PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus DCAF5 PFDN5 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G MRPS11 DCAF5 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G RWDD2B DCAF5 26186194 biogrid exp G GP G P GP G GP GP G GP G GP G G G GP G G G GP G GP G G GP GP GP G CCT3 DCAF5 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CCDC84 DCAF5 26186194 biogrid exp G GP G G G G G G GP G GP G G G G GP G GP GP G GP GP G G GP G GP GP G DYRK2 DCAF5 19287380 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP GP G TSGA10IP DCAF5 26186194 biogrid exp G UBC DCAF5 16196087 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G DCAF5 PIP5K1A 26186194 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G G GP GP GP G GP GP G G G GP GP GP G CCT6A DCAF5 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G VBP1 DCAF5 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G GRK5 DCAF5 22952844 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G DCAF5 CCT7 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G PFDN6 DCAF5 26186194 biogrid exp GP GP G G G GP G GP GP G GP G G GP G GP GP GP GP G GP GP GP G GP GP GP GP G TCP1 DCAF5 26186194 biogrid exp P P P P P P P P P P P P P P P P P P P P P LHX4 DCAF5 26186194 biogrid exp G G G G G G G G G G G G DCAF5 PFDN4 26186194 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP G G GP GP GP GP G DCAF5 PDRG1 26186194 biogrid exp G GP G G G GP G GP GP G GP G GP G G GP GP GP GP G GP G G G GP G GP GP G SFRP4 DCAF5 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G GP G HSPD1 DCAF5 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CCT2 DCAF5 26186194 biogrid exp GP GP G G GP GP G GP GP G G GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G CCT6B DCAF5 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CUL4A DCAF5 16949367,21145461,16964240, 25402006 innatedb,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DCAF5 DDA1 19295130,20562859, 25402006 biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP G GP GP GP P G GP GP GP G GP GP GP GP G DDB1 DCAF5 19966799,16949367,16964240, 25402006 biogrid,dip exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G DCAF11 DCAF5 25402006, 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G COPS6 DCAF5 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G TRPC4AP DCAF5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP GP GP GP G TSC1 DCAF5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G WDR17 DCAF5 23023127 pred G GP G P P G P GP P G DCAF5 PRPF19 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CDKN1A DCAF5 25402006 pred GP GP G G GP G G G GP G G G GP G G GP G G G G GP G G G GP G G GP G NEDD8 DCAF5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G DET1 DCAF5 25402006 pred G G G G GP GP G G G G G GP GP GP G GP GP G GP G GP G G G GP G GP G G UBXN1 DCAF5 25402006 pred GP GP G G G GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G G GP GP GP GP G TLE2 DCAF5 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G G GP G GP GP G DDB2 DCAF5 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP G GP GP G GP GP G WDTC1 DCAF5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DCAF17 DCAF5 25402006 pred G GP G G G GP G GP G G P G G G GP GP DCAF12L2 DCAF5 23023127 pred P P P P P G P P P P P P P P P GP G DCAF12 DCAF5 25402006 pred G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP G GP GP GP G G DCAF5 DTL 25402006 pred P P G GP P G P P P G P GP P P P G G G GP BCR DCAF5 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DCAF5 BTRC 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DCAF5 DCAF16 25402006 pred G G G G G GP G G GP G G G G G G G GP G G G G GP GP G G G GP GP G WDR48 DCAF5 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G DCAF5 DMXL1 23023127 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G DCAF5 AMBRA1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G P G GP GP GP G GP G GP GP G DCAF7 DCAF5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CAND1 DCAF5 25402006 pred G GP G G G G G G GP G GP GP G G G GP G GP G G G G GP G GP G G GP G DCAF4 DCAF5 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DCAF5 DDIT4 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RBX1 DCAF5 25402006 pred G G G