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G G G G G G G TRIM21 UBE2N 25260751 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G TRIM21 MAP1LC3A 20562859 intact exp G GP G G G GP G G GP G G GP G G G GP GP G GP G G G G G GP G G GP G HSP90AB1 TRIM21 25036637 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP19 TRIM21 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM21 UBE2L3 16472766 biogrid exp GP G G G G GP G GP GP G GP G G G G GP GP G GP G G G GP GP GP G GP GP G TRIM21 CASP8AP2 20697732 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM21 HAUS2 23443559 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM21 TRIM39 25416956,22493164 biogrid,intact exp P P P P P P P P P P P P P TRIM21 NOS2 23438482 biogrid exp P P G G P G P GP P P P P GP GP G GP G P P P P GP P P G ERG TRIM21 21575865 biogrid,intact exp G GP G GP P GP GP GP GP GP GP G GP P G 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G G GP GP GP G GP GP G GP G GP GP GP G TRIM21 CUL1 16880511, 25402006, 23023127 innatedb,biogrid exp, pred GP G G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM21 USP4 11461834,23105109,16403452,16472766, 23023127 hprd,biogrid,intact exp, pred G GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP G GP GP GP G GP GP G UBE2C TRIM21 16472766, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM21 FADD 21183682, 23023127 innatedb,biogrid exp, pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP G GP GP GP GP GP GP G TRIM21 FCGR2B ortho G GP G GP G GP G P G G GP G G GP G G P G GP G G TRIM21 PSMD2 ortho GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM21 UVRAG ortho G G G G G GP G GP G G GP G GP G G G GP G G G GP G G G G G GP GP G TRIM21 RPS27A ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM21 PSMC4 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM21 PSMC6 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PSMD14 TRIM21 ortho GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G G GP GP G GP GP G TRIM21 PSMD6 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G GJA1 TRIM21 ortho GP GP G G GP GP G GP GP G GP G GP GP G GP GP G G G GP GP G G GP GP GP GP G TRIM21 PSMC1 ortho GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G TRIM21 PSMD1 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM21 DDX41 ortho GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G TRIM21 SIGLEC10 ortho G G G GP P GP G P G GP GP G G GP P GP G G P G GP GP P G PSMD11 TRIM21 ortho G GP G G GP GP G GP GP G GP G GP G G G GP G G G GP G G G G G G GP G TRIM21 PSMC2 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP 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TRIM21 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM21 CYLD 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP CNOT4 TRIM21 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G A2M TRIM21 23023127 pred G G G G G GP G G GP G G GP G G G G GP G G G GP G G G G G G G G TRIM21 TNFAIP3 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G TRIM21 TRIM72 23023127 pred P P P GP G G P TRIM21 FBXO4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G TNFRSF1A TRIM21 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM21 TRIM56 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP G P GP GP GP GP G TRIM21 NMI 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G TRIM21 HLA-F 25402006 pred G G G G G G G G G G G G G G G G G G G 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GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G EGF TRIM21 23023127 pred P P P P GP P GP P P P G P P GP P GP GP GP GP P P P TRIM75P TRIM21 23023127 pred CSTA TRIM21 23023127 pred GP G G GP G G G GP GP GP G G G GP GP G G G GP GP G TRIM21 RLIM 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM21 CKS1B 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CXCL11 TRIM21 25402006 pred P P P P P P P P P P P P P GP P P P P P P P P TRIM21 UBE2R2 23023127 pred G G G G GP G G G G G G G G GP G G G G G G G G G G G GP GP G G VEGFA TRIM21 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM21 CTGF 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IGLC1 TRIM21 23023127 pred TRIM21 MDM2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM21 AMFR 23023127 pred GP GP G G 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23023127 pred TRIM21 RNF220 23023127 pred G GP G G GP GP G G GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP G G IFITM1 TRIM21 25402006 pred GP G G G GP GP G G GP G GP G G GP G G GP GP G G G G GP G G GP G G G ISG15 TRIM21 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM21 NLRP3 23023127 pred P G GP P P P P P P P P TRIM21 CHFR 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PDGFRB TRIM21 23023127 pred G G G G G GP G G G G GP G G G G G GP GP G G GP GP G G G G GP GP G TRIM38 TRIM21 23023127 pred GP GP G GP P G GP GP GP GP GP GP G GP GP GP GP GP GP GP GP GP GP GP P G TRIM21 TRIM54 23023127 pred P P P GP P P P P G P GP GP P P TRIM21 TNFSF4 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP P GP GP P G P GP GP GP GP G GP GP G TRIM21 CALM1, CALM2, CALM3 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TGFB1 TRIM21 23023127 pred G G G G GP G G G G G G G G G G GP G G G G GP G G GP GP GP G G TRIM21 RNF41 23023127 pred GP GP G G G GP G GP GP G GP P G G GP GP P P G P G P GP GP GP GP P TRIM21 SOX17 23023127 pred GP GP G G GP P G GP GP GP GP GP GP G GP GP GP GP G GP GP P GP GP GP GP GP G TRIM21 DNAJC1 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TRIM21 NFAM1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP GP GP GP G TRIM21 TRIM6 23023127 pred G GP G G G GP GP G G G G G G GP G G G G G GP G TRIM21 TNFRSF4 23023127 pred P GP GP G TRIM21 FNTA 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IFIT3 TRIM21 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP G G GP GP GP G GP G GP GP G OAS1 TRIM21 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP P G TRIM13 TRIM21 