PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus APP FBXW9 21832049 biogrid exp G GP G G GP GP G G GP G G G G G G GP GP G G G G GP G G GP G G GP G FBXW9 COPS6 19615732,21145461 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G G G G GP GP G GP G GP GP G FBXW9 COPS5 21145461 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G G GP GP GP GP G GP GP G CUL1 FBXW9 21145461, 25402006 biogrid exp, pred GP G G G G GP G GP GP G GP GP GP G G GP GP G G G G GP GP GP GP G GP GP G SKP1 FBXW9 19159283, 25402006 biogrid,intact exp, pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G G G G GP GP G GP G GP GP G FBXW9 CDCA3 25402006 pred G GP G G GP P G GP GP P P GP GP G GP P G G G G GP GP GP G GP GP G FBXW9 FBXO6 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G G G GP GP GP GP G GP GP G FBXW9 FBXO46 25402006 pred GP G G G G GP G G GP G G G G G G GP GP G G G G G G GP GP G GP GP G FBXW9 FBXL8 25402006 pred P P P P P P P P P P P P P FBXW9 FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G FBXW9 FBXO2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW9 FBXW2 25402006 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G G G G G GP GP GP G GP GP G NFKBIB FBXW9 25402006 pred GP P G GP GP G GP P G GP GP GP GP G GP GP G G G GP GP GP GP G GP GP G FBXW9 FBXO34 25402006 pred G GP G G G G G G GP G G G G G G G G G G G G G G GP G G GP GP G FBXW9 FBXO4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G CUL7 FBXW9 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G G GP GP GP GP G GP GP G FBXW9 ZC3HC1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G G GP GP GP GP G GP GP G FBXO31 FBXW9 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G G G G GP GP GP GP G GP GP G FBXW9 CACYBP 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP G G G G GP GP G GP G GP GP G FBXW9 FBXW8 25402006 pred P P P P P P P P P P P P P P P P P P FBXW9 FAF1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G G G G GP GP GP GP G GP GP G FBXW9 FBXL3 25402006 pred G G G G GP G G G G G G G G G G G G G G G G G G G G G G G G RBX1 FBXW9 25402006 pred G G G G G GP G GP G G G G GP G G G GP G G G G GP G G G G G GP G FBXW9 FBXO44 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP G GP GP G FBXW9 FBXW5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G G G G GP GP GP GP G GP GP G FBXW9 FBXO18 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G G GP GP GP GP G GP GP G FBXW9 FBXW11 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW9 FBXO17 25402006 pred G G G G G G G G G G G FBXW9 FBXW7 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP G GP GP

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SKP1 FBXW9 MI:0231(mammalian protein protein interaction trap)|MI:0018(two hybrid)|MI:0231(mammalian protein protein interaction trap)|MI:0231(mammalian protein protein interaction trap)|MI:0018(two hybrid)|MI:0231(mammalian protein protein interaction trap) 19159283 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact)|(intact)|(biogrid)|(intact) UniProt_168272|BIOGRID_197023|UniProt_98768|UniProt_98769|BIOGRID_197003|UniProt_98779 bait|prey|bait|bait|bait|bait prey|bait|prey|prey|prey|prey APP FBXW9 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229668 prey bait UBC FBXW9 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21890473,21906983,21963094 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_266149|BIOGRID_176074|BIOGRID_180553 bait|bait|bait prey|prey|prey FBXW9 COPS5 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205212 prey bait FBXW9 COPS6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_205720|BIOGRID_120731|UniProt_100633 prey|prey|prey bait|bait|bait CUL1 FBXW9 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_204537 bait prey

PPI - HINT Gene A Gene B PMID Method Quality CUL1 FBXW9 21145461 0004 HT FBXW9 COPS6 19615732,21145461,19615732 0004,0004,0007 HT FBXW9 COPS5 21145461 0004 HT CUL1 FBXW9 21145461 0004 HT FBXW9 COPS6 19615732,21145461,19615732 0004,0004,0007 HT FBXW9 COPS5 21145461 0004 HT SKP1 FBXW9 19159283,19159283,19159283,19159283 0007,0231,0004,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5XUX1 P05067 FBXW9 APP 0.183 21832049 Q9WTX5 Q5XUX1 SKP1 FBXW9 0.236 26496610 Q5XUX1 P63208 FBXW9 SKP1 0.765 19159283,27705803 Q7L5N1 Q5XUX1 COPS6 FBXW9 0.332 19615732,21145461 Q92905 Q5XUX1 COPS5 FBXW9 0.126 21145461 Q5XUX1 Q13616 FBXW9 CUL1 0.126 21145461

