PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus USPL1 USPL1 19615732 intact exp GP G G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SUMO3 USPL1 25416956,22878415,doi:10.1038/embor.2012.125 biogrid,mint,intact exp GP G G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KRT85 USPL1 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G USPL1 FAM96B 23891004 biogrid exp GP G G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G COIL USPL1 22878415,24413172,doi:10.1038/embor.2012.125 biogrid,mint,intact exp GP G G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP G GP GP G GP GP G USPL1 NXF1 22658674 biogrid exp GP G G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USPL1 MMS19 22678362 biogrid exp GP G G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PKLR USPL1 19615732 biogrid,intact exp G G GP GP P GP GP KIF5B USPL1 19615732 biogrid,intact exp GP G G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PGD USPL1 19615732 biogrid,intact exp GP G G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G POLR2A USPL1 24413172 biogrid exp GP G G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USPL1 ANKFY1 19615732 biogrid,intact exp GP G G G G GP G GP GP G GP GP G G G GP GP G G G GP G G G GP G GP GP G SP100 USPL1 22878415 biogrid exp GP G G G P G GP GP GP GP GP GP G GP P GP P G GP GP GP GP GP GP GP P G RANGAP1 USPL1 22878415 biogrid exp GP G G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SUMO1 USPL1 22878415,doi:10.1038/embor.2012.125 biogrid,mint,intact exp GP G G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CKB USPL1 19615732 biogrid,intact exp G G G G G GP G GP GP G G G G G G G GP G G G G GP G GP G G GP G G KRT4 USPL1 19615732 biogrid,intact exp GP GP G G G G G ELL USPL1 24413172,19615732 biogrid,intact exp GP G G G P P P P P P P P P G G G GP G G P P GP G PIP USPL1 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G GP G G G G USPL1 ICE1 24413172,19615732 biogrid,intact exp GP G G G G GP G GP GP G GP GP GP GP G G GP GP GP G GP G GP GP G G GP GP G USPL1 MOV10 22658674 biogrid exp G G G G G G G G G G G G G G G G G G G G G G SUMO2 USPL1 22878415,21988832,doi:10.1038/embor.2012.125 biogrid,mint,intact exp GP G G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ANXA1 USPL1 19615732 biogrid,intact exp GP G G G G GP G G GP G GP G GP GP G G GP G G G GP GP GP G G GP G G G SHMT2 USPL1 22658674 biogrid exp GP G G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q5W0Q7 affinity chromatography technology 19615732 physical association X 2 Q9Y2F5 Q5W0Q7 imaging technique 24413172 colocalization X 2 Q9Y2F5 Q5W0Q7 imaging technique 24413172 colocalization X 2 Q9Y2F5 Q5W0Q7 affinity chromatography technology 19615732 physical association X 2 Q5W0Q7 P61956-2 pull down 22878415 direct interaction X 2 Q5W0Q7 P61956-2 two hybrid 21988832 direct interaction X 2 Q5W0Q7 P61956-2 enzymatic study 22878415 direct interaction X 2 Q5W0Q7 P23497-7 enzymatic study 22878415 direct interaction X 2 Q5W0Q7 affinity chromatography technology 19615732 physical association X 2 Q9Y3D0 Q5W0Q7 affinity chromatography technology 23891004 physical association X 2 P78386 Q5W0Q7 affinity chromatography technology 19615732 physical association X 2 P55199 Q5W0Q7 affinity chromatography technology 24413172 physical association X 2 P55199 Q5W0Q7 affinity chromatography technology 24413172 physical association X 2 P55199 Q5W0Q7 affinity chromatography technology 19615732 physical association X 2 P12273 Q5W0Q7 affinity chromatography technology 19615732 physical association X 2 P38432 Q5W0Q7 imaging technique 22878415 colocalization X 2 P38432 Q5W0Q7 imaging technique 24413172 colocalization X 2 Q5W0Q7 A0A024R3Z2 pull down 22878415 direct interaction X 2 Q5W0Q7 A0A024R1U0 enzymatic study 22878415 direct interaction X 2 Q5W0Q7 Q96T76 affinity chromatography technology 22678362 physical association X 2 Q5W0Q7 A0A024R3Z2 enzymatic study 22878415 