23023127 pred GP GP G G G GP G G GP G G GP GP G G GP GP G G G G GP G GP GP G GP GP G TRIM21 BCL3 23023127 pred G G G GP G GP GP G G G 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PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P19474 P11308 affinity chromatography technology 21575865 physical association X 2 P19474 affinity chromatography technology 20697732 physical association X 2 P19474 two hybrid 20697732 direct interaction X 2 P19474 Q9UKL3 two hybrid 20697732 direct interaction X 2 P19474 E2GIM6 affinity chromatography technology 22479513 physical association X 2 P19474 E2GIM6 affinity chromatography technology 18641315 physical association X 2 P19474 E2GIM6 affinity chromatography technology 18641315 physical association X 2 P19474 biochemical 10785401 association X 2 P19474 P22681 affinity chromatography technology 19380743 physical association X 2 P19474 P0CG48 affinity chromatography technology 22505724 physical association X 2 P19474 pull down 16472766 direct interaction X 2 P19474 P62837 pull down 16472766 direct interaction X 2 P19474 O00762 pull down 16472766 direct interaction X 2 P19474 P62837 pull down 16403452 direct interaction X 2 P19474 P62837 pull down 19675099 direct interaction X 2 P19474 O15205 affinity chromatography technology 22797925 physical association X 2 P19474 P55072 affinity chromatography technology 23383273 physical association X 2 P19474 P01106 affinity chromatography technology 21150319 physical association X 2 P19474 P0CG48 enzymatic study 23455675 direct interaction X 2 P19474 Q504Q3-3 affinity chromatography technology 23398456 physical association X 2 P19474 A0A024RCP5 two hybrid 22493164 direct interaction X 2 P19474 O15205 affinity chromatography technology 23862649 physical association X 2 P19474 Q9NRD1 affinity chromatography technology 22268729 physical association X 2 P19474 P0CG48 affinity chromatography technology 24816145 physical association X 2 P19474 P62837 pull down 16297862 direct interaction X 2 P19474 P0CG48 affinity chromatography technology 16297862 physical association X 2 P19474 P0CG48 affinity chromatography technology 16316627 physical association X 2 P19474 A0A024R9P0 affinity chromatography technology 23443559 physical association X 2 P19474 P63279 two hybrid 25416956 direct interaction X 2 P19474 A0A024RCP5 two hybrid 25416956 direct interaction X 2 P19474 Q15788 affinity chromatography technology 11971985 physical association X 2 P19474 Q9Y6Q9-5 affinity chromatography technology 11971985 physical association X 2 P19474 P0CG48 affinity chromatography technology 18312418 physical association X 2 P19474 Q13309-2 affinity chromatography technology 16880511 physical association X 2 P19474 Q13309-2 affinity chromatography technology 16880511 physical association X 2 P19474 Q13309-2 affinity chromatography technology 16880511 physical association X 2 P19474 P63208 affinity chromatography technology 16880511 physical association X 2 P19474 Q13309-2 biochemical 16880511 colocalization X 2 P19474 P63208 biochemical 16880511 colocalization X 2 P19474 pull down 16880511 direct interaction X 2 P19474 affinity chromatography technology 16880511 physical association X 2 P19474 Q13309-2 pull down 16880511 direct interaction X 2 P19474 two hybrid 20936779 direct interaction X 2 P19474 P0CG48 affinity chromatography technology 12127959 physical association X 2 P19474 Q13547 affinity chromatography technology 20585571 physical association X 2 P19474 P0CG48 affinity chromatography technology 16403452 physical association X 2 P19474 P0CG48 affinity chromatography technology 16335966 physical association X 2 P19474 E2GIM6 affinity chromatography technology 19265157 physical association X 2 P19474 E2GIM6 affinity chromatography technology 19265157 physical association X 2 P19474 E2GIM6 pull down 19265157 direct interaction X 2 P19474 E2GIM6 affinity chromatography technology 19265157 physical association X 2 P19474 Q13158 affinity chromatography technology 21183682 physical association X 2 P19474 Q13158 affinity chromatography technology 21183682 physical association X 2 P19474 Q13158 pull down 21183682 direct interaction X 2 P19474 P0CG48 affinity chromatography technology 21183682 physical association X 2 P19474 B4E1P5 affinity chromatography technology 19167051 physical association X 2 P19474 P0CG48 pull down 18022694 direct interaction X 2 P19474 Q9Y6Q9-5 affinity chromatography technology 16051665 physical association X 2 P19474 Q13501 affinity chromatography technology 19201866 physical association X 2 P19474 Q13501 affinity chromatography technology 19201866 physical association X 2 P19474 P0CG48 affinity chromatography technology 19201866 physical association X 2 P19474 D0PNI1 affinity chromatography technology 15324660 physical association X 2 P19474 Q92985-3 affinity chromatography technology 20668674 physical association X 2 P19474 P0CG48 affinity chromatography technology 21987572 physical association X 2 P19474 P0CG48 pull down 21045130 direct interaction X 2 P19474 A0A024RB77 affinity chromatography technology 21319273 physical association X 2 P19474 Q8IX07 affinity chromatography technology 17118455 physical association X 2 P19474 P31358 affinity chromatography technology 17118455 physical association X 2 P19474 P12318 affinity chromatography technology 17118455 physical association X 2 P19474 P12318 affinity chromatography technology 17118455 physical association X 2 P19474 P19474 pull down 17156811 direct interaction X 2 P19474 Q9C035 pull down 16775307 direct interaction X 2 P19474 Q8IU60 affinity chromatography technology 18361920 physical association X 2 P19474 Q8IU60 pull down 18361920 direct interaction X 2 P19474 Q8IU60 affinity chromatography technology 18361920 physical association X 2 P19474 P19474 two hybrid 15916807 direct interaction X 2 P19474 P15731 pull down 18022694 direct interaction X 