PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBE2D3 RNF38 19549727 biogrid,intact exp GP G G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G G GP GP G DTX3 RNF38 22493164 biogrid,intact exp GP GP G G G GP G G GP G GP GP G G G GP GP GP P G G G GP GP GP G GP GP G TP73 RNF38 20308539 biogrid exp G G G G G RNF38 RNF38 23973461 biogrid exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G TP53 RNF38 20308539,23973461 biogrid exp G G G G G G G G G G G G G G G GP G G G G GP G G G GP G G GP G ELAVL1 RNF38 19322201 biogrid exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE2H RNF38 19549727 biogrid,intact exp GP GP G G G GP G G G G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G UBE2D2 RNF38 19549727,23973461 biogrid,intact exp GP G G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G G GP GP G RNF38 RNF114 22493164 biogrid,intact exp GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G RNF38 UBE2D4 19549727 biogrid,intact exp GP G G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G G GP GP G RNF38 TP63 20308539 biogrid exp GP G G G G G G G G G G G G G G G G G G GP GP G G G G G ZDHHC17 RNF38 24705354 biogrid,intact exp G GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G LDB1 RNF38 12874135 biogrid exp GP GP G G G GP G G GP G GP G GP GP G GP GP GP GP G GP GP G GP GP G GP GP G UBE2D1 RNF38 19549727 biogrid,intact exp GP G G G G GP G G GP G GP GP GP GP G G GP GP GP G GP GP G GP G G GP GP G DZIP3 RNF38 22493164 biogrid,intact exp GP GP G G G GP G G GP G GP G GP GP G GP GP GP GP G P GP GP GP GP G GP GP G PRPF40A RNF38 23023127 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A087WW00 Q9H0F5 two hybrid 19549727 direct interaction X 2 Q8IUH5 Q9H0F5 two hybrid 24705354 direct interaction X 2 Q9H0F5 affinity chromatography technology 12874135 physical association X 2 Q9H0F5 Q86Y13 two hybrid 22493164 direct interaction X 2 Q9H0F5 Q9H0F5 enzymatic study 23973461 direct interaction X 2 Q9H0F5 P04637-7 pull down 23973461 direct interaction X 2 Q9H0F5 P04637-7 affinity chromatography technology 23973461 physical association X 2 Q9H0F5 P04637-7 enzymatic study 23973461 direct interaction X 2 Q9H0F5 P04637-7 affinity chromatography technology 20308539 physical association X 2 Q9H0F5 Q9H3D4-7 affinity chromatography technology 20308539 physical association X 2 Q9H0F5 A0A024RA90 two hybrid 19549727 direct interaction X 2 Q9Y508 Q9H0F5 two hybrid 22493164 direct interaction X 2 P0CG48 Q9H0F5 affinity chromatography technology 22505724 physical association X 2 P0CG48 Q9H0F5 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q9H0F5 affinity chromatography technology 21906983 physical association X 2 A0A024RB96 Q9H0F5 two hybrid 22493164 direct interaction X 2 Q9H0F5 P62837 pull down 23973461 direct interaction X 2 Q9H0F5 O15350-4 affinity chromatography technology 20308539 physical association X 2 Q9H0F5 P62837 two hybrid 19549727 direct interaction X 2 Q9H0F5 P61077-3 two hybrid 19549727 direct interaction X 2 Q9H0F5 two hybrid 19549727 direct interaction X 2 A0A024RDH2 Q9H0F5 two hybrid array 19549727 physical association X 2 Q8IUH5 Q9H0F5 two hybrid array 24705354 physical association X 2 Q9H0F5 A0A024RA90 two hybrid array 19549727 physical association X 2 Q9H0F5 Q86Y13 two hybrid array 22493164 physical association X 2 A4D1L5 Q9H0F5 two hybrid array 19549727 physical association X 2 Q9Y508 Q9H0F5 two hybrid array 22493164 physical association X 2 A0A024QZJ2 Q9H0F5 two hybrid array 19549727 physical association X 2 A0A024RB96 Q9H0F5 two hybrid array 22493164 physical association X 2 Q9H0F5 P62837 two hybrid array 19549727 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B UBE2H RNF38 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124512|UniProt_101353 bait|bait prey|prey DZIP3 RNF38 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284014|UniProt_122521 bait|prey prey|bait NRF1 RNF38 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_294832 bait prey ELAVL1 RNF38 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187047 bait prey DTX3 RNF38 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284112|UniProt_122613 prey|prey bait|bait UBE2D1 RNF38 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124508|UniProt_101246 bait|bait prey|prey UBE2D2 RNF38 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0415(enzymatic study) 19549727,23973461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(intact)|(biogrid) BIOGRID_124509|UniProt_101270|BIOGRID_289188 bait|bait|prey prey|prey|bait TP73 RNF38 MI:0004(affinity chromatography technology) 20308539 