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PARK2 UBE2G1 20940148,16862145,15603737,11439185, 25402006, 23023127 hprd,biogrid exp, ortho, pred P GP G P GP G GP GP G GP P P G P GP GP P G P GP GP GP P GP G UBE2G1 FBXL2 26037928, 16082366 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G UBE2E1 UBE2G1 8393731, 23023127 hprd,bci exp, pred GP GP G G G GP G G GP G GP G G GP G GP GP GP G G GP G G GP GP G GP GP G UBE2G1 SMURF2 15761153, 23023127, 16082366 i2d exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2G1 RBX1 22323446, 23023127 biogrid exp, pred G G G G G GP G GP G G G G GP G G G GP G GP G GP GP G G G G G GP G WWP2 UBE2G1 22939629, 23023127, 16082366 biogrid exp, pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G UBE2G1 DVL3 19888210, 23023127 i2d exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2G1 MAP3K1 25260751, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2G1 ITCH 22826439,16446428, 23023127 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2G1 CUL1 22660580, 16082366 intact exp, pred GP G G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2G1 UBE3A 10558980, 25402006, 23023127, 21836163, 16082366 hprd,bci exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CBL UBE2G1 11032556, 23023127, 21836163 hprd exp, pred G GP G G GP GP G G GP G GP G GP GP G G GP GP G G G G G G G GP G GP G ISG15 UBE2G1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2G1 HECTD3 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE2G1 RNF151 23023127 pred P G G GP GP GP GP GP G P G GP G G P GP G P G GP UBE2G1 UBA3 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CDC34 UBE2G1 23023127, 16082366 pred GP GP G G GP GP G 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G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM13 UBE2G1 23023127 pred GP GP G G G GP G G GP G G GP GP G G GP GP G G G G GP G GP GP G GP GP G UBE2G1 RNF6 23023127 pred G GP G G GP GP G G GP G GP G GP G G GP GP G G G GP G G G GP GP GP GP G UBE2G1 UBQLN1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2G1 SF3A1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SUMO3 UBE2G1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RAG1 UBE2G1 23023127 pred UBE2G1 TRAF6 23023127 pred GP GP G G GP G G GP GP G GP GP GP G G GP G GP G G GP GP GP G GP GP GP GP G ARIH2 UBE2G1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2G1 UBE3C 16082366 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP GP GP GP G UBE2G1 AKTIP 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2G1 RNF215 23023127 pred P GP P P GP GP P P P P G GP P GP G P P P GP GP P GP P G UBE2G1 NBR1 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96J02-2 P62253 pull down 16446428 direct interaction X 2 Q96J02-2 P62253 pull down 22826439 direct interaction X 2 Q9UKV5 P62253 pull down 21209460 direct interaction X 2 Q9UKV5 P62253 pull down 12847084 direct interaction X 2 Q9UKV5 P62253 pull down 19661182 direct interaction X 2 Q9UKV5 P62253 pull down 22101235 direct interaction X 2 Q9UKV5 P62253 x-ray crystallography 19560420 association X 2 P0CG48 P62253 affinity chromatography technology 22505724 physical association X 2 P0CG48 P62253 affinity chromatography technology 21963094 physical association X 2 P0CG48 P62253 affinity chromatography technology 23000965 physical association X 2 P0CG48 P62253 affinity chromatography technology 24816145 physical association X 2 P0CG48 P62253 affinity chromatography technology 21139048 physical association X 2 P0CG48 P62253 affinity chromatography technology 21890473 physical association X 2 P62253 Q9HCP7 pull down 12933904 direct interaction X 2 P62253 biochemical 22939629 colocalization X 2 P62253 A0A024R1A3 pull down 17597759 direct interaction X 2 P62253 Q9HCP7 fluorescent resonance energy transfer 17452445 direct interaction X 2 P62253 two hybrid 19549727 direct interaction X 2 A0A024R9W5 P62253 pull down 22016339 direct interaction X 2 P62253 Q05086 pull down 17131388 direct interaction X 2 P62253 O60260-5 pull down 15603737 direct interaction