PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SPA17 FBXO44 26186194 biogrid exp GP G G G G GP G GP GP G GP G G GP GP GP G G G GP GP G GP G FBXO44 AXIN2 19888210 i2d exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G NKD1 FBXO44 19888210 i2d exp G G G G G P G G G P GP CSNK1A1 FBXO44 19888210 i2d exp G G G G G G G G G G G G G G G G G G P G G G G G G G G G G DDB1 FBXO44 25970626 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G COPS6 FBXO44 19615732,21145461 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP P G GP GP GP G GP GP GP GP G RGS2 FBXO44 25970626 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G ECM29 FBXO44 20682791 biogrid exp G GP G G G G G G GP G GP GP GP G G GP G GP P G G GP GP G GP G GP GP G C17orf59 FBXO44 25416956 biogrid,intact exp P P P P G P P P P P GP P P P P P GP G P P P CSNK1E FBXO44 19888210 i2d exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP GP GP GP G BRCA1 FBXO44 23086937 biogrid exp P P G GP P P P P P P P GP P P P P P P P P P P GP UBC FBXO44 23314748 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G COPS5 FBXO44 21145461 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G CUL4B FBXO44 25970626 biogrid exp GP GP G G GP GP G GP GP G GP GP G GP G GP GP G P G GP GP GP GP GP GP GP GP G FBXO44 SERTAD3 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDK13 FBXO44 26186194 biogrid exp G G G G G G G GP G G GP G G G G GP G G G GP G G G GP G GP GP G TGFBR1 FBXO44 15761153 i2d exp GP G G G GP GP G GP GP G GP GP GP G G GP GP G G G G G G GP G GP G G ACVR1 FBXO44 15761153 i2d exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP P G GP GP G GP GP GP GP GP G BMPR1B FBXO44 15761153 i2d exp P GP G G GP GP G GP GP G GP P GP G GP GP GP P G P GP P GP GP GP GP GP G BARD1 FBXO44 23086937 biogrid exp P G GP P P GP P P P GP G GP P G P P GP P GP P GP GP GP G SMAD1 FBXO44 15761153 i2d exp G G G G G G G G GP G G G G G G G G G G G G G G G G G GP G RBX1 FBXO44 21640084,18203720, 25402006 innatedb,biogrid exp, pred G G G G G GP G GP G G G G GP G G G GP G P G GP GP G G G G G GP G SKP1 FBXO44 19159283,26186194,20057081,25416956,21640084,10531035,17215248,25970626,18203720, 25402006 innatedb,hprd,biogrid,intact exp, pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP P G GP GP GP G GP GP GP GP G CUL1 FBXO44 21640084,17215248,25970626,26186194,18203720,21145461, 25402006 innatedb,biogrid exp, pred GP G G G G GP G GP GP G GP GP GP G G GP GP GP P G GP GP GP GP GP GP GP GP G FBXO44 FBXO34 25402006 pred G GP G G G G G G GP G G G G G G G G G G GP G G GP G G GP GP G LNX1 FBXO44 23023127 pred GP G G GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP G GP P GP GP FBXO46 FBXO44 25402006 pred GP G G G G GP G G GP G G G G G G GP GP G G G G G GP GP G GP GP G FBXO44 FBXO2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXW5 FBXO44 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G P G GP GP GP GP GP G GP GP G FBXO27 FBXO44 23023127 pred GP P G GP G GP GP G GP G P GP G P GP G G P GP GP GP GP GP GP G FBXO31 FBXO44 25402006 pred GP GP G P GP G GP GP G GP G GP GP G GP GP G P G GP GP GP GP GP GP GP GP G APBB1 FBXO44 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G G GP G P G GP GP GP GP G GP GP GP G ZC3HC1 FBXO44 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G PTPN3 FBXO44 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP P GP GP G FBXW7 FBXO44 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G P GP GP GP GP GP GP GP CDCA3 FBXO44 25402006 pred G GP G G GP P G GP GP P P GP GP G GP P G G GP GP GP GP GP GP GP G NFKBIA FBXO44 25402006 pred G GP G G GP GP G GP GP G G G GP GP G GP GP G P G GP GP GP GP GP GP GP GP G CUL7 FBXO44 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G FBXW8 FBXO44 25402006 pred P P P P P P P P P P P P P P P P P P P P P FBXL8 FBXO44 25402006 pred P P P P P P P P P P P P P P P P FBXO44 FBXO6 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G FBXO17 FBXO44 25402006 pred G G G G G G G G G G G FBXO44 FBXW2 25402006 pred G GP G G GP GP G GP GP G GP GP GP G G GP GP G P G G G GP GP GP G GP GP G FBXO44 FBXL3 25402006 pred G G G G GP G G G G G G G G G G G G G G G G G G G GP G G G FBXO18 FBXO44 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP GP GP GP G NFKBIE FBXO44 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P GP GP GP GP GP GP GP GP G FBXO44 BTRC 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP G GP GP G FBXW9 FBXO44 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G G G GP GP GP GP G GP GP G FBXO44 FBXO4 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G SKP2 FBXO44 25402006 pred GP GP G G GP GP G GP GP G G GP GP GP G GP GP G P G GP G G GP GP GP GP GP G FBXO44 FBXW11 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO44 FBXL2 25402006 pred G G G G G G G G G G G G G G G G G G G G G FBXO44 SUGT1 25402006 pred G G G G G G G GP GP G GP G G G G GP G G P G G G G GP GP G GP GP G FBXO44 CACYBP 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP P G GP GP GP G GP GP GP GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B RBX1 FBXO44 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18203720,21640084 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_201335|BIOGRID_199919 prey|prey bait|bait BRCA1 FBXO44 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23086937 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_227256|BIOGRID_227259 bait|prey prey|bait COPS6 FBXO44 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_120775|BIOGRID_205730|UniProt_100633 bait|bait|bait prey|prey|prey ECM29 FBXO44 MI:0018(two hybrid) 20682791 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_199739 bait prey FBXO44 HDAC6 MI:0004(affinity chromatography technology) 22318606 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0796(suppressive genetic interaction defined by inequality) (biogrid) BIOGRID_192994 prey bait COPS5 FBXO44 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205207 bait prey SKP1 FBXO44 MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0231(mammalian protein protein interaction trap)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0492(in vitro) 10531035,17215248,18203720,19159283,20057081,21640084 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0914(association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|- (biogrid)|(biogrid)|(biogrid)|(intact)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd) BIOGRID_110746|BIOGRID_196414|BIOGRID_110747|UniProt_98764|BIOGRID_197049|BIOGRID_199918|BIOGRID_197042|BIOGRID_196997|BIOGRID_201339|HPRD_9130 bait|bait|bait|bait|bait|prey|prey|bait|prey|- prey|prey|prey|prey|prey|bait|bait|prey|bait|- UBC FBXO44 MI:0096(pull down) 23314748 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248020 bait prey BARD1 FBXO44 MI:0004(affinity chromatography technology) 23086937 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_227262 prey bait CUL1 FBXO44 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17215248,18203720,21145461,21640084 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_204540|BIOGRID_197045|BIOGRID_199917|BIOGRID_201331 bait|prey|prey|prey prey|bait|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality RBX1 FBXO44 18203720,21640084 0004,0004 LC SKP1 FBXO44 18203720,17215248,21640084,10531035,26186194,25970626,10531035 0004,0004,0004,0096,0004,0004,0018 LC,HT CUL1 FBXO44 18203720,17215248,21640084,21145461,26186194,25970626 0004,0004,0004,0004,0004,0004 LC,HT CDK13 FBXO44 26186194 0004 HT SPA17 FBXO44 26186194 0004 HT COPS6 FBXO44 19615732,21145461,19615732 0004,0004,0007 HT COPS5 FBXO44 21145461 0004 HT SKP1 FBXO44 26186194 0004 HT CUL1 FBXO44 21145461,26186194 0004,0004 HT CDK13 FBXO44 26186194 0004 HT SPA17 FBXO44 26186194 0004 HT COPS6 FBXO44 19615732,21145461,19615732 0004,0004,0007 HT COPS5 FBXO44 21145461 0004 HT RBX1 FBXO44 18203720,21640084 0004,0004 LC SKP1 FBXO44 18203720,17215248,21640084,10531035,25970626,10531035 0004,0004,0004,0096,0004,0018 LC