PTM - CPLM Gene Name UniProt ID Type Position Code PML; MYL; PP8675; RNF71; TRIM19 P29590 Acetylation 487 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Acetylation 515 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Sumoylation 65 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Sumoylation 160 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Sumoylation 380 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Sumoylation 400 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Sumoylation 490 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Sumoylation 497 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Sumoylation 616 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Ubiquitination 394 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Ubiquitination 623 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Ubiquitination 476 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Ubiquitination 380 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Ubiquitination 68 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Ubiquitination 337 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Ubiquitination 65 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Ubiquitination 226 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Ubiquitination 478 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Ubiquitination 401 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Ubiquitination 183 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Ubiquitination 727 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Ubiquitination 400 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Ubiquitination 426 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Ubiquitination 725 K PML; MYL; PP8675; RNF71; TRIM19 P29590 Ubiquitination 497 K

PTM - dbPAF Gene Name UniProt ID Position Type Species PML; MYL; PP8675; RNF71; TRIM19 P29590 117 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 184 T Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 190 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 196 T Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 22 T Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 28 T Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 309 Y Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 36 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 38 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 399 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 40 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 403 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 408 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 409 T Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 42 T Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 48 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 480 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 482 T Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 493 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 504 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 505 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 512 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 513 T Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 514 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 518 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 527 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 530 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 535 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 542 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 547 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 560 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 561 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 562 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 565 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 570 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 578 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 579 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 580 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 582 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 583 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 625 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 8 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 804 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 866 S Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 867 T Homo sapiens(Human) PML; MYL; PP8675; RNF71; TRIM19 P29590 879 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA P29590 K487-ac Acetylation sQtQCPRkVIkMEsE P29590 K490-ac Acetylation QCPRkVIkMEsEEGk P29590 K497-ac Acetylation kMEsEEGkEARLARs P29590 K515-ac Acetylation QPRPsTSkAVsPPHL P29590 K725-m1 Methylation VPGASSFkLkNLAQT P29590 K727-m1 Methylation GASSFkLkNLAQTYL P29590 R872-m1 Methylation VStPLAGrGLAERAs P29590 S8-p Phosphorylation MEPAPARsPRPQQDP P29590 T22-p Phosphorylation PARPQEPtMPPPEtP P29590 T28-p Phosphorylation PtMPPPEtPSEGRQP P29590 S36-p Phosphorylation PSEGRQPsPsPsPtE P29590 S38-p Phosphorylation EGRQPsPsPsPtERA P29590 S40-p Phosphorylation RQPsPsPsPtERAPA P29590 T42-p Phosphorylation PsPsPsPtERAPAsE P29590 S48-p Phosphorylation PtERAPAsEEEFQFL P29590 T184-p Phosphorylation FLDGTRktNNIFCsN P29590 S190-p Phosphorylation ktNNIFCