Mutation - TCGA Type Chromosome Start Position End Position Strand Variant Classification Variant Type Reference Allele Tumor_seq Allele 1 Tumor_seq Allele 2 Tumor Sample Barcode Matched Norm Sample Barcode Genome Change cDNA Change Codon Change Protein Change COAD 14 64066365 64066365 + Missense_Mutation SNP G G A TCGA-G4-6628-01A-11D-1835-10 TCGA-G4-6628-10A-01D-1835-10 g.chr14:64066365G>A c.296C>T c.(295-297)gCt>gTt p.A99V COADREAD 14 64065578 64065578 + Missense_Mutation SNP C C A TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr14:64065578C>A c.1083G>T c.(1081-1083)gaG>gaT p.E361D COADREAD 14 64066022 64066022 + Silent SNP A A G TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr14:64066022A>G c.639T>C c.(637-639)tgT>tgC p.C213C COADREAD 14 64066365 64066365 + Missense_Mutation SNP G G A TCGA-G4-6628-01A-11D-1835-10 TCGA-G4-6628-10A-01D-1835-10 g.chr14:64066365G>A c.296C>T c.(295-297)gCt>gTt p.A99V COADREAD 14 64066562 64066562 + Missense_Mutation SNP C C A TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr14:64066562C>A c.99G>T c.(97-99)aaG>aaT p.K33N ESCA 14 64066414 64066414 + Missense_Mutation SNP C C T TCGA-LN-A4A8-01A-32D-A27G-09 TCGA-LN-A4A8-10A-01D-A27G-09 g.chr14:64066414C>T c.247G>A c.(247-249)Gac>Aac p.D83N HNSC 14 64066011 64066011 + Missense_Mutation SNP G G A TCGA-BA-4075-01A-01D-1434-08 TCGA-BA-4075-10A-01D-1434-08 g.chr14:64066011G>A c.650C>T c.(649-651)tCa>tTa p.S217L KIPAN 14 64066630 64066630 + Silent SNP G G A TCGA-CJ-4897-01A-03D-1429-08 TCGA-CJ-4897-11A-01D-1429-08 g.chr14:64066630G>A c.31C>T c.(31-33)Ctg>Ttg p.L11L KIRC 14 64066630 64066630 + Silent SNP G G A TCGA-CJ-4897-01A-03D-1429-08 TCGA-CJ-4897-11A-01D-1429-08 g.chr14:64066630G>A c.31C>T c.(31-33)Ctg>Ttg p.L11L LIHC 14 64065604 64065604 + Missense_Mutation SNP T T C TCGA-DD-AACP-01A-11D-A40R-10 TCGA-DD-AACP-10A-01D-A40U-10 g.chr14:64065604T>C c.1057A>G c.(1057-1059)Ata>Gta p.I353V LIHC 14 64066253 64066253 + Frame_Shift_Del DEL T T - TCGA-DD-A1EG-01A-11D-A20W-10 TCGA-DD-A1EG-10A-01D-A20W-10 g.chr14:64066253delT c.408delA c.(406-408)aaafs p.K136fs LUAD 14 64065999 64065999 + Missense_Mutation SNP C C A TCGA-55-7995-01A-11D-2184-08 TCGA-55-7995-10A-01D-2184-08 g.chr14:64065999C>A c.662G>T c.(661-663)tGt>tTt p.C221F LUAD 14 64066078 64066078 + Missense_Mutation SNP C C A TCGA-78-8662-01A-11D-2393-08 TCGA-78-8662-10A-01D-2393-08 g.chr14:64066078C>A c.583G>T c.(583-585)Gta>Tta p.V195L LUAD 14 64066267 64066267 + Missense_Mutation SNP C C A TCGA-05-4424-01A-22D-1855-08 TCGA-05-4424-10A-01D-1855-08 g.chr14:64066267C>A c.394G>T c.(394-396)Gct>Tct p.A132S LUAD 14 64066555 64066555 + Nonsense_Mutation SNP G G A TCGA-05-4384-01A-01D-1753-08 TCGA-05-4384-10A-01D-1753-08 g.chr14:64066555G>A c.106C>T c.(106-108)Caa>Taa p.Q36* OV 14 64065625 64065625 + Silent SNP A A G TCGA-30-1855-01A-01W-0639-09 TCGA-30-1855-10A-01W-0639-09 g.chr14:64065625A>G c.1036T>C c.(1036-1038)Tta>Cta p.L346L PAAD 14 64066119 64066119 + Missense_Mutation SNP C C T TCGA-IB-7651-01A-11D-2154-08 TCGA-IB-7651-10A-01D-2154-08 g.chr14:64066119C>T c.542G>A c.(541-543)aGc>aAc p.S181N PAAD 14 64066609 64066609 + Missense_Mutation SNP A A T TCGA-3A-A9J0-01A-11D-A40W-08 TCGA-3A-A9J0-10A-01D-A40W-08 g.chr14:64066609A>T c.52T>A c.(52-54)Tta>Ata p.L18I READ 14 64065578 64065578 + Missense_Mutation SNP C C A TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr14:64065578C>A c.1083G>T c.(1081-1083)gaG>gaT p.E361D READ 14 64066022 64066022 + Silent SNP A A G TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr14:64066022A>G c.639T>C c.(637-639)tgT>tgC p.C213C READ 14 64066562 64066562 + Missense_Mutation SNP C C A TCGA-AG-A002-01A-01W-A00K-09 TCGA-AG-A002-10A-01W-A00K-09 g.chr14:64066562C>A c.99G>T c.(97-99)aaG>aaT p.K33N SKCM 14 64065642 64065642 + Missense_Mutation SNP C C T TCGA-EE-A2GC-06A-11D-A197-08 TCGA-EE-A2GC-10A-01D-A199-08 g.chr14:64065642C>T c.1019G>A c.(1018-1020)gGa>gAa p.G340E SKCM 14 64066610 64066610 + Silent SNP G G A TCGA-FW-A3R5-06A-11D-A23B-08 TCGA-FW-A3R5-10A-01D-A23B-08 g.chr14:64066610G>A c.51C>T c.(49-51)tcC>tcT p.S17S SKCM 14 64066611 64066611 + Missense_Mutation SNP G G A TCGA-FW-A3R5-06A-11D-A23B-08 TCGA-FW-A3R5-10A-01D-A23B-08 g.chr14:64066611G>A c.50C>T c.(49-51)tCc>tTc p.S17F SKCM 14 64066643 64066643 + Missense_Mutation SNP T T A TCGA-EE-A3JD-06A-11D-A20D-08 TCGA-EE-A3JD-10A-01D-A20D-08 g.chr14:64066643T>A c.18A>T c.(16-18)gaA>gaT p.E6D

Mutation - ICGC Project Code Chromosome Chromosome Start Chromosome End Mutation Type Mutated from Allele Mutated to Allele Consequence Type AA Mutation CDS Mutation BRCA-EU 14 64059746 64059746 single base substitution C T downstream_gene_variant BRCA-EU 14 64060143 64060143 deletion of <=200bp T - downstream_gene_variant BRCA-EU 14 64061550 64061550 single base substitution G A downstream_gene_variant BRCA-EU 14 64061698 64061698 single base substitution G A downstream_gene_variant BRCA-EU 14 64062852 64062852 single base substitution C T downstream_gene_variant BRCA-EU 14 64063577 64063577 single base substitution C T downstream_gene_variant BRCA-EU 14 64065222 64065222 single base substitution G C 3_prime_UTR_variant BRCA-EU 14 64065222 64065222 single base substitution G C downstream_gene_variant BRCA-EU 14 64065559 64065559 single base substitution A C downstream_gene_variant BRCA-EU 14 64065559 64065559 single base substitution A C missense_variant S368A 1102T>G BRCA-EU 14 64067943 64067943 single base substitution G T intron_variant BRCA-EU 14 64068953 64068953 single base substitution