PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus FOXR2 RCBTB1 25609649 intact exp P P P GP P HSP90AA1 RCBTB1 22939624 biogrid exp G GP G G G GP G G GP G G G G G G G GP G G G G G G G G G G G G CUL3 RCBTB1 19256485,21145461 biogrid exp G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP GP GP G GP G G GABARAPL2 RCBTB1 20562859 intact exp G GP G G G GP G GP GP G GP G G G G GP GP G GP G G GP GP G GP G GP G G HSP90AB1 RCBTB1 22939624 intact exp G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP GP GP G GP G G PTBP3 RCBTB1 22575643 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RCBTB1 MAP1LC3A 20562859 intact exp G GP G G G GP G G GP G G GP G G G GP GP G GP G G G G G GP G G G G GABARAP RCBTB1 20562859 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G APP RCBTB1 21832049 biogrid exp G GP G G G GP G G GP G G G G G G GP GP G GP G G GP G G GP G G G G ANKRD40 RCBTB1 26186194 biogrid exp G GP G G G GP G GP GP G GP GP G G G GP GP G GP G G GP GP GP GP G GP G G RCBTB1 GABARAPL1 20562859 intact exp G GP G G G GP G GP GP G GP GP G G G GP GP G G G G G GP GP GP G GP G G RCBTB1 COPS5 21145461 biogrid exp G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP GP GP G GP G G HELZ RCBTB1 26186194 biogrid exp G GP G G G GP G GP GP G GP GP G G G G GP G GP G G G GP GP G G GP G G CUL1 RCBTB1 21145461 biogrid exp G G G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP GP GP G GP G G RCBTB1 CUL5 21145461 biogrid exp G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP GP GP G GP G G HERC3 RCBTB1 26186194 biogrid exp G GP G G G GP G GP GP G GP GP G G GP GP P G GP GP GP P G GP G RCBTB1 MAP1LC3B 20562859 intact exp G GP G G G GP G GP GP G GP G G G G GP GP G G G G G G GP GP G GP G G RCBTB1 UBE2E3 19256485 biogrid exp, ortho G GP G G G GP G G GP G GP G G G G GP GP GP G G G G G GP GP G GP G G CUL2 RCBTB1 21145461, 23023127 biogrid exp, pred G GP G G G GP G G GP G GP GP G G G G GP GP GP G G GP GP G G G GP G G TRAF1 RCBTB1 ortho G G G G G GP G G GP G GP G G G G G GP G G G G G G G G G G G SKP1 RCBTB1 23023127 pred G GP G G G GP G G GP G GP GP G G G GP GP GP GP G G GP GP G GP G GP G G ZBTB17 RCBTB1 23023127 pred G GP G G G GP G GP GP G GP GP G G G GP GP GP GP G G GP GP GP GP G GP G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A090N7U0 Q8NDN9 affinity chromatography technology 21145461 physical association X 2 A0A024R7W9 Q8NDN9 affinity chromatography technology 21145461 physical association X 2 Q8NDN9 Q93034 affinity chromatography technology 21145461 physical association X 2 Q8NDN9 P05067-7 pull down 21832049 direct interaction X 2 Q8NDN9 P07900-2 affinity chromatography technology 22939624 physical association X 2 P52483 Q8NDN9 pull down 19256485 direct interaction X 2 Q969T4 Q8NDN9 pull down 19256485 direct interaction X 2 Q13617 Q8NDN9 affinity chromatography technology 21145461 physical association X 2 P0CG48 Q8NDN9 affinity chromatography technology 21906983 physical association X 2 Q8NDN9 A0A024R475 affinity chromatography technology 21145461 physical association X 2 Q8NDN9 A0A024R475 affinity chromatography technology 19256485 physical association X 2 Q8NDN9 A0A024R475 pull down 19256485 direct interaction X 2 Q8NDN9 A0A024R475 pull down 19256485 direct interaction X 2 Q81U51 Q8NDN9 two hybrid pooling approach 20711500 physical association X 2 Q8NDN9 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CUL3 RCBTB1 MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 19256485,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_202312|BIOGRID_214466|BIOGRID_214465|BIOGRID_214464 bait|prey|bait|prey prey|bait|prey|bait APP RCBTB1 MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_229527 prey bait CUL1 RCBTB1 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_204669 bait prey HSP90AB1 RCBTB1 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125074 prey bait RCBTB1 UBE2E3 MI:0096(pull down) 19256485 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_214476 prey bait HSP90AA1 RCBTB1 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255465 bait prey UBC RCBTB1 MI:0004(affinity chromatography technology) 21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_180979 bait prey RCBTB1 COPS5 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_205456 prey bait CUL2 RCBTB1 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_203936 bait prey RCBTB1 CUL5 MI:0004(affinity chromatography technology) 21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_203568 prey bait