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_123814 bait prey UBC RNF38 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21906983,21963094,22505724 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_179260|BIOGRID_223540|BIOGRID_266143 bait|bait|bait prey|prey|prey p53 RNF38 MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 20308539,23973461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_289189|BIOGRID_289191|BIOGRID_289190|BIOGRID_123757 bait|prey|bait|bait prey|bait|prey|prey LDB1 RNF38 MI:0004(affinity chromatography technology) 12874135 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_200784 bait prey RNF38 TP63 MI:0004(affinity chromatography technology) 20308539 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_123783 prey bait UBE2D3 RNF38 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101294|BIOGRID_124510 bait|bait prey|prey RNF38 RNF114 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284012|UniProt_122571 prey|bait bait|prey RNF38 UBE2D4 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101465|BIOGRID_124511 prey|prey bait|bait ZDHHC17 RNF38 MI:0397(two hybrid array)|MI:0397(two hybrid array) 24705354 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(intact) UniProt_176441|UniProt_133210 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality UBC RNF38 25801170,25801170,25801170 0114,0415,0096 LC UBE2D2 RNF38 23973461,25801170,25801170 0096,0114,0096 LC Q53GA5 RNF38 23973461,23973461,23973461,20308539 0096,0415,0004,0004 LC UBC RNF38 25801170,25801170,25801170 0114,0415,0096 LC UBE2D2 RNF38 23973461,25801170,25801170 0096,0114,0096 LC Q53GA5 RNF38 23973461,23973461,23973461,20308539 0096,0415,0004,0004 LC UBC RNF38 25801170,25801170,25801170 0114,0415,0096 LC UBE2D1 RNF38 19549727,19549727 0397,0018 HT UBE2D3 RNF38 19549727,19549727 0397,0018 HT UBE2H RNF38 19549727,19549727 0397,0018 HT UBE2D2 RNF38 25801170,19549727,19549727,25801170 0114,0397,0018,0096 LC,HT Q53GA5 RNF38 23973461,23973461,23973461 0096,0415,0004 LC DZIP3 RNF38 22493164,22493164 0018,0397 HT ZDHHC17 RNF38 24705354,24705354 0397,0018 HT DTX3 RNF38 22493164,22493164 0018,0397 HT RNF38 RNF38 23973461,25801170 0415,0415 LC RNF38 UBE2D4 19549727,19549727 0397,0018 HT RNF38 RNF114 22493164,22493164 0018,0397 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H0F5 P61077 RNF38 UBE2D3 0.286 19549727 Q9H0F5 O15350 RNF38 TP73 0.126 20308539 Q9H0F5 Q8N9I9 RNF38 DTX3 0.286 22493164 Q9H0F5 Q8IUH5 RNF38 ZDHHC17 0.286 24705354 Q9H0F5 P04637 RNF38 TP53 0.671 23973461,20308539 Q9H0F5 P0CG48 RNF38 UBC 0.523 25801170 Q9H0F5 Q86Y13 RNF38 DZIP3 0.286 22493164 Q9H0F5 P62256 RNF38 UBE2H 0.376 19549727 Q9Y508 Q9H0F5 RNF114 RNF38 0.286 22493164 Q9Y2X8 Q9H0F5 UBE2D4 RNF38 0.376 19549727 Q9H3D4 Q9H0F5 TP63 RNF38 0.126 20308539 Q9H0F5 Q86U70 RNF38 LDB1 0.21 12874135 Q9H0F5 B8A4K4 RNF38 CYSRT1 {ECO:0000313|ENSEMBL:ENSP00000386453} 0.236 unassigned1304 Q9H0F5 P60410 RNF38 KRTAP10-8 0.236 unassigned1304 Q9H0F5 P62837 RNF38 UBE2D2 0.659 19549727,23973461,25801170 Q9H0F5 Q14847 RNF38 LASP1 0.236 unassigned1304 Q9H0F5 Q3LI66 RNF38 KRTAP6-2 0.236 unassigned1304 Q9H0F5 Q5T749 RNF38 KPRP 0.236 unassigned1304 Q9H0F5 Q8IUC1 RNF38 KRTAP11-1 0.236 unassigned1304 Q9H0F5 Q8IUC2 RNF38 KRTAP8-1 0.236 unassigned1304 Q9H0F5 Q8TDS5 RNF38 OXER1 0.236 unassigned1304 Q9H0F5 Q9H0F5 RNF38 RNF38 0.554 23973461,25801170 Q9H0F5 P51668 RNF38 UBE2D1 0.286 19549727 Q9H0F5 Q15717 RNF38 ELAVL1 0.126 19322201

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TP73 RNF38 MI:0045 experimental interaction detection MI:0461 interaction database TP53 RNF38 MI:0045 experimental interaction detection MI:0461 interaction database UBC RNF38 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 RNF38 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 RNF38 MI:0045 experimental interaction detection MI:0461 interaction database UBE2H RNF38 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 RNF38 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 RNF38 MI:0045 experimental interaction detection MI:0461 interaction database LDB1 RNF38 MI:0045 experimental interaction detection MI:0461 interaction database DZIP3 RNF38 MI:0045 experimental interaction detection MI:0461 interaction database ZDHHC17 RNF38 MI:0045 experimental interaction detection MI:0461 interaction database DTX3 RNF38 MI:0045 experimental interaction detection MI:0461 interaction database RNF38 TP63 MI:0045 experimental interaction detection MI:0461 interaction database RNF38 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database RNF38 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database