PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus NME2 HERC6 18535780 biogrid exp P P P P P P P P P FUS HERC6 25192599 biogrid exp G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G HSP90AB1 HERC6 22939624 intact exp G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G HSP90AA1 HERC6 22939624 biogrid exp G G G GP G G GP G G G G G G G GP G G G GP G G G G G G G G HERC3 HERC6 18535780 innatedb,hprd,biogrid exp G G G GP G G GP G GP G GP G G GP P G P G G G GP G G HERC4 HERC6 18535780 hprd,biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G HERC6 UBQLN2 18535780 biogrid exp G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G HERC6 AGO2 ortho G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G UBE2N HERC6 16082366 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G IFIT5 HERC6 25402006 pred G G G GP G G G G G G G G G G GP G G G G G G G G G G G UBE2M HERC6 16082366 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G IFIT3 HERC6 25402006 pred G G G P GP G G GP G GP G G GP G G GP G G G GP G G G G G G G G HERC6 UBE2T 16082366 pred G GP G GP P P G GP P GP G G G G UBE2D2 HERC6 16082366 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G OAS2 HERC6 25402006 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G UBE2S HERC6 16082366 pred G G G G G G GP G G G GP G G G G G G G G G G G G G MX1 HERC6 25402006 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G HERC6 RSAD2 25402006 pred G G G P GP G G GP G GP G G G G GP G GP G GP G G G G GP G G PSMB8 HERC6 25402006 pred G G P P G G GP GP G G GP G G P G GP GP G G G GP G G HERC6 BIRC6 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G HERC6 HERC5 25402006 pred G G G GP G G GP G GP G G G G G GP G G G GP G G G G G G G G STAT1 HERC6 25402006 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G UBE2E1 HERC6 16082366 pred G G G GP G G GP G GP G G GP G G GP G G G GP G G G G G G G G PLSCR1 HERC6 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G HERC6 UBE2Z 16082366 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G UBE2L6 HERC6 25402006, 16082366 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G UBE2L3 HERC6 16082366 pred G G G GP G G GP G GP G G G G G GP G GP G G G G G G G G G G DDX58 HERC6 25402006 pred G G G P GP G G GP G GP G G GP G G GP G P G GP G G G G GP G G G HERC6 OAS3 25402006 pred G G G G G G GP G GP G G GP G G G G GP G GP G G G G G G G G SP100 HERC6 25402006 pred G G P P G G GP GP G G GP G G P G P G GP G G G G GP G G IFI35 HERC6 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G IFIT1 HERC6 25402006 pred G G G GP G G GP G GP G G GP G G GP G P G G G G G G G G G UBE2A HERC6 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G IFI27 HERC6 25402006 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G IFI44L HERC6 25402006 pred G G G P GP G G GP G GP G G G G G GP G P G P G G G G GP G G HERC6 UBE2E3 16082366 pred G G G GP G G GP G GP G G GP G G GP G G G GP G G G G G G G G OAS1 HERC6 25402006 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G MX2 HERC6 25402006 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G UBE2B HERC6 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G HERC6 UBE2F 16082366 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G HERC6 UBE2D4 16082366 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G UBE2U HERC6 16082366 pred P P P P P P P P G HERC6 UFC1 16082366 pred G G G GP G G GP G GP G G G G G GP G GP G GP G G G G G G G G HERC6 TSG101 16082366 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G UBE2C HERC6 16082366 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G UBE2R2 HERC6 16082366 pred G G G P G G G G G G G G GP G G G G G G G G G G G GP G G G UBE2G1 HERC6 16082366 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G HERC6 AKTIP 16082366 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G IFI6 HERC6 25402006 pred G G G GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G CDC34 HERC6 16082366 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G ISG15 HERC6 25402006 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G HERC6 DDX60 25402006 pred G G P P G G GP GP G G GP G G GP G P G GP G G G G GP G G UBE2H HERC6 16082366 pred G G G P GP G G G G GP G G GP G G GP G GP G GP G G G G GP G G G UBE2I HERC6 16082366 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G UBE2D1 HERC6 16082366 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G UBE2V2 HERC6 16082366 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G HERC6 16082366 pred HERC6 SP110 25402006 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G HERC6 PARP12 25402006 pred G G G P GP G G GP G GP G G GP G G GP G GP G GP G G G G GP G G G XAF1 HERC6 25402006 pred G G G P GP G G GP G GP G G G G G GP G P G GP G G G G G G G G HERC6 IFI44 25402006 pred G G G P GP G G GP G GP G G G G G GP G GP G GP G G G G GP G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8IVU3 A0A024QZN8 in vivo 18535780 - X 2 Q8IVU3 A0A024QZN8 in vivo 18535780 - X 2 Q15034 Q8IVU3 in vivo 18535780 - X 2 Q15034 Q8IVU3 in vivo 18535780 - X 2 Q8IVU3 A0A024RD80 luminescence based mammalian interactome mapping 22939624 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B HSP90AA1 HERC6 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255445 bait prey HERC6 UBQLN2 MI:0004(affinity chromatography technology) 18535780 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_117216 bait prey UBC HERC6 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17370265,21890473,21906983 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_161322|BIOGRID_176790|BIOGRID_263714 bait|bait|bait prey|prey|prey HERC4 HERC6 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 18535780 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_33187|BIOGRID_117215 -|prey -|bait HERC3 HERC6 MI:0493(in vivo)|MI:0004(affinity chromatography technology) 18535780 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(biogrid) HPRD_33186|BIOGRID_117214 -|prey -|bait HSP90AB1 HERC6 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_125015 prey bait NME2 HERC6 MI:0004(affinity chromatography technology) 18535780 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_117225 prey bait

PPI - HINT Gene A Gene B PMID Method Quality HSP90AB1 HERC6 22939624 0729 HT NME2 HERC6 18535780 0018 LC HERC6 HERC6 26949039 0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9UHD9 Q8IVU3 UBQLN2 HERC6 0.21 18535780 Q8IVU3 Q8IVU3 HERC6 HERC6 0.332 26949039 Q8IVU3 Q5GLZ8 HERC6 HERC4 0.21 18535780 Q8IVU3 P08238 HERC6 HSP90AB1 0.126 22939624 Q8IVU3 Q15034 HERC6 HERC3 0.21 18535780 Q8IVU3 P22392 HERC6 NME2 0.309 18535780 Q8IVU3 P68036 HERC6 UBE2L3 0.309 26949039 Q8IVU3 P07900 HERC6 HSP90AA1 0.126 22939624 Q8IVU3 P35637 HERC6 FUS 0.126 25192599

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SIAH2 HERC6 MI:0362 inference MI:1106 pathways database FBXO21 HERC6 MI:0362 inference MI:1106 pathways database HSP90AA1 HERC6 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 HERC6 MI:0045 experimental interaction detection MI:0461 interaction database UBB HERC6 MI:0362 inference MI:1106 pathways database UBC HERC6 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database TRIM21 HERC6 MI:0362 inference MI:1106 pathways database NME2 HERC6 MI:0045 experimental interaction detection MI:0461 interaction database FUS HERC6 MI:0045 experimental interaction detection MI:0461 interaction database CCNF HERC6 MI:0362 inference MI:1106 pathways database UBE2A HERC6 MI:0362 inference MI:1106 pathways database FBXW4 HERC6 MI:0362 inference MI:1106 pathways database RBX1 HERC6 MI:0362 inference MI:1106 pathways database RPS27A HERC6 MI:0362 inference MI:1106 pathways database UBA52 HERC6 MI:0362 inference MI:1106 pathways database SKP1 HERC6 MI:0362 inference MI:1106 pathways database UBE2L3 HERC6 MI:0045 experimental interaction detection MI:0461 interaction database SKP2 HERC6 MI:0362 inference MI:1106 pathways database CUL1 HERC6 MI:0362 inference MI:1106 pathways database TRIP12 HERC6 MI:0362 inference MI:1106 pathways database HERC3 HERC6 MI:0045 experimental interaction detection MI:0461 interaction database LONRF1 HERC6 MI:0362 inference MI:1106 pathways database HERC4 HERC6 MI:0045 experimental interaction detection MI:0461 interaction