2 P19474 A0A087WW00 pull down 21045130 direct interaction X 2 P19474 A0A087WW00 pull down 17579016 direct interaction X 2 P19474 A0A024R1A4 pull down 16472766 direct interaction X 2 P19474 A0A024R1Z1 pull down 16472766 direct interaction X 2 P19474 O75604-2 two hybrid 23105109 direct interaction X 2 P19474 Q13107-3 two hybrid 23105109 direct interaction X 2 P19474 Q9Y4E8-2 two hybrid 23105109 direct interaction X 2 P19474 Q01973-3 affinity chromatography technology 23153538 physical association X 2 P19474 affinity chromatography technology 21565611 physical association X 2 P19474 P35228 affinity chromatography technology 23438482 physical association X 2 P19474 P06748-2 affinity chromatography technology 23402259 physical association X 2 P19474 A0A024R5T5 two hybrid 22493164 direct interaction X 2 P19474 Q86Y13 two hybrid 22493164 direct interaction X 2 P19474 P14373 two hybrid 22493164 direct interaction X 2 P19474 two hybrid 22493164 direct interaction X 2 P19474 two hybrid 22493164 direct interaction X 2 P19474 Q9BZR9 two hybrid 22493164 direct interaction X 2 P19474 P19474 enzymatic study 16297862 direct interaction X 2 P19474 P19474 two hybrid 25416956 direct interaction X 2 P19474 Q9Y4E8-2 two hybrid 25416956 direct interaction X 2 P19474 Q13588 two hybrid 25416956 direct interaction X 2 P19474 Q99757 two hybrid 25416956 direct interaction X 2 P19474 P19474 two hybrid 11331580 direct interaction X 2 P19474 Q13107-3 two hybrid 11461834 direct interaction X 2 P19474 Q02556 affinity chromatography technology 17579016 physical association X 2 P19474 Q02556 affinity chromatography technology 17579016 physical association X 2 P19474 Q02556 pull down 17579016 direct interaction X 2 P19474 Q02556 enzymatic study 17579016 direct interaction X 2 P19474 affinity chromatography technology 19615732 physical association X 2 P19474 A0A090N7U0 affinity chromatography technology 16880511 physical association X 2 P19474 A0A090N7U0 biochemical 16880511 colocalization X 2 P19474 A0A090N7U0 pull down 16880511 direct interaction X 2 P19474 P46527 affinity chromatography technology 16880511 physical association X 2 P19474 Q13107-3 enzymatic study 16472766 direct interaction X 2 P19474 P19474 enzymatic study 16403452 direct interaction X 2 P19474 Q13107-3 enzymatic study 16403452 direct interaction X 2 P19474 Q9HCK5 affinity chromatography technology 19167051 physical association X 2 P19474 affinity chromatography technology 19675099 physical association X 2 P19474 enzymatic study 19675099 direct interaction X 2 P19474 P19474 enzymatic study 18022694 direct interaction X 2 P19474 D7RIH8 two hybrid 18022694 direct interaction X 2 P19474 D7RIH8 affinity chromatography technology 18022694 physical association X 2 P19474 P61981 affinity chromatography technology 15324660 physical association X 2 P19474 P19474 enzymatic study 21045130 direct interaction X 2 P19474 Q9GZT8-3 two hybrid 16189514 direct interaction X 2 P19474 in vivo 11251884 - X 2 P19474 in vivo 15324660 - X 2 P19474 in vivo 15324660 - X 2 P19474 in vivo 11251884 - X 2 P19474 P19474 two hybrid 11331580 - X 2 P19474 A0A024R2X6 two hybrid 11461834 - X 2 P19474 Q9GZT8-3 two hybrid 16189514 - X 2 P19474 A0A024R2X6 two hybrid 11461834 - X 2 P19474 Q9GZT8-3 two hybrid 16189514 - X 2 P19474 anti bait coimmunoprecipitation 22575643 association C 122 P19474 anti tag coimmunoprecipitation 19167051 association C 42 P19474 tandem affinity purification 21150319 association C 87 P19474 affinity chromatography technology 11971985 association C 7 P19474 affinity chromatography technology 11971985 association C 4 P19474 anti bait coimmunoprecipitation 23153538 association C 4 P19474 anti tag coimmunoprecipitation 21565611 association C 171 P19474 P29692 two hybrid 11461834 physical association X 2 P19474 D0PNI1 coimmunoprecipitation 15324660 physical association X 2 P19474 A0A024R688 two hybrid array 22493164 physical association X 2 P19474 A0A024RCP5 two hybrid array 22493164 physical association X 2 P19474 Q7KZS0 two hybrid prey pooling approach 25416956 physical association X 2 P19474 A0A024RCP5 two hybrid prey pooling approach 25416956 physical association X 2 P19474 Q7KZS0 two hybrid array 25416956 physical association X 2 P19474 A0A024RCP5 two hybrid array 25416956 physical association X 2 P19474 Q7KZS0 validated two hybrid 25416956 physical association X 2 P19474 A0A024RCP5 validated two hybrid 25416956 physical association X 2 P19474 tandem affinity purification 22810585 association C 7 P19474 anti bait coimmunoprecipitation 23153538 association C 5 P19474 anti bait coimmunoprecipitation 23153538 association C 5 P19474 tandem affinity purification 19380743 association C 12 P19474 anti tag coimmunoprecipitation 21575865 association C 23 P19474 anti tag coimmunoprecipitation 21575865 association C 23 P19474 ubiquitinase assay 25260751 ubiquitination reaction C 4 P19474 A0A024R2T0 two hybrid 11461834 physical association X 2 P19474 P19429 two hybrid 11461834 physical association X 2 P19474 A0A024R2T0 two hybrid 11461834 physical association X 2 P19474 A0A024R2T0 two hybrid 11461834 physical association X 2 P19474 P61981 coimmunoprecipitation 15324660 physical association X 2 P19474 A0A024R3V7 two hybrid pooling approach 16189514 physical association X 2 P19474 P25054 two hybrid pooling approach 20936779 physical association X 2 P19474 P14373 two hybrid array 22493164 physical association X 2 P19474 Q86Y13 two hybrid array 22493164 physical association X 2 P19474 Q9BYM8 two hybrid array 22493164 physical association X 2 P19474 Q9BZR9 two hybrid array 22493164 physical association X 2 P19474 P19474 anti tag coimmunoprecipitation 22493164 physical association X 2 P19474 Q6ZNA4 two hybrid array 22493164 physical association X 2 P19474 P19474 two hybrid 22829933 physical association X 2 P19474 Q6PK50 luminescence based mammalian interactome mapping 25036637 