G C intron_variant BRCA-EU 14 64070164 64070164 single base substitution G C intron_variant BRCA-EU 14 64071856 64071856 single base substitution G T intron_variant BRCA-EU 14 64076703 64076703 single base substitution G C intron_variant BRCA-EU 14 64076793 64076793 single base substitution C T intron_variant BRCA-EU 14 64078636 64078636 single base substitution G C intron_variant BRCA-EU 14 64078638 64078638 single base substitution G A intron_variant BRCA-EU 14 64080082 64080090 multiple base substitution (>=2bp and <=200bp) CTTAATGTT CTAT intron_variant BRCA-EU 14 64082188 64082188 deletion of <=200bp A - intron_variant BRCA-EU 14 64083122 64083122 single base substitution A G intron_variant BRCA-EU 14 64083481 64083481 single base substitution G A intron_variant BRCA-EU 14 64083985 64083985 single base substitution G A intron_variant BRCA-EU 14 64084040 64084040 single base substitution C T intron_variant BRCA-EU 14 64084688 64084688 single base substitution G C intron_variant BRCA-EU 14 64084708 64084708 single base substitution G C intron_variant BRCA-EU 14 64085348 64085348 single base substitution T A intron_variant BRCA-EU 14 64085749 64085749 single base substitution T C intron_variant BRCA-EU 14 64086844 64086844 single base substitution T A intron_variant BRCA-EU 14 64088680 64088680 single base substitution G T intron_variant BRCA-EU 14 64089285 64089285 single base substitution C T intron_variant BRCA-EU 14 64089395 64089395 single base substitution G C intron_variant BRCA-EU 14 64090276 64090276 single base substitution G T intron_variant BRCA-EU 14 64091367 64091367 deletion of <=200bp G - intron_variant BRCA-EU 14 64092501 64092501 single base substitution G A intron_variant BRCA-EU 14 64094331 64094331 insertion of <=200bp - CT intron_variant BRCA-EU 14 64094647 64094647 single base substitution C A intron_variant BRCA-EU 14 64094738 64094738 single base substitution G C intron_variant BRCA-EU 14 64094812 64094812 single base substitution G A intron_variant BRCA-EU 14 64094862 64094862 single base substitution G C intron_variant BRCA-EU 14 64095733 64095733 single base substitution G A intron_variant BRCA-EU 14 64096912 64096912 single base substitution T C intron_variant BRCA-EU 14 64100399 64100399 single base substitution T C intron_variant BRCA-EU 14 64102754 64102754 single base substitution A G intron_variant BRCA-EU 14 64103961 64103961 single base substitution A C intron_variant BRCA-EU 14 64104670 64104670 single base substitution A T intron_variant BRCA-EU 14 64105407 64105407 single base substitution G A intron_variant BRCA-EU 14 64106479 64106479 single base substitution A G intron_variant BRCA-EU 14 64107333 64107333 single base substitution A T intron_variant BRCA-EU 14 64107471 64107471 single base substitution G A intron_variant BRCA-EU 14 64108185 64108185 single base substitution G C intron_variant BRCA-EU 14 64108185 64108185 single base substitution G C upstream_gene_variant BRCA-EU 14 64108297 64108297 single base substitution C T intron_variant BRCA-EU 14 64108297 64108297 single base substitution C T upstream_gene_variant BRCA-EU 14 64108806 64108806 single base substitution C A upstream_gene_variant BRCA-EU 14 64111706 64111706 single base substitution G C upstream_gene_variant BRCA-EU 14 64111826 64111826 single base substitution C T upstream_gene_variant BRCA-EU 14 64112220 64112220 single base substitution G A upstream_gene_variant BRCA-EU 14 64113267 64113267 single base substitution G T upstream_gene_variant BRCA-EU 14 64113461 64113461 single base substitution G T upstream_gene_variant BRCA-FR 14 64108297 64108297 single base substitution C T intron_variant BRCA-FR 14 64108297 64108297 single base substitution C T upstream_gene_variant BRCA-FR 14 64113396 64113396 single base substitution G T upstream_gene_variant BRCA-UK 14 64071888 64071888 single base substitution A C intron_variant BRCA-UK 14 64082348 64082348 single base substitution C G intron_variant BRCA-UK 14 64098762 64098762 single base substitution G T intron_variant CLLE-ES 14 64074257 64074257 single base substitution G C intron_variant CLLE-ES 14 64090445 64090445 single base substitution A T intron_variant COAD-US 14 64066365 64066365 single base substitution G A missense_variant A99V 296C>T COCA-CN 14 64061325 64061325 single base substitution G A downstream_gene_variant COCA-CN 14 64065728 64065728 single base substitution G A downstream_gene_variant COCA-CN 14 64065728 64065728 single base substitution G A synonymous_variant T311T 933C>T COCA-CN 14 64065868 64065868 single base substitution C A downstream_gene_variant COCA-CN 14 64065868 64065868 single base substitution C A stop_gained E265* 793G>T COCA-CN 14 64066373 64066373 single base substitution G A synonymous_variant C96C 288C>T COCA-CN 14 64066379 64066379 single base substitution C T synonymous_variant V94V 282G>A COCA-CN 14 64066395 64066395 single base substitution C T missense_variant C89Y 266G>A COCA-CN 14 64066398 64066398 single base substitution G C missense_variant A88G 263C>G COCA-CN 14 64066424 64066424 single base substitution T C synonymous_variant A79A 237A>G COCA-CN 14 64066431 64066431 single base substitution C T missense_variant R77K 230G>A COCA-CN 14 64068277 64068277 single base substitution T C intron_variant COCA-CN 14 64071888 64071888 single base substitution A C intron_variant COCA-CN 14 64071890 64071890 single base substitution A C intron_variant COCA-CN 14 64071892 64071892 single base substitution