G G GP G GP G G G G GP G G G GP G GP G GP GP G G G G G GP G NF2 DCAF5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G DCAF5 FBXW11 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL4B DCAF5 25402006 pred GP GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP G GP GP GP GP G PHIP DCAF5 25402006 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G DCAF8 DCAF5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G DCAF5 COPS3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G DCAF10 DCAF5 25402006 pred G G G G G GP G GP G G G G GP G G G GP G G G G G G G G G GP G G ERCC8 DCAF5 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DCAF5 DCAF13 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP G GP GP GP GP G DCAF5 VPRBP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G RFWD2 DCAF5 25402006 pred G G G G G GP G G GP G G G G G G G GP G G G GP G G G G G GP G G COPS5 DCAF5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G DCAF5 COPS7B 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G DCAF6 DCAF5 25402006, 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DCAF5 CDT1 25402006 pred P P G GP P GP GP P P P P GP P GP GP G P P P GP P GP P G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96JK2 B2RBV7 affinity chromatography technology 21145461 physical association X 2 Q96JK2 P34947 affinity chromatography technology 22952844 physical association X 2 Q96JK2 Q9BW61 affinity chromatography technology 19295130 physical association X 2 Q96JK2 P0CG48 affinity chromatography technology 23000965 physical association X 2 Q96JK2 B2RBV7 affinity chromatography technology 16949367 physical association X 2 Q96JK2 B2RBV7 affinity chromatography technology 16964240 physical association X 2 Q96JK2 Q9BW61 affinity chromatography technology 20562859 physical association X 2 Q96JK2 P0CG48 affinity chromatography technology 16196087 physical association X 2 Q96JK2 P0CG48 affinity chromatography technology 21987572 physical association X 2 Q96JK2 P0CG48 affinity chromatography technology 21963094 physical association X 2 Q96JK2 P0CG48 affinity chromatography technology 21139048 physical association X 2 Q96JK2 P0CG48 affinity chromatography technology 21906983 physical association X 2 Q96JK2 Q16531 affinity chromatography technology 16949367 physical association X 2 Q96JK2 Q16531 affinity chromatography technology 16964240 physical association X 2 Q96JK2 Q16531 affinity chromatography technology 16949367 physical association X 2 Q96JK2 x-ray crystallography 19966799 direct interaction X 2 Q96JK2 anti tag coimmunoprecipitation 20562859 physical association C 42

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B DCAF5 DDA1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19295130,20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_221649|BIOGRID_125185 prey|prey bait|bait DDB1 DCAF5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography) 16949367,16964240,19966799 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid)|MI:0465(dip) BIOGRID_122496|BIOGRID_122880|BIOGRID_122847|DIP_55181 bait|prey|bait|- prey|bait|prey|- GRK5 DCAF5 MI:0004(affinity chromatography technology) 22952844 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_218399 bait prey UBC DCAF5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 16196087,21139048,21906983,21963094,21987572,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_166258|BIOGRID_268079|BIOGRID_143208|BIOGRID_171036|BIOGRID_163214|BIOGRID_180238 bait|bait|bait|bait|bait|bait prey|prey|prey|prey|prey|prey CUL4B DCAF5 MI:0004(affinity chromatography technology) 16949367 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_122912 prey bait CUL4A DCAF5 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16949367,16964240,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_202964|BIOGRID_122523|BIOGRID_122897 bait|bait|prey prey|prey|bait

PPI - HINT Gene A Gene B PMID Method Quality PFDN6 DCAF5 26186194 0004 HT HSPD1 DCAF5 26186194 0004 HT TCP1 DCAF5 26186194 0004 HT CCT6A DCAF5 26186194 0004 HT RWDD2B DCAF5 26186194 0004 HT VBP1 DCAF5 26186194 0004 HT MRPS11 DCAF5 26186194 0004 HT CUL4A DCAF5 16949367,16964240,21145461,16949367 0004,0004,0004,0096 LC,HT DDB1 DCAF5 16949367,16964240,16949367 0004,0004,0096 LC TSGA10IP DCAF5 26186194 0004 HT Q59H77 DCAF5 26186194 0004 HT SFRP4 DCAF5 26186194 0004 HT CCDC84 DCAF5 26186194 0004 HT CCT6B DCAF5 26186194 0004 HT LHX4 DCAF5 26186194 0004 HT DCAF5 PFDN5 26186194 0004 HT DCAF5 PIP5K1A 26186194 0004 HT DCAF5 CCT7 26186194 0004 HT DCAF5 DDA1 20562859,20562859,19295130 0007,0004,0004 HT,LC DCAF5 PFDN4 26186194 0004 HT DCAF5 PDRG1 26186194 0004 HT DCAF5 HEL-S-100N 26186194 0004 HT PFDN6 DCAF5 26186194 0004 HT HSPD1 DCAF5 26186194 0004 HT TCP1 DCAF5 26186194 0004 HT CCT6A DCAF5 26186194 0004 HT RWDD2B DCAF5 26186194 0004 HT VBP1 DCAF5 26186194 0004 HT MRPS11 DCAF5 26186194 0004 HT CUL4A DCAF5 21145461 0004 HT TSGA10IP DCAF5 26186194 0004 HT Q59H77 DCAF5 26186194 0004 HT SFRP4 DCAF5 26186194 0004 HT CCDC84 DCAF5 26186194 0004 HT CCT6B DCAF5 26186194 0004 HT LHX4 DCAF5 26186194 0004 HT DCAF5 PFDN5 26186194 0004 HT DCAF5 PIP5K1A 26186194 0004 HT DCAF5 CCT7 26186194 0004 HT DCAF5 DDA1 20562859,20562859 0007,0004 HT DCAF5 PFDN4 26186194 0004 HT DCAF5 PDRG1 26186194 0004 HT DCAF5 HEL-S-100N 26186194 0004 HT CUL4A DCAF5 16949367,16964240,16949367 0004,0004,0096 LC DDB1 DCAF5 16949367,16964240,16949367 0004,0004,0096 LC DCAF5 DDA1 19295130 0004 LC DDB1 DCAF5 19966799 0114 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q96JK2 P57060 DCAF5 RWDD2B 0.126 26186194 Q96JK2 P0CG48 DCAF5 UBC 0.126 16196087 Q96JK2 Q6FHJ7 DCAF5 SFRP4 0.126 26186194 Q96JK2 Q86UT8 DCAF5 CCDC84 0.126 26186194 Q96JK2 Q16531 DCAF5 DDB1 0.539 16964240,19966799,16949367 Q9BW61 Q96JK2 DDA1 DCAF5 0.332 20562859,19295130 Q96JK2 Q969G2 DCAF5 LHX4 0.126 26186194 Q96JK2 Q92630 DCAF5 DYRK2 0.21 19287380 Q96JK2 O15212 DCAF5 PFDN6 0.126 26186194 Q96JK2 P10809 DCAF5 HSPD1 0.126 26186194 Q96JK2 P17987 DCAF5 TCP1 0.126 26186194 Q96JK2 P40227 DCAF5 CCT6A 0.126 26186194 Q96JK2 P49368 DCAF5 CCT3 0.126 26186194 Q96JK2 P61758 DCAF5 VBP1 0.126 26186194 Q96JK2 P78371 DCAF5 CCT2 0.126 26186194 Q96JK2 Q13619 DCAF5 CUL4A 0.332 16964240,21145461,16949367 Q96JK2 Q92526 DCAF5 CCT6B 0.126 26186194 Q99471 Q96JK2 PFDN5 DCAF5 0.126 26186194 Q99832 Q96JK2 CCT7 DCAF5 0.126 26186194 Q9NQP4 Q96JK2 PFDN4 DCAF5 0.126 26186194 Q9NUG6 Q96JK2 PDRG1 DCAF5 0.126 26186194 Q99755 Q96JK2 PIP5K1A DCAF5 0.126 26186194 Q96JK2 P34947 DCAF5 GRK5 0.126 22952844 Q96JK2 P82912 DCAF5 MRPS11 0.126 26186194 Q96JK2 Q3SY00 DCAF5 TSGA10IP 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 PFDN6 DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database UBC DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database HSPD1 DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database TCP1 DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database GRK5 DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database CCT6A DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database CCT3 DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database RWDD2B DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database VBP1 DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database CCT2 DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database MRPS11 DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database CUL4A DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database DDB1 DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database TSGA10IP DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database SFRP4 DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database CCDC84 DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database CCT6B DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database DYRK2 DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database LHX4 DCAF5 MI:0045 experimental interaction detection MI:0461 interaction database DCAF5 PFDN5 MI:0045 experimental interaction detection MI:0461 interaction database DCAF5 PIP5K1A MI:0045 experimental interaction detection MI:0461 interaction database DCAF5 CCT7 MI:0045 experimental interaction detection MI:0461 interaction database DCAF5 DDA1 MI:0045 experimental interaction detection MI:0461 interaction database DCAF5 PFDN4 MI:0045 experimental interaction detection MI:0461 interaction database DCAF5 PDRG1 MI:0045 experimental interaction detection MI:0461 interaction database