physical association X 2 P19474 P19474 two hybrid array 25416956 physical association X 2 P19474 Q13588 two hybrid prey pooling approach 25416956 physical association X 2 P19474 Q99757 two hybrid prey pooling approach 25416956 physical association X 2 P19474 Q9Y4E8 two hybrid prey pooling approach 25416956 physical association X 2 P19474 Q13588 two hybrid array 25416956 physical association X 2 P19474 Q99757 two hybrid array 25416956 physical association X 2 P19474 Q9Y4E8 two hybrid array 25416956 physical association X 2 P19474 Q13588 validated two hybrid 25416956 physical association X 2 P19474 Q99757 validated two hybrid 25416956 physical association X 2 P19474 Q9Y4E8 validated two hybrid 25416956 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B TRIM21 NOS2 MI:0004(affinity chromatography technology) 23438482 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_258340 prey bait TRIM21 UBE2D2 MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 16403452,16472766,19675099 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_225719|BIOGRID_225923|BIOGRID_226072 bait|bait|bait prey|prey|prey NPM1 TRIM21 MI:0004(affinity chromatography technology) 23402259 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_274480 bait prey TRIM21 ROR1 MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation)|MI:0006(anti bait coimmunoprecipitation) 23153538 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0914(association)|MI:0914(association) (intact)|(biogrid)|(intact)|(intact) UniProt_126264|BIOGRID_253634|UniProt_126266|UniProt_126265 prey|prey|prey|prey bait|bait|bait|bait TRIM21 DZIP3 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284102|UniProt_122493 bait|bait prey|prey TRIM21 YWHAZ MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0019(coimmunoprecipitation) 15324660 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) MI:0471(mint)|(intact)|(biogrid)|MI:0468(hprd)|MI:0471(mint) MINT_55829|UniProt_79534|BIOGRID_150304|HPRD_25862|MINT_58660 prey|prey|prey|-|prey bait|bait|bait|-|bait TRIM21 SKP1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16880511 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_123011|BIOGRID_123008 bait|bait prey|prey TRIM21 NIF3L1 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|(biogrid)|MI:0468(hprd)|MI:0471(mint)|(intact) MINT_67376|BIOGRID_79966|HPRD_20326|MINT_38193|UniProt_152811 bait|bait|-|bait|unspecified role prey|prey|-|prey|unspecified role TRIM21 TRIM5 MI:0096(pull down) 16775307 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_212747 bait prey TRIM21 EIF2C4 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19167051 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_145763|UniProt_98607 prey|prey bait|bait TRIM21 TRIM39 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122414|BIOGRID_283995 bait|bait prey|prey TRIM21 MNAT1 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122474|BIOGRID_284155 prey|prey bait|bait TRIM21 TRIM8 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122495|BIOGRID_284162 prey|bait bait|prey TRIM21 UBE2D1 MI:0004(affinity chromatography technology)|MI:0415(enzymatic study) 17579016,21045130 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_225680|BIOGRID_223176 bait|bait prey|prey TRIM21 RBCK1 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284139|UniProt_122494 bait|bait prey|prey TRIM21 EIF2C3 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19167051 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_145729|UniProt_98606 prey|prey bait|bait TRIM21 EEF1D MI:0018(two hybrid) 11461834 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_67932 bait prey TRIM21 CDC34 MI:0415(enzymatic study) 16472766 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225722 bait prey TRIM21 DCP2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18361920 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_214209|BIOGRID_214211|BIOGRID_214210 prey|bait|prey bait|prey|bait TNNI3 TRIM21 MI:0018(two hybrid) 11461834 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_67931 prey bait TRIM21 NCOA3 MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11971985,16051665 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_69625|BIOGRID_148558|BIOGRID_112629 neutral component|prey|prey neutral component|bait|bait ERG TRIM21 MI:0004(affinity chromatography technology) 21575865 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_195710 bait prey TRIM21 USP15 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248200 prey bait FCGR2A TRIM21 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17118455 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_211279|BIOGRID_211280 prey|bait bait|prey TRIM21 FBXO6 MI:0004(affinity chromatography technology) 22268729 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_292535 prey bait TRIM21 IRF7 MI:0004(affinity chromatography technology) 20668674 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_154887 prey bait UBC TRIM21 MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 12127959,16335966,16403452,18022694,18312418,19201866,21045130,21183682,21987572,22505724,23455675 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_132696|BIOGRID_164994|BIOGRID_117312|BIOGRID_148316|BIOGRID_140732|BIOGRID_224940|BIOGRID_258060|BIOGRID_140004|BIOGRID_148981|BIOGRID_163179|BIOGRID_142539 prey|prey|prey|prey|bait|bait|prey|prey|bait|bait|prey bait|bait|bait|bait|prey|prey|bait|bait|prey|prey|bait TRIM21 VCP MI:0004(affinity chromatography technology) 23383273 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_249809 prey bait HLA-DRB1 TRIM21 MI:0415(enzymatic study)|MI:0415(enzymatic study) 18022694 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_148318|BIOGRID_148317 bait|prey prey|bait TRIM21 HDAC1 MI:0004(affinity chromatography technology) 20585571 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_138845 prey bait TRIM21 CUL1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16880511 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_123009|BIOGRID_123185|BIOGRID_123006 bait|bait|bait prey|prey|prey TRIM21 SQSTM1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19201866 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_148979|BIOGRID_148977 bait|prey prey|bait TRIM21 SKP2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16880511 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_123184|BIOGRID_123003|BIOGRID_123005|BIOGRID_123010|BIOGRID_123007 bait|prey|prey|bait|bait prey|bait|bait|prey|prey TRIM21 FADD MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21183682 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_142536|BIOGRID_142537|BIOGRID_142538 prey|prey|prey bait|bait|bait TRIM21 USP4 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0415(enzymatic study)|MI:0018(two hybrid)|MI:0415(enzymatic study)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 11461834,16403452,16472766,23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0407(direct interaction) (intact)|(intact)|(biogrid)|(biogrid)|(biogrid)|(intact)|MI:0468(hprd)|(biogrid) UniProt_67933|UniProt_67934|BIOGRID_140005|BIOGRID_116504|BIOGRID_124751|UniProt_67930|HPRD_5594|BIOGRID_248185 bait|bait|prey|bait|bait|bait|-|prey null|null|bait|prey|prey|null|-|bait TRIM21 CD52 MI:0004(affinity chromatography technology) 17118455 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_211278 bait prey IKBKB TRIM21 MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 11971985,19675099 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid) UniProt_69625|BIOGRID_148198|BIOGRID_148201 neutral component|prey|prey neutral component|bait|bait TROVE2 TRIM21 MI:0493(in vivo)|MI:0401(biochemical) 10785401,11251884 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0914(association) MI:0468(hprd)|(biogrid) HPRD_5613|BIOGRID_212360 -|bait -|prey TRIM21 UBE2L3 MI:0415(enzymatic study) 16472766 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225720 bait prey TRIM27 TRIM21 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284121|UniProt_122492 prey|prey bait|bait TRIM21 CASP8AP2 MI:0004(affinity chromatography technology) 20697732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_199987 bait prey TRIM21 FBXW11 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16880511 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_123183|BIOGRID_123182 bait|prey prey|bait MYC TRIM21 MI:0676(tandem affinity purification)|MI:0401(biochemical) 21150319 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_110256|BIOGRID_252314 bait|bait prey|prey TRIM21 ZFPM1 MI:0004(affinity chromatography technology) 17118455 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_211276 bait prey TRIM21 DAXX MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 20697732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_199985|BIOGRID_199986 bait|bait prey|prey TRIM21 APC MI:0096(pull down)|MI:0018(two hybrid) 20936779 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_110346|BIOGRID_126833 prey|prey bait|bait TRIM21 PAN2 MI:0004(affinity chromatography technology) 23398456 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_273193 prey bait TRIM21 UBE2H MI:0415(enzymatic study) 16472766 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225718 bait prey TRIM21 IQCB1 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 21565611 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association)|MI:0914(association) (intact)|(biogrid)|(intact) UniProt_205051|BIOGRID_257268|UniProt_113722 prey|prey|prey bait|bait|bait USP2 TRIM21 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248161 bait prey UBE2C TRIM21 MI:0415(enzymatic study) 16472766 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225721 prey bait TRIM21 YWHAG MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0019(coimmunoprecipitation)|MI:0019(coimmunoprecipitation) 15324660 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint)|MI:0471(mint) UniProt_79407|BIOGRID_150216|MINT_55664|MINT_58487 prey|prey|prey|prey bait|bait|bait|bait TRIM21 CDK2 MI:0004(affinity chromatography technology) 21319273 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_204305 prey bait TRIM21 CBL MI:0006(anti bait coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19380743 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_99105|BIOGRID_219456 prey|prey bait|bait TRIM21 NCOA1 MI:0019(coimmunoprecipitation)|MI:0004(affinity chromatography technology) 11971985 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0914(association)|MI:0915(physical association) (intact)|(biogrid) UniProt_69626|BIOGRID_112627 neutral component|prey neutral component|bait TRIM21 IRF8 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17579016 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_118975|BIOGRID_118977|BIOGRID_118985|BIOGRID_118979 prey|prey|bait|bait bait|bait|prey|prey UBD TRIM21 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 22797925,23862649 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_226623|BIOGRID_284468 bait|bait prey|prey USP19 TRIM21 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119807|UniProt_100665 bait|bait prey|prey TRIM21 CDKN1B MI:0004(affinity chromatography technology) 16880511 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_123186 bait prey TRIM21 RNF111 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284024|UniProt_122435 bait|bait prey|prey TRIM21 IRF3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18641315,19265157,22479513 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_141971|BIOGRID_141972|BIOGRID_141970|BIOGRID_201039|BIOGRID_200791|BIOGRID_201040|BIOGRID_141974 prey|prey|prey|prey|bait|bait|bait bait|bait|bait|bait|prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality PFKFB2 TRIM21 