PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus HERC2 HERC3 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G HERC3 UBQLN2 18535780 innatedb,hprd,biogrid exp GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G KCNA6 HERC3 26186194 biogrid exp P P G GP G P P G P GP P P GP GP P P P GP P P P GP P ARHGAP25 HERC3 26186194 biogrid exp G G G P P GP G P GP G P G GP GP P G HERC3 MOGAT2 26186194 biogrid exp GP P P G P GP GP GP P P G GP P P G P GP GP P P GP P G HERC3 TMTC4 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G TK1 HERC3 21900206 biogrid,mint,intact exp GP GP G G P G G GP G GP P GP GP P G P G G P GP CCL22 HERC3 21988832 biogrid,intact exp G FAM189B HERC3 26186194 biogrid exp G GP G G G GP G GP GP G GP G P GP G GP GP P G P G GP GP P G GP P G UBC HERC3 11163799 biogrid,mint,intact exp GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G HERC3 MOV10 22658674 biogrid exp G G G G G G G G G G G G G G G G G CD33 HERC3 21988832 biogrid,intact exp G G P P P P HERC3 UBQLN1 18535780 innatedb,hprd,biogrid exp GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G HERC3 NXF1 22658674 biogrid exp GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G RHBDL1 HERC3 26186194 biogrid exp P P G P P P P P P P P P P P P P P P P P HERC3 RDH5 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G HERC3 FBXW11 25515538 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G SRPK2 HERC3 26167880 biogrid exp GP GP G G G GP G G GP G GP GP GP G G GP G P G G GP GP G P G NME2 HERC3 18535780 biogrid exp P P P P P P P P P P P P P P P P P P TMEM62 HERC3 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP G G GP GP G P GP G GP P G GP P G HSD17B3 HERC3 26186194 biogrid exp P G G G G G G G GP GP P G P G G P P P G HERC3 HERC6 18535780 innatedb,hprd,biogrid exp G G G GP G G GP G GP G GP G G GP P G P G G G GP G G HERC3 FAM189A2 26186194 biogrid exp GP GP G G G GP G GP GP G GP GP GP G GP GP P G P GP GP GP P GP GP P G HERC3 RCBTB1 26186194 biogrid exp G GP G G G GP G GP GP G GP GP G G GP GP P G GP GP GP P G GP G UBA52 HERC3 11163799 innatedb,hprd exp GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G SHMT2 HERC3 22658674 biogrid exp GP GP G G G GP G G GP G GP GP P GP G GP GP P G P GP GP G P GP GP P G UBE2D1 HERC3 9575161, 16082366 biogrid exp, pred GP G G G G GP G G GP G GP GP P GP G G GP P G P GP G GP GP GP P G UBE2L3 HERC3 9575161, 16082366 biogrid exp, pred GP G G G G GP G GP GP G GP G G G GP GP P G G GP GP P G GP P G UBE2I HERC3 16082366 pred GP GP G G G GP G GP GP G GP G P GP G GP GP P G P GP GP G P GP GP P G HERC3 AKTIP 16082366 pred GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G UBE2E1 HERC3 16082366 pred GP GP G G G GP G G GP G GP G GP G GP GP G P G G GP P G GP P G RAB5A HERC3 21836163 pred GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G UBE2A HERC3 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G HERC3 RAB26 23023127 pred P G G G G G G GP GP G GP G P G G GP G G P GP GP GP P GP P G HERC3 UBE2R2 16082366 pred G G G G G G G G G G G G GP G G G G G G G GP GP G UBE2N HERC3 16082366 pred GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G CDC34 HERC3 16082366 pred GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G HERC3 UFC1 16082366 pred GP GP G G G GP G GP GP G GP G P G G GP GP P G P GP GP GP P G GP P G HERC3 UBE2S 16082366 pred G G G G G G G G GP G G GP G G G G G G G G P G HERC3 16082366 pred RAB3A HERC3 23023127 pred GP G G G GP G G G G G G G GP P G G G G G UBE3A HERC3 25402006 pred GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G HERC3 ADRM1 25402006 pred GP GP G G G GP G G GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G HERC3 UBE2Z 16082366 pred GP GP G G G GP G G GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G UBE2D2 HERC3 16082366 pred GP G G G G GP G G GP G GP GP P GP G G GP P G P GP G GP GP GP P G UBE2L6 HERC3 16082366 pred GP GP G G G GP G G GP G GP GP P GP G GP GP P G P GP GP G P GP GP P G HERC3 BIRC6 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G UBE2C HERC3 16082366 pred GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G HERPUD1 HERC3 25402006 pred GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G UBE2G1 HERC3 16082366 pred GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G PSMD4 HERC3 25402006 pred GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P G GP P G HERC3 UBE2D4 16082366 pred GP G G G G GP G G GP G GP GP P GP G G GP P G P GP G GP GP GP P G HERC3 UBE2U 16082366 pred P P P P P P P P P P P P P P P P P P P P HERC3 UBE2V2 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G HERC3 CHMP2B 21836163 pred G G G G G G G G GP G GP GP P GP G GP G P G G G G P G G G HERC3 UBE2T 16082366 pred G G G GP G GP P P P GP GP P P P G P P P G HERC3 VPS36 21836163 pred G GP G G G GP G GP GP G GP GP P G G GP GP P G P GP GP GP P G GP P G HERC3 ARL6IP1 21836163 pred GP GP G G G GP G GP GP G GP GP P G G GP GP P G P GP GP GP P G GP P G SNX3 HERC3 21836163 pred GP GP G G G GP G GP GP G GP G P GP G GP GP P G P GP GP GP P GP GP P G UBE2B HERC3 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G HERC3 UBE2F 16082366 pred GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G UBE2H HERC3 16082366 pred GP GP G G G GP G GP G G GP GP P GP G GP GP P G P GP GP GP P GP GP P G HERC3 TSG101 16082366 pred GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G HERC3 UBE2E3 16082366 pred GP GP G G G GP G G GP G GP G GP G GP GP G P G G GP P G GP P G UBE2M HERC3 16082366 pred GP GP G G G GP G GP GP G GP G P GP G GP GP P G P G GP GP P GP GP P G STAMBP HERC3 21836163 pred GP GP G G G GP G GP GP G GP GP P GP G GP GP P G P GP GP GP P GP GP P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q15034 two hybrid 21988832 direct interaction X 2 Q15034 Q8IVU3-2 affinity chromatography technology 18535780 physical association X 2 Q15034 P22392-2 two hybrid 18535780 direct interaction X 2 Q15034 A0A024R284 affinity chromatography technology 18535780 physical association X 2 Q15034 P0CG48 affinity chromatography technology 18535780 physical association X 2 Q15034 P0CG48 pull down 11163799 direct interaction X 2 Q15034 P0CG48 affinity chromatography technology 16196087 physical association X 2 Q15034 P0CG48 affinity chromatography technology 21987572 physical association X 2 Q15034 P0CG48 affinity chromatography technology 21139048 physical association X 2 Q15034 P0CG48 affinity chromatography technology 21890473 physical association X 2 Q15034 P0CG48 affinity chromatography technology 21906983 physical association X 2 Q15034 A0A087WW00 pull down 9575161 direct interaction X 2 Q15034 A0A024R1A4 pull down 9575161 direct interaction X 2 Q15034 O00626 two hybrid 21988832 direct interaction X 2 Q15034 Q9UHD9 affinity chromatography technology 18535780 physical association X 2 Q15034 Q9UHD9 two hybrid 18535780 direct interaction X 2 Q15034 Q9UHD9 affinity chromatography technology 18535780 physical association X 2 Q15034 P04183 two hybrid 21900206 direct interaction X 2 Q15034 Q9UHD9 in vivo 18535780 - X 2 Q15034 A0A024R258 in vivo 18535780 - X 2 Q15034 P62987 in vitro 11163799 - X 2 Q15034 P62987 in vivo 11163799 - X 2 Q15034 Q8IVU3 in vivo 18535780 - X 2 Q15034 P62987 in vivo 11163799 - X 2 Q15034 P62987 in vitro 11163799 - X 2 Q15034 Q8IVU3 in vivo 18535780 - X 2 Q15034 Q9UHD9 in vivo 18535780 - X 2 Q15034 A0A024R258 in vivo 18535780 - X 2 Q15034 P0CG48 pull down 11163799 direct interaction X 2 Q15034 P04183 two hybrid 21900206 physical association X 2 Q15034 