PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus VPS36 VPS28 17215868,18539118 biogrid exp G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G ATG7 VPS36 22863883 biogrid exp G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G ELAVL1 VPS36 19322201 biogrid exp G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS36 CDC5L 20467437 intact exp G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G SPRY2 VPS36 21543492 biogrid exp G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G VPS36 TRMT61A 26344197,22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TNFAIP2 VPS36 22939629 biogrid exp G G G G G GP G G G G GP GP GP G G G GP G GP G G GP GP G G G G G G VPS36 RILP 17010938 biogrid exp G GP G G G GP G G GP G GP GP GP G G G GP GP GP G GP GP GP G G G GP GP G VPS36 VPS35 22939629 biogrid exp G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G VPS36 ZNHIT2 22939629 biogrid exp GP P P P P P G VPS36 CUL5 21145461 biogrid exp G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G MAP2K1 VPS36 20936779 i2d exp G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G GCNT1 VPS36 23027862 intact exp G GP G G G GP G GP GP G GP GP GP G G GP GP GP G GP GP GP GP GP G GP GP G VPS36 WDR12 22863883 biogrid exp G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G HDLBP VPS36 22939629 biogrid exp G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G GP GP GP GP GP G GP GP G PPP3CB VPS36 22863883 biogrid exp G G G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G ECM29 VPS36 20682791 biogrid exp G GP G G G G G G GP G GP GP GP G G GP G GP GP G G GP GP G GP G GP GP G VPS36 NXT1 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TWF2 VPS36 22939629 biogrid exp G G G G G G G G G G G G GP G G G G G G G G G G G G G GP GP G TTC4 VPS36 22939629 biogrid exp G GP G G G GP G GP GP G GP GP P G G GP GP GP GP G P GP GP GP GP G GP GP UBA52 VPS36 17057716 dip exp G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS36 NXF1 22658674 biogrid exp G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS36 SLC25A41 26186194 biogrid exp P P P P P P P P GP VPS36 ACBD3 22863883 biogrid exp G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G VPS36 MOV10 22658674 biogrid exp G G G G G G G G G G G G G G G G G G G G G G USP1 VPS36 22939629 biogrid exp G GP G G G GP G G GP G GP GP G G G GP GP G G G GP G GP GP GP G GP GP G UBE4B VPS36 22939629 biogrid exp G GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP G GP G GP GP G SRSF5 VPS36 22863883 biogrid exp G G G G G GP G G GP G GP GP G G G GP GP GP GP G GP GP G G GP G GP GP G VPS36 VPS36 16973552 biogrid exp, ortho G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G UBC VPS36 17057716,16973552 biogrid exp, ortho G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS36 VPS25 18539118,26344197,17010938,22939629,16371348,16973552,11278625,22863883,14505570, 25402006, 21836163 hprd,biogrid,i2d exp, ortho, pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS36 SNF8 18539118,11278625,26344197,17010938,14505570,16371348,16973552, 25402006, 21836163 hprd,biogrid,i2d exp, ortho, pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP GP G VPS36 CHMP6 14505570, 25402006, 21836163 hprd,biogrid,i2d exp, pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS36 SNX15 22939629, 21836163 biogrid exp, pred G GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G VPS36 VPS29 22939629, 21836163 biogrid exp, pred G GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS26A VPS36 22939629, 21836163 biogrid exp, pred G GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G VPS36 TSG101 14505570,16973552, 21836163 hprd,biogrid,i2d exp, pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G RBBP5 VPS36 ortho G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP EIF3J VPS36 ortho G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G DNAJB1 VPS36 ortho G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G YWHAE VPS36 ortho G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS36 CHMP4B 21836163 ortho, pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP G GP GP G GP GP G CHMP2A VPS36 21836163 ortho, pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G ELL VPS36 25402006, 21836163 pred G G G G P P P P P P P P G G G GP G G P P GP G VPS36 CHMP5 21836163 pred G GP G G G GP G GP GP G GP G G G G GP GP G GP G GP GP G G GP G GP GP G CEP55 VPS36 21836163 pred P G G P P GP P P P GP P P P P P GP GP GP VPS36 PIK3C3 21836163 pred G GP G G G GP G GP GP G GP GP GP G G P GP GP GP G GP GP GP GP GP G GP GP G VPS36 RIN2 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP P G TMF1 VPS36 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS36 NDFIP1 21836163 pred G GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS36 PDCD6IP 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS37C VPS36 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G RABEP1 VPS36 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS36 VPS4A 21836163 pred G GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS36 CHMP4A 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G VPS36 PIKFYVE 21836163 pred G GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS36 VPS37B 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G PLIN3 VPS36 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G NEDD4 VPS36 21836163 pred G GP G G P G GP GP GP G GP G G GP GP GP GP G GP GP GP GP GP G GP P G IQGAP1 VPS36 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G VPS36 TICAM1 21836163 pred G GP G P G GP GP GP GP GP G G GP P GP GP GP GP GP GP GP G GP P G VPS36 CHMP2B 21836163 pred G G G G G G G G GP G GP GP GP G G GP G G GP G G G G G GP G G G G VPS36 CHMP7 21836163 pred G GP G G G GP G GP GP G GP G GP G G GP GP GP G G GP GP GP GP GP G GP GP G VPS36 CHMP1A 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP GP G VPS36 CHMP4C 21836163 pred G GP P GP GP GP GP GP G GP P GP G GP GP GP P GP G GP P G STAMBP VPS36 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G PDLIM4 VPS36 21836163 pred G GP G GP G GP GP G GP P GP G G GP GP G GP G G G GP G GP G GP G G VPS36 CHMP3 21836163 pred P P P P P P P P P P P P P P P P P P VPS36 DNAJC15 21836163 pred G G G G G G G GP GP G GP GP GP G G G G G G GP GP GP G G G GP GP G VPS36 VPS37A 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS4B VPS36 21836163 pred G G G G G GP G G GP G GP G G G G GP GP G GP G GP GP GP G GP G GP GP G LRSAM1 VPS36 21836163 pred GP G GP G P GP G GP GP P G P GP GP GP G P GP P P P G P P G RABEPK VPS36 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G MCM2 VPS36 25402006 pred G G G G G G G G GP G G G G G G GP G GP G G GP GP G G GP G GP GP G VAC14 VPS36 21836163 pred GP G GP G P P G GP GP GP G G GP GP GP P G P GP GP G GP G GP GP ARL6IP1 VPS36 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS36 ALG2 21836163 pred G GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP GP G HERC3 VPS36 21836163 pred G GP G G G GP G GP GP G GP GP P G G GP GP P G P GP GP GP P G GP P G VAMP4 VPS36 21836163 pred G GP G G G GP G GP GP G GP G G G G GP GP G GP G G GP GP GP GP G GP GP G PACS1 VPS36 21836163 pred G GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP GP GP GP GP G GP GP G VPS36 STAMBPL1 21836163 pred G GP G G G GP G GP GP G GP G GP G G GP GP G GP G P GP GP GP GP G GP GP VPS36 NEDD4L 21836163 pred G GP G GP G GP GP G GP G GP G GP GP GP GP G GP GP G G GP G GP G VPS36 SNX18 21836163 pred G GP G G G GP G G GP G GP G GP G G GP GP GP G G GP GP GP G GP G GP GP G NDUFB6 VPS36 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q86VN1 A0A024R1X3 x-ray crystallography 18539118 association X 2 Q86VN1 A0A024R1X3 two hybrid 16973552 direct