A C intron_variant ESAD-UK 14 64068523 64068523 single base substitution C T intron_variant ESAD-UK 14 64069090 64069090 single base substitution G A intron_variant ESAD-UK 14 64069641 64069641 deletion of <=200bp T - intron_variant ESAD-UK 14 64073185 64073185 single base substitution A G intron_variant ESAD-UK 14 64073503 64073503 single base substitution C T intron_variant ESAD-UK 14 64073891 64073891 deletion of <=200bp T - intron_variant ESAD-UK 14 64073981 64073981 single base substitution C T intron_variant ESAD-UK 14 64078429 64078429 single base substitution A T intron_variant ESAD-UK 14 64078590 64078590 single base substitution G A intron_variant ESAD-UK 14 64078735 64078735 single base substitution C T intron_variant ESAD-UK 14 64080445 64080445 single base substitution C G intron_variant ESAD-UK 14 64082727 64082727 single base substitution G A intron_variant ESAD-UK 14 64084807 64084807 single base substitution T G intron_variant ESAD-UK 14 64085535 64085535 single base substitution C T intron_variant ESAD-UK 14 64086313 64086313 insertion of <=200bp - A intron_variant ESAD-UK 14 64087781 64087781 single base substitution T C intron_variant ESAD-UK 14 64087856 64087856 single base substitution T A intron_variant ESAD-UK 14 64088373 64088373 single base substitution G A intron_variant ESAD-UK 14 64088693 64088693 single base substitution A G intron_variant ESAD-UK 14 64088881 64088881 single base substitution G A intron_variant ESAD-UK 14 64092110 64092110 single base substitution C T intron_variant ESAD-UK 14 64092178 64092178 single base substitution A C intron_variant ESAD-UK 14 64093674 64093674 insertion of <=200bp - A intron_variant ESAD-UK 14 64094725 64094725 single base substitution G A intron_variant ESAD-UK 14 64097349 64097349 single base substitution A G intron_variant ESAD-UK 14 64097902 64097902 single base substitution C T intron_variant ESAD-UK 14 64098312 64098312 single base substitution C T intron_variant ESAD-UK 14 64098590 64098590 single base substitution G A intron_variant ESAD-UK 14 64099493 64099493 single base substitution G C intron_variant ESAD-UK 14 64103678 64103678 single base substitution T A intron_variant ESAD-UK 14 64103765 64103765 single base substitution C T intron_variant ESAD-UK 14 64108443 64108443 single base substitution G C intron_variant ESAD-UK 14 64108443 64108443 single base substitution G C upstream_gene_variant ESAD-UK 14 64109345 64109345 single base substitution G T upstream_gene_variant ESAD-UK 14 64111785 64111785 deletion of <=200bp A - upstream_gene_variant ESCA-CN 14 64066279 64066279 single base substitution G A missense_variant H128Y 382C>T KIRC-US 14 64065889 64065889 single base substitution A C downstream_gene_variant KIRC-US 14 64065889 64065889 single base substitution A C missense_variant L258V 772T>G KIRC-US 14 64066630 64066630 single base substitution G A synonymous_variant L11L 31C>T LICA-CN 14 64065517 64065517 single base substitution T C downstream_gene_variant LICA-CN 14 64065517 64065517 single base substitution T C missense_variant K382E 1144A>G LICA-FR 14 64062943 64062943 single base substitution T C downstream_gene_variant LICA-FR 14 64072955 64072955 single base substitution T C intron_variant LICA-FR 14 64076983 64076983 single base substitution G A intron_variant LICA-FR 14 64078467 64078467 single base substitution C G intron_variant LICA-FR 14 64092578 64092578 deletion of <=200bp T - intron_variant LICA-FR 14 64099105 64099105 single base substitution T C intron_variant LICA-FR 14 64101123 64101123 single base substitution C G intron_variant LICA-FR 14 64104733 64104733 single base substitution G T intron_variant LICA-FR 14 64108894 64108894 single base substitution G A upstream_gene_variant LINC-JP 14 64064206 64064206 single base substitution T A 3_prime_UTR_variant LINC-JP 14 64064206 64064206 single base substitution T A downstream_gene_variant LINC-JP 14 64065621 64065621 single base substitution A G downstream_gene_variant LINC-JP 14 64065621 64065621 single base substitution A G missense_variant L347P 1040T>C LINC-JP 14 64074616 64074616 single base substitution G A intron_variant LINC-JP 14 64078624 64078624 single base substitution T G intron_variant LINC-JP 14 64078650 64078650 single base substitution T G intron_variant LINC-JP 14 64080540 64080540 deletion of <=200bp T - intron_variant LINC-JP 14 64084265 64084265 single base substitution G T intron_variant LINC-JP 14 64092452 64092452 single base substitution T G intron_variant LINC-JP 14 64105293 64105293 single base substitution T C intron_variant LIRI-JP 14 64060167 64060167 single base substitution T C downstream_gene_variant LIRI-JP 14 64060353 64060353 single base substitution C T downstream_gene_variant LIRI-JP 14 64060770 64060770 deletion of <=200bp C - downstream_gene_variant LIRI-JP 14 64062003 64062003 single base substitution T A downstream_gene_variant LIRI-JP 14 64064114 64064114 single base substitution T C 3_prime_UTR_variant LIRI-JP 14 64064114 64064114 single base substitution T C downstream_gene_variant LIRI-JP 14 64065473 64065473 deletion of <=200bp C - 3_prime_UTR_variant LIRI-JP 14 64065473 64065473 deletion of <=200bp C - downstream_gene_variant LIRI-JP 14 64065737 64065743 deletion of <=200bp TGACATG - downstream_gene_variant LIRI-JP 14 64065737 64065743 deletion of <=200bp TGACATG - frameshift_variant SMS306 LIRI-JP 14 64068580 64068580 single base substitution C T intron_variant LIRI-JP 14 64069325 64069325 single base