O00626 two hybrid array 21988832 physical association X 2 Q15034 P20138 two hybrid array 21988832 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B HERC3 UBQLN2 MI:0004(affinity chromatography technology)|MI:0493(in vivo)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18535780 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid)|(biogrid) BIOGRID_117220|HPRD_33188|BIOGRID_117217|BIOGRID_117218 prey|-|bait|bait bait|-|prey|prey HERC3 UBQLN1 MI:0004(affinity chromatography technology)|MI:0493(in vivo) 18535780 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|- (biogrid)|MI:0468(hprd) BIOGRID_117221|HPRD_33190 prey|- bait|- UBE2D1 HERC3 MI:0415(enzymatic study) 9575161 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225961 prey bait CD33 HERC3 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_287148|UniProt_116881 bait|unspecified role prey|unspecified role HERC3 HERC6 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 18535780 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_33186|BIOGRID_117214 -|prey -|bait TK1 HERC3 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_157517|UniProt_178115|BIOGRID_157360 bait|bait|bait prey|prey|prey NME2 HERC3 MI:0004(affinity chromatography technology) 18535780 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_117219 prey bait CCL22 HERC3 MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_117458|BIOGRID_286340 unspecified role|bait unspecified role|prey UBC HERC3 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down)|MI:0415(enzymatic study) 11163799,16196087,18535780,21139048,21890473,21906983,21987572 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|MI:0471(mint)|(biogrid)|(biogrid)|(intact)|MI:0471(mint)|(biogrid) BIOGRID_173708|BIOGRID_117222|BIOGRID_137872|BIOGRID_179823|MINT_56387|BIOGRID_142958|BIOGRID_170590|UniProt_68745|MINT_85403|BIOGRID_162921 bait|bait|bait|bait|prey|bait|bait|prey|prey|bait prey|prey|prey|prey|bait|prey|prey|bait|bait|prey UBE2L3 HERC3 MI:0415(enzymatic study) 9575161 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225962 prey bait HERC3 uniprotkb:(gene name) MI:0493(in vivo) 11163799 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_26372 - -

PPI - HINT Gene A Gene B PMID Method Quality RHBDL1 HERC3 26186194 0004 HT HERC2 HERC3 26186194 0004 HT UBC HERC3 18535780,11163799 0004,0096 LC KCNA6 HERC3 26186194 0004 HT HSD17B3 HERC3 26186194 0004 HT TMEM62 HERC3 26186194 0004 HT HERC3 MOGAT2 26186194 0004 HT HERC3 TMTC4 26186194 0004 HT HERC3 RCBTB1 26186194 0004 HT HERC3 Q8WU02 26186194 0004 HT HERC3 RDH5 26186194 0004 HT HERC3 UBQLN1 18535780,18535780,26476452 0004,0007,0004 LC HERC3 Q9Y6J7 26186194 0004 HT HERC3 HEL-S-308 26186194 0004 HT RHBDL1 HERC3 26186194 0004 HT HERC2 HERC3 26186194 0004 HT KCNA6 HERC3 26186194 0004 HT HSD17B3 HERC3 26186194 0004 HT TMEM62 HERC3 26186194 0004 HT HERC3 MOGAT2 26186194 0004 HT HERC3 TMTC4 26186194 0004 HT HERC3 RCBTB1 26186194 0004 HT HERC3 Q8WU02 26186194 0004 HT HERC3 RDH5 26186194 0004 HT HERC3 Q9Y6J7 26186194 0004 HT HERC3 HEL-S-308 26186194 0004 HT UBC HERC3 18535780,11163799 0004,0096 LC HERC3 UBQLN1 18535780,18535780,26476452 0004,0007,0004 LC CCL22 HERC3 21988832,21988832 0397,0018 HT TK1 HERC3 21900206 0018 HT CD33 HERC3 21988832,21988832 0397,0018 HT NME2 HERC3 18535780 0018 LC SRPK2 HERC3 26167880 0415 LC HERC3 UBQLN2 18535780,18535780,18535780 0004,0007,0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q15034 Q0P6H9 HERC3 TMEM62 0.126 26186194 Q5T4D3 Q15034 TMTC4 HERC3 0.126 26186194 Q9HCE1 Q15034 MOV10 HERC3 0.126 22658674 Q8NDN9 Q15034 RCBTB1 HERC3 0.126 26186194 Q8IVU3 Q15034 HERC6 HERC3 0.21 18535780 Q15034 O75783 HERC3 RHBDL1 0.126 26186194 Q15034 O95714 HERC3 HERC2 0.126 