CUL1 FBXO44 18203720,17215248,21640084,25970626 0004,0004,0004,0004 LC BMPR1B FBXO44 15761153 0019 HT TGFBR1 FBXO44 15761153 0019 HT BRCA1 FBXO44 23086937,23086937 0415,0004 LC SKP1 FBXO44 25416956,19159283,25416956,20057081,10531035,25416956,19159283,26460611,10531035,25416956 1112,0231,0397,0114,0096,0018,0018,0114,0018,1356 HT,LC ACVR1 FBXO44 15761153 0019 HT SMAD1 FBXO44 15761153 0019 HT C17ORF59 FBXO44 25416956,25416956,25416956,25416956,25416956 1112,0397,0018,0231,1356 HT FBXO44 SMURF1 15761153 0019 HT FBXO44 SERTAD3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H4M3 Q5VYK3 FBXO44 ECM29 0.126 20682791 Q9UJW9 Q9H4M3 SERTAD3 FBXO44 0.454 25416956 Q9H4M3 Q99728 FBXO44 BARD1 0.21 23086937 Q9H4M3 Q13620 FBXO44 CUL4B 0.21 25970626 Q9H4M3 Q16531 FBXO44 DDB1 0.21 25970626 Q9H4M3 Q15506 FBXO44 SPA17 0.126 26186194 Q9H4M3 P0CG48 FBXO44 UBC 0.183 23314748 Q9NQX1 Q9H4M3 PRDM5 FBXO44 0.236 unassigned1304 Q9H4M3 P62877 FBXO44 RBX1 0.376 21640084,18203720 Q9H4M3 A4D127 FBXO44 MEOX2 {ECO:0000313|EMBL:EAL24289.1} 0.236 unassigned1304 Q9H4M3 O75031 FBXO44 HSF2BP 0.236 unassigned1304 Q9H4M3 Q7L5N1 FBXO44 COPS6 0.332 19615732,21145461 Q9H4M3 Q96GS4 FBXO44 C17ORF59 0.636 25416956,unassigned1304 Q9H4M3 P63208 FBXO44 SKP1 0.991 19159283,25416956,18203720,25970626,26186194,unassigned1304,21640084,10531035,27705803,20057081,26460611,17215248 Q9H4M3 Q92905 FBXO44 COPS5 0.126 21145461 Q9H4M3 P38398 FBXO44 BRCA1 0.569 23086937 Q9H4M3 P41220 FBXO44 RGS2 0.376 25970626 Q9H4M3 Q13616 FBXO44 CUL1 0.702 18203720,21145461,21640084,17215248,25970626,26186194 Q9H4M3 Q14004 FBXO44 CDK13 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 BMPR1B FBXO44 MI:0045 experimental interaction detection MI:0461 interaction database SIAH2 FBXO44 MI:0362 inference MI:1106 pathways database FBXO21 FBXO44 MI:0362 inference MI:1106 pathways database UBB FBXO44 MI:0362 inference MI:1106 pathways database UBC FBXO44 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM21 FBXO44 MI:0362 inference MI:1106 pathways database TGFBR1 FBXO44 MI:0045 experimental interaction detection MI:0461 interaction database BRCA1 FBXO44 MI:0045 experimental interaction detection MI:0461 interaction database CCNF FBXO44 MI:0362 inference MI:1106 pathways database RGS2 FBXO44 MI:0045 experimental interaction detection MI:0461 interaction database UBE2A FBXO44 MI:0362 inference MI:1106 pathways database FBXW4 FBXO44 MI:0362 inference MI:1106 pathways database RBX1 FBXO44 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RPS27A FBXO44 MI:0362 inference MI:1106 pathways database UBA52 FBXO44 MI:0362 inference MI:1106 pathways database SKP1 FBXO44 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database ACVR1 FBXO44 MI:0045 experimental interaction detection MI:0461 interaction database SKP2 FBXO44 MI:0362 inference MI:1106 pathways database CUL1 FBXO44 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CUL4B FBXO44 MI:0045 experimental interaction detection MI:0461 interaction database CDK13 FBXO44 MI:0045 experimental interaction detection MI:0461 interaction database TRIP12 FBXO44 MI:0362 inference MI:1106 pathways database SPA17 FBXO44 MI:0045 experimental interaction detection MI:0461 interaction database SMAD1 FBXO44 MI:0045 experimental interaction detection MI:0461 interaction database DDB1 FBXO44 MI:0045 experimental interaction detection MI:0461 interaction database LONRF1 FBXO44 MI:0362 inference MI:1106 pathways database HECTD2 FBXO44 MI:0362 inference MI:1106 pathways database ECM29 FBXO44 MI:0045 experimental interaction detection MI:0461 interaction database FBXO31 FBXO44 MI:0362 inference MI:1106 pathways database FBXW9 FBXO44 MI:0362 inference MI:1106 pathways database FBXW10 FBXO44 MI:0362 inference MI:1106 pathways database RNF213 FBXO44 MI:0362 inference MI:1106 pathways database FBXL22 FBXO44 MI:0362 inference MI:1106 pathways database FBXL19 FBXO44 MI:0362 inference MI:1106 pathways database FBXW12 FBXO44 MI:0362 inference