substitution T C intron_variant LIRI-JP 14 64070227 64070227 single base substitution T C intron_variant LIRI-JP 14 64070446 64070446 single base substitution A C intron_variant LIRI-JP 14 64074368 64074368 single base substitution G A intron_variant LIRI-JP 14 64075488 64075488 single base substitution T A intron_variant LIRI-JP 14 64076378 64076378 single base substitution C A intron_variant LIRI-JP 14 64077061 64077061 single base substitution T C intron_variant LIRI-JP 14 64078799 64078799 single base substitution T C intron_variant LIRI-JP 14 64082884 64082884 single base substitution C A intron_variant LIRI-JP 14 64083111 64083111 single base substitution T A intron_variant LIRI-JP 14 64083420 64083420 single base substitution A T intron_variant LIRI-JP 14 64085366 64085366 single base substitution C T intron_variant LIRI-JP 14 64089793 64089793 single base substitution T C intron_variant LIRI-JP 14 64089942 64089942 single base substitution T C intron_variant LIRI-JP 14 64091989 64091989 single base substitution G A intron_variant LIRI-JP 14 64096303 64096303 insertion of <=200bp - A intron_variant LIRI-JP 14 64097088 64097088 single base substitution C T intron_variant LIRI-JP 14 64102047 64102047 single base substitution C T intron_variant LIRI-JP 14 64102229 64102229 single base substitution A G intron_variant LIRI-JP 14 64105294 64105294 single base substitution A T intron_variant LIRI-JP 14 64105368 64105368 single base substitution T C intron_variant LIRI-JP 14 64107030 64107030 single base substitution T A intron_variant LIRI-JP 14 64108014 64108014 single base substitution T G intron_variant LIRI-JP 14 64108014 64108014 single base substitution T G splice_region_variant LIRI-JP 14 64108140 64108140 single base substitution T C intron_variant LIRI-JP 14 64108140 64108140 single base substitution T C upstream_gene_variant LIRI-JP 14 64108558 64108558 single base substitution C T 5_prime_UTR_variant LIRI-JP 14 64108558 64108558 single base substitution C T upstream_gene_variant LIRI-JP 14 64109651 64109651 single base substitution A G upstream_gene_variant LIRI-JP 14 64110719 64110719 single base substitution T A upstream_gene_variant LIRI-JP 14 64113306 64113306 single base substitution C T upstream_gene_variant LUSC-KR 14 64065424 64065424 single base substitution T A 3_prime_UTR_variant LUSC-KR 14 64065424 64065424 single base substitution T A downstream_gene_variant LUSC-KR 14 64079920 64079920 single base substitution G C intron_variant LUSC-KR 14 64085518 64085518 single base substitution G A intron_variant LUSC-KR 14 64090450 64090450 single base substitution T A intron_variant LUSC-KR 14 64097560 64097560 single base substitution G A intron_variant LUSC-KR 14 64101749 64101749 single base substitution T A intron_variant LUSC-KR 14 64103479 64103479 single base substitution T C intron_variant LUSC-KR 14 64103703 64103703 single base substitution G C intron_variant LUSC-KR 14 64107196 64107196 single base substitution T C intron_variant LUSC-KR 14 64112788 64112788 single base substitution G C upstream_gene_variant MALY-DE 14 64059996 64060000 deletion of <=200bp TTTGT - downstream_gene_variant MALY-DE 14 64064375 64064375 single base substitution T G 3_prime_UTR_variant MALY-DE 14 64064375 64064375 single base substitution T G downstream_gene_variant MALY-DE 14 64069982 64069983 deletion of <=200bp AC - intron_variant MALY-DE 14 64098264 64098264 single base substitution T A intron_variant MALY-DE 14 64101738 64101738 single base substitution A T intron_variant MALY-DE 14 64101776 64101776 single base substitution A T intron_variant MALY-DE 14 64101781 64101781 single base substitution A C intron_variant MELA-AU 14 64059336 64059336 single base substitution G A downstream_gene_variant MELA-AU 14 64059447 64059447 single base substitution C T downstream_gene_variant MELA-AU 14 64059494 64059494 single base substitution G A downstream_gene_variant MELA-AU 14 64060374 64060374 single base substitution G T downstream_gene_variant MELA-AU 14 64060660 64060660 single base substitution C T downstream_gene_variant MELA-AU 14 64060686 64060686 single base substitution G A downstream_gene_variant MELA-AU 14 64060858 64060858 single base substitution C T downstream_gene_variant MELA-AU 14 64061417 64061417 single base substitution G A downstream_gene_variant MELA-AU 14 64061511 64061511 single base substitution G A downstream_gene_variant MELA-AU 14 64061684 64061684 single base substitution G A downstream_gene_variant MELA-AU 14 64061975 64061975 single base substitution G A downstream_gene_variant MELA-AU 14 64062045 64062045 single base substitution C T downstream_gene_variant MELA-AU 14 64062220 64062220 single base substitution G A downstream_gene_variant MELA-AU 14 64062898 64062898 single base substitution G A downstream_gene_variant MELA-AU 14 64063536 64063536 single base substitution T C downstream_gene_variant MELA-AU 14 64063911 64063911 single base substitution C T 3_prime_UTR_variant MELA-AU 14 64063911 64063911 single base substitution C T downstream_gene_variant MELA-AU 14 64066122 64066122 single base substitution G A missense_variant P180L 539C>T MELA-AU 14 64068387 64068387 single base substitution G A intron_variant MELA-AU 14 64068452 64068452 single base substitution G A intron_variant MELA-AU 14 64068705 64068705 single base substitution C T intron_variant MELA-AU 14 64068768 64068768 single base substitution A T intron_variant MELA-AU 14 64068805 64068805 single base substitution G A intron_variant MELA-AU 14 64070958 64070958 deletion of <=200bp C - intron_variant MELA-AU 14 64071651 64071651 single base substitution A G intron_variant MELA-AU 14 64071778 64071778 single base substitution G A intron_variant MELA-AU 14 64071884 64071884 single base substitution C A intron_variant MELA-AU 14 64071885 64071885 insertion of <=200bp - TA intron_variant MELA-AU 14 64071901 64071901 single base substitution C T intron_variant MELA-AU 14 64072237 64072237 single base substitution G A intron_variant MELA-AU 14 64073539 64073539 single base substitution G A intron_variant MELA-AU 14 64073923 64073923 single base substitution C T intron_variant MELA-AU 14 64074032 64074032 single base substitution C T intron_variant MELA-AU 14 64074039 64074039 deletion of <=200bp C - intron_variant MELA-AU 14 64074462 64074462 single base substitution G A intron_variant MELA-AU 14 64074526 64074526 single base substitution G A intron_variant MELA-AU 14 64074688 64074688 insertion of <=200bp - G intron_variant MELA-AU 14 64074708 64074708 single base substitution G A intron_variant MELA-AU 14 64075036 64075036 single base substitution G A intron_variant MELA-AU 14 64075269 64075269 single base substitution G A intron_variant MELA-AU 14 64076713 64076713 single base substitution G A intron_variant MELA-AU 14 64076865 64076866 multiple base substitution (>=2bp and <=200bp) GA AC intron_variant MELA-AU 14 64077688 64077688 single base substitution G A intron_variant MELA-AU 14 64077700 64077700 single base substitution G T intron_variant MELA-AU 14 64077974 64077974 single base substitution G A intron_variant MELA-AU 14 64078058 64078058 single base substitution A C intron_variant MELA-AU 14 64078386 64078386 single base substitution T C intron_variant MELA-AU 14 64079143 64079143 single base substitution G C intron_variant MELA-AU 14 64079460 64079460 single base substitution G A intron_variant MELA-AU 14 64079499 64079499 single base substitution A G intron_variant MELA-AU 14 64079612 64079612 single base substitution G A intron_variant MELA-AU 14 64079874 64079874 single base substitution G A intron_variant MELA-AU 14 64080404 64080404 single base substitution G A intron_variant MELA-AU 14 64083196 64083196 single base substitution G A intron_variant MELA-AU 14 64083704 64083704 single base substitution C G intron_variant MELA-AU 14 64083727 64083727 single base substitution C T intron_variant MELA-AU 14 64083923 64083923 single base substitution A C intron_variant MELA-AU 14 64085141 64085142 multiple base substitution (>=2bp and <=200bp) GG AA intron_variant MELA-AU 14 64085222 64085222 single base substitution C T intron_variant MELA-AU 14 64085903 64085903 single base substitution G A intron_variant MELA-AU 14 64086285 64086285 single base substitution G A intron_variant MELA-AU 14 64086629 64086629 single base substitution A C intron_variant MELA-AU 14 64087543 64087543 single base substitution G A intron_variant MELA-AU 14 64087703 64087703 single base substitution T C intron_variant MELA-AU 14 64087864 64087864 single base substitution G A intron_variant MELA-AU 14 64088267 64088267 single base substitution G A intron_variant MELA-AU 14 64089096 64089096 single base substitution G A intron_variant MELA-AU 14 64089627 64089627 single base substitution G A intron_variant MELA-AU 14 64090867 64090867 single base substitution A G intron_variant MELA-AU 14 64090869 64090869 single base substitution C T intron_variant MELA-AU 14 64092952 64092952 single base substitution G A intron_variant MELA-AU 14 64093337 64093337 single base substitution C A intron_variant MELA-AU 14 64093384 64093384 single base substitution G A intron_variant MELA-AU 14 64093646 64093646 single base substitution G A intron_variant MELA-AU 14 64093673 64093673 single base substitution C G intron_variant MELA-AU 14 64093866 64093866 single base substitution A T intron_variant MELA-AU 14 64094775 64094775 single base substitution G A intron_variant MELA-AU 14 64095287 64095287 single base substitution G A intron_variant MELA-AU 14 64095606 64095606 single base substitution T C intron_variant MELA-AU 14 64095889 64095889 single base substitution G A intron_variant MELA-AU 14 64096217 64096217 single base substitution G T intron_variant MELA-AU 14 64096473 64096473 single base substitution C T intron_variant MELA-AU 14 64096747 64096747 single base substitution C T intron_variant MELA-AU 14 64096780 64096780 single base substitution C T intron_variant MELA-AU 14 64097764 64097764 single base substitution G A intron_variant MELA-AU 14 64097850 64097850 single base substitution G T intron_variant MELA-AU 14 64098014 64098014 single base substitution G A intron_variant MELA-AU 14 64098171 64098171 single base substitution T A intron_variant MELA-AU 14 64098375 64098375 single base substitution G A intron_variant MELA-AU 14 64098816 64098816 single base substitution G A intron_variant MELA-AU 14 64099490 64099490 single base substitution G A intron_variant MELA-AU 14 64100434 64100434 single base substitution G A intron_variant MELA-AU 14 64100834 64100834 single base substitution G A intron_variant MELA-AU 14 64101149 64101149 single base substitution G A intron_variant MELA-AU 14 64102462 64102462 single base substitution G A intron_variant MELA-AU 14 64103148 64103148 single base substitution G A intron_variant MELA-AU 14 64104727 64104727 single base substitution G A intron_variant MELA-AU 14 64105128 64105128 single base