26496610,26496610 0007,0004 HT USP19 TRIM21 19615732,19615732 0004,0007 HT UBC TRIM21 18312418,18022694,19201866,21183682,21045130,12127959,16335966,16403452 0004,0096,0004,0004,0096,0004,0004,0004 LC TRIM21 TRIM21 17156811,22493164 0096,0007 LC TRIM21 CBL 19380743,19380743 0004,0676 HT TRIM21 UBE2D1 17579016,21045130 0096,0096 LC TRIM21 GABARAPL2 20562859,26347139 0007,0096 HT,LC TRIM21 YWHAG 15324660,15324660 0004,0019 HT TRIM21 UBE2D2 16297862,19675099,16403452,16472766 0096,0096,0096,0096 LC TRIM21 YWHAZ 15324660,15324660 0004,0019 HT TRIM21 IRF8 17579016,17579016,17579016,22096565 0415,0096,0004,0007 LC TRIM21 SQSTM1 19201866,26347139,26043024 0004,0096,0004 LC TRIM21 IRF3 18641315,19265157,22479513,18641315,19265157,18641315,19265157 0004,0096,0004,0096,0007,0007,0004 LC TRIM21 IQCB1 21565611,21565611 0004,0007 HT TRIM21 IRF7 20668674,20668674,18641315 0004,0007,0096 LC TRIM21 MAP1LC3B 20562859,26347139 0007,0096 HT,LC TRIM21 GABARAPL1 20562859,26347139 0007,0096 HT,LC TRIM21 MAP1LC3A 20562859,26347139 0007,0096 HT,LC TRIM21 HAUS2 23443559 0004 HT TRIM21 NCOA3 16051665,11971985 0004,0004 LC PFKFB2 TRIM21 26496610,26496610 0007,0004 HT USP19 TRIM21 19615732,19615732 0004,0007 HT TRIM21 CBL 19380743,19380743 0004,0676 HT TRIM21 GABARAPL2 20562859 0007 HT TRIM21 YWHAG 15324660,15324660 0004,0019 HT TRIM21 YWHAZ 15324660,15324660 0004,0019 HT TRIM21 IQCB1 21565611,21565611 0004,0007 HT TRIM21 MAP1LC3B 20562859 0007 HT TRIM21 GABARAPL1 20562859 0007 HT TRIM21 MAP1LC3A 20562859 0007 HT TRIM21 HAUS2 23443559 0004 HT UBC TRIM21 18312418,18022694,19201866,21183682,21045130,12127959,16335966,16403452 0004,0096,0004,0004,0096,0004,0004,0004 LC TRIM21 TRIM21 17156811,22493164 0096,0007 LC TRIM21 UBE2D1 17579016,21045130 0096,0096 LC TRIM21 GABARAPL2 26347139 0096 LC TRIM21 UBE2D2 16297862,19675099,16403452,16472766 0096,0096,0096,0096 LC TRIM21 IRF8 17579016,17579016,17579016,22096565 0415,0096,0004,0007 LC TRIM21 SQSTM1 19201866,26347139,26043024 0004,0096,0004 LC TRIM21 IRF3 18641315,19265157,22479513,18641315,19265157,18641315,19265157 0004,0096,0004,0096,0007,0007,0004 LC TRIM21 IRF7 20668674,20668674,18641315 0004,0007,0096 LC TRIM21 MAP1LC3B 26347139 0096 LC TRIM21 GABARAPL1 26347139 0096 LC TRIM21 MAP1LC3A 26347139 0096 LC TRIM21 NCOA3 16051665,11971985 0004,0004 LC IKBKB TRIM21 19675099,19675099 0415,0004 LC USP2 TRIM21 23105109 0018 LC IGHG1 TRIM21 17400754 0114 LC HSP90AB1 TRIM21 25036637 0729 HT UBC TRIM21 23455675 0415 LC TROVE2 TRIM21 10785401 0401 LC HLA-DRB1 TRIM21 18022694,18022694 0004,0018 LC TRIM27 TRIM21 22493164,22493164 0018,0397 HT TNNI3 TRIM21 11461834 0018 LC TRIM21 TRIM21 22829933,16297862,21045130,25416956,25416956,16403452,18022694,11331580,15916807 0018,0415,0415,0397,0018,0415,0415,0018,0018 LC,HT TRIM21 UBA1 25260751 0997 LC TRIM21 APC 20936779,20936779 0398,0018 HT TRIM21 EEF1D 11461834 0018 LC TRIM21 MNAT1 22493164,22493164 0018,0397 HT TRIM21 UBE2N 25260751 0997 LC TRIM21 YWHAG 15324660,15324660 0004,0019 LC TRIM21 YWHAZ 15324660,15324660 0004,0019 LC TRIM21 SKP1 16880511,16880511 0004,0401 LC TRIM21 UBE2I 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM21 IRF8 17579016,17579016,17579016 0415,0096,0004 LC TRIM21 USP4 23105109,11461834,16472766,16403452 0018,0018,0415,0415 LC TRIM21 SKP2 16880511,16880511,16880511 0096,0004,0401 LC TRIM21 UBE2V1 25260751 0997 LC TRIM21 GRAP 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM21 CUL1 16880511,16880511,16880511,16880511 0007,0096,0004,0401 LC TRIM21 RNF111 22493164,22493164 0018,0397 HT TRIM21 DZIP3 22493164,22493164 0018,0397 HT TRIM21 TXN2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT TRIM21 RBCK1 22493164,22493164 0018,0397 HT TRIM21 TRIM8 22493164,22493164 0018,0397 HT TRIM21 NIF3L1 16189514,16189514 0398,0018 HT TRIM21 TRIM39 22493164,25416956,25416956,25416956,25416956,22493164 0018,1112,0397,0018,1356,0397 HT TRIM21 DAXX 20697732,20697732 0018,0004 LC TRIM21 CASP8AP2 20697732 0018 LC TRIM21 USP15 23105109,25416956,25416956,25416956,25416956 0018,1112,0397,0018,1356 LC,HT TRIM21 HEL-S-99N 8666824,8666824 0096,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P19474 B2Y833 TRIM21 ERG 0.126 21575865 P19474 O14744 TRIM21 PRMT5 0.21 26658161 Q5TC82 P19474 RC3H1 TRIM21 0.21 26170170 P23804 P19474 MDM2 TRIM21 0.126 24980433 P24941 P19474 CDK2 TRIM21 0.126 21319273 Q9H9S0 P19474 NANOG TRIM21 0.126 26687479 Q9NRD1 P19474 FBXO6 TRIM21 0.126 22268729 Q9NVX0 P19474 HAUS2 TRIM21 0.126 23443559 Q9H2C0 P19474 GAN TRIM21 0.126 26460568 P19474 O75604 TRIM21 USP2 0.183 23105109 Q7L190 P19474 DPPA4 TRIM21 0.126 26687479 P19474 P10155 TRIM21 TROVE2 0.21 10785401 P19474 P10225 TRIM21 UL41 0.126 22810585 Q88489 P19474 Q88489 TRIM21 0.126 22014111 P19474 O95166 TRIM21 GABARAP 0.309 26347139 P19474 P11308 TRIM21 ERG 0.126 21575865 P19474 O95758 TRIM21 PTBP3 0.126 22575643 P19474 P06748 TRIM21 NPM1 0.126 23402259 Q9Y6Q9 P19474 NCOA3 TRIM21 0.309 16051665,11971985 Q9Y613 P19474 FHOD1 TRIM21 0.236 unassigned1304 P19474 P01106 TRIM21 MYC 0.236 21150319 Q9Y4E8 P19474 USP15 TRIM21 0.554 25416956,23105109 Q9NUJ3 P19474 TCP11L1 TRIM21 0.236 unassigned1304 Q8IZW8 P19474 TNS4 TRIM21 0.236 unassigned1304 Q9NXE8 P19474 CWC25 TRIM21 0.236 unassigned1304 Q8TBB1 P19474 LNX1 TRIM21 0.236 unassigned1304 Q99459 P19474 CDC5L TRIM21 0.236 20467437 Q96IK5 P19474 GMCL1 TRIM21 0.236 unassigned1304 P19474 P09450 TRIM21 JUNB 0.236 26496610 Q9BW85 P19474 CCDC94 TRIM21 0.236 unassigned1304 Q9GZQ8 P19474 MAP1LC3B TRIM21 0.396 20562859,26347139 Q15051 P19474 IQCB1 TRIM21 0.236 21565611 Q9H0R8 P19474 GABARAPL1 TRIM21 0.396 20562859,26347139 Q9H492 P19474 MAP1LC3A TRIM21 0.396 20562859,26347139 Q05516 P19474 ZBTB16 TRIM21 0.236 unassigned1304 P19474 O14920 TRIM21 IKBKB 0.454 19675099 P51668 P19474 UBE2D1 TRIM21 0.523 21045130,17579016 P27797 P19474 CALR TRIM21 0.523 8666824 P63208 P19474 SKP1 TRIM21 0.309 16880511 Q8IYI6 P19474 EXOC8 