X 2 P62253 O60260-5 pull down 16862145 direct interaction X 2 P62253 P62877 pull down 22323446 direct interaction X 2 P62253 P05067-7 pull down 21832049 direct interaction X 2 P62253 B4DHF6 biochemical 22939629 colocalization X 2 P62253 O60337 pull down 15673284 direct interaction X 2 P62253 O60260-5 pull down 20940148 direct interaction X 2 P62253 P62253 enzymatic study 20061386 direct interaction X 2 P62253 P62253 pull down 20061386 direct interaction X 2 P62253 O60260-5 affinity chromatography technology 11439185 physical association X 2 P22681 P62253 in vitro 11032556 - X 2 P22681 P62253 in vitro 11032556 - X 2 Q05086-2 P62253 in vitro 10558980 - X 2 Q05086-2 P62253 in vitro 10558980 - X 2 P62253 O60260-6 in vitro 11439185 - X 2 P62253 A0A024R2K3 in vitro 8393731 - X 2 P62253 O60260-6 in vitro 11439185 - X 2 P62253 A0A024R2K3 in vitro 8393731 - X 2 P62253 P62253 two hybrid 10521492 - X 2 P62253 P62253 in vitro 10521492 - X 2 Q9BYM8 P62253 two hybrid array 19549727 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2G1 RBCK1 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101093|BIOGRID_124227 bait|bait prey|prey UBE2G1 DIO2 MI:0096(pull down)|MI:0055(fluorescent resonance energy transfer) 12933904,17452445 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_196335|BIOGRID_121735 prey|prey bait|bait APP UBE2G1 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_228904 prey bait ATXN3 UBE2G1 MI:0096(pull down) 20940148 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_221515 bait prey UBC UBE2G1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21963094,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_170047|BIOGRID_172857|BIOGRID_270251|BIOGRID_225039|BIOGRID_266301 bait|bait|bait|bait|bait prey|prey|prey|prey|prey UBE2G1 RBX1 MI:0004(affinity chromatography technology) 22323446 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226074 prey bait UBE2G1 UBE2G1 MI:0492(in vitro) 10521492 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_9341 - - UBE2G1 ITCH MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 16446428,22826439 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_225844|BIOGRID_225853 prey|prey bait|bait UBE2G1 UBE3A MI:0096(pull down)|MI:0492(in vitro) 10558980,17131388 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_221573|HPRD_9343 prey|- bait|- UBE2E1 UBE2G1 MI:0492(in vitro)|MI:0096(pull down) 8393731 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_9345|BIOGRID_92720 -|prey -|bait USP8 UBE2G1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239655 prey bait UBE2G1 HUWE1 MI:0004(affinity chromatography technology) 22016339 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225653 prey bait UBE2G1 AMFR MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0114(x-ray crystallography) 12847084,19560420,19661182,21209460 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0914(association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_226005|BIOGRID_226111|BIOGRID_221597|BIOGRID_150543 prey|prey|prey|bait bait|bait|bait|prey PARK2 UBE2G1 MI:0096(pull down)|MI:0096(pull down)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0492(in vitro) 11439185,15603737,16862145,20940148 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_221519|BIOGRID_225706|BIOGRID_106982|BIOGRID_223183|HPRD_9344 bait|bait|bait|bait|- prey|prey|prey|prey|- UBE2G1 ELAVL1 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187547 prey bait CBL UBE2G1 MI:0492(in vitro) 11032556 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_463 - - UBE2G1 SIRT3 MI:0004(affinity chromatography technology) 22318606 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0796(suppressive genetic interaction defined by inequality) (biogrid) BIOGRID_193423 prey bait

