PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MGRN1 UBE2Q2 19549727 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 WDR77 16300736 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PRMT5 UBE2Q2 16300736 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G XIAP UBE2Q2 19549727 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PCGF2 UBE2Q2 19690564 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 UBE2Q2 20061386 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM25 UBE2Q2 19549727 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF111 UBE2Q2 19549727 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ELAVL1 UBE2Q2 19322201 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBA1 UBE2Q2 25527291 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TAF9 UBE2Q2 20195357 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARPC4 UBE2Q2 16300736 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G BIRC3 UBE2Q2 21113135 biogrid exp G G G G G G G G G G G G G G G G G G G GSN UBE2Q2 16300736 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DBN1 UBE2Q2 16300736 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF10 UBE2Q2 19549727 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MYO1C UBE2Q2 16300736 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ACTG1 UBE2Q2 16300736 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARPC2 UBE2Q2 16300736 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EXOSC7 UBE2Q2 19549727 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CAPZB UBE2Q2 16300736 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BIRC2 UBE2Q2 21113135, 23023127 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 UBA5 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 STUB1 23023127 ortho, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D2 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2B UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D3 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2D1 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 ITCH 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CNOT4 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DVL2 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2R2 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UFM1 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 DVL3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 AKTIP 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 RNF5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE4A UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SUMO1 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2L6 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBA3 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 ATG5 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 UBE2F 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SUMO3 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2C UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 UHRF2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DTX3L UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2L3 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 TRAF6 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G AXIN1 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2E1 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2G1 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CDC34 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2M UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2V2 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2K UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 UBQLN1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2H UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2A UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 UBE2E3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2V1 UBE2Q2 23023127 pred RNF4 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NEDD8 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE3A UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM13 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 UBE2D4 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2J2 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2U UBE2Q2 23023127 pred G RBX1 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 UBE2E2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2S UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 UBE2T 23023127 pred G G G G G G G G G G G G G UBE2I UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PARK2 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G UBE2Q2 RNF6 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SUMO2 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G RNF135 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2NL UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARIH2 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2Q2 RNF167 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SIAH1 UBE2Q2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBC UBE2Q2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2G2 UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2N UBE2Q2 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q8WVN8 P98170 two hybrid array 19549727 physical association X 2 Q8WVN8 A0A024RBP0 two hybrid array 19549727 physical association X 2 Q8WVN8 O60291 two hybrid array 19549727 physical association X 2 Q8WVN8 A0A024R1V6 two hybrid array 19690564 physical association X 2 Q8WVN8 A0A0A6YY93 display technology 20195357 physical association X 2 Q8WVN8 Q6ZNA4 two hybrid array 19549727 physical association X 2 Q8WVN8 Q14258 two hybrid array 19549727 physical association