PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBE2H RNF128 12705856 biogrid exp GP GP G P GP G P G G GP GP GP GP G GP GP P GP G GP GP GP GP GP GP P UBE2E1 RNF128 12705856 biogrid exp GP GP G GP G GP G GP G G GP G GP GP P G G GP G G GP GP GP P RNF128 UBE2T 19549727 biogrid,intact exp G GP G GP P P P GP GP P GP P G GP P P RNF128 OTUB1 14661020 biogrid exp GP GP G P GP G P GP G GP GP GP GP G GP GP P GP G GP GP GP GP GP GP P UBE2D1 RNF128 12705856 biogrid exp GP G G P GP G GP G GP GP GP GP G G GP P GP G GP GP G GP G GP P CD40LG RNF128 18641297 hprd,biogrid exp P P P P GP P P P P CD81 RNF128 18713730 hprd exp G G G P GP G P G G G G G GP G G GP P GP G GP G G G G G P UBE2N RNF128 12705856 hprd,biogrid exp GP GP G P GP G P GP G GP GP GP GP G GP GP GP G GP GP GP GP GP GP P CEP76 RNF128 25416956 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P RNF128 APPBP2 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G RNF128 RNF128 12705856,14661020 hprd,biogrid exp GP GP G P GP G P GP G GP GP GP GP G GP GP P GP G GP GP GP GP GP GP P UBE2I RNF128 19549727 biogrid,intact exp GP GP G P GP G P GP G GP G GP GP G GP GP P GP G GP GP GP G GP GP P TP53 RNF128 23370271 biogrid exp, ortho G G G G G G G G G G G G GP G G G GP G G G GP G P CD151 RNF128 18713730, 25402006 hprd exp, ortho, pred GP GP G P GP G P GP G GP GP GP GP G GP GP P GP G GP GP GP GP GP GP P USP8 RNF128 14661020, 21836163 biogrid exp, pred G GP G P GP G GP G GP G GP G G GP GP GP G GP GP G GP GP GP P STAT6 RNF128 ortho GP GP G P GP G GP G GP G GP GP G GP GP P G G GP GP GP G GP GP P RNF128 ASB1 23023127 pred G GP G GP G P GP G G G GP G G GP GP GP G G G G G GP GP ANKRD39 RNF128 23023127 pred GP GP G P GP G P GP G GP GP GP GP GP GP P GP G P GP GP GP GP GP P ELANE RNF128 23023127 pred P G G RNF128 TRAF6 23023127 pred GP GP G P G G P GP G GP GP GP G G GP G P G G GP GP GP G GP GP P STAMBP RNF128 25402006 pred GP GP G P GP G P GP G GP GP GP GP G GP GP P GP G GP GP GP GP GP GP P PRKCQ RNF128 23023127 pred G G G G G G G G G G G G G G G G G G G G G G UBE2D2 RNF128 25402006 pred GP G G P GP G GP G GP GP GP GP G G GP P GP G GP GP G GP G GP P CD40 RNF128 25402006 pred G G G G G G G G G G GP G G G G G G G G G G G ARHGDIA RNF128 21836163 pred GP GP G P GP G P GP G GP GP GP GP G GP GP P GP G GP GP GP GP GP GP P SYK RNF128 23023127 pred GP G G P GP G GP G GP G GP GP G GP GP GP G G G G G GP GP P RNF128 INPP5D 23023127 pred G GP G P GP G P G G GP G G GP G G GP P G G G G GP GP G G SIGIRR RNF128 23023127 pred GP GP G P GP G P GP G GP GP GP GP G GP GP GP G G GP GP G GP GP P RNF128 IGF2BP1 23023127 pred P P INHBA RNF128 23023127 pred P P P P P P P GP GP P P P P GP GP GP P P GP P P REL RNF128 25402006 pred GP G G P GP G GP G GP G GP GP G GP GP P GP G P GP GP G GP GP P GNB2L1 RNF128 25402006 pred P P P P P P P P P P P P P P P P P AZU1 RNF128 23023127 pred P P P P P P P P P P P CBL RNF128 21836163 pred G GP G P GP G GP G GP G GP GP G G GP P G G G G G G G G P RNF128 IGF2BP2 23023127 pred GP GP P GP G P GP GP GP GP GP G GP GP P GP G GP G GP P GP GP P CX3CL1 RNF128 23023127 pred GP GP G P GP G P GP G GP GP GP GP G GP GP P GP G GP GP GP GP GP GP P TIA1 RNF128 23023127 pred G G G G G G G G G G G G G G G G G G G G G G BCL3 RNF128 23023127 