TRIM21 0.236 unassigned1304 Q13568 P19474 IRF5 TRIM21 0.454 25084355 Q86Y13 P19474 DZIP3 TRIM21 0.286 22493164 Q9BZR9 P19474 TRIM8 TRIM21 0.286 22493164 Q9Y2B5 P19474 VPS9D1 TRIM21 0.236 unassigned1304 P19474 O15296 TRIM21 ALOX15B 0.236 unassigned1304 Q08426 P19474 EHHADH TRIM21 0.236 unassigned1304 P22681 P19474 CBL TRIM21 0.236 19380743 Q01973 P19474 ROR1 TRIM21 0.376 23153538 Q13158 P19474 FADD TRIM21 0.454 21183682 P19474 O00257 TRIM21 CBX4 0.236 unassigned1304 P19474 O94966 TRIM21 USP19 0.236 19615732 Q86VF2 P19474 IGFN1 TRIM21 0.236 unassigned1304 P19474 O60825 TRIM21 PFKFB2 0.236 26496610 P41241 P19474 CSK TRIM21 0.236 26496610 P19474 O75382 TRIM21 TRIM3 0.236 unassigned1304 P60520 P19474 GABARAPL2 TRIM21 0.396 20562859,26347139 P61981 P19474 YWHAG TRIM21 0.236 15324660 Q14653 P19474 IRF3 TRIM21 0.787 19265157,18641315,22479513 P32622 P19474 YEF1 TRIM21 0.332 27107014 Q13107 P19474 USP4 TRIM21 0.872 16472766,23105109,11461834,16403452 Q99757 P19474 TXN2 TRIM21 0.583 25416956,unassigned1304 Q9H9G7 P19474 AGO3 TRIM21 0.332 19167051 P62837 P19474 UBE2D2 TRIM21 0.671 16297862,16472766,19675099 Q13616 P19474 CUL1 TRIM21 0.523 16880511 Q9HCM9 P19474 TRIM39 TRIM21 0.702 25416956,unassigned1304,22493164 P19474 P19474 TRIM21 TRIM21 0.984 25416956,21045130,22829933,22493164,15916807,17156811,16297862,11331580,unassigned1304,16403452,18022694 Q92985 P19474 IRF7 TRIM21 0.21 20668674 P29692 P19474 EEF1D TRIM21 0.309 11461834 P35228 P19474 NOS2 TRIM21 0.126 23438482 Q91B85 P19474 Q91B85 TRIM21 0.126 22014111 P35240 P19474 NF2 TRIM21 0.126 26549023 Q9BXW4 P19474 MAP1LC3C TRIM21 0.309 26347139 Q9BYM8 P19474 RBCK1 TRIM21 0.286 22493164 Q9UKB1 P19474 FBXW11 TRIM21 0.454 16880511 P46379 P19474 BAG6 TRIM21 0.21 24981174 Q13547 P19474 HDAC1 TRIM21 0.21 20585571 Q13588 P19474 GRAP TRIM21 0.583 25416956,unassigned1304 P80217 P19474 IFI35 TRIM21 0.21 26342464 Q13287 P19474 NMI TRIM21 0.376 26342464 Q13309 P19474 SKP2 TRIM21 0.623 16880511 P49915 P19474 GMPS TRIM21 0.376 24462112 P63104 P19474 YWHAZ TRIM21 0.236 15324660 P19474 O00762 TRIM21 UBE2C 0.309 16472766 P19474 O75385 TRIM21 ULK1 0.21 26347139 P19474 P01911 TRIM21 HLA-DRB1 0.454 18022694 P19474 P01912 TRIM21 HLA-DRB1 0.454 18022694 P19474 P0CG48 TRIM21 UBC 0.309 23455675 P19474 P12318 TRIM21 FCGR2A 0.376 17118455 P19474 P13761 TRIM21 HLA-DRB1 0.454 18022694 P19474 P14373 TRIM21 TRIM27 0.286 22493164 P19474 P15731 TRIM21 UBC4 0.309 18022694 P19474 P19429 TRIM21 TNNI3 0.309 11461834 P22314 P19474 UBA1 TRIM21 0.033 25260751 P25054 P19474 APC TRIM21 0.286 20936779 P31358 P19474 CD52 TRIM21 0.21 17118455 P46527 P19474 CDKN1B TRIM21 0.21 16880511 P49427 P19474 CDC34 TRIM21 0.309 16472766 P51948 P19474 MNAT1 TRIM21 0.286 22493164 P61088 P19474 UBE2N TRIM21 0.033 25260751 P62256 P19474 UBE2H TRIM21 0.309 16472766 P63279 P19474 UBE2I TRIM21 0.183 25416956 P68036 P19474 UBE2L3 TRIM21 0.309 16472766 Q13404 P19474 UBE2V1 TRIM21 0.033 25260751 Q13501 P19474 SQSTM1 TRIM21 0.659 19201866,26043024,26347139 Q14457 P19474 BECN1 TRIM21 0.21 26347139 Q29974 P19474 HLA-DRB1 TRIM21 0.454 18022694 Q6PK50 P19474 HSP90AB1 TRIM21 0.126 25036637 Q6ZNA4 P19474 RNF111 TRIM21 0.286 22493164 Q7KZS0 P19474 UBE2I {ECO:0000313|EMBL:EAW85674.1} TRIM21 0.332 25416956 Q8IU60 P19474 DCP2 TRIM21 0.569 18361920 Q8IX07 P19474 ZFPM1 TRIM21 0.21 17118455 Q9C035 P19474 TRIM5 TRIM21 0.309 16775307 Q9GZT8 P19474 NIF3L1 TRIM21 0.286 16189514 Q9HCK5 P19474 AGO4 TRIM21 0.332 19167051 P68431 P19474 HIST1H3J TRIM21 0.126 26527279 Q02556 P19474 IRF8 TRIM21 0.623 17579016 Q15788 P19474 NCOA1 TRIM21 0.21 11971985 P55072 P19474 VCP TRIM21 0.126 23383273 Q504Q3 P19474 PAN2 TRIM21 0.126 23398456

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBE2C TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database PRMT5 TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database IKBKB TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database CHUK TRIM21 MI:0362 inference MI:0461 interaction database UBD TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database SIAH2 TRIM21 MI:0362 inference MI:1106 pathways database TBC1D4 TRIM21 MI:0362 inference MI:0461 interaction database PFKFB2 TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database ULK1 TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database USP2 TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database FBXO21 TRIM21 MI:0362 inference MI:1106 pathways database USP19 TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database GABARAP TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database PTBP3 TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database MYC TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database HLA-DRB1 TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database HLA-DRB1 TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database NPM1 TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database UBB TRIM21 MI:0362 inference MI:1106 pathways database UBC TRIM21 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TROVE2 TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database ERG TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database FCGR2A TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database HLA-DRB1 TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database TRIM27 TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database JUNB TRIM21 MI:0362 inference MI:0461 interaction database GJA1 TRIM21 MI:0362 inference MI:0461 interaction database TNNI3 TRIM21 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 UBA1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 CBL MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 CDK2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 APC MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 CALR MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 EEF1D MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 