direct interaction X 2 Q5W0Q7 imaging technique 24413172 colocalization X 2 Q5W0Q7 affinity chromatography technology 19615732 physical association X 2 P33176 Q5W0Q7 affinity chromatography technology 19615732 physical association X 2 P12277 Q5W0Q7 affinity chromatography technology 19615732 physical association X 2 P55854 Q5W0Q7 pull down 22878415 direct interaction X 2 P55854 Q5W0Q7 enzymatic study 22878415 direct interaction X 2 P55854 Q5W0Q7 two hybrid 25416956 direct interaction X 2 P04083 Q5W0Q7 affinity chromatography technology 19615732 physical association X 2 P52209 Q5W0Q7 affinity chromatography technology 19615732 physical association X 2 P88992 Q5W0Q7 two hybrid 22028648 direct interaction X 2 Q5NH48 Q5W0Q7 two hybrid pooling approach 20711500 physical association X 2 P38432 Q5W0Q7 fluorescence microscopy 22878415 colocalization X 2 P38432 Q5W0Q7 fluorescence microscopy 22878415 colocalization X 2 A0A024R8S3 Q5W0Q7 anti tag coimmunoprecipitation 22878415 physical association X 2 Q5W0Q7 A0A024R3Z2 enzymatic study 22878415 cleavage reaction X 2 Q5W0Q7 A0A024R3Z2 enzymatic study 22878415 cleavage reaction X 2 Q5W0Q7 A0A024R3Z2 pull down 22878415 direct interaction X 2 Q5W0Q7 A0A024R3Z2 enzymatic study 22878415 cleavage reaction X 2 Q5W0Q7 A0A024R3Z2 anti tag coimmunoprecipitation 22878415 physical association X 2 P55854 Q5W0Q7 enzymatic study 22878415 cleavage reaction X 2 P55854 Q5W0Q7 enzymatic study 22878415 cleavage reaction X 2 P55854 Q5W0Q7 enzymatic study 22878415 cleavage reaction X 2 P55854 Q5W0Q7 enzymatic study 22878415 cleavage reaction X 2 P55854 Q5W0Q7 enzymatic study 22878415 cleavage reaction X 2 P55854 Q5W0Q7 enzymatic study 22878415 cleavage reaction X 2 P55854 Q5W0Q7 pull down 22878415 direct interaction X 2 P55854 Q5W0Q7 pull down 22878415 direct interaction X 2 P55854 Q5W0Q7 pull down 22878415 direct interaction X 2 P55854 Q5W0Q7 pull down 22878415 direct interaction X 2 P55854 Q5W0Q7 pull down 22878415 direct interaction X 2 P55854 Q5W0Q7 pull down 22878415 direct interaction X 2 P55854 Q5W0Q7 enzymatic study 22878415 cleavage reaction X 2 P55854 Q5W0Q7 two hybrid prey pooling approach 25416956 physical association X 2 P55854 Q5W0Q7 two hybrid array 25416956 physical association X 2 P55854 Q5W0Q7 validated two hybrid 25416956 physical association X 2 P88992 Q5W0Q7 two hybrid array 22028648 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SUMO3 USPL1 MI:0030(cross-linking study)|MI:0030(cross-linking study)|MI:0096(pull down)|MI:0030(cross-linking study)|MI:0030(cross-linking study)|MI:0030(cross-linking study)|MI:0030(cross-linking study)|MI:0030(cross-linking study)|MI:0030(cross-linking study)|MI:0030(cross-linking study)|MI:0030(cross-linking study)|MI:0030(cross-linking study)|MI:0096(pull down)|MI:0030(cross-linking study)|MI:0030(cross-linking study) 22878415 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0194(cleavage reaction)|MI:0407(direct interaction)|MI:0194(cleavage reaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0194(cleavage reaction)|MI:0194(cleavage reaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0194(cleavage reaction)|MI:0194(cleavage reaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0194(cleavage reaction) (intact)|(intact)|(biogrid)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(intact)|(biogrid)|(intact)|(intact) UniProt_126150|UniProt_126161|BIOGRID_208441|UniProt_126159|UniProt_126149|UniProt_126148|UniProt_126152|UniProt_126154|UniProt_126147|UniProt_126146|UniProt_126164|UniProt_126163|BIOGRID_208440|UniProt_126144|UniProt_126162 bait|neutral component|prey|neutral component|bait|bait|neutral component|neutral component|bait|bait|neutral component|neutral component|bait|bait|neutral component prey|neutral component|bait|neutral component|prey|prey|neutral component|neutral component|prey|prey|neutral component|neutral component|prey|prey|neutral component KIF5B USPL1 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100700|BIOGRID_119534 prey|prey bait|bait SUMO2 USPL1 MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0030(cross-linking study)|MI:0397(two hybrid array) 21988832,22878415 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact)|(intact) BIOGRID_208444|BIOGRID_287924|UniProt_126143|UniProt_119383 bait|bait|bait|unspecified role prey|prey|prey|unspecified role PKLR USPL1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119653|UniProt_100700 prey|prey bait|bait COIL USPL1 MI:0096(pull down)|MI:0030(cross-linking study)|MI:0030(cross-linking study) 22878415 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization)|MI:0403(colocalization)|MI:0403(colocalization) (biogrid)|(intact)|(intact) BIOGRID_208450|UniProt_126168|UniProt_126167 prey|neutral component|neutral component bait|neutral component|neutral component CKB USPL1 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100700|BIOGRID_119398 prey|prey bait|bait KRT85 USPL1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119563|UniProt_100700 prey|prey bait|bait KRT4 USPL1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119545|UniProt_100700 prey|prey bait|bait SUMO1 USPL1 MI:0096(pull down)|MI:0030(cross-linking study)|MI:0030(cross-linking study)|MI:0030(cross-linking study)|MI:0030(cross-linking study)|MI:0030(cross-linking study) 22878415 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0194(cleavage reaction)|MI:0915(physical association)|MI:0194(cleavage reaction)|MI:0194(cleavage reaction)|MI:0407(direct interaction) (biogrid)|(intact)|(intact)|(intact)|(intact)|(intact) BIOGRID_208341|UniProt_126151|UniProt_126142|UniProt_126153|UniProt_126158|UniProt_126145 bait|neutral component|bait|neutral component|neutral component|bait prey|neutral component|prey|neutral component|neutral component|prey ANXA1 USPL1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119347|UniProt_100700 prey|prey bait|bait PIP USPL1 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100700|BIOGRID_119650 prey|prey bait|bait USPL1 KIAA0947 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100700|BIOGRID_120316 bait|bait prey|prey RANGAP1 USPL1 MI:0096(pull down) 22878415 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_208445 prey bait USPL1 MMS19 MI:0004(affinity chromatography technology) 22678362 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_271346 prey bait ELL USPL1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119895|UniProt_100700 prey|prey bait|bait PGD USPL1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119645|UniProt_100700 prey|prey bait|bait USPL1 ANKFY1 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120458|UniProt_100700 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality B4DRS2 USPL1 19615732 0004 HT IGHA2 USPL1 19615732 0004 HT ANXA1 USPL1 19615732,19615732 0004,0007 HT PIP USPL1 19615732,19615732 0004,0007 HT CKB USPL1 19615732,19615732 0004,0007 HT KRT4 USPL1 19615732 0007 HT PKLR USPL1 19615732,19615732 0004,0007 HT KIF5B USPL1 19615732,19615732 0004,0007 HT COIL USPL1 22878415,22878415,24413172 0416,0428,0428 LC PGD USPL1 19615732,19615732 0004,0007 HT ELL USPL1 19615732,19615732,24413172 0004,0007,0004 HT,LC KRT85 USPL1 19615732,19615732 0004,0007 HT USPL1 ANKFY1 19615732,19615732 0004,0007 HT USPL1 ICE1 19615732,19615732,24413172 0004,0007,0428 HT,LC USPL1 HEL-S-61 19615732 0004 HT USPL1 HEL-S-29 19615732 0004 HT B4DRS2 USPL1 19615732 0004 HT IGHA2 USPL1 19615732 0004 HT ANXA1 USPL1 19615732,19615732 0004,0007 HT PIP USPL1 19615732,19615732 0004,0007 HT CKB USPL1 19615732,19615732 0004,0007 HT KRT4 USPL1 19615732 0007 HT PKLR USPL1 19615732,19615732 0004,0007 HT KIF5B USPL1 19615732,19615732 0004,0007 HT PGD USPL1 19615732,19615732 0004,0007 HT ELL USPL1 19615732,19615732 0004,0007 HT KRT85 USPL1 19615732,19615732 0004,0007 HT USPL1 ANKFY1 19615732,19615732 0004,0007 