interaction X 2 Q86VN1 A0A024R1X3 two hybrid 16973552 direct interaction X 2 Q86VN1 Q99816 two hybrid 16973552 direct interaction X 2 Q86VN1 Q99816 two hybrid 16973552 direct interaction X 2 Q86VN1 Q99816 two hybrid 14505570 direct interaction X 2 Q86VN1 A0A024R1X3 two hybrid 14505570 direct interaction X 2 Q86VN1 Q93034 affinity chromatography technology 21145461 physical association X 2 Q86VN1 A0A024R1X3 affinity chromatography technology 17010938 physical association X 2 Q86VN1 Q96NA2 pull down 17010938 direct interaction X 2 Q86VN1 A0A024R1X3 biochemical 22939629 colocalization X 2 Q86VN1 O75436 biochemical 22939629 colocalization X 2 Q86VN1 A0A024R6Q2 biochemical 22939629 colocalization X 2 Q86VN1 O94782 biochemical 22939629 colocalization X 2 Q86VN1 Q9UBQ0 biochemical 22939629 colocalization X 2 Q86VN1 Q9UHR6 biochemical 22939629 colocalization X 2 Q86VN1 Q6IBS0 biochemical 22939629 colocalization X 2 Q86VN1 Q9UKK6 biochemical 22939629 colocalization X 2 Q86VN1 Q03169 biochemical 22939629 colocalization X 2 Q86VN1 P16298-3 biochemical 22863883 colocalization X 2 Q86VN1 A0A024R1X3 biochemical 22863883 colocalization X 2 Q86VN1 A0A024R1X3 two hybrid 16371348 direct interaction X 2 Q86VN1 A0A024R1X3 two hybrid 16371348 direct interaction X 2 Q86VN1 A0A024R1X3 pull down 16371348 direct interaction X 2 Q96H20 Q86VN1 x-ray crystallography 18539118 association X 2 Q96H20 Q86VN1 two hybrid 16973552 direct interaction X 2 Q96H20 Q86VN1 two hybrid 16973552 direct interaction X 2 Q96H20 Q86VN1 two hybrid 14505570 direct interaction X 2 Q96H20 Q86VN1 affinity chromatography technology 17010938 physical association X 2 Q96H20 Q86VN1 two hybrid 16371348 direct interaction X 2 Q96H20 Q86VN1 two hybrid 16371348 direct interaction X 2 Q86VN1 affinity chromatography technology 18539118 physical association X 2 Q86VN1 Q86VN1 two hybrid 16973552 direct interaction X 2 Q86VN1 Q96FZ7 two hybrid 14505570 direct interaction X 2 Q86VN1 O43597 two hybrid 21543492 direct interaction X 2 Q86VN1 O43597 two hybrid 21543492 direct interaction X 2 Q86VN1 O95801 biochemical 22939629 colocalization X 2 Q86VN1 O95155-3 biochemical 22939629 colocalization X 2 Q86VN1 E5KQS5 biochemical 22939629 colocalization X 2 Q86VN1 O95352 biochemical 22863883 colocalization X 2 Q86VN1 A0A024R6D8 biochemical 22863883 colocalization X 2 Q86VN1 A0A024R3P9 biochemical 22863883 colocalization X 2 Q86VN1 x-ray crystallography 17215868 association X 2 Q86VN1 P47142 two hybrid 16371348 direct interaction X 2 Q96QK1 Q86VN1 biochemical 22939629 colocalization X 2 Q04272 Q86VN1 two hybrid 16371348 direct interaction X 2 Q53T99 Q86VN1 biochemical 22863883 colocalization X 2 P0CG48 Q86VN1 x-ray crystallography 17057716 association X 2 P0CG48 Q86VN1 pull down 17057716 direct interaction X 2 P0CG48 Q86VN1 pull down 16973552 direct interaction X 2 P0CG48 Q86VN1 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q86VN1 affinity chromatography technology 21890473 physical association X 2 J3KN16 Q86VN1 affinity chromatography technology 20682791 physical association X 2 Q00341-2 Q86VN1 biochemical 22939629 colocalization X 2 Q86VN1 anti tag coimmunoprecipitation 14519844 association C 3 Q86VN1 Q99816 two hybrid 14505570 - X 2 Q86VN1 A0A024R1X3 two hybrid 11278625,16371348 - X 2 Q86VN1 A0A024R1X3 in vivo 11278625,16371348 - X 2 Q86VN1 Q99816 two hybrid 14505570 - X 2 Q86VN1 A0A024R1X3 in vivo 11278625,16371348 - X 2 Q86VN1 A0A024R1X3 two hybrid 11278625,16371348 - X 2 Q96H20 Q86VN1 in vivo 11278625 - X 2 Q96H20 Q86VN1 in vivo 11278625 - X 2 Q86VN1 Q96FZ7 two hybrid 14505570 - X 2 Q86VN1 Q96FZ7 two hybrid 14505570 - X 2 Q86VN1 Q02742 two hybrid 23027862 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B USP1 VPS36 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240147 bait prey VPS36 WDR12 