substitution G A intron_variant MELA-AU 14 64105357 64105357 single base substitution G A intron_variant MELA-AU 14 64105620 64105620 single base substitution T A intron_variant MELA-AU 14 64105749 64105749 single base substitution G T intron_variant MELA-AU 14 64105871 64105871 single base substitution G A intron_variant MELA-AU 14 64106194 64106194 single base substitution G A intron_variant MELA-AU 14 64108509 64108509 single base substitution C T intron_variant MELA-AU 14 64108509 64108509 single base substitution C T upstream_gene_variant MELA-AU 14 64108702 64108702 single base substitution G A upstream_gene_variant MELA-AU 14 64108742 64108742 single base substitution C T upstream_gene_variant MELA-AU 14 64109215 64109216 multiple base substitution (>=2bp and <=200bp) GG AA upstream_gene_variant MELA-AU 14 64109229 64109229 single base substitution C T upstream_gene_variant MELA-AU 14 64110187 64110187 single base substitution C T upstream_gene_variant MELA-AU 14 64110728 64110728 single base substitution C T upstream_gene_variant MELA-AU 14 64111061 64111061 single base substitution G A upstream_gene_variant MELA-AU 14 64111719 64111719 single base substitution C T upstream_gene_variant MELA-AU 14 64111740 64111740 single base substitution C T upstream_gene_variant MELA-AU 14 64112753 64112753 single base substitution C T upstream_gene_variant MELA-AU 14 64112782 64112782 single base substitution C T upstream_gene_variant MELA-AU 14 64113283 64113283 single base substitution C T upstream_gene_variant MELA-AU 14 64113315 64113315 single base substitution C T upstream_gene_variant MELA-AU 14 64113436 64113436 single base substitution C T upstream_gene_variant MELA-AU 14 64113437 64113437 single base substitution C T upstream_gene_variant ORCA-IN 14 64073019 64073019 single base substitution A G intron_variant ORCA-IN 14 64086645 64086645 single base substitution C T intron_variant ORCA-IN 14 64090409 64090409 single base substitution G C intron_variant ORCA-IN 14 64090969 64090969 single base substitution G C intron_variant ORCA-IN 14 64098567 64098567 single base substitution C T intron_variant ORCA-IN 14 64100934 64100934 single base substitution G A intron_variant OV-AU 14 64067208 64067208 single base substitution G C intron_variant OV-AU 14 64072042 64072042 single base substitution C T intron_variant OV-AU 14 64072856 64072856 single base substitution G C intron_variant OV-AU 14 64075027 64075027 single base substitution C T intron_variant OV-AU 14 64077490 64077490 single base substitution G A intron_variant OV-AU 14 64079189 64079189 single base substitution G A intron_variant OV-AU 14 64085331 64085331 single base substitution A G intron_variant OV-AU 14 64087161 64087161 single base substitution G C intron_variant OV-AU 14 64090610 64090610 single base substitution A C intron_variant OV-AU 14 64102788 64102788 single base substitution G A intron_variant OV-AU 14 64112858 64112858 single base substitution T G upstream_gene_variant PACA-AU 14 64061119 64061119 single base substitution G T downstream_gene_variant PACA-AU 14 64065161 64065161 single base substitution G T 3_prime_UTR_variant PACA-AU 14 64065161 64065161 single base substitution G T downstream_gene_variant PACA-AU 14 64067663 64067663 single base substitution G C intron_variant PACA-AU 14 64068381 64068381 single base substitution C G intron_variant PACA-AU 14 64068415 64068415 single base substitution T C intron_variant PACA-AU 14 64070002 64070002 single base substitution A C intron_variant PACA-AU 14 64070791 64070791 single base substitution C T intron_variant PACA-AU 14 64072287 64072287 single base substitution C T intron_variant PACA-AU 14 64088769 64088769 deletion of <=200bp T - intron_variant PACA-AU 14 64093168 64093168 single base substitution C A intron_variant PACA-AU 14 64098833 64098833 single base substitution A C intron_variant PACA-AU 14 64098898 64098898 single base substitution G A intron_variant PACA-AU 14 64099996 64099996 single base substitution G C intron_variant PACA-AU 14 64107828 64107828 single base substitution A G intron_variant PACA-AU 14 64109128 64109128 single base substitution G A upstream_gene_variant PACA-AU 14 64112409 64112409 single base substitution A C upstream_gene_variant PACA-CA 14 64064079 64064079 single base substitution C T 3_prime_UTR_variant PACA-CA 14 64064079 64064079 single base substitution C T downstream_gene_variant PACA-CA 14 64067752 64067752 single base substitution G A intron_variant PACA-CA 14 64068651 64068651 insertion of <=200bp - A intron_variant PACA-CA 14 64069726 64069726 single base substitution G A intron_variant PACA-CA 14 64070653 64070653 single base substitution C A intron_variant PACA-CA 14 64081408 64081417 deletion of <=200bp AATTTAGAGA - intron_variant PACA-CA 14 64084209 64084209 deletion of <=200bp T - intron_variant PACA-CA 14 64084869 64084870 deletion of <=200bp GT - intron_variant PACA-CA 14 64093224 64093238 deletion of <=200bp ATCTCTACTAAAAAT - intron_variant PACA-CA 14 64094262 64094262 deletion of <=200bp A - intron_variant PACA-CA 14 64094958 64094958 single base substitution A T intron_variant PACA-CA 14 64094959 64094959 single base substitution A T intron_variant PACA-CA 14 64099833 64099833 single base substitution T C intron_variant PACA-CA 14 64100421 64100421 single base substitution C T intron_variant PACA-CA 14 64101011 64101011 single base substitution G A intron_variant PACA-CA 14 64106950 64106950 single base substitution C A