CD52 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 FCGR2B MI:0362 inference MI:0461 interaction database TRIM21 NOS2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 NF2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 CCNF MI:0362 inference MI:1106 pathways database TRIM21 CSK MI:0362 inference MI:0461 interaction database TRIM21 CDKN1B MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 CDC34 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 UBE2A MI:0362 inference MI:1106 pathways database TRIM21 GMPS MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 UBE2D1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 MNAT1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 UBE2E1 MI:0362 inference MI:0461 interaction database TRIM21 VCP MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 FBXW4 MI:0362 inference MI:1106 pathways database TRIM21 GABARAPL2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 UBE2N MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 YWHAG MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 UBE2H MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 UBE2D2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 RBX1 MI:0362 inference MI:1106 pathways database TRIM21 RPS27A MI:0362 inference MI:1106 pathways database TRIM21 UBA52 MI:0362 inference MI:1106 pathways database TRIM21 YWHAZ MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 SKP1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM21 UBE2I MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 UBE2L3 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 HIST1H3A MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 IFI35 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 MDM2 MI:0362 inference MI:0461 interaction database TRIM21 ROR1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 IRF8 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 USP4 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 FADD MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 NMI MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 SKP2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM21 UBE2V1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 SQSTM1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 HDAC1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 IRF5 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 GRAP MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 CUL1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM21 MORC3 MI:0362 inference MI:0461 interaction database TRIM21 BECN1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 IRF3 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 TRIP12 MI:0362 inference MI:1106 pathways database TRIM21 IQCB1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 NCOA2 MI:0362 inference MI:0461 interaction database TRIM21 NCOA1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 LONRF1 MI:0362 inference MI:1106 pathways database TRIM21 HLA-DRB1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 PAN2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 HECTD2 MI:0362 inference MI:1106 pathways database TRIM21 FBXO31 MI:0362 inference MI:1106 pathways database TRIM21 FBXW9 MI:0362 inference MI:1106 pathways database TRIM21 FBXW10 MI:0362 inference MI:1106 pathways database TRIM21 RNF213 MI:0362 inference MI:1106 pathways database TRIM21 FBXL22 MI:0362 inference MI:1106 pathways database TRIM21 FBXL19 MI:0362 inference MI:1106 pathways database TRIM21 FBXW12 MI:0362 inference MI:1106 pathways database TRIM21 RNF19B MI:0362 inference MI:1106 pathways database TRIM21 RNF111 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 DPPA4 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 RNF144B MI:0362 inference MI:1106 pathways database TRIM21 RBBP6 MI:0362 inference MI:1106 pathways database TRIM21 HUWE1 MI:0362 inference MI:1106 pathways database TRIM21 TBC1D1 MI:0362 inference MI:0461 interaction database TRIM21 TRIM69 MI:0362 inference MI:1106 pathways database TRIM21 DZIP3 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 DCP2 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pathways database TRIM21 FBXO41 MI:0362 inference MI:1106 pathways database TRIM21 LMO7 MI:0362 inference MI:1106 pathways database TRIM21 MYLIP MI:0362 inference MI:1106 pathways database TRIM21 CREBBP MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 IRF7 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 FBXW7 MI:0362 inference MI:1106 pathways database TRIM21 FBXO32 MI:0362 inference MI:1106 pathways database TRIM21 UBE2E3 MI:0362 inference MI:0461 interaction database TRIM21 FBXW5 MI:0362 inference MI:1106 pathways database TRIM21 MIB2 MI:0362 inference MI:1106 pathways database TRIM21 SPSB1 MI:0362 inference MI:1106 pathways database TRIM21 FBXL8 MI:0362 inference MI:1106 pathways database TRIM21 FBXO17 MI:0362 inference MI:1106 pathways database TRIM21 FBXL20 MI:0362 inference MI:1106 pathways database TRIM21 UBE2E2 MI:0362 inference MI:0461 interaction database TRIM21 FBXL18 MI:0362 inference MI:1106 pathways database 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inference MI:1106 pathways database TRIM21 FBXL3 MI:0362 inference MI:1106 pathways database TRIM21 FBXW2 MI:0362 inference MI:1106 pathways database TRIM21 BTRC MI:0362 inference MI:1106 pathways database TRIM21 UBE2D4 MI:0362 inference MI:0461 interaction database TRIM21 FBXO7 MI:0362 inference MI:1106 pathways database TRIM21 USP15 MI:0045 experimental interaction detection MI:0461 interaction database TRIM21 RNF115 MI:0362 inference MI:1106 pathways database TRIM21 RNF114 MI:0362 inference MI:1106 pathways database TRIM21 WSB1 MI:0362 inference MI:1106 pathways database TRIM21 IKBKG MI:0362 inference MI:0461 interaction database TRIM21 NCOA3 MI:0045 experimental interaction detection MI:0461 interaction database