X 2 Q8WVN8 A0A024R2P7 two hybrid 19549727 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B EXOSC7 UBE2Q2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_100952 prey bait XIAP UBE2Q2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_101510 prey bait UBC UBE2Q2 MI:0004(affinity chromatography technology) 21139048 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_172296 bait prey BIRC3 UBE2Q2 MI:0018(two hybrid) 21113135 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_143877 bait prey TAF9 UBE2Q2 MI:0034(display technology) 20195357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_105214 bait prey BIRC2 UBE2Q2 MI:0018(two hybrid) 21113135 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_143871 bait prey PRMT5 UBE2Q2 MI:0004(affinity chromatography technology) 16300736 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_196075 prey bait CAPZB UBE2Q2 MI:0004(affinity chromatography technology) 16300736 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_196078 prey bait ARPC2 UBE2Q2 MI:0004(affinity chromatography technology) 16300736 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_196077 prey bait ELAVL1 UBE2Q2 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_186970 bait prey UBE2Q2 WDR77 MI:0004(affinity chromatography technology) 16300736 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_196076 bait prey GSN UBE2Q2 MI:0004(affinity chromatography technology) 16300736 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_196074 prey bait DBN1 UBE2Q2 MI:0004(affinity chromatography technology) 16300736 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_196073 prey bait RNF10 UBE2Q2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_101512 prey bait MGRN1 UBE2Q2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_101513 prey bait RNF111 UBE2Q2 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124483|UniProt_101509 prey|prey bait|bait PCGF2 UBE2Q2 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102624|BIOGRID_123635 prey|prey bait|bait ACTG1 UBE2Q2 MI:0004(affinity chromatography technology) 16300736 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_196080 prey bait ARPC4 UBE2Q2 MI:0004(affinity chromatography technology) 16300736 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_196079 prey bait MYO1C UBE2Q2 MI:0004(affinity chromatography technology) 16300736 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_196072 prey bait TRIM25 UBE2Q2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_101511 prey bait

PPI - HINT Gene A Gene B PMID Method Quality MGRN1 UBE2Q2 19549727 0397 HT UBA1 UBE2Q2 25527291 0415 LC PCGF2 UBE2Q2 19690564,19690564 0397,0018 HT XIAP UBE2Q2 19549727 0397 HT BIRC3 UBE2Q2 21113135 0018 LC BIRC2 UBE2Q2 21113135 0018 LC TRIM25 UBE2Q2 19549727 0397 HT EXOSC7 UBE2Q2 19549727 0018 HT TAF9 UBE2Q2 20195357 0034 LC RNF111 UBE2Q2 19549727,19549727 0397,0018 HT RNF10 UBE2Q2 19549727 0397 HT UBE2Q2 UBE2Q2 20061386,22496338 0415,0114 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8WVN8 P22314 UBE2Q2 UBA1 0.309 25527291 Q9HBD1 Q8WVN8 RC3H2 UBE2Q2 0.309 26489670 Q8WVN8 P35227 UBE2Q2 PCGF2 0.286 19690564 Q8WVN8 O15144 UBE2Q2 ARPC2 0.21 16300736 Q8WVN8 O14744 UBE2Q2 PRMT5 0.21 16300736 Q8WVN8 O00159 UBE2Q2 MYO1C 0.21 16300736 Q8WVN8 Q15024 UBE2Q2 EXOSC7 0.332 19549727 Q8WVN8 P47756 UBE2Q2 CAPZB 0.21 16300736 Q8WVN8 O60291 UBE2Q2 MGRN1 0.126 19549727 Q8WVN8 P06396 UBE2Q2 GSN 0.21 16300736 Q8WVN8 Q14258 UBE2Q2 TRIM25 0.236 19549727 Q8WVN8 P59998 UBE2Q2 ARPC4 0.21 16300736 Q8WVN8 P63261 UBE2Q2 ACTG1 0.21 16300736 Q8WVN8 Q16643 UBE2Q2 DBN1 0.21 16300736 Q8WVN8 Q16594 UBE2Q2 TAF9 0.126 20195357 Q9BQA1 Q8WVN8 WDR77 UBE2Q2 0.21 16300736 Q8WVN8 Q6ZNA4 UBE2Q2 RNF111 0.286 19549727 Q8WVN8 Q8N5U6 UBE2Q2 RNF10 0.236 19549727 Q8WVN8 P98170 UBE2Q2 XIAP 0.126 19549727 Q8WVN8 Q13489 UBE2Q2 BIRC3 0.309 21113135 Q8WVN8 Q13490 UBE2Q2 BIRC2 0.309 21113135 Q8WVN8 Q15717 UBE2Q2 ELAVL1 0.126 19322201

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MYO1C UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database PRMT5 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database ARPC2 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database MGRN1 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database GSN UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database UBC UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database B4GALT1 UBE2Q2 MI:0362 inference MI:0461 interaction database UBA1 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database PCGF2 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database CAPZB UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database ARPC4 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database ACTG1 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database XIAP UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database BIRC3 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database BIRC2 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM25 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database EXOSC7 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database TAF9 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database DBN1 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database RNF111 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database RNF10 UBE2Q2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2Q2 WDR77 MI:0045 experimental interaction detection MI:0461 interaction database UBE2Q2 UBA5 MI:0362 inference MI:0461 interaction database UBE2Q2 RC3H2 MI:0045 experimental interaction detection MI:0461 interaction database UBE2Q2 STUB1 MI:0362 inference MI:0461 interaction database