction database GCH1 PRKAR2B MI:0045 experimental interaction detection MI:0461 interaction database GCH1 DNAJA1 MI:0362 inference MI:0461 interaction database GCH1 STIP1 MI:0362 inference MI:0461 interaction database GCH1 PRDX2 MI:0362 inference MI:0461 interaction database GCH1 HIST1H2BB MI:0362 inference MI:0461 interaction database GCH1 HSPA1L MI:0362 inference MI:0461 interaction database GCH1 HSPA4 MI:0362 inference MI:0461 interaction database GCH1 CBS MI:0362 inference MI:0461 interaction database GCH1 GCK MI:0362 inference MI:0461 interaction database GCH1 ATP5C1 MI:0362 inference MI:0461 interaction database GCH1 DLST MI:0362 inference MI:0461 interaction database GCH1 TALDO1 MI:0362 inference MI:0461 interaction database GCH1 HSPA9 MI:0362 inference MI:0461 interaction database GCH1 CAP2 MI:0362 inference MI:0461 interaction database GCH1 PSMC4 MI:0362 inference MI:0461 interaction database GCH1 VDAC2 MI:0362 inference MI:0461 interaction database GCH1 MAP2K4 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 ALDH1A3 MI:0362 inference MI:0461 interaction database GCH1 PSMD8 MI:0362 inference MI:0461 interaction database GCH1 CCT3 MI:0362 inference MI:0461 interaction database GCH1 SARS MI:0362 inference MI:0461 interaction database GCH1 PSMB3 MI:0362 inference MI:0461 interaction database GCH1 PSMB2 MI:0362 inference MI:0461 interaction database GCH1 EIF2B2 MI:0362 inference MI:0461 interaction database GCH1 RGS19 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 CCT8 MI:0362 inference MI:0461 interaction database GCH1 RAB5C MI:0362 inference MI:0461 interaction database GCH1 IDH3G MI:0362 inference MI:0461 interaction database GCH1 PRKX MI:0362 inference MI:0461 interaction database GCH1 PGD MI:0362 inference MI:0461 interaction database GCH1 KPNA1 MI:0362 inference MI:0461 interaction database GCH1 SUCLG1 MI:0362 inference MI:0461 interaction database GCH1 COPA MI:0362 inference MI:0461 interaction database GCH1 CLTCL1 MI:0362 inference MI:0461 interaction database GCH1 MAPK12 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 MAPK10 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 HSPA2 MI:0362 inference MI:0461 interaction database GCH1 VCP MI:0362 inference MI:0461 interaction database GCH1 NAP1L1 MI:0362 inference MI:0461 interaction database GCH1 EIF6 MI:0362 inference MI:0461 interaction database GCH1 HIST1H2BD MI:0362 inference MI:0461 interaction database GCH1 DNAJB13 MI:0362 inference MI:0461 interaction database GCH1 ACTB MI:0362 inference MI:0461 interaction database GCH1 EIF4A1 MI:0362 inference MI:0461 interaction database GCH1 DSTN MI:0362 inference MI:0461 interaction database GCH1 RAB5B MI:0362 inference MI:0461 interaction database GCH1 ACTR2 MI:0362 inference MI:0461 interaction database GCH1 PSMC5 MI:0362 inference MI:0461 interaction database GCH1 YWHAE MI:0362 inference MI:0461 interaction database GCH1 PPP2CB MI:0362 inference MI:0461 interaction database GCH1 ACTA2 MI:0362 inference MI:0461 interaction database GCH1 HIST1H2BC MI:0362 inference MI:0461 interaction database GCH1 PPIA MI:0362 inference MI:0461 interaction database GCH1 RPS27A MI:0362 inference MI:0461 interaction database GCH1 UBA52 MI:0362 inference MI:0461 interaction database GCH1 YWHAZ MI:0045 experimental interaction detection MI:0461 interaction database GCH1 SKP1 MI:0362 inference MI:0461 interaction database GCH1 EIF5A MI:0362 inference MI:0461 interaction database GCH1 ACTG1 MI:0362 inference MI:0461 interaction database GCH1 ACTG2 MI:0362 inference MI:0461 interaction database GCH1 PPP2CA MI:0362 inference MI:0461 interaction database GCH1 CSNK2B MI:0045 experimental interaction detection MI:0461 interaction database GCH1 ACTC1 MI:0362 inference MI:0461 interaction database GCH1 EEF1A1 MI:0362 inference MI:0461 interaction database GCH1 ACTA1 MI:0362 inference MI:0461 interaction database GCH1 TUBA1B MI:0362 inference MI:0461 interaction database GCH1 TUBA4A MI:0362 inference MI:0461 interaction database GCH1 TUBB4B MI:0362 inference MI:0461 interaction database GCH1 CSNK2A1 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 MAT1A MI:0362 inference MI:0461 interaction database GCH1 CLTC MI:0362 inference MI:0461 interaction database GCH1 GALK2 MI:0362 inference MI:0461 interaction database GCH1 CAP1 MI:0362 inference MI:0461 interaction database GCH1 PFKP MI:0362 inference MI:0461 interaction database GCH1 SP3 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 EEF1A2 MI:0362 inference MI:0461 interaction database GCH1 PPID MI:0362 inference MI:0461 interaction database GCH1 ACACA MI:0362 inference MI:0461 interaction database GCH1 RLF MI:0045 experimental interaction detection MI:0461 interaction database GCH1 PRDX4 MI:0362 inference MI:0461 interaction database