26186194 Q15034 P04183 HERC3 TK1 0.332 21900206 Q15034 O00626 HERC3 CCL22 0.286 21988832 Q15034 P37058 HERC3 HSD17B3 0.126 26186194 Q92781 Q15034 RDH5 HERC3 0.126 26186194 Q9UBU9 Q15034 NXF1 HERC3 0.126 22658674 Q9UHD9 Q15034 UBQLN2 HERC3 0.569 18535780 Q9UKB1 Q15034 FBXW11 HERC3 0.126 25515538 Q15034 P34897 HERC3 SHMT2 0.126 22658674 Q15034 P17658 HERC3 KCNA6 0.126 26186194 Q15034 P78362 HERC3 SRPK2 0.183 26167880 Q15034 P81408 HERC3 FAM189B 0.126 26186194 Q15034 P0CG48 HERC3 UBC 0.523 11163799 Q15034 P20138 HERC3 CD33 0.286 21988832 Q15034 P22392 HERC3 NME2 0.309 18535780 Q15034 P25789 HERC3 PSMA4 0.21 26476452 Q15034 P35998 HERC3 PSMC2 0.21 26476452 Q15034 P43686 HERC3 PSMC4 0.21 26476452 Q15034 P55036 HERC3 PSMD4 0.376 26476452 Q15034 P62195 HERC3 PSMC5 0.21 26476452 Q15034 Q04206 HERC3 RELA 0.376 26476452 Q15034 Q13200 HERC3 PSMD2 0.21 26476452 Q9UMX0 Q15034 UBQLN1 HERC3 0.507 18535780,26476452 Q15034 P42331 HERC3 ARHGAP25 0.126 26186194 Q15884 Q15034 FAM189A2 HERC3 0.126 26186194 Q3SYC2 Q15034 MOGAT2 HERC3 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 CCL22 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database RHBDL1 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database HERC2 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database TK1 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database UBC HERC3 MI:0045 experimental interaction detection MI:0461 interaction database KCNA6 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database CD33 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database TAF1 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database NME2 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database PSMA4 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database SHMT2 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database PSMC2 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database HSD17B3 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database ARHGAP25 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database PSMC4 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database PSMD4 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database MAX HERC3 MI:0045 experimental interaction detection MI:0461 interaction database PSMC5 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database UBE2L3 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database SRPK2 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database FAM189B HERC3 MI:0045 experimental interaction detection MI:0461 interaction database RELA HERC3 MI:0045 experimental interaction detection MI:0461 interaction database TMEM62 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database PSMD2 HERC3 MI:0045 experimental interaction detection MI:0461 interaction database HERC3 FAM189A2 MI:0045 experimental interaction detection MI:0461 interaction database HERC3 MOGAT2 MI:0045 experimental interaction detection MI:0461 interaction database HERC3 TMTC4 MI:0045 experimental interaction detection MI:0461 interaction database HERC3 HERC6 MI:0045 experimental interaction detection MI:0461 interaction database HERC3 RCBTB1 MI:0045 experimental interaction detection MI:0461 interaction database HERC3 RDH5 MI:0045 experimental interaction detection MI:0461 interaction database HERC3 MOV10 MI:0045 experimental interaction detection MI:0461 interaction database HERC3 NXF1 MI:0045 experimental interaction detection MI:0461 interaction database HERC3 UBQLN2 MI:0045 experimental interaction detection MI:0461 interaction database HERC3 FBXW11 MI:0045 experimental interaction detection MI:0461 interaction database HERC3 UBQLN1 MI:0045 experimental interaction detection MI:0461 interaction database