PTM - CPLM Gene Name UniProt ID Type Position Code BIN1; AMPHL O00499 Ubiquitination 146 K

PTM - dbPAF Gene Name UniProt ID Position Type Species BIN1; AMPHL O00499 150 Y Homo sapiens(Human) BIN1; AMPHL O00499 296 S Homo sapiens(Human) BIN1; AMPHL O00499 298 S Homo sapiens(Human) BIN1; AMPHL O00499 303 S Homo sapiens(Human) BIN1; AMPHL O00499 307 T Homo sapiens(Human) BIN1; AMPHL O00499 323 T Homo sapiens(Human) BIN1; AMPHL O00499 327 T Homo sapiens(Human) BIN1; AMPHL O00499 331 S Homo sapiens(Human) BIN1; AMPHL O00499 333 S Homo sapiens(Human) BIN1; AMPHL O00499 348 T Homo sapiens(Human) BIN1; AMPHL O00499 350 S Homo sapiens(Human) BIN1; AMPHL O00499 365 T Homo sapiens(Human) BIN1; AMPHL O00499 488 S Homo sapiens(Human) BIN1; AMPHL O00499 489 S Homo sapiens(Human) BIN1; AMPHL O00499 510 S Homo sapiens(Human) BIN1; AMPHL O00499 56 T Homo sapiens(Human) BIN1; AMPHL O00499 71 S Homo sapiens(Human) BIN1; AMPHL O00499 79 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA O00499 K28-ac Acetylation KLTRAQEkVLQKLGK O00499 R66-m1 Methylation TRLQKDLrTYLAsVK O00499 S71-p Phosphorylation DLrTYLAsVKAMHEA O00499 S79-p Phosphorylation VKAMHEAsKKLNECL O00499 Y150-p Phosphorylation RGRkLVDyDsARHHY O00499 S152-p Phosphorylation RkLVDyDsARHHYES O00499 S276-p Phosphorylation GLEKQHGsNTFTVKA O00499 S296-p Phosphorylation APAKGNKsPsPPDGs O00499 S298-p Phosphorylation AKGNKsPsPPDGsPA O00499 S303-p Phosphorylation sPsPPDGsPAAtPEI O00499 T307-p Phosphorylation PDGsPAAtPEIRVNH O00499 T323-p Phosphorylation PEPAGGAtPGAtLPK O00499 T327-p Phosphorylation GGAtPGAtLPKsPsQ O00499 S331-p Phosphorylation PGAtLPKsPsQLRKG O00499 S333-p Phosphorylation AtLPKsPsQLRKGPP O00499 T348-p Phosphorylation VPPPPKHtPSKEVKQ O00499 T534-p Phosphorylation AQHDYTAtDTDELQL O00499 K146-ub Ubiquitination RIAKRGRkLVDyDsA

