PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus LRRC41 RBPMS 16189514 hprd,biogrid,mint,intact exp G G G G G G G G GP G GP G GP GP G GP G G G G G G G G GP G GP GP G LRRC41 TEAD2 25609649 intact exp G G G G G G G G G G G G G G G G G G G G G G MYO9B LRRC41 16169070 hprd,biogrid,i2d,mint,intact exp G G G G GP G G GP GP G GP G GP GP G GP G G GP G GP G G GP GP G GP GP G LRRC41 NXF1 22658674 biogrid exp G G G G GP G G GP GP G GP G GP GP G GP G G GP G GP G G GP GP G GP GP G LRRC41 LIPH 26186194 biogrid exp P P GP GP P G G P G G G GP P LRRC41 DCUN1D1 21145461 biogrid exp G G G G G P P G P P P G G GP G GP G GP GP P GP G LRRC41 DRG1 26186194 biogrid exp G G G G GP G G GP GP G GP G GP GP G GP G G GP G GP G G G GP G GP GP G LRRC41 RNF7 15601820 innatedb exp G G G G GP G G G GP G GP G G GP G GP G G GP G GP G G G GP G GP GP G NTRK1 LRRC41 25921289 biogrid exp G P P P P P P P P P P LRRC41 BARD1 22990118 biogrid exp G GP P GP P P GP G GP G P P G GP P G GP GP G LRRC41 CPSF3 26496610 biogrid,intact exp G G G G GP G G GP GP G GP G GP GP G GP G G GP G GP G G GP GP G GP GP G PPP3CC LRRC41 26186194 biogrid exp G G G G GP G G G GP G G G GP GP G G G G GP G GP G G G G G GP GP G FBL LRRC41 26186194 biogrid exp G G G G G G G G GP G GP G G GP G GP G G GP G GP G G GP GP G GP GP G LRRC41 TCEB2 18187417,11384984,15601820 innatedb,hprd,biogrid,bci exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRRC41 TCEB1 18187417,11384984,15601820, 25402006 innatedb,hprd,biogrid,bci exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRRC41 CUL5 15601820,21145461, 21836163 innatedb,biogrid,bci exp, pred G G G G GP G G GP GP G GP G GP GP G GP G G GP G GP G G GP GP G GP GP G RHOBTB3 LRRC41 ortho G G G G GP G G G GP G G G GP G G G G G GP G GP G G G G G G GP G LRRC41 LRRC41 ortho G G G G GP G G GP GP G GP G GP GP G GP G G GP G GP G G GP GP G GP GP G LRRC41 SPSB4 25402006 pred G LRRC41 MED8 25402006 pred G G G G GP G G GP GP G GP G GP GP G GP G G GP G GP G G GP GP G GP GP G LRRC41 FEM1B 25402006 pred G G G G GP G G GP GP G GP G GP G G GP G G GP G GP G G GP GP G GP GP G RBX1 LRRC41 25402006, 21836163 pred G G G G G G G GP G G G G GP G G G G G GP G GP G G G G G G GP G LRRC41 LRR1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G LRRC41 SPSB2 25402006 pred G G G G G G G G P G GP G GP G GP G G GP G G G G GP G GP GP G LRRC41 SOCS4 25402006 pred G G G G GP G G G GP G GP G GP GP G GP G G G G GP G G GP GP G GP GP G SOCS2 LRRC41 25402006 pred G G G G GP G G GP GP G GP G GP GP G GP G G GP G GP G G GP GP G GP GP G LRRC41 SPSB1 25402006 pred G G G G GP G G GP G G GP G GP G G G G G GP G GP G G GP G GP GP G LRRC41 RAB40C 25402006 pred G G G G GP G G GP GP G GP G GP G G GP G G GP G G G G GP GP G GP GP G VHL LRRC41 25402006 pred G G G G G G G G G G GP G GP G G G G G P G G G G G G G G GP G SOCS3 LRRC41 25402006 pred G G G G GP G G GP GP G GP G GP G G GP G G GP G GP G G GP GP G GP GP G SOCS1 LRRC41 25402006, 21836163 pred G G P GP GP GP G GP GP G GP G GP G GP G P GP G GP GP G SOCS5 LRRC41 25402006 pred G G G G GP G G GP GP G GP G GP GP G GP G G GP G GP G G GP GP G GP GP G CUL2 LRRC41 25402006 pred G G G G G G G G GP G GP G GP GP G G G G GP G GP G G G G G GP GP G LRRC41 WSB1 21836163 pred G G G G G G G G GP G GP G G G G GP G G GP G GP G G G GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q15345 Q15370-2 affinity chromatography technology 18187417 physical association X 2 Q15345 Q93034 affinity chromatography technology 21145461 physical association X 2 Q15345 B4E3T4 two hybrid 16189514 direct interaction X 2 Q15345 Q15369-2 affinity