PPI - HINT Gene A Gene B PMID Method Quality WWP2 UBE2G1 22939629 0401 HT PARK2 UBE2G1 15603737,16862145,20940148,11439185 0096,0096,0096,0004 LC USP8 UBE2G1 22939629 0401 HT UBE2G1 RBX1 21068446,22323446 0096,0096 LC UBE2G1 APOA1BP 26344197 0401 HT UBE2G1 RDH5 26186194 0004 HT UBE2G1 ITCH 22826439,16446428 0096,0096 LC UBE2G1 AMFR 19661182,25451919,12847084,22101235,21209460 0096,0096,0096,0096,0096 LC WWP2 UBE2G1 22939629 0401 HT USP8 UBE2G1 22939629 0401 HT UBE2G1 APOA1BP 26344197 0401 HT UBE2G1 RDH5 26186194 0004 HT PARK2 UBE2G1 15603737,16862145,20940148,11439185 0096,0096,0096,0004 LC UBE2G1 RBX1 21068446,22323446 0096,0096 LC UBE2G1 ITCH 22826439,16446428 0096,0096 LC UBE2G1 AMFR 19661182,25451919,12847084,22101235,21209460 0096,0096,0096,0096,0096 LC WWP2 UBE2G1 22939629 0401 LC USP8 UBE2G1 22939629 0401 LC UBE2G1 UBE2G1 20061386,20061386,10521492 0415,0096,0018 LC UBE2G1 MAP3K1 25260751 0415 LC UBE2G1 CUL1 22660580 0997 LC UBE2G1 APOA1BP 26344197 0401 LC UBE2G1 DIO2 17452445 0055 LC UBE2G1 RBCK1 19549727,19549727 0397,0018 HT UBE2G1 SMURF2 15761153 0019 HT UBE2G1 SMURF1 20804422 0415 LC UBE2G1 Q9HCP7 17452445 0055 LC UBE2G1 AMFR 19560420 0114 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P62253 P22314 UBE2G1 UBA1 0.309 17597759 Q5TC82 P62253 RC3H1 UBE2G1 0.309 26489670 P62253 O00308 UBE2G1 WWP2 0.081 22939629 P62253 P05067 UBE2G1 APP 0.183 21832049 P62253 P40818 UBE2G1 USP8 0.081 22939629 Q9UKV5 P62253 AMFR UBE2G1 0.843 19661182,21209460,22101235,19560420,25451919 Q9HCE7 P62253 SMURF1 UBE2G1 0.183 20804422 Q8NCW5 P62253 APOA1BP UBE2G1 0.081 26344197 P62253 O60337 UBE2G1 MARCH6 0.309 15673284 Q8IWT3 P62253 CUL9 UBE2G1 0.309 25028717 Q7Z6Z7 P62253 HUWE1 UBE2G1 0.309 22016339 P62253 P08684 UBE2G1 CYP3A4 0.21 25451919 Q92813 P62253 DIO2 UBE2G1 0.523 17452445,12933904 Q96J02 P62253 ITCH UBE2G1 0.523 22826439,16446428 Q9D1D4 P62253 TMED10 UBE2G1 0.236 26496610 P62877 P62253 RBX1 UBE2G1 0.523 21068446,22323446 P62253 O60260 UBE2G1 PARK2 0.74 15603737,16862145,11439185,20940148 Q92781 P62253 RDH5 UBE2G1 0.126 26186194 Q9BYM8 P62253 RBCK1 UBE2G1 0.376 19549727 Q9C0B0 P62253 UNK UBE2G1 0.126 25737280 Q9UKC9 P62253 FBXL2 UBE2G1 0.309 26037928 Q15717 P62253 ELAVL1 UBE2G1 0.126 19322201 Q13233 P62253 MAP3K1 UBE2G1 0.183 25260751

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PARK2 UBE2G1 MI:0045 experimental interaction detection MI:0461 interaction database MARCH6 UBE2G1 MI:0045 experimental interaction detection MI:0461 interaction database APP UBE2G1 MI:0045 experimental interaction detection MI:0461 interaction database CYP3A4 UBE2G1 MI:0045 experimental interaction detection MI:0461 interaction database UBC UBE2G1 MI:0045 experimental interaction detection MI:0461 interaction database UBA1 UBE2G1 MI:0045 experimental interaction detection MI:0461 interaction database TMED10 UBE2G1 MI:0362 inference MI:0461 interaction database UBE2D1 UBE2G1 MI:0362 inference MI:0461 interaction database UBE2G1 RBX1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G1 SKP1 MI:0362 inference MI:0461 interaction database UBE2G1 RASSF7 MI:0362 inference MI:0461 interaction database UBE2G1 UBE3A MI:0045 experimental interaction detection MI:0461 interaction database UBE2G1 MAP3K1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G1 CUL1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G1 ELAVL1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G1 RC3H1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G1 FBXL19 MI:0362 inference MI:0461 interaction database UBE2G1 HUWE1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G1 CUL9 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G1 RASSF8 MI:0362 inference MI:0461 interaction database UBE2G1 RDH5 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G1 DIO2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G1 ITCH MI:0045 experimental interaction detection MI:0461 interaction database UBE2G1 RBCK1 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G1 UNK MI:0045 experimental interaction detection MI:0461 interaction database UBE2G1 SMURF2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G1 FBXL2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2G1 AMFR MI:0045 experimental interaction detection MI:0461 interaction database