intron_variant PACA-CA 14 64108993 64108993 single base substitution C T upstream_gene_variant PACA-CA 14 64111326 64111326 single base substitution G A upstream_gene_variant PACA-CA 14 64112489 64112489 single base substitution G T upstream_gene_variant PAEN-AU 14 64069180 64069180 single base substitution C A intron_variant PAEN-AU 14 64092863 64092863 single base substitution C A intron_variant PAEN-AU 14 64113168 64113168 single base substitution C T upstream_gene_variant PAEN-IT 14 64091510 64091510 single base substitution A T intron_variant PAEN-IT 14 64107406 64107406 single base substitution G A intron_variant PBCA-DE 14 64061781 64061785 deletion of <=200bp GTTAA - downstream_gene_variant PBCA-DE 14 64067037 64067037 insertion of <=200bp - C intron_variant PBCA-DE 14 64069982 64069983 deletion of <=200bp AC - intron_variant PBCA-DE 14 64071884 64071884 single base substitution C A intron_variant PBCA-DE 14 64071930 64071931 deletion of <=200bp AC - intron_variant PBCA-DE 14 64072830 64072835 deletion of <=200bp TAATTT - intron_variant PBCA-DE 14 64074831 64074831 single base substitution G C intron_variant PBCA-DE 14 64075385 64075386 deletion of <=200bp CA - intron_variant PBCA-DE 14 64080216 64080216 single base substitution G T intron_variant PBCA-DE 14 64092220 64092220 single base substitution A T intron_variant PBCA-DE 14 64093674 64093674 insertion of <=200bp - A intron_variant PBCA-DE 14 64094846 64094846 single base substitution T C intron_variant PBCA-DE 14 64098253 64098253 insertion of <=200bp - A intron_variant PBCA-DE 14 64104272 64104273 deletion of <=200bp GT - intron_variant PBCA-DE 14 64107173 64107173 single base substitution C T intron_variant PBCA-DE 14 64108771 64108771 single base substitution C A upstream_gene_variant PBCA-DE 14 64111507 64111507 single base substitution T A upstream_gene_variant PRAD-CA 14 64071888 64071888 single base substitution A C intron_variant PRAD-CA 14 64075549 64075549 single base substitution C T intron_variant PRAD-CA 14 64093870 64093870 single base substitution T A intron_variant PRAD-CA 14 64093872 64093872 single base substitution T A intron_variant PRAD-UK 14 64081753 64081753 single base substitution A G intron_variant PRAD-UK 14 64083577 64083577 single base substitution G C intron_variant PRAD-UK 14 64103800 64103800 single base substitution C T intron_variant RECA-EU 14 64059098 64059098 single base substitution C T downstream_gene_variant RECA-EU 14 64062455 64062455 single base substitution T C downstream_gene_variant RECA-EU 14 64071572 64071572 single base substitution T G intron_variant RECA-EU 14 64086740 64086740 single base substitution A G intron_variant RECA-EU 14 64102525 64102525 single base substitution A G intron_variant RECA-EU 14 64103860 64103860 single base substitution C T intron_variant RECA-EU 14 64112830 64112830 single base substitution C A upstream_gene_variant SKCA-BR 14 64060314 64060314 single base substitution A C downstream_gene_variant SKCA-BR 14 64064520 64064520 single base substitution T C 3_prime_UTR_variant SKCA-BR 14 64064520 64064520 single base substitution T C downstream_gene_variant SKCA-BR 14 64064557 64064557 single base substitution G A 3_prime_UTR_variant SKCA-BR 14 64064557 64064557 single base substitution G A downstream_gene_variant SKCA-BR 14 64066431 64066431 single base substitution C T missense_variant R77K 230G>A SKCA-BR 14 64067030 64067030 single base substitution G A intron_variant SKCA-BR 14 64067031 64067031 single base substitution G A intron_variant SKCA-BR 14 64071999 64071999 single base substitution C A intron_variant SKCA-BR 14 64076937 64076938 deletion of <=200bp TA - intron_variant SKCA-BR 14 64077420 64077420 insertion of <=200bp - CT intron_variant SKCA-BR 14 64078078 64078078 single base substitution G C intron_variant SKCA-BR 14 64082897 64082897 single base substitution T C intron_variant SKCA-BR 14 64086722 64086722 insertion of <=200bp - CA intron_variant SKCA-BR 14 64089728 64089728 single base substitution G A intron_variant SKCA-BR 14 64091229 64091230 deletion of <=200bp TA - intron_variant SKCA-BR 14 64091243 64091243 single base substitution G A intron_variant SKCA-BR 14 64092577 64092578 deletion of <=200bp CT - intron_variant SKCA-BR 14 64094634 64094634 single base substitution G A intron_variant SKCA-BR 14 64096859 64096859 single base substitution T G intron_variant SKCA-BR 14 64097846 64097846 single base substitution A G intron_variant SKCA-BR 14 64100925 64100925 single base substitution C T intron_variant SKCA-BR 14 64104651 64104651 single base substitution C T intron_variant SKCA-BR 14 64106182 64106182 single base substitution C A intron_variant SKCA-BR 14 64107840 64107840 single base substitution G A intron_variant SKCA-BR 14 64109441 64109441 single base substitution A G upstream_gene_variant SKCM-US 14 64065642 64065642 single base substitution C T downstream_gene_variant SKCM-US 14 64065642 64065642 single base substitution C T missense_variant G340E 1019G>A STAD-US 14 64065892 64065892 single base substitution G A downstream_gene_variant STAD-US 14 64065892 64065892 single base substitution G A missense_variant R257C 769C>T STAD-US 14 64066595 64066595 single base substitution C T synonymous_variant E22E 66G>A UCEC-US 14 64066033 64066033 single base substitution C T missense_variant V210I 628G>A UCEC-US 14 64066083 64066083 single base substitution C T missense_variant G193D 578G>A UCEC-US 14 64066162 64066162 single base substitution C A stop_gained E167* 499G>T UCEC-US 14 64066239 64066239 single base substitution G A missense_variant A141V 422C>T