PPI - HINT Gene A Gene B PMID Method Quality HELZ RCBTB1 26186194 0004 HT GABARAPL2 RCBTB1 20562859 0007 HT CUL1 RCBTB1 21145461 0004 HT CUL2 RCBTB1 21145461 0004 HT CUL3 RCBTB1 19256485,21145461,19256485 0004,0004,0096 LC,HT HERC3 RCBTB1 26186194 0004 HT PCID2 RCBTB1 20562859 0007 HT ANKRD40 RCBTB1 26186194 0004 HT FOXR2 RCBTB1 25609649,25609649 0676,0004 HT RCBTB1 COPS5 21145461 0004 HT RCBTB1 CUL5 21145461 0004 HT RCBTB1 MAP1LC3B 20562859 0007 HT RCBTB1 GABARAPL1 20562859 0007 HT RCBTB1 MAP1LC3A 20562859 0007 HT HELZ RCBTB1 26186194 0004 HT GABARAPL2 RCBTB1 20562859 0007 HT CUL1 RCBTB1 21145461 0004 HT CUL2 RCBTB1 21145461 0004 HT CUL3 RCBTB1 21145461 0004 HT HERC3 RCBTB1 26186194 0004 HT PCID2 RCBTB1 20562859 0007 HT ANKRD40 RCBTB1 26186194 0004 HT FOXR2 RCBTB1 25609649,25609649 0676,0004 HT RCBTB1 COPS5 21145461 0004 HT RCBTB1 CUL5 21145461 0004 HT RCBTB1 MAP1LC3B 20562859 0007 HT RCBTB1 GABARAPL1 20562859 0007 HT RCBTB1 MAP1LC3A 20562859 0007 HT CUL3 RCBTB1 19256485,19256485 0004,0096 LC HSP90AB1 RCBTB1 22939624 0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8NDN9 P60520 RCBTB1 GABARAPL2 0.126 20562859 Q9H492 Q8NDN9 MAP1LC3A RCBTB1 0.126 20562859 Q8NDN9 P05067 RCBTB1 APP 0.183 21832049 Q8NDN9 P08238 RCBTB1 HSP90AB1 0.126 22939624 Q8NDN9 P42694 RCBTB1 HELZ 0.126 26186194 Q8NDN9 Q15034 RCBTB1 HERC3 0.126 26186194 Q8NDN9 Q6AI12 RCBTB1 ANKRD40 0.126 26186194 Q8NDN9 Q81U51 RCBTB1 Q81U51 0.126 20711500 Q9GZQ8 Q8NDN9 MAP1LC3B RCBTB1 0.126 20562859 Q9H0R8 Q8NDN9 GABARAPL1 RCBTB1 0.126 20562859 Q8NDN9 P07900 RCBTB1 HSP90AA1 0.126 22939624 Q8NDN9 O95166 RCBTB1 GABARAP 0.126 20562859 Q8NDN9 O95758 RCBTB1 PTBP3 0.126 22575643 Q8NDN9 Q13618 RCBTB1 CUL3 0.671 19256485,21145461 Q8NDN9 Q6PJQ5 RCBTB1 FOXR2 0.236 25609649 Q92905 Q8NDN9 COPS5 RCBTB1 0.126 21145461 Q93034 Q8NDN9 CUL5 RCBTB1 0.126 21145461 Q969T4 Q8NDN9 UBE2E3 RCBTB1 0.309 19256485 Q8NDN9 Q13616 RCBTB1 CUL1 0.126 21145461 Q8NDN9 Q13617 RCBTB1 CUL2 0.126 21145461 Q8NDN9 P52483 RCBTB1 UBE2E3 0.309 19256485

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 GABARAP RCBTB1 MI:0045 experimental interaction detection MI:0461 interaction database PTBP3 RCBTB1 MI:0045 experimental interaction detection MI:0461 interaction database APP RCBTB1 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AA1 RCBTB1 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 RCBTB1 MI:0045 experimental interaction detection MI:0461 interaction database UBC RCBTB1 MI:0045 experimental interaction detection MI:0461 interaction database HELZ RCBTB1 MI:0045 experimental interaction detection MI:0461 interaction database GABARAPL2 RCBTB1 MI:0045 experimental interaction detection MI:0461 interaction database TRAF1 RCBTB1 MI:0362 inference MI:0461 interaction database CUL1 RCBTB1 MI:0045 experimental interaction detection MI:0461 interaction database CUL2 RCBTB1 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 RCBTB1 MI:0045 experimental interaction detection MI:0461 interaction database HERC3 RCBTB1 MI:0045 experimental interaction detection MI:0461 interaction database ANKRD40 RCBTB1 MI:0045 experimental interaction detection MI:0461 interaction database FOXR2 RCBTB1 MI:0045 experimental interaction detection MI:0461 interaction database RCBTB1 COPS5 MI:0045 experimental interaction detection MI:0461 interaction database RCBTB1 CUL5 MI:0045 experimental interaction detection MI:0461 interaction database RCBTB1 UBE2E3 MI:0045 experimental interaction detection MI:0461 interaction database RCBTB1 NDN MI:0362 inference MI:0461 interaction database RCBTB1 MAP1LC3B MI:0045 experimental interaction detection MI:0461 interaction database RCBTB1 GABARAPL1 MI:0045 experimental interaction detection MI:0461 interaction database RCBTB1 MAP1LC3A MI:0045 experimental interaction detection MI:0461 interaction database