Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 15 67975599 rs8042567 G A rs8042567 9.52E-04 GEMCITABINE|CYTARABINE MANNOSYLTRANSFERASES|PIGB PROTEIN, HUMAN|RNA, SMALL INTERFERING|DEOXYCYTIDINE Response to cytidine analogues (gemcitabine) HPOID:0002664 DOID:162 G intron GWASdb_drug 15 68076533 rs12902904 G A rs12902904 7.73E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G intron GWASdb_drug 15 67971949 rs2414975 A T rs2414975 1.34E-04 Multiple complex diseases HPOID:0000118 NA T intron GWASdb_trait 15 67972988 rs2414976 T C rs2414976 4.96E-04 Multiple complex diseases HPOID:0000118 NA T intron GWASdb_trait 15 67975599 rs8042567 G A rs8042567 9.52E-04 Response to cytidine analogues (gemcitabine) HPOID:0002664 DOID:162 G intron GWASdb_trait 15 67988586 rs72751410 A G rs72751410 0.000023 Menopause (age at onset) HPOID:0100805 DOID:9970|DOID:9352|DOID:1287|DOID:11476|DOID:1612|DOID:10652 A intron GWASdb_trait 15 68016343 rs997295 G T rs997295 0.0000055 Body mass index (males) HPOID:0001507 DOID:9970 G intron GWASdb_trait 15 68016343 rs997295 G T rs997295 1.43E-08 Body mass index HPOID:0001507 DOID:9970 G intron GWASdb_trait 15 68036852 rs12593813 A G rs12593813 1.00E-15 Restless legs syndrome HPOID:0002981 DOID:0050425 A intron GWASdb_trait 15 68036852 rs12593813 A G rs12593813 1.00E-22 Restless legs syndrome HPOID:0002981 DOID:0050425 A intron GWASdb_trait 15 68037578 rs11635424 A G rs11635424 3.65E-16 Restless legs syndrome HPOID:0002981 DOID:0050425 A intron GWASdb_trait 15 68043057 rs8028313 C G rs8028313 1.00E-11 Obesity HPOID:0001513 DOID:9970 C intron GWASdb_trait 15 68043057 rs8028313 C G rs8028313 6.00E-13 Obesity HPOID:0001513 DOID:9970 C intron GWASdb_trait 15 68054388 rs884202 G A rs884202 1.17E-05 Restless legs syndrome HPOID:0002981 DOID:0050425 G intron GWASdb_trait 15 68054996 rs868037 A G rs868037 2.11E-04 Type 2 diabetes HPOID:0005978 DOID:9352 T intron GWASdb_trait 15 68058903 rs11071959 A G rs11071959 9.89E-06 F-cell distribution HPOID:0008346 DOID:10923 A intron GWASdb_trait 15 68060389 rs745213 T G rs745213 8.65E-05 Orofacial clefts HPOID:0000202 DOID:0050567 G intron GWASdb_trait 15 68072075 rs4489954 T G rs4489954 9.10E-04 Type 2 diabetes HPOID:0005978 DOID:9352 T intron GWASdb_trait 15 68072075 rs4489954 T G rs4489954 2.68E-15 Restless legs syndrome HPOID:0002981 DOID:0050425 T intron GWASdb_trait 15 68072275 rs3784709 C T rs3784709 3.83E-04 Type 2 diabetes HPOID:0005978 DOID:9352 T intron GWASdb_trait 15 68072275 rs3784709 C T rs3784709 4.06E-16 Restless legs syndrome HPOID:0002981 DOID:0050425 T intron GWASdb_trait 15 68076533 rs12902904 G A rs12902904 7.73E-04 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G intron GWASdb_trait 15 68080886 rs4776970 A T rs4776970 2.00E-09 Body mass index HPOID:0001507 DOID:9970 T intron GWASdb_trait 15 68080886 rs4776970 A T rs4776970 3.00E-07 Body mass index HPOID:0001507 DOID:9970 T intron GWASdb_trait 15 68086838 rs2241423 G A rs2241423 1.00E-18 Body mass index HPOID:0001507 DOID:9970 G intron GWASdb_trait 15 68086838 rs2241423 G A rs2241423 6.02E-07 Body mass index HPOID:0001507 DOID:9970 G intron GWASdb_trait 15 68086838 rs2241423 G A rs2241423 1.19E-18 Body mass index HPOID:0001507 DOID:9970 G intron GWASdb_trait 15 68090700 rs11856999 C T rs11856999 6.34E-05 Orofacial clefts HPOID:0000202 DOID:0050567 C intron GWASdb_trait 15 68095085 rs1026732 G A rs1026732 3.77E-04 Type 2 diabetes HPOID:0005978 DOID:9352 A intron GWASdb_trait 15 68095085 rs1026732 G A rs1026732 6.09E-17 Restless legs syndrome HPOID:0002981 DOID:0050425 A intron GWASdb_trait

Disease associated variation - OMIM Ensembl_gene_ID Approved Gene Symbol MIM Number ENSG00000137764.19 MAP2K5 602520