PTM - dbPTM UniProt ID Position Code Type Resources References O00499 296 S Phosphorylation Swiss-Prot 1010711 15302935;17081983;18187866;18669648;19413330 O00499 298 S Phosphorylation Swiss-Prot 1010711 15302935;17081983;17924679;18669648;19413330 O00499 303 S Phosphorylation Swiss-Prot 1010711 15302935;17081983;18669648;19413330 O00499 307 T Phosphorylation Swiss-Prot 1010711 18669648;19367720 O00499 323 T Phosphorylation Swiss-Prot 1010711 18669648 O00499 331 S Phosphorylation Swiss-Prot 1010711 17081983;18669648 O00499 296 S Phosphorylation PhosphoELM.10011 18669648;17081983;15302935 O00499 298 S Phosphorylation PhosphoELM.10011 18669648;17081983;15302935 O00499 303 S Phosphorylation PhosphoELM.10011 18669648;17081983;15302935 O00499 331 S Phosphorylation PhosphoELM.10011 18669648;17081983 O00499 333 S Phosphorylation PhosphoELM.10011 18669648 O00499 488 S Phosphorylation PhosphoELM.10011 18669648 O00499 489 S Phosphorylation PhosphoELM.10011 18669648 O00499 307 T Phosphorylation PhosphoELM.10011 18669648;17081983 O00499 323 T Phosphorylation PhosphoELM.10011 18669648 O00499 327 T Phosphorylation PhosphoELM.10011 18669648 O00499 296 S Phosphorylation Phosphositeplus.1010730 15302935;18187866;18510355;18669648;19276368;19362540;19367720;19664994;20044836;20058876;20068231;20166139;20363803;20886841;21406692 O00499 298 S Phosphorylation Phosphositeplus.1010730 15302935;18510355;18669648;19367720;19664994;20058876;20166139;20363803;20886841;21406692 O00499 303 S Phosphorylation Phosphositeplus.1010730 15302935;18510355;18669648;19276368;19415658;20044836;20166139;20886841;22115753 O00499 331 S Phosphorylation Phosphositeplus.1010730 18669648;19276368;20068231;20166139 O00499 333 S Phosphorylation Phosphositeplus.1010730 19276368;20068231;21406692 O00499 307 T Phosphorylation Phosphositeplus.1010730 18669648;19367720;20068231;20166139 O00499 323 T Phosphorylation Phosphositeplus.1010730 18669648;19276368;20068231;20886841 O00499 71 S Phosphorylation HPRD 9.0 20068231 O00499 296 S Phosphorylation HPRD 9.0 15302935,18669648,19413330,19651622,19664994,18510355,18767875,20166139,20068231,20058876 O00499 298 S Phosphorylation HPRD 9.0 17322306,18669648,19413330,17924679,19651622,19664994,18510355,18452278,20166139,20068231,20058876 O00499 303 S Phosphorylation HPRD 9.0 17322306,18669648,19413330,19415658,18212344,19651622,18510355,20166139,20068231 O00499 331 S Phosphorylation HPRD 9.0 17081983,18669648,20166139,20068231 O00499 333 S Phosphorylation HPRD 9.0 18669648,20068231 O00499 56 T Phosphorylation HPRD 9.0 20068231 O00499 307 T Phosphorylation HPRD 9.0 17081983,18669648,20166139,20068231 O00499 307 T Phosphorylation HPRD 9.0 18669648,20068231 O00499 307 T Phosphorylation HPRD 9.0 20068231 O00499 323 T Phosphorylation HPRD 9.0 18669648,20068231 O00499 323 T Phosphorylation HPRD 9.0 20068231 O00499 327 T Phosphorylation HPRD 9.0 18669648,20068231 O00499 348 T Phosphorylation HPRD 9.0 20068231 O00499 296 S Phosphorylation SysPTM 1.1 18669648 O00499 298 S Phosphorylation SysPTM 1.1 18669648 O00499 303 S Phosphorylation SysPTM 1.1 18669648;18212344 O00499 331 S Phosphorylation SysPTM 1.1 18669648;17081983 O00499 296 S Phosphorylation SysPTM 1.1 18510355 O00499 298 S Phosphorylation SysPTM 1.1 18510355 O00499 303 S Phosphorylation SysPTM 1.1 18510355 O00499 296 S Phosphorylation SysPTM 1.1 17081983 O00499 298 S Phosphorylation SysPTM 1.1 17081983 O00499 303 S Phosphorylation SysPTM 1.1 17081983 O00499 307 T Phosphorylation SysPTM 1.1 18669648 O00499 323 T Phosphorylation SysPTM 1.1 18669648 O00499 307 T Phosphorylation SysPTM 1.1 17081983