database HECTD2 HERC6 MI:0362 inference MI:1106 pathways database FBXO31 HERC6 MI:0362 inference MI:1106 pathways database FBXW9 HERC6 MI:0362 inference MI:1106 pathways database FBXW10 HERC6 MI:0362 inference MI:1106 pathways database RNF213 HERC6 MI:0362 inference MI:1106 pathways database FBXL22 HERC6 MI:0362 inference MI:1106 pathways database FBXL19 HERC6 MI:0362 inference MI:1106 pathways database FBXW12 HERC6 MI:0362 inference MI:1106 pathways database RNF19B HERC6 MI:0362 inference MI:1106 pathways database RNF144B HERC6 MI:0362 inference MI:1106 pathways database RBBP6 HERC6 MI:0362 inference MI:1106 pathways database HUWE1 HERC6 MI:0362 inference MI:1106 pathways database TRIM69 HERC6 MI:0362 inference MI:1106 pathways database SIAH1 HERC6 MI:0362 inference MI:1106 pathways database HERC6 UBR2 MI:0362 inference MI:1106 pathways database HERC6 FBXL14 MI:0362 inference MI:1106 pathways database HERC6 FBXW8 MI:0362 inference MI:1106 pathways database HERC6 FBXL16 MI:0362 inference MI:1106 pathways database HERC6 FBXO15 MI:0362 inference MI:1106 pathways database HERC6 ZNRF1 MI:0362 inference MI:1106 pathways database HERC6 FBXL13 MI:0362 inference MI:1106 pathways database HERC6 FBXO22 MI:0362 inference MI:1106 pathways database HERC6 ZNRF2 MI:0362 inference MI:1106 pathways database HERC6 FBXO27 MI:0362 inference MI:1106 pathways database HERC6 FBXO30 MI:0362 inference MI:1106 pathways database HERC6 RNF217 MI:0362 inference MI:1106 pathways database HERC6 DTX3L MI:0362 inference MI:1106 pathways database HERC6 FBXO41 MI:0362 inference MI:1106 pathways database HERC6 LMO7 MI:0362 inference MI:1106 pathways database HERC6 MYLIP MI:0362 inference MI:1106 pathways database HERC6 FBXW7 MI:0362 inference MI:1106 pathways database HERC6 FBXO32 MI:0362 inference MI:1106 pathways database HERC6 FBXW5 MI:0362 inference MI:1106 pathways database HERC6 MIB2 MI:0362 inference MI:1106 pathways database HERC6 SPSB1 MI:0362 inference MI:1106 pathways database HERC6 FBXL8 MI:0362 inference MI:1106 pathways database HERC6 FBXO17 MI:0362 inference MI:1106 pathways database HERC6 FBXL20 MI:0362 inference MI:1106 pathways database HERC6 FBXL18 MI:0362 inference MI:1106 pathways database HERC6 NEDD4L MI:0362 inference MI:1106 pathways database HERC6 RBCK1 MI:0362 inference MI:1106 pathways database HERC6 FBXL15 MI:0362 inference MI:1106 pathways database HERC6 FBXO44 MI:0362 inference MI:1106 pathways database HERC6 AGO3 MI:0362 inference MI:0461 interaction database HERC6 UNKL MI:0362 inference MI:1106 pathways database HERC6 SMURF2 MI:0362 inference MI:1106 pathways database HERC6 AGO4 MI:0362 inference MI:0461 interaction database HERC6 TRIM36 MI:0362 inference MI:1106 pathways database HERC6 FBXO6 MI:0362 inference MI:1106 pathways database HERC6 RNF19A MI:0362 inference MI:1106 pathways database HERC6 RLIM MI:0362 inference MI:1106 pathways database HERC6 FBXL12 MI:0362 inference MI:1106 pathways database HERC6 FBXO40 MI:0362 inference MI:1106 pathways database HERC6 UBQLN2 MI:0045 experimental interaction detection MI:0461 interaction database HERC6 HERC5 MI:0362 inference MI:1106 pathways database HERC6 FBXL7 MI:0362 inference MI:1106 pathways database HERC6 FBXO2 MI:0362 inference MI:1106 pathways database HERC6 FBXO10 MI:0362 inference MI:1106 pathways database HERC6 FBXO9 MI:0362 inference MI:1106 pathways database HERC6 FBXL5 MI:0362 inference MI:1106 pathways database HERC6 FBXL4 MI:0362 inference MI:1106 pathways database HERC6 FBXW11 MI:0362 inference MI:1106 pathways database HERC6 FBXO4 MI:0362 inference MI:1106 pathways database HERC6 FBXL21 MI:0362 inference MI:1106 pathways database HERC6 FBXL3 MI:0362 inference MI:1106 pathways database HERC6 FBXW2 MI:0362 inference MI:1106 pathways database HERC6 AGO2 MI:0362 inference MI:0461 interaction database HERC6 BTRC MI:0362 inference MI:1106 pathways database HERC6 FBXO7 MI:0362 inference MI:1106 pathways database HERC6 RNF115 MI:0362 inference MI:1106 pathways database HERC6 RNF114 MI:0362 inference MI:1106 pathways database HERC6 WSB1 MI:0362 inference MI:1106 pathways database