pred G G P G P GP G G G GP G GP G GP G G G GP GP RNF128 FOXP3 23023127 pred G G P P G G G P IGF2BP3 RNF128 23023127 pred P P P P P P P P P P P P P GP P P G P P P INHA RNF128 23023127 pred GP G G G G GP P G G P G G GP G G P CALM1, CALM2, CALM3 RNF128 21836163 pred GP GP G P GP G P GP G GP GP GP GP G GP GP P GP G GP GP GP GP GP GP P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A087WW00 Q8TEB7 pull down 12705856 direct interaction X 2 A0A024R9A9 Q8TEB7 two hybrid 19549727 direct interaction X 2 Q8TAP6 Q8TEB7 two hybrid 25416956 direct interaction X 2 Q8TEB7 pull down 12705856 direct interaction X 2 Q8TEB7 A0A024QZ47 two hybrid 25416956 direct interaction X 2 Q8TEB7 Q8TEB7 enzymatic study 12705856 direct interaction X 2 P63279 Q8TEB7 two hybrid 19549727 direct interaction X 2 Q99PT1 Q8TEB7 enzymatic study 17114425 direct interaction X 2 Q99PT1 Q8TEB7 affinity chromatography technology 17114425 physical association X 2 Q96FW1 Q8TEB7 two hybrid 14661020 direct interaction X 2 Q96FW1 Q8TEB7 affinity chromatography technology 14661020 physical association X 2 Q96FW1 Q8TEB7 pull down 14661020 direct interaction X 2 P29965 Q8TEB7 affinity chromatography technology 18641297 physical association X 2 P29965 Q8TEB7 enzymatic study 18641297 direct interaction X 2 A0A024R2K3 Q8TEB7 pull down 12705856 direct interaction X 2 Q61599 Q8TEB7 affinity chromatography technology 17114425 physical association X 2 P61088 Q8TEB7 pull down 12705856 direct interaction X 2 Q8TEB7 P04637-7 pull down 23370271 direct interaction X 2 Q8TEB7 P04637-7 pull down 23370271 direct interaction X 2 Q8TEB7 P04637-7 two hybrid 23370271 direct interaction X 2 Q8TEB7 affinity chromatography technology 14661020 physical association X 2 A0A024R9A9 Q8TEB7 two hybrid array 19549727 physical association X 2 Q8TAP6 Q8TEB7 two hybrid prey pooling approach 25416956 physical association X 2 Q8TAP6 Q8TEB7 two hybrid array 25416956 physical association X 2 Q8TAP6 Q8TEB7 validated two hybrid 25416956 physical association X 2 Q8TEB7 A0A024QZ47 two hybrid prey pooling approach 25416956 physical association X 2 Q8TEB7 A0A024QZ47 two hybrid array 25416956 physical association X 2 Q8TEB7 A0A024QZ47 validated two hybrid 25416956 physical association X 2 P63279 Q8TEB7 two hybrid array 19549727 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CD40LG RNF128 MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18641297 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association) MI:0468(hprd)|(biogrid)|(biogrid) HPRD_33509|BIOGRID_116634|BIOGRID_116632 -|prey|bait -|bait|prey CD151 RNF128 MI:0493(in vivo) 18713730 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_33418 - - UBE2I RNF128 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101371|BIOGRID_124436 bait|bait prey|prey UBE2D1 RNF128 MI:0096(pull down) 12705856 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226017 prey bait UBE2H RNF128 MI:0096(pull down) 12705856 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226016 prey bait UBE2E1 RNF128 MI:0096(pull down) 12705856 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_226015 prey bait CD81 RNF128 MI:0493(in vivo) 18713730 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_33419 - - RNF128 OTUB1 MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14661020 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) HPRD_40482|BIOGRID_87289|BIOGRID_87288|BIOGRID_87287 -|bait|prey|bait -|prey|bait|prey RNF128 UBE2T MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101438|BIOGRID_124437 prey|prey bait|bait USP8 RNF128 MI:0493(in vivo)|MI:0018(two hybrid) 14661020 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_40482|BIOGRID_87291 -|bait -|prey UBE2N RNF128 MI:0096(pull down)|MI:0018(two hybrid) 12705856 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_89584|HPRD_5728 bait|- prey|-

PPI - HINT Gene A Gene B PMID Method Quality CD40LG RNF128 18641297,18641297 0415,0004 LC UBE2N RNF128 12705856,12705856 0096,0018 LC UBE2I RNF128 19549727,19549727 0397,0018 HT Q53GA5 RNF128 23370271,23370271 0018,0096 LC CEP76 RNF128 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT RNF128 RNF128 12705856 0415 LC RNF128 APPBP2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT RNF128 OTUB1 14661020,14661020,14661020 0096,0004,0018 LC RNF128 UBE2T 19549727,19549727 0397,0018 HT RNF128 HEL-S-71 12705856,12705856 0096,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8TEB7 P61088 RNF128 UBE2N 0.309 12705856 Q8TEB7 Q8TAP6 RNF128 CEP76 0.583 25416956,unassigned1304 Q8TEB7 P04637 RNF128 TP53 0.671 23370271 Q8TEB7 P63279 RNF128 UBE2I 0.376 19549727 Q8TEB7 Q61599 RNF128 ARHGDIB 0.21 17114425 Q8TEB7 Q8TEB7 RNF128 RNF128 0.332 12705856 Q92624 Q8TEB7 APPBP2 RNF128 0.454 25416956 Q9NPD8 Q8TEB7 UBE2T RNF128 0.376 19549727 Q9UHD9 Q8TEB7 UBQLN2 RNF128 0.236 unassigned1304 Q99PT1 Q8TEB7 ARHGDIA RNF128 0.454 17114425 Q8TEB7 Q15036 RNF128 SNX17 0.236 unassigned1304 Q8TEB7 A0A0G2JQ02 RNF128 A0A0G2JQ02 0.236 unassigned1304 Q8TEB7 P29965 RNF128 CD40LG 0.454 18641297 Q96FW1 Q8TEB7 OTUB1 RNF128 0.623 14661020 Q8TEB7 P40818 RNF128 USP8 0.21 14661020

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TP53 RNF128 MI:0045 experimental interaction detection MI:0461 interaction database CD40LG RNF128 MI:0045 experimental interaction detection MI:0461 interaction database USP8 RNF128 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database STAT6 RNF128 MI:0362 inference MI:0461 interaction database CD151 RNF128 MI:0362 inference MI:0461 interaction database UBE2D1 RNF128 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 RNF128 MI:0045 experimental interaction detection MI:0461 interaction database ARHGDIA RNF128 MI:0362 inference MI:0461 interaction database ARHGDIB RNF128 MI:0362 inference MI:0461 interaction database CD81 RNF128 MI:0362 inference MI:0461 interaction database UBE2N RNF128 MI:0045 experimental interaction detection MI:0461 interaction database UBE2H RNF128 MI:0045 experimental interaction detection MI:0461 interaction database UBE2I RNF128 MI:0045 experimental interaction detection MI:0461 interaction database CEP76 RNF128 MI:0045 experimental interaction detection MI:0461 interaction database RNF128 APPBP2 MI:0045 experimental interaction detection MI:0461 interaction database RNF128 OTUB1 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RNF128 UBE2T MI:0045 experimental interaction detection MI:0461 interaction database