MI:1106 pathways database RNF19B FBXO44 MI:0362 inference MI:1106 pathways database COPS6 FBXO44 MI:0045 experimental interaction detection MI:0461 interaction database RNF144B FBXO44 MI:0362 inference MI:1106 pathways database RBBP6 FBXO44 MI:0362 inference MI:1106 pathways database HUWE1 FBXO44 MI:0362 inference MI:1106 pathways database TRIM69 FBXO44 MI:0362 inference MI:1106 pathways database SIAH1 FBXO44 MI:0362 inference MI:1106 pathways database HERC6 FBXO44 MI:0362 inference MI:1106 pathways database UBR2 FBXO44 MI:0362 inference MI:1106 pathways database FBXL14 FBXO44 MI:0362 inference MI:1106 pathways database FBXW8 FBXO44 MI:0362 inference MI:1106 pathways database FBXL16 FBXO44 MI:0362 inference MI:1106 pathways database FBXO15 FBXO44 MI:0362 inference MI:1106 pathways database ZNRF1 FBXO44 MI:0362 inference MI:1106 pathways database FBXL13 FBXO44 MI:0362 inference MI:1106 pathways database FBXO22 FBXO44 MI:0362 inference MI:1106 pathways database ZNRF2 FBXO44 MI:0362 inference MI:1106 pathways database FBXO27 FBXO44 MI:0362 inference MI:1106 pathways database FBXO30 FBXO44 MI:0362 inference MI:1106 pathways database RNF217 FBXO44 MI:0362 inference MI:1106 pathways database DTX3L FBXO44 MI:0362 inference MI:1106 pathways database FBXO41 FBXO44 MI:0362 inference MI:1106 pathways database LMO7 FBXO44 MI:0362 inference MI:1106 pathways database MYLIP FBXO44 MI:0362 inference MI:1106 pathways database COPS5 FBXO44 MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FBXO44 MI:0362 inference MI:1106 pathways database FBXO32 FBXO44 MI:0362 inference MI:1106 pathways database FBXW5 FBXO44 MI:0362 inference MI:1106 pathways database MIB2 FBXO44 MI:0362 inference MI:1106 pathways database SPSB1 FBXO44 MI:0362 inference MI:1106 pathways database FBXL8 FBXO44 MI:0362 inference MI:1106 pathways database FBXO17 FBXO44 MI:0362 inference MI:1106 pathways database C17orf59 FBXO44 MI:0045 experimental interaction detection MI:0461 interaction database FBXL20 FBXO44 MI:0362 inference MI:1106 pathways database FBXL18 FBXO44 MI:0362 inference MI:1106 pathways database NEDD4L FBXO44 MI:0362 inference MI:1106 pathways database BARD1 FBXO44 MI:0045 experimental interaction detection MI:0461 interaction database RBCK1 FBXO44 MI:0362 inference MI:1106 pathways database FBXL15 FBXO44 MI:0362 inference MI:1106 pathways database FBXO44 UNKL MI:0362 inference MI:1106 pathways database FBXO44 SMURF2 MI:0362 inference MI:1106 pathways database FBXO44 SMURF1 MI:0045 experimental interaction detection MI:0461 interaction database FBXO44 TRIM36 MI:0362 inference MI:1106 pathways database FBXO44 FBXO6 MI:0362 inference MI:1106 pathways database FBXO44 RNF19A MI:0362 inference MI:1106 pathways database FBXO44 RLIM MI:0362 inference MI:1106 pathways database FBXO44 FBXL12 MI:0362 inference MI:1106 pathways database FBXO44 FBXO40 MI:0362 inference MI:1106 pathways database FBXO44 HERC5 MI:0362 inference MI:1106 pathways database FBXO44 FBXL7 MI:0362 inference MI:1106 pathways database FBXO44 SERTAD3 MI:0045 experimental interaction detection MI:0461 interaction database FBXO44 FBXO2 MI:0362 inference MI:1106 pathways database FBXO44 FBXO10 MI:0362 inference MI:1106 pathways database FBXO44 FBXO9 MI:0362 inference MI:1106 pathways database FBXO44 FBXL5 MI:0362 inference MI:1106 pathways database FBXO44 FBXL4 MI:0362 inference MI:1106 pathways database FBXO44 FBXW11 MI:0362 inference MI:1106 pathways database FBXO44 FBXO4 MI:0362 inference MI:1106 pathways database FBXO44 FBXL21 MI:0362 inference MI:1106 pathways database FBXO44 FBXL3 MI:0362 inference MI:1106 pathways database FBXO44 FBXW2 MI:0362 inference MI:1106 pathways database FBXO44 BTRC MI:0362 inference MI:1106 pathways database FBXO44 FBXO7 MI:0362 inference MI:1106 pathways database FBXO44 RNF115 MI:0362 inference MI:1106 pathways database FBXO44 RNF114 MI:0362 inference MI:1106 pathways database FBXO44 WSB1 MI:0362 inference MI:1106 pathways database