chromatography technology 18187417 physical association X 2 Q15345 Q96GG9 affinity chromatography technology 21145461 physical association X 2 Q15345 P0CG48 affinity chromatography technology 22505724 physical association X 2 Q15345 Q99728 affinity chromatography technology 22990118 physical association X 2 Q15345 P0CG48 affinity chromatography technology 23000965 physical association X 2 Q15345 Q8WVD2 two hybrid 16169070 direct interaction X 2 Q15345 P0CG48 affinity chromatography technology 21963094 physical association X 2 Q15345 P0CG48 affinity chromatography technology 21139048 physical association X 2 Q15345 P0CG48 affinity chromatography technology 21890473 physical association X 2 Q15345 P0CG48 affinity chromatography technology 21906983 physical association X 2 Q15345 in vivo 11384984 - C 5 Q15345 in vivo 11384984 - C 5 Q15345 in vivo 11384984 - C 5 Q15345 in vivo 11384984 - C 5 Q15345 in vivo 11384984 - C 5 Q15345 in vivo 11384984 - C 5 Q15345 in vivo 11384984 - C 5 Q15345 in vivo 11384984 - C 5 Q15345 in vivo 11384984 - C 5 Q15345 in vivo 11384984 - C 5 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 in vivo 11384984 - C 9 Q15345 Q15370-2 in vitro 11384984 - X 2 Q15345 Q15370-2 in vitro 11384984 - X 2 Q15345 Q15369-2 in vitro 11384984 - X 2 Q15345 Q13459-2 two hybrid 16169070 - X 2 Q15345 Q15369-2 in vitro 11384984 - X 2 Q15345 Q13459-2 two hybrid 16169070 - X 2 Q93062 Q15345 two hybrid 16189514 - X 2 Q93062 Q15345 two hybrid 16189514 - X 2 Q15345 B0I1T6 two hybrid pooling approach 16169070 physical association X 2 Q93062 Q15345 two hybrid pooling approach 16189514 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B LRRC41 DCUN1D1 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_206009 prey bait LRRC41 MYO9B MI:0492(in vitro) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_28999 - - LRRC41 CUL5 MI:0004(affinity chromatography technology)|MI:0492(in vitro)|MI:0492(in vitro) 11384984,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|- (biogrid)|MI:0468(hprd)|MI:0468(hprd) BIOGRID_203516|HPRD_40522|HPRD_40453 prey|-|- bait|-|- LRRC41 RBPMS MI:0018(two hybrid)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|(intact)|MI:0471(mint)|(biogrid)|MI:0471(mint) HPRD_23461|UniProt_152365|MINT_37763|BIOGRID_79520|MINT_66945 -|unspecified role|bait|bait|bait -|unspecified role|prey|prey|prey MYO9B LRRC41 MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|MI:0471(mint)|MI:0471(mint) UniProt_156345|BIOGRID_93772|MINT_63382|MINT_34426 prey|prey|prey|prey bait|bait|bait|bait LRRC41 BARD1 MI:0004(affinity chromatography technology) 22990118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_245544 prey bait UBC LRRC41 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983,21963094,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_166265|BIOGRID_178850|BIOGRID_268584|BIOGRID_223286|BIOGRID_173803|BIOGRID_169545 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey LRRC41 TCEB1 MI:0492(in vitro)|MI:0492(in vitro)|MI:0492(in vitro)|MI:0004(affinity chromatography technology) 11384984,18187417 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|-|MI:0915(physical association) MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|(biogrid) HPRD_40522|HPRD_40453|HPRD_7731|BIOGRID_199527 -|-|-|bait -|-|-|prey LRRC41 TCEB2 MI:0492(in vitro)|MI:0492(in vitro)|MI:0492(in vitro)|MI:0004(affinity chromatography technology) 11384984,18187417 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|-|-|MI:0915(physical association) MI:0468(hprd)|MI:0468(hprd)|MI:0468(hprd)|(biogrid) HPRD_40522|HPRD_40453|HPRD_7723|BIOGRID_199526 -|-|-|bait -|-|-|prey

