PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CSNK1E PREB 19888210 i2d exp GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G HSP90AB1 PREB 25036637,22939624 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HSP90AA1 PREB 22939624 biogrid exp GP GP G G G GP G G GP G G G G G G G GP G G G GP G G G G G G GP G TCTN3 PREB 26638075 biogrid,intact exp G GP G G G GP G GP GP G G G G G G GP GP G GP G GP GP G GP GP G GP G G EVC2 PREB 26638075 biogrid,intact exp GP P P P P GP P P GP GP G P P GP GP P GP GP P P P GP P G PREB NUDC 25036637 intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CSNK1A1 PREB 19888210 i2d exp G G G G G G G G G G G G G G G G G G GP G G G G G G G G G G TMEM17 PREB 26638075 biogrid,intact exp P GP G P GP G P P G GP P P G G P GP P GP G P GP GP P P P P GP SCLT1 PREB 26638075 biogrid,intact exp GP GP G G GP GP G GP P G P GP GP GP G GP GP GP GP G P GP P P GP GP GP GP TCTN2 PREB 26638075 biogrid,intact exp GP G G G GP GP G GP GP G G G GP G G GP GP G GP G GP G G G GP GP GP GP G NKD1 PREB 19888210 i2d exp G G G G G P G G G G P GP TGFBR1 PREB 15761153 hprd,i2d exp GP G G G GP GP G GP GP G GP GP GP G G GP GP G G G G G G G GP G GP G G PREB WWOX 24550385 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PREB CORO1C 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PREB TMEM216 26638075 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TMEM67 PREB 26638075 biogrid,intact exp P P P P GP P GP P GP P P P GP GP G P P P P P P P GP SMAD1 PREB 15761153, 21836163 hprd,i2d exp, pred G G G G G G G G GP G G G G G G G G G G G G G G G G G G GP G TRIP13 PREB ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G GP G SSBP4 PREB ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G YWHAE PREB ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ABHD1 PREB 21836163 pred GP GP G G GP P G GP GP G GP GP P P P P P GP G P P GP GP GP P GP GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9HCU5 P07900-2 affinity chromatography technology 22939624 physical association X 2 Q9HCU5 P0CG48 affinity chromatography technology 21963094 physical association X 2 Q9HCU5 P0CG48 affinity chromatography technology 23000965 physical association X 2 Q9HCU5 P0CG48 affinity chromatography technology 24816145 physical association X 2 Q9HCU5 Q9WUQ2 affinity chromatography technology 20360068 physical association X 2 Q9HCU5 P0CG48 affinity chromatography technology 21139048 physical association X 2 Q9HCU5 P0CG48 affinity chromatography technology 21890473 physical association X 2 Q9HCU5 P0CG48 affinity chromatography technology 21906983 physical association X 2 Q9HCU5 A0A024RBI5 biochemical 22939629 colocalization X 2 Q9HCU5 Q9WB91 affinity chromatography technology 22190034 physical association X 2 Q9HCU5 Q9NZC7-5 affinity chromatography technology 24550385 physical association X 2 Q9HCU5 P36897-3 in vivo 15761153 - X 2 Q9HCU5 Q15797 in vivo 15761153 - X 2 Q9HCU5 Q15797 in vivo 15761153 - X 2 Q9HCU5 P36897-3 in vivo 15761153 - X 2 Q9HCU5 anti tag coimmunoprecipitation 22190034 association C 36 Q9HCU5 Q9WUQ2 tandem affinity purification 20360068 physical association X 2 Q9HCU5 Q6PK50 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q9HCU5 Q9Y266 luminescence based mammalian interactome mapping 25036637 physical association X 2 Q9HCU5 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B HSP90AA1 PREB MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255489 bait prey TGFBR1 PREB MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17883 - - PREB WWOX MI:0004(affinity chromatography technology) 24550385 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309136 prey bait SMAD1 PREB MI:0493(in vivo) 15761153 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_17882 - - NRF1 PREB MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295968 bait prey UBC PREB MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983,21963094,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_170916|BIOGRID_180139|BIOGRID_270227|BIOGRID_266271|BIOGRID_175859 bait|bait|bait|bait|bait prey|prey|prey|prey|prey HSP90AB1 PREB MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125069 prey bait PREB CORO1C MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243303 prey bait