GCH1 MAP2K5 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 MAPK7 MI:0362 inference MI:0461 interaction database GCH1 EIF3I MI:0362 inference MI:0461 interaction database GCH1 PPP2R5C MI:0362 inference MI:0461 interaction database GCH1 TUBB3 MI:0362 inference MI:0461 interaction database GCH1 CUL1 MI:0362 inference MI:0461 interaction database GCH1 CUL2 MI:0362 inference MI:0461 interaction database GCH1 TUBA3C MI:0362 inference MI:0461 interaction database GCH1 TUBB2A MI:0362 inference MI:0461 interaction database GCH1 EIF3A MI:0362 inference MI:0461 interaction database GCH1 GIT2 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 EIF4A2 MI:0362 inference MI:0461 interaction database GCH1 PPP2R5D MI:0362 inference MI:0461 interaction database GCH1 KPNB1 MI:0362 inference MI:0461 interaction database GCH1 PPP2R5A MI:0362 inference MI:0461 interaction database GCH1 PPP2R5B MI:0362 inference MI:0461 interaction database GCH1 PPA1 MI:0362 inference MI:0461 interaction database GCH1 MPPED2 MI:0362 inference MI:0461 interaction database GCH1 PPP2R5E MI:0362 inference MI:0461 interaction database GCH1 CDC37 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 HIST2H2BE MI:0362 inference MI:0461 interaction database GCH1 TUBB8 MI:0362 inference MI:0461 interaction database GCH1 HIST2H2BF MI:0362 inference MI:0461 interaction database GCH1 ATL3 MI:0362 inference MI:0461 interaction database GCH1 EIF5AL1 MI:0362 inference MI:0461 interaction database GCH1 TUBA3E MI:0362 inference MI:0461 interaction database GCH1 DHRS11 MI:0362 inference MI:0461 interaction database GCH1 TUBA1A MI:0362 inference MI:0461 interaction database GCH1 H2BFWT MI:0362 inference MI:0461 interaction database GCH1 PGAM4 MI:0362 inference MI:0461 interaction database GCH1 HIST3H2BB MI:0362 inference MI:0461 interaction database GCH1 CAMKK1 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 ATL2 MI:0362 inference MI:0461 interaction database GCH1 THOC2 MI:0362 inference MI:0461 interaction database GCH1 CALML6 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 IPO4 MI:0362 inference MI:0461 interaction database GCH1 DNAJA4 MI:0362 inference MI:0461 interaction database GCH1 ATL1 MI:0362 inference MI:0461 interaction database GCH1 HSPH1 MI:0362 inference MI:0461 interaction database GCH1 HIST1H2BH MI:0362 inference MI:0461 interaction database GCH1 HIST1H2BA MI:0362 inference MI:0461 interaction database GCH1 DNAJA3 MI:0362 inference MI:0461 interaction database GCH1 CNRIP1 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 SDSL MI:0362 inference MI:0461 interaction database GCH1 OSBPL9 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 EIF3C MI:0362 inference MI:0461 interaction database GCH1 NAP1L4 MI:0362 inference MI:0461 interaction database GCH1 CCT7 MI:0362 inference MI:0461 interaction database GCH1 HIST1H2BN MI:0362 inference MI:0461 interaction database GCH1 HIST1H2BM MI:0362 inference MI:0461 interaction database GCH1 HIST1H2BL MI:0362 inference MI:0461 interaction database GCH1 AGPAT1 MI:0362 inference MI:0461 interaction database GCH1 SH3GL2 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 TUBB6 MI:0362 inference MI:0461 interaction database GCH1 NTMT1 MI:0362 inference MI:0461 interaction database GCH1 TUBB2B MI:0362 inference MI:0461 interaction database GCH1 MLST8 MI:0362 inference MI:0461 interaction database GCH1 RIOK2 MI:0362 inference MI:0461 interaction database GCH1 FUT8 MI:0362 inference MI:0461 interaction database GCH1 WDR12 MI:0362 inference MI:0461 interaction database GCH1 EIF5A2 MI:0362 inference MI:0461 interaction database GCH1 NACA2 MI:0362 inference MI:0461 interaction database GCH1 SLC25A31 MI:0362 inference MI:0461 interaction database GCH1 DDX47 MI:0362 inference MI:0461 interaction database GCH1 PPA2 MI:0362 inference MI:0461 interaction database GCH1 TUBB1 MI:0362 inference MI:0461 interaction database GCH1 CSNK1G1 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 TUBA8 MI:0362 inference MI:0461 interaction database GCH1 CALML5 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 DNAJB4 MI:0362 inference MI:0461 interaction database GCH1 PACSIN3 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 RAB26 MI:0045 experimental interaction detection MI:0461 interaction database GCH1 NAP1L2 MI:0362 inference MI:0461 interaction database GCH1 PPIE MI:0362 inference MI:0461 interaction database GCH1 RUVBL2 MI:0362 inference MI:0461 interaction database GCH1 VDAC3 MI:0362 inference MI:0461 interaction database GCH1 CFL2 MI:0362 inference MI:0461 interaction database GCH1 RPH3A MI:0045 experimental interaction detection MI:0461 interaction database GCH1 GMPPB MI:0362 inference MI:0461 interaction database GCH1 PSAT1 MI:0362 inference MI:0461 interaction database