HT USPL1 ICE1 19615732,19615732 0004,0007 HT USPL1 HEL-S-61 19615732 0004 HT USPL1 HEL-S-29 19615732 0004 HT COIL USPL1 22878415,22878415,24413172 0416,0428,0428 LC ELL USPL1 24413172 0004 LC USPL1 ICE1 24413172 0428 LC COIL USPL1 22878415,22878415 0416,0428 LC SUMO3 USPL1 22878415,25416956,25416956,25416956,25416956,22878415 0415,1112,0397,0018,1356,0096 LC,HT SUMO2 USPL1 22878415,22878415,21988832,22878415 0096,0007,0018,0415 LC,HT SUMO1 USPL1 22878415,22878415,22878415 0096,0007,0415 LC USPL1 FLJ00340 22878415 0415 LC USPL1 Q9BSK3 22878415 0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5W0Q7 Q5NH48 USPL1 TIG 0.126 20711500 Q5W0Q7 P19013 USPL1 KRT4 0.126 19615732 Q5W0Q7 P23497 USPL1 SP100 0.309 22878415 Q5W0Q7 P24928 USPL1 POLR2A 0.126 24413172 Q5W0Q7 P46060 USPL1 RANGAP1 0.309 22878415 Q9HCE1 Q5W0Q7 MOV10 USPL1 0.126 22658674 Q9Y3D0 Q5W0Q7 FAM96B USPL1 0.126 23891004 Q9Y2F5 Q5W0Q7 KIAA0947 USPL1 0.416 19615732,24413172 Q5W0Q7 P52209 USPL1 PGD 0.236 19615732 Q5W0Q7 P12277 USPL1 CKB 0.236 19615732 Q5W0Q7 P04083 USPL1 ANXA1 0.236 19615732 Q5W0Q7 P12273 USPL1 PIP 0.236 19615732 Q5W0Q7 P30613 USPL1 PKLR 0.236 19615732 Q5W0Q7 P33176 USPL1 KIF5B 0.236 19615732 Q5W0Q7 P78386 USPL1 KRT85 0.236 19615732 Q5W0Q7 P61956 USPL1 SUMO2 0.748 22878415,21988832 Q5W0Q7 P63165 USPL1 SUMO1 0.648 22878415 Q9P2R3 Q5W0Q7 ANKFY1 USPL1 0.236 19615732 Q5W0Q7 P55854 USPL1 SUMO3 0.832 25416956,22878415 Q5W0Q7 P38432 USPL1 COIL 0.416 24413172,22878415 Q96T76 Q5W0Q7 MMS19 USPL1 0.126 22678362 Q9UBU9 Q5W0Q7 NXF1 USPL1 0.126 22658674 Q5W0Q7 P34897 USPL1 SHMT2 0.126 22658674 Q5W0Q7 P88992 USPL1 BKRF1 0.126 22028648 Q5W0Q7 P55199 USPL1 ELL 0.523 19615732,24413172

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MYC USPL1 MI:0045 experimental interaction detection MI:0461 interaction database ANXA1 USPL1 MI:0045 experimental interaction detection MI:0461 interaction database PIP USPL1 MI:0045 experimental interaction detection MI:0461 interaction database CKB USPL1 MI:0045 experimental interaction detection MI:0461 interaction database KRT4 USPL1 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 USPL1 MI:0045 experimental interaction detection MI:0461 interaction database SP100 USPL1 MI:0045 experimental interaction detection MI:0461 interaction database PKLR USPL1 MI:0045 experimental interaction detection MI:0461 interaction database KIF5B USPL1 MI:0045 experimental interaction detection MI:0461 interaction database SHMT2 USPL1 MI:0045 experimental interaction detection MI:0461 interaction database HNF4A USPL1 MI:0045 experimental interaction detection MI:0461 interaction database RANGAP1 USPL1 MI:0045 experimental interaction detection MI:0461 interaction database PGD USPL1 MI:0045 experimental interaction detection MI:0461 interaction database ELL USPL1 MI:0045 experimental interaction detection MI:0461 interaction database SUMO3 USPL1 MI:0045 experimental interaction detection MI:0461 interaction database MAX USPL1 MI:0045 experimental interaction detection MI:0461 interaction database SUMO2 USPL1 MI:0045 experimental interaction detection MI:0461 interaction database SUMO1 USPL1 MI:0045 experimental interaction detection MI:0461 interaction database KRT85 USPL1 MI:0045 experimental interaction detection MI:0461 interaction database E2F1 USPL1 MI:0045 experimental interaction detection MI:0461 interaction database USPL1 MMS19 MI:0045 experimental interaction detection MI:0461 interaction database USPL1 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database USPL1 ANKFY1 MI:0045 experimental interaction detection MI:0461 interaction database USPL1 ONECUT1 MI:0045 experimental interaction detection MI:0461 interaction database USPL1 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database USPL1 ICE1 MI:0045 experimental interaction detection MI:0461 interaction database USPL1 FAM96B MI:0045 experimental interaction detection MI:0461 interaction database