PTM - HPRD Symbol Position Code Type References BIN1 265 S Phosphorylation 15302935,18669648,19413330,19651622,19664994,18510355,18767875,20166139,20068231,20058876 BIN1 267 S Phosphorylation 17322306,18669648,19413330,17924679,19651622,19664994,18510355,18452278,20166139,20068231,20058876 BIN1 272 S Phosphorylation 17322306,18669648,19413330,19415658,18212344,19651622,18510355,20166139,20068231 BIN1 276 T Phosphorylation 17081983,18669648,20166139,20068231 BIN1 280 S Phosphorylation 15302935,18669648,19413330,19651622,19664994,18510355,18767875,20166139,20068231,20058876 BIN1 282 S Phosphorylation 17322306,18669648,19413330,17924679,19651622,19664994,18510355,18452278,20166139,20068231,20058876 BIN1 287 S Phosphorylation 17322306,18669648,19413330,19415658,18212344,19651622,18510355,20166139,20068231 BIN1 291 T Phosphorylation 17081983,18669648,20166139,20068231 BIN1 292 T Phosphorylation 18669648,20068231 BIN1 292 T Phosphorylation 20068231 BIN1 296 S Phosphorylation 15302935,18669648,19413330,19651622,19664994,18510355,18767875,20166139,20068231,20058876 BIN1 296 T Phosphorylation 18669648,20068231 BIN1 298 S Phosphorylation 17322306,18669648,19413330,17924679,19651622,19664994,18510355,18452278,20166139,20068231,20058876 BIN1 300 S Phosphorylation 17081983,18669648,20166139,20068231 BIN1 302 S Phosphorylation 18669648,20068231 BIN1 303 S Phosphorylation 17322306,18669648,19413330,19415658,18212344,19651622,18510355,20166139,20068231 BIN1 304 S Phosphorylation 18669648 BIN1 305 S Phosphorylation 18669648 BIN1 307 T Phosphorylation 17081983,18669648,20166139,20068231 BIN1 307 T Phosphorylation 18669648,20068231 BIN1 307 T Phosphorylation 20068231 BIN1 311 T Phosphorylation 18669648,20068231 BIN1 315 S Phosphorylation 17081983,18669648,20166139,20068231 BIN1 317 S Phosphorylation 18669648,20068231 BIN1 317 T Phosphorylation 20068231 BIN1 323 T Phosphorylation 18669648,20068231 BIN1 323 T Phosphorylation 20068231 BIN1 327 T Phosphorylation 18669648,20068231 BIN1 331 S Phosphorylation 17081983,18669648,20166139,20068231 BIN1 332 T Phosphorylation 20068231 BIN1 333 S Phosphorylation 18669648,20068231 BIN1 348 T Phosphorylation 20068231 BIN1 56 T Phosphorylation 20068231 BIN1 71 S Phosphorylation 20068231

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type O00499 323 T 18669648 HTP Phosphorylation O00499 327 T 18669648 HTP Phosphorylation O00499 488 S 18669648 HTP Phosphorylation O00499 489 S 18669648 HTP Phosphorylation O00499 298 S 18669648 HTP Phosphorylation O00499 298 S 17081983 HTP Phosphorylation O00499 298 S 15302935 HTP Phosphorylation O00499 331 S 18669648 HTP Phosphorylation O00499 331 S 17081983 HTP Phosphorylation O00499 333 S 18669648 HTP Phosphorylation O00499 303 S 18669648 HTP Phosphorylation O00499 303 S 17081983 HTP Phosphorylation O00499 303 S 15302935 HTP Phosphorylation O00499 296 S 18669648 HTP Phosphorylation O00499 296 S 17081983 HTP Phosphorylation O00499 296 S 15302935 HTP Phosphorylation O00499 307 T 18669648 HTP Phosphorylation O00499 307 T 17081983 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs O00499 2 N-acetylalanine 22814378 O00499 296 Phosphoserine 18669648;20068231;23186163;24275569 O00499 298 Phosphoserine 18669648;23186163;24275569 O00499 303 Phosphoserine 17081983;18669648;23186163 O00499 307 Phosphothreonine 18669648;19367720 O00499 323 Phosphothreonine 18669648;20068231 O00499 331 Phosphoserine 18669648;20068231

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type BIN1 IPI00186966 S 296 PAKGNKpSPSPPDG phosphorylation BIN1 IPI00186966 S 298 KGNKSPpSPPDGSP phosphorylation BIN1 IPI00186966 S 303 PSPPDGpSPAATPE phosphorylation BIN1 IPI00186966 S 331 GATLPKpSPSQLRK phosphorylation BIN1 IPI00186966 S 333 TLPKSPpSQLRKGP phosphorylation BIN1 IPI00186966 T 307 DGSPAApTPEIRVN phosphorylation BIN1 IPI00186966 T 323 EPAGGApTPGATLP phosphorylation