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SIAH2 FBXW9 MI:0362 inference MI:1106 pathways database FBXO21 FBXW9 MI:0362 inference MI:1106 pathways database APP FBXW9 MI:0045 experimental interaction detection MI:0461 interaction database UBB FBXW9 MI:0362 inference MI:1106 pathways database UBC FBXW9 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM21 FBXW9 MI:0362 inference MI:1106 pathways database TAF1 FBXW9 MI:0045 experimental interaction detection MI:0461 interaction database CCNF FBXW9 MI:0362 inference MI:1106 pathways database UBE2A FBXW9 MI:0362 inference MI:1106 pathways database FBXW4 FBXW9 MI:0362 inference MI:1106 pathways database RBX1 FBXW9 MI:0362 inference MI:1106 pathways database RPS27A FBXW9 MI:0362 inference MI:1106 pathways database UBA52 FBXW9 MI:0362 inference MI:1106 pathways database SKP1 FBXW9 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SKP2 FBXW9 MI:0362 inference MI:1106 pathways database CUL1 FBXW9 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIP12 FBXW9 MI:0362 inference MI:1106 pathways database LONRF1 FBXW9 MI:0362 inference MI:1106 pathways database HECTD2 FBXW9 MI:0362 inference MI:1106 pathways database FBXO31 FBXW9 MI:0362 inference MI:1106 pathways database FBXW9 FBXW10 MI:0362 inference MI:1106 pathways database FBXW9 RNF213 MI:0362 inference MI:1106 pathways database FBXW9 FBXL22 MI:0362 inference MI:1106 pathways database FBXW9 FBXL19 MI:0362 inference MI:1106 pathways database FBXW9 FBXW12 MI:0362 inference MI:1106 pathways database FBXW9 RNF19B MI:0362 inference MI:1106 pathways database FBXW9 COPS6 MI:0045 experimental interaction detection MI:0461 interaction database FBXW9 RNF144B MI:0362 inference MI:1106 pathways database FBXW9 RBBP6 MI:0362 inference MI:1106 pathways database FBXW9 HUWE1 MI:0362 inference MI:1106 pathways database FBXW9 TRIM69 MI:0362 inference MI:1106 pathways database FBXW9 SIAH1 MI:0362 inference MI:1106 pathways database FBXW9 HERC6 MI:0362 inference MI:1106 pathways database FBXW9 UBR2 MI:0362 inference MI:1106 pathways database FBXW9 FBXL14 MI:0362 inference MI:1106 pathways database FBXW9 FBXW8 MI:0362 inference MI:1106 pathways database FBXW9 FBXL16 MI:0362 inference MI:1106 pathways database FBXW9 FBXO15 MI:0362 inference MI:1106 pathways database FBXW9 ZNRF1 MI:0362 inference MI:1106 pathways database FBXW9 FBXL13 MI:0362 inference MI:1106 pathways database FBXW9 FBXO22 MI:0362 inference MI:1106 pathways database FBXW9 ZNRF2 MI:0362 inference MI:1106 pathways database FBXW9 FBXO27 MI:0362 inference MI:1106 pathways database FBXW9 FBXO30 MI:0362 inference MI:1106 pathways database FBXW9 RNF217 MI:0362 inference MI:1106 pathways database FBXW9 DTX3L MI:0362 inference MI:1106 pathways database FBXW9 FBXO41 MI:0362 inference MI:1106 pathways database FBXW9 LMO7 MI:0362 inference MI:1106 pathways database FBXW9 MYLIP MI:0362 inference MI:1106 pathways database FBXW9 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database FBXW9 FBXW7 MI:0362 inference MI:1106 pathways database FBXW9 FBXO32 MI:0362 inference MI:1106 pathways database FBXW9 FBXW5 MI:0362 inference MI:1106 pathways database FBXW9 MIB2 MI:0362 inference MI:1106 pathways database FBXW9 SPSB1 MI:0362 inference MI:1106 pathways database FBXW9 FBXL8 MI:0362 inference MI:1106 pathways database FBXW9 FBXO17 MI:0362 inference MI:1106 pathways database FBXW9 FBXL20 MI:0362 inference MI:1106 pathways database FBXW9 FBXL18 MI:0362 inference MI:1106 pathways database FBXW9 NEDD4L MI:0362 inference MI:1106 pathways database FBXW9 RBCK1 MI:0362 inference MI:1106 pathways database FBXW9 FBXL15 MI:0362 inference MI:1106 pathways database FBXW9 FBXO44 MI:0362 inference MI:1106 pathways database FBXW9 UNKL MI:0362 inference MI:1106 pathways database FBXW9 SMURF2 MI:0362 inference MI:1106 pathways database FBXW9 TRIM36 MI:0362 inference MI:1106 pathways database FBXW9 FBXO6 MI:0362 inference MI:1106 pathways database FBXW9 RNF19A MI:0362 inference MI:1106 pathways database FBXW9 RLIM MI:0362 inference MI:1106 pathways database FBXW9 FBXL12 MI:0362 inference MI:1106 pathways database FBXW9 FBXO40 MI:0362 inference MI:1106 pathways database FBXW9 HERC5 MI:0362 inference MI:1106 pathways database FBXW9 FBXL7 MI:0362 inference MI:1106 pathways database FBXW9 FBXO2 MI:0362 inference MI:1106 pathways database FBXW9 FBXO10 MI:0362 inference MI:1106 pathways database FBXW9 FBXO9 MI:0362 inference MI:1106 pathways database FBXW9 FBXL5 MI:0362 inference MI:1106 pathways database FBXW9 FBXL4 MI:0362 inference MI:1106 pathways database FBXW9 FBXW11 MI:0362 inference MI:1106 pathways database FBXW9 FBXO4 MI:0362 inference MI:1106 pathways database FBXW9 FBXL21 MI:0362 inference MI:1106 pathways database FBXW9 FBXL3 MI:0362 inference MI:1106 pathways database FBXW9 FBXW2 MI:0362 inference MI:1106 pathways database FBXW9 BTRC MI:0362 inference MI:1106 pathways database FBXW9 FBXO7 MI:0362 inference MI:1106 pathways database FBXW9 RNF115 MI:0362 inference MI:1106 pathways database FBXW9 RNF114 MI:0362 inference MI:1106 pathways database FBXW9 WSB1 MI:0362 inference MI:1106 pathways database