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304975 bait prey VPS36 ACBD3 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304948 prey bait UBE4B VPS36 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238617 bait prey ATG7 VPS36 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_298664 prey bait VPS36 SNF8 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0114(x-ray crystallography)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0018(two hybrid) 11278625,14505570,16371348,16973552,17010938,18539118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0914(association)|MI:0407(direct interaction)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid) BIOGRID_124886|BIOGRID_192148|BIOGRID_192137|BIOGRID_192165|BIOGRID_124884|HPRD_24028|BIOGRID_212173|BIOGRID_192151 bait|prey|bait|prey|prey|-|prey|bait prey|bait|prey|bait|bait|-|bait|prey VPS36 CHMP6 MI:0018(two hybrid)|MI:0018(two hybrid) 14505570 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_26042|BIOGRID_192168 -|bait -|prey VPS36 TRMT61A MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236234 prey bait VPS36 SNX15 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241890 prey bait VPS36 RILP MI:0004(affinity chromatography technology) 17010938 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_212175 prey bait VPS36 VPS35 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236148 prey bait RPS27A VPS36 MI:0107(surface plasmon resonance) 17057716 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) MI:0465(dip) DIP_53648 - - GCNT1 VPS36 MI:0018(two hybrid) 23027862 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_124237 bait prey PPP3CB VPS36 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_302168 prey bait VPS36 ZNHIT2 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240983 bait prey VPS36 VPS28 MI:0114(x-ray crystallography) 18539118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_192141 prey bait VPS36 NXT1 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243202 prey bait ELAVL1 VPS36 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_186497 bait prey TTC4 VPS36 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237966 bait prey VPS36 TSG101 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 14505570,16973552 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid)|(biogrid) BIOGRID_192156|HPRD_26041|BIOGRID_192154|BIOGRID_192169 prey|-|bait|bait bait|-|prey|prey VPS36 VPS29 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240387 prey bait HDLBP VPS36 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236828 bait prey SRSF5 VPS36 MI:0401(biochemical) 22863883 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_304144 prey bait TNFAIP2 VPS36 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243282 bait prey TWF2 VPS36 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241386 bait prey VPS36 VPS25 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0401(biochemical)|MI:0018(two hybrid)|MI:0401(biochemical)|MI:0114(x-ray crystallography)|MI:0018(two hybrid)|MI:0493(in vivo)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 11278625,14505570,16371348,16973552,17010938,18539118,22863883,22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0403(colocalization)|MI:0914(association)|MI:0407(direct interaction)|-|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) BIOGRID_124903|BIOGRID_192187|BIOGRID_304949|BIOGRID_192145|BIOGRID_231080|BIOGRID_192138|BIOGRID_124885|HPRD_24033|BIOGRID_192153|BIOGRID_124881|BIOGRID_212174 prey|prey|prey|prey|prey|bait|bait|-|bait|prey|prey bait|bait|bait|bait|bait|prey|prey|-|prey|bait|bait VPS36 CUL5 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_203695 prey bait SPRY2 VPS36 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21543492 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_195506|BIOGRID_195504 prey|bait bait|prey ECM29 VPS36 MI:0018(two hybrid) 20682791 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_199732 bait prey VPS26A VPS36 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236147 bait prey UBC VPS36 MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0114(x-ray crystallography) 16973552,17057716,21139048,21890473 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0914(association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_170928|BIOGRID_192160|BIOGRID_175641|BIOGRID_192142|BIOGRID_192143 bait|prey|bait|prey|prey prey|bait|prey|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality VPS26A VPS36 22939629 0401 HT USP1 VPS36 22939629 0401 HT UBE4B VPS36 22939629 0401 HT ATG7 VPS36 22863883 0401 HT TTC4 VPS36 22939629 0401 HT UBC VPS36 17057716,17057716,16973552,17057716 0107,0114,0096,0096 LC PPP3CB VPS36 22863883 0401 HT HDLBP VPS36 22939629 0401 HT TNFAIP2 VPS36 22939629 0401 HT SRSF5 VPS36 22863883 0401 HT TWF2 VPS36 22939629 0401 HT VPS36 SLC25A41 26186194 0004 HT VPS36 CUL5 21145461 0004 HT VPS36 TRMT61A 26344197,22939629 0401,0401 HT VPS36 SNF8 26344197,17010938 0401,0004 HT,LC VPS36 VPS35 22939629 0401 HT VPS36 VPS25 26344197,16371348,22863883,17010938,16371348,22939629 0401,0018,0401,0004,0096,0401 HT,LC VPS36 WDR12 22863883 0401 HT VPS36 ACBD3 22863883 0401 HT VPS36 SNX15 22939629 0401 HT VPS36 VPS29 22939629 0401 HT VPS36 ZNHIT2 22939629 0401 HT VPS36 NXT1 22939629 0401 HT VPS26A VPS36 22939629 0401 HT USP1 VPS36 22939629 0401 HT UBE4B VPS36 22939629 0401 HT ATG7 VPS36 22863883 0401 HT TTC4 VPS36 22939629 0401 HT PPP3CB VPS36 22863883 0401 HT HDLBP VPS36 22939629 0401 HT TNFAIP2 VPS36 22939629 0401 HT SRSF5 VPS36 22863883 0401 HT TWF2 VPS36 22939629 0401 HT VPS36 SLC25A41 26186194 0004 HT VPS36 CUL5 21145461 0004 HT VPS36 TRMT61A 26344197,22939629 0401,0401 HT VPS36 SNF8 26344197 0401 HT VPS36 VPS35 22939629 0401 HT VPS36 VPS25 26344197,22863883,22939629 0401,0401,0401 HT VPS36 WDR12 22863883 0401 HT VPS36 ACBD3 22863883 0401 HT VPS36 SNX15 22939629 0401 HT VPS36 VPS29 22939629 0401 HT VPS36 ZNHIT2 22939629 0401 HT VPS36 NXT1 22939629 0401 HT UBC VPS36 17057716,17057716,16973552,17057716 0107,0114,0096,0096 LC VPS36 SNF8 17010938 0004 LC VPS36 VPS25 16371348,17010938,16371348 0018,0004,0096 LC SPRY2 VPS36 21543492 0018 LC VPS26A VPS36 22939629 0401 LC USP1 VPS36 22939629 0401 LC UBE4B VPS36 22939629 0401 LC ATG7 VPS36 22863883 0401 LC TTC4 VPS36 22939629 0401 LC UBC VPS36 17057716,17057716,17057716 0107,0114,0096 LC PPP3CB VPS36 22863883 0401 LC UBA52 VPS36 17057716,17057716 0107,0114 LC HDLBP VPS36 22939629 0401 LC GCNT1 VPS36 23027862 0018 LC TNFAIP2 VPS36 22939629 0401 LC SRSF5 VPS36 22863883 0401 LC TWF2 VPS36 22939629 0401 LC VPS36 VPS36 16973552 0018 LC VPS36 TRMT61A 26344197,22939629 0401,0401 LC VPS36 CHMP6 14505570 0018 LC VPS36 SNF8 26344197,16371348,14505570,16973552,18539118 0401,0018,0018,0018,0114 LC VPS36 VPS35 22939629 0401 LC VPS36 TSG101 14505570,16973552 0018,0018 LC VPS36 VPS25 26344197,16371348,22863883,18539118,14505570,11278625,16371348,22939629,16973552 0401,0018,0401,0114,0018,0018,0096,0401,0018 LC VPS36 WDR12 22863883 0401 LC VPS36 ACBD3 22863883 0401 LC VPS36 SNX15 22939629 0401 LC VPS36 VPS29 22939629 0401 LC VPS36 ZNHIT2 22939629 0401 LC VPS36 VPS28 17215868 0114 LC VPS36 NXT1 22939629 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q86VN1 Q5VYK3 VPS36 ECM29 0.126 20682791 Q86VN1 O43597 VPS36 SPRY2 0.523 21543492 Q9HCE1 Q86VN1 MOV10 VPS36 0.126 22658674 Q9NRS6 Q86VN1 SNX15 VPS36 0.081 22939629 Q9H3P7 Q86VN1 ACBD3 VPS36 0.081 22863883 Q86VN1 O75436 VPS36 VPS26A 0.081 22939629 Q86VN1 Q6IBS0 VPS36 TWF2 0.081 22939629 Q86VN1 O94782 VPS36 USP1 0.081 22939629 Q86VN1 O95352 VPS36 ATG7 0.081 22863883 Q86VN1 P16298 VPS36 PPP3CB 0.081 22863883 Q86VN1 Q04272 VPS36 VPS20 0.309 16371348 Q86VN1 Q13243 VPS36 SRSF5 0.081 22863883 Q86VN1 Q86VN1 VPS36 VPS36 0.332 16973552 Q96FZ7 Q86VN1 CHMP6 VPS36 0.309 14505570 Q9GZL7 Q86VN1 WDR12 VPS36 0.081 22863883 Q9UHR6 Q86VN1 ZNHIT2 VPS36 0.081 22939629 Q86VN1 O95155 VPS36 UBE4B 0.081 22939629 Q86VN1 O95801 VPS36 TTC4 0.081 22939629 Q9UK41 Q86VN1 VPS28 VPS36 0.454 18539118,17215868 Q99459 Q86VN1 CDC5L VPS36 0.236 20467437 Q9CQ80 Q86VN1 VPS25 VPS36 0.236 26496610 Q9CZ28 Q86VN1 SNF8 VPS36 0.236 26496610 Q86VN1 P62988 VPS36 UBA52 0.523 17057716 Q86VN1 P0CG48 VPS36 UBC 0.671 16973552,17057716 Q96H20 Q86VN1 SNF8 VPS36 0.934 unassigned1304,16371348,18539118,17010938,16973552,14505570 Q9BRG1 Q86VN1 VPS25 VPS36 0.962 14505570,22863883,unassigned1304,16371348,18539118,26344197,17010938,16973552 Q93034 Q86VN1 CUL5 VPS36 0.126 21145461 Q96FX7 Q86VN1 TRMT61A VPS36 0.155 22939629,26344197 Q96NA2 Q86VN1 RILP VPS36 0.309 17010938 Q96QK1 Q86VN1 VPS35 VPS36 0.081 22939629 Q99816 Q86VN1 TSG101 VPS36 0.671 16973552,14505570 Q9UBQ0 Q86VN1 VPS29 VPS36 0.081 22939629 Q9UBU9 Q86VN1 NXF1 VPS36 0.126 22658674 Q9UKK6 Q86VN1 NXT1 VPS36 0.081 22939629 Q86VN1 P47142 VPS36 VPS25 0.309 16371348 Q86VN1 Q00341 VPS36 HDLBP 0.081 22939629 Q86VN1 Q15717 VPS36 ELAVL1 0.126 19322201 Q86VN1 Q03169 VPS36 TNFAIP2 0.081 22939629

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 VPS37C VPS36 MI:0362 inference MI:1106 pathways database SPRY2 VPS36 MI:0045 experimental interaction detection MI:0461 interaction database CHMP2A VPS36 MI:0362 inference MI:1106 pathways database EIF3J VPS36 MI:0362 inference MI:0461 interaction database UBB VPS36 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBC VPS36 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database RPS27A VPS36 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBA52 VPS36 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database GCNT1 VPS36 MI:0045 experimental interaction detection MI:0461 interaction database RBBP5 VPS36 MI:0362 inference MI:0461 interaction database ELAVL1 VPS36 MI:0045 experimental interaction detection MI:0461 interaction database ECM29 VPS36 MI:0045 experimental interaction detection MI:0461 interaction database VPS36 VPS37D MI:0362 inference MI:1106 pathways database VPS36 SLC25A41 MI:0045 experimental interaction detection MI:0461 interaction database VPS36 VPS37A MI:0362 inference MI:1106 pathways database VPS36 CHMP7 MI:0362 inference MI:1106 pathways database VPS36 CUL5 MI:0045 experimental interaction detection MI:0461 interaction database VPS36 CHMP4C MI:0362 inference MI:1106 pathways database VPS36 CHMP6 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database VPS36 SNF8 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database VPS36 RILP MI:0045 experimental interaction detection MI:0461 interaction database VPS36 CDC5L MI:0045 experimental interaction detection MI:0461 interaction database VPS36 TSG101 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database VPS36 VPS25 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database VPS36 CHMP4A MI:0362 inference MI:1106 pathways database VPS36 CHMP4B MI:0362 inference MI:1106 pathways database VPS36 VPS37B MI:0362 inference MI:1106 pathways database VPS36 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database VPS36 HEYL MI:0362 inference MI:0461 interaction database VPS36 XPNPEP1 MI:0362 inference MI:0461 interaction database VPS36 HEY2 MI:0362 inference MI:0461 interaction database VPS36 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database VPS36 VPS28 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database VPS36 CHMP2B MI:0362 inference MI:1106 pathways database VPS36 CHMP3 MI:0362 inference MI:1106 pathways database VPS36 HEY1 MI:0362 inference MI:0461 interaction database