PPI - HINT Gene A Gene B PMID Method Quality TMEM67 PREB 26638075,26638075 1314,1313 HT TCTN3 PREB 26638075,26638075 1314,1313 HT EVC2 PREB 26638075,26638075 1314,1313 HT TMEM17 PREB 26638075,26638075 1314,1313 HT TCTN2 PREB 26638075,26638075 1314,1313 HT SCLT1 PREB 26638075,26638075 1314,1313 HT PREB TMEM216 26638075,26638075 1314,1313 HT PREB CORO1C 22939629 0401 HT TMEM67 PREB 26638075,26638075 1314,1313 HT TCTN3 PREB 26638075,26638075 1314,1313 HT EVC2 PREB 26638075,26638075 1314,1313 HT TMEM17 PREB 26638075,26638075 1314,1313 HT TCTN2 PREB 26638075,26638075 1314,1313 HT SCLT1 PREB 26638075,26638075 1314,1313 HT PREB TMEM216 26638075,26638075 1314,1313 HT PREB CORO1C 22939629 0401 HT HSP90AB1 PREB 25036637,22939624 0729,0729 HT TGFBR1 PREB 15761153 0019 HT SMAD1 PREB 15761153 0019 HT PREB CORO1C 22939629 0401 LC PREB NUDC 25036637 0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9HCU5 P08238 PREB HSP90AB1 0.126 22939624 Q9HCU5 Q6PK50 PREB HSP90AB1 0.126 25036637 Q9WUQ2 Q9HCU5 PREB PREB 0.236 20360068 Q9Y266 Q9HCU5 NUDC PREB 0.126 25036637 Q9NZC7 Q9HCU5 WWOX PREB 0.126 24550385 Q9HCU5 P07900 PREB HSP90AA1 0.126 22939624 Q9HCU5 P0C739 PREB P0C739 0.126 22810586 Q9HCU5 P03182 PREB P03182 0.126 22810586 Q9HCU5 P03246 PREB P03246 0.126 22810586 Q9HCU5 P05919 PREB VPU 0.126 22190034 Q9HCU5 P06461 PREB P06461 0.126 22810586 Q9HCU5 P06792 PREB E5 0.126 22810586 Q9P0N5 Q9HCU5 TMEM216 PREB 0.236 26638075 Q9HCU5 Q96NL6 PREB SCLT1 0.236 26638075 Q9HCU5 Q96GX1 PREB TCTN2 0.236 26638075 Q9HCU5 Q5HYA8 PREB TMEM67 0.236 26638075 Q9HCU5 Q6NUS6 PREB TCTN3 0.236 26638075 Q9HCU5 Q86UK5 PREB EVC2 0.236 26638075 Q9HCU5 Q86X19 PREB TMEM17 0.236 26638075 Q9HCU5 P35240 PREB NF2 0.126 26549023 Q9ULV4 Q9HCU5 CORO1C PREB 0.081 22939629 Q9HCU5 P69901 PREB P69901 0.126 22810586 Q9HCU5 Q2MG95 PREB BVLF1 {ECO:0000313|EMBL:CAJ75461.1} 0.126 22810586

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 CTAGE5 PREB MI:0362 inference MI:1106 pathways database HSP90AA1 PREB MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 PREB MI:0045 experimental interaction detection MI:0461 interaction database UBC PREB MI:0045 experimental interaction detection MI:0461 interaction database NF2 PREB MI:0045 experimental interaction detection MI:0461 interaction database TGFBR1 PREB MI:0045 experimental interaction detection MI:0461 interaction database SEC24C PREB MI:0362 inference MI:1106 pathways database COL7A1 PREB MI:0362 inference MI:1106 pathways database SEC23A PREB MI:0362 inference MI:1106 pathways database TRIP13 PREB MI:0362 inference MI:0461 interaction database SMAD1 PREB MI:0045 experimental interaction detection MI:0461 interaction database TMEM67 PREB MI:0045 experimental interaction detection MI:0461 interaction database MIA3 PREB MI:0362 inference MI:1106 pathways database TCTN3 PREB MI:0045 experimental interaction detection MI:0461 interaction database EVC2 PREB MI:0045 experimental interaction detection MI:0461 interaction database TMEM17 PREB MI:0045 experimental interaction detection MI:0461 interaction database TCTN2 PREB MI:0045 experimental interaction detection MI:0461 interaction database SCLT1 PREB MI:0045 experimental interaction detection MI:0461 interaction database SSBP4 PREB MI:0362 inference MI:0461 interaction database PREB WWOX MI:0045 experimental interaction detection MI:0461 interaction database PREB TMEM216 MI:0045 experimental interaction detection MI:0461 interaction database PREB NUDC MI:0045 experimental interaction detection MI:0461 interaction database PREB SAR1B MI:0362 inference MI:1106 pathways database