PPI - HINT Gene A Gene B PMID Method Quality FBL LRRC41 26186194 0004 HT PPP3CC LRRC41 26186194 0004 HT LRRC41 TCEB1 15601820,18187417 0007,0004 LC LRRC41 TCEB2 15601820,18187417 0007,0004 LC LRRC41 TEAD2 25609649,25609649 0676,0004 HT LRRC41 LIPH 26186194 0004 HT LRRC41 CUL5 21145461,15601820 0004,0007 HT,LC LRRC41 DCUN1D1 21145461 0004 HT LRRC41 CPSF3 26496610,26496610 0007,0004 HT LRRC41 DRG1 26186194 0004 HT FBL LRRC41 26186194 0004 HT PPP3CC LRRC41 26186194 0004 HT LRRC41 TEAD2 25609649,25609649 0676,0004 HT LRRC41 LIPH 26186194 0004 HT LRRC41 CUL5 21145461 0004 HT LRRC41 DCUN1D1 21145461 0004 HT LRRC41 CPSF3 26496610,26496610 0007,0004 HT LRRC41 DRG1 26186194 0004 HT LRRC41 TCEB1 15601820,18187417 0007,0004 LC LRRC41 TCEB2 15601820,18187417 0007,0004 LC LRRC41 CUL5 15601820 0007 LC B0I1T6 LRRC41 16169070,16169070 0018,0398 HT MYO9B LRRC41 16169070,16169070 0018,0398 HT LRRC41 RBPMS 16189514,16189514 0398,0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q15345 P57078 LRRC41 RIPK4 0.126 26972000 Q9Y295 Q15345 DRG1 LRRC41 0.126 26186194 Q15345 P04629 LRRC41 NTRK1 0.126 25921289 Q15562 Q15345 TEAD2 LRRC41 0.236 25609649 Q93034 Q15345 CUL5 LRRC41 0.126 21145461 Q93062 Q15345 RBPMS LRRC41 0.286 16189514 Q8WWY8 Q15345 LIPH LRRC41 0.126 26186194 Q96GG9 Q15345 DCUN1D1 LRRC41 0.126 21145461 Q99728 Q15345 BARD1 LRRC41 0.126 22990118 Q9UBU9 Q15345 NXF1 LRRC41 0.126 22658674 Q9UKF6 Q15345 CPSF3 LRRC41 0.126 26496610 Q15345 P48454 LRRC41 PPP3CC 0.126 26186194 Q15345 Q13459 LRRC41 MYO9B 0.286 16169070 Q15369 Q15345 TCEB1 LRRC41 0.126 18187417 Q15370 Q15345 TCEB2 LRRC41 0.126 18187417 Q15345 Q01860 LRRC41 POU5F1 0.126 26687479 Q15345 P22087 LRRC41 FBL 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 RHOBTB1 LRRC41 MI:0362 inference MI:0461 interaction database RHOBTB3 LRRC41 MI:0362 inference MI:0461 interaction database NTRK1 LRRC41 MI:0045 experimental interaction detection MI:0461 interaction database UBC LRRC41 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 LRRC41 MI:0045 experimental interaction detection MI:0461 interaction database FBL LRRC41 MI:0045 experimental interaction detection MI:0461 interaction database PPP3CC LRRC41 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 LRRC41 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database POU5F1 LRRC41 MI:0045 experimental interaction detection MI:0461 interaction database MYO9B LRRC41 MI:0045 experimental interaction detection MI:0461 interaction database LRRC41 TCEB1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database LRRC41 TCEB2 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database LRRC41 TEAD2 MI:0045 experimental interaction detection MI:0461 interaction database LRRC41 LIPH MI:0045 experimental interaction detection MI:0461 interaction database LRRC41 CUL5 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database LRRC41 RBPMS MI:0045 experimental interaction detection MI:0461 interaction database LRRC41 DCUN1D1 MI:0045 experimental interaction detection MI:0461 interaction database LRRC41 BARD1 MI:0045 experimental interaction detection MI:0461 interaction database LRRC41 RHOBTB2 MI:0362 inference MI:0461 interaction database LRRC41 RNF7 MI:0362 inference MI:0461 interaction database LRRC41 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database LRRC41 CPSF3 MI:0045 experimental interaction detection MI:0461 interaction database LRRC41 DRG1 MI:0045 experimental interaction detection MI:0461 interaction database