PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus APEX1 KLHL36 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HSP90AB1 KLHL36 22939624 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KLHL36 COPS5 21145461 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CUL3 KLHL36 21145461 innatedb,biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KLHL36 PACRG 26186194 biogrid exp G G G G G G G G G G G G G KLHL36 AAR2 26186194 biogrid exp G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP G GP GP GP GP GP GP G RNASEH2A KLHL36 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KLHL36 CXorf56 26186194 biogrid exp P GP G P GP G P GP G GP P P GP G P GP GP P G GP P GP P P GP P GP SGOL1 KLHL36 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP GP GP GP G NUDCD3 KLHL36 25036637 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HSP90AA1 KLHL36 22939624 biogrid exp GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G KBTBD6 KLHL36 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G G GP GP G G G G GP G G GP G G G KLHL36 KLHL23 23023127 pred G G G G G P P G G G GP P GP G G G TCEB2 KLHL36 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KLHL36 KLHL31 23023127 pred GP GP G P GP GP GP P P GP G G GP G G GP GP P GP G P G KLHL36 ZBTB26 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G KLHL38 KLHL36 23023127 pred P P P P P P P P P P P P P P P P P P P P P ZBTB16 KLHL36 23023127 pred G GP G G G GP G G GP G G G GP G G GP GP G GP G G GP GP G GP G G GP G BCL6 KLHL36 23023127 pred G G G G GP G G G G G G G G GP G G G G G G GP G G G G GP G G G KLHL36 BTBD6 23023127 pred G G G G GP G G G GP G G G G GP G GP G G G G G G G GP GP G G G G KLHL40 KLHL36 23023127 pred GP G SOCS3 KLHL36 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP GP GP G GP GP G KLHL36 GAN 23023127 pred P P P P P P P P P P P P P P P P P P P KLHL36 KLHL25 23023127 pred GP GP G G G GP G P GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP G KLHL36 ZBTB44 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G BACH1 KLHL36 23023127 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G KLHL36 KBTBD7 23023127 pred GP G G G GP GP G GP GP G GP GP GP G G GP GP GP GP G G GP G G GP G GP GP G KLHL22 KLHL36 23023127 pred G GP G G G G G GP GP G GP G GP G G GP G G GP G GP G GP GP GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A024R7W9 Q8N4N3 affinity chromatography technology 21145461 physical association X 2 P0CG48 Q8N4N3 affinity chromatography technology 21906983 physical association X 2 Q8N4N3 A0A024R475 affinity chromatography technology 21145461 physical association X 2 Q8N4N3 P07900-2 affinity chromatography technology 22939624 physical association X 2 Q8N4N3 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2 Q8N4N3 Q8IVD9 luminescence based mammalian interactome mapping 25036637 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CUL3 KLHL36 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_201875 bait prey KLHL36 COPS5 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205317 prey bait HSP90AB1 KLHL36 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125042 prey bait UBC KLHL36 MI:0004(affinity chromatography technology) 21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_178735 bait prey HSP90AA1 KLHL36 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255403 bait prey

PPI - HINT Gene A Gene B PMID Method Quality RNASEH2A KLHL36 26496610,26496610 0007,0004 HT APEX1 KLHL36 26186194 0004 HT CUL3 KLHL36 21145461 0004 HT SGOL1 KLHL36 26496610,26496610 0007,0004 HT KLHL36 COPS5 21145461 0004 HT KLHL36 PACRG 26186194 0004 HT KLHL36 CXORF56 26186194 0004 HT KLHL36 AAR2 26186194 0004 HT RNASEH2A KLHL36 26496610,26496610 0007,0004 HT APEX1 KLHL36 26186194 0004 HT CUL3 KLHL36 21145461 0004 HT SGOL1 KLHL36 26496610,26496610 0007,0004 HT KLHL36 COPS5 21145461 0004 HT KLHL36 PACRG 26186194 0004 HT KLHL36 CXORF56 26186194 0004 HT KLHL36 AAR2 26186194 0004 HT HSP90AB1 KLHL36 22939624 0729 HT NUDCD3 KLHL36 25036637 0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N4N3 A2APR8 KLHL36 A2APR8 0.126 26496610 Q8N4N3 P08238 KLHL36 HSP90AB1 0.126 22939624 Q8N4N3 Q8IVD9 KLHL36 NUDCD3 0.126 25036637 Q9H5V9 Q8N4N3 CXORF56 KLHL36 0.126 26186194 Q8N4N3 P07900 KLHL36 HSP90AA1 0.126 22939624 Q9Y312 Q8N4N3 AAR2 KLHL36 0.126 26186194 Q8N4N3 Q5FBB7 KLHL36 SGOL1 0.236 26496610 Q8N4N3 O75792 KLHL36 RNASEH2A 0.236 26496610 Q92905 Q8N4N3 COPS5 KLHL36 0.126 21145461 Q96M98 Q8N4N3 PACRG KLHL36 0.126 26186194 Q8N4N3 P27695 KLHL36 APEX1 0.126 26186194 Q8N4N3 Q13618 KLHL36 CUL3 0.126 21145461 Q8N4N3 Q14CS0 KLHL36 UBXN2B 0.126 26389662 Q8N4N3 O08901 KLHL36 BUB1 0.126 26496610

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 BUB1 KLHL36 MI:0362 inference MI:0461 interaction database RNASEH2A KLHL36 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 KLHL36 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 KLHL36 MI:0045 experimental interaction detection MI:0461 interaction database UBC KLHL36 MI:0045 experimental interaction detection MI:0461 interaction database APEX1 KLHL36 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 KLHL36 MI:0045 experimental interaction detection MI:0461 interaction database UBXN2B KLHL36 MI:0045 experimental interaction detection MI:0461 interaction database SGO1 KLHL36 MI:0045 experimental interaction detection MI:0461 interaction database NUDCD3 KLHL36 MI:0045 experimental interaction detection MI:0461 interaction database KLHL36 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database KLHL36 PACRG MI:0045 experimental interaction detection MI:0461 interaction database KLHL36 CXorf56 MI:0045 experimental interaction detection MI:0461 interaction database KLHL36 AAR2 MI:0045 experimental interaction detection MI:0461 interaction database