Mutation - COSMIC Sample Name Mutation ID Mutation CDS Mutation AA Mutation Description Mutation Genome Position Mutation Strand 18195 COSM5346214 c.210T>C p.P70P Substitution - coding silent 14:63599733-63599733 - sysucc-1213T COSM5764373 c.266G>A p.C89Y Substitution - Missense 14:63599677-63599677 - 325 COSM3724176 c.1112_1114delAAC p.Q371delQ Deletion - In frame 14:63598829-63598831 - PD13299a COSM5776764 c.1102T>G p.S368A Substitution - Missense 14:63598841-63598841 - TCGA-EE-A2GC-06 COSM3496879 c.1019G>A p.G340E Substitution - Missense 14:63598924-63598924 - 1946219 COSM1578208 c.781C>T p.Q261* Substitution - Nonsense 14:63599162-63599162 - TCGA-AP-A051-01 COSM956881 c.422C>T p.A141V Substitution - Missense 14:63599521-63599521 - TCGA-AG-A002-01 COSM264697 c.99G>T p.K33N Substitution - Missense 14:63599844-63599844 - 426 COSM4432857 c.646A>G p.I216V Substitution - Missense 14:63599297-63599297 - LUAD-NYU1219 COSM369897 c.791G>T p.R264I Substitution - Missense 14:63599152-63599152 - sysucc-1213T COSM5764246 c.288C>T p.C96C Substitution - coding silent 14:63599655-63599655 - ESO-859 COSM1240651 c.317C>T p.P106L Substitution - Missense 14:63599626-63599626 - sysucc-1213T COSM5764199 c.230G>A p.R77K Substitution - Missense 14:63599713-63599713 - sysucc-1213T COSM5764303 c.282G>A p.V94V Substitution - coding silent 14:63599661-63599661 - HCC159T COSM3706340 c.1040T>C p.L347P Substitution - Missense 14:63598903-63598903 - HCC061T COSM5805851 c.1144A>G p.K382E Substitution - Missense 14:63598799-63598799 - ESCC_112 COSM5639450 c.277A>T p.T93S Substitution - Missense 14:63599666-63599666 - TCGA-CJ-4897-01 COSM470104 c.31C>T p.L11L Substitution - coding silent 14:63599912-63599912 - sysucc-1213T COSM5764223 c.263C>G p.A88G Substitution - Missense 14:63599680-63599680 - TCGA-AP-A051-01 COSM956878 c.628G>A p.V210I Substitution - Missense 14:63599315-63599315 - TCGA-BS-A0UT-01 COSM956880 c.499G>T p.E167* Substitution - Nonsense 14:63599444-63599444 - 2158 COSM5012777 c.260C>A p.S87* Substitution - Nonsense 14:63599683-63599683 - CSCC-18-T COSM4489022 c.341C>T p.P114L Substitution - Missense 14:63599602-63599602 - I2L-P23-Tumor-Organoid COSM5362555 c.877G>A p.G293R Substitution - Missense 14:63599066-63599066 - 587376 COSM1232701 c.661T>G p.C221G Substitution - Missense 14:63599282-63599282 - MAVER-1 COSM1740090 c.973C>T p.R325C Substitution - Missense 14:63598970-63598970 - TCGA-BS-A0UV-01 COSM956881 c.422C>T p.A141V Substitution - Missense 14:63599521-63599521 - I2L-P23-Tumor-Biopsy COSM5362555 c.877G>A p.G293R Substitution - Missense 14:63599066-63599066 - 18195 COSM5346522 c.208C>T p.P70S Substitution - Missense 14:63599735-63599735 - 17802 COSM5346712 c.309A>T p.R103S Substitution - Missense 14:63599634-63599634 - HCC10T COSM131163 c.35A>G p.H12R Substitution - Missense 14:63599908-63599908 - TCGA-AX-A0J1-01 COSM956879 c.578G>A p.G193D Substitution - Missense 14:63599365-63599365 - TCGA-BR-4280-01 COSM4051668 c.769C>T p.R257C Substitution - Missense 14:63599174-63599174 - TCGA-AK-3445-01 COSM3361181 c.772T>G p.L258V Substitution - Missense 14:63599171-63599171 - ESCC-183T COSM3936570 c.382C>T p.H128Y Substitution - Missense 14:63599561-63599561 - 31 COSM5733245 c.986G>C p.W329S Substitution - Missense 14:63598957-63598957 - TCGA-30-1855-01 COSM1323456 c.1036T>C p.L346L Substitution - coding silent 14:63598907-63598907 - sysucc-1317T COSM5448674 c.933C>T p.T311T Substitution - coding silent 14:63599010-63599010 - HN_62601 COSM128484 c.780C>A p.I260I Substitution - coding silent 14:63599163-63599163 - PT38 COSM5923102 c.603T>A p.N201K Substitution - Missense 14:63599340-63599340 - HCC159 COSM3706340 c.1040T>C p.L347P Substitution - Missense 14:63598903-63598903 - pfg068T COSM4756497 c.656T>C p.V219A Substitution - Missense 14:63599287-63599287 - CLL115 COSM1290304 c.417T>C p.D139D Substitution - coding silent 14:63599526-63599526 - TCGA-AG-A002-01 COSM264696 c.639T>C p.C213C Substitution - coding silent 14:63599304-63599304 - TCGA-G4-6628-01 COSM1370471 c.296C>T p.A99V Substitution - Missense 14:63599647-63599647 - 395 COSM4428646 c.949C>T p.Q317* Substitution - Nonsense 14:63598994-63598994 - sysucc-1213T COSM5764347 c.237A>G p.A79A Substitution - coding silent 14:63599706-63599706 - TCGA-BR-7707-01 COSM4051669 c.66G>A p.E22E Substitution - coding silent 14:63599877-63599877 -

Mutation - CGAP UNIGENE CYTOBAND OMIM SNP Hs.655665;Hs.655666 14q23.2 Hs.741323 14q23.2

Mutation - IntOGen Mutated from(ref) Mutated to(alt) Consequence Type AA Mutation CDS Mutation Chr Pos Cancer A C Missense p.L258V c.772T>G 14 64065889 RCCC A G Synonymous p.D139D c.417T>C 14 64066244 CLL C A IntronicSNV . c.1-5224G>T 14 64071884 CLL C A Missense p.A132S c.394G>T 14 64066267 LUAD C A Missense p.D139Y c.415G>T 14 64066246 LUAD C A Nonsense p.E167* c.499G>T 14 64066162 UCEC C T Missense p.G340E c.1019G>A 14 64065642 CM G A Missense p.P106L c.317C>T 14 64066344 ESCA G A Missense p.R257C c.769C>T 14 64065892 STAD G A Missense p.S217L c.650C>T 14 64066011 HNSC G A Nonsense p.Q36* c.106C>T 14 64066555 LUAD G A Synonymous p.L11L c.31C>T 14 64066630 RCCC G C Missense p.S315R c.945C>G 14 64065716 LUAD G T Missense p.R325S c.973C>A 14 64065688 CM G T Synonymous p.I260I c.780C>A 14 64065881 HNSC T A Missense p.E6D c.18A>T 14 64066643 CM T C 3-UTRSNV . c.1161+1386A>G 14 64064114 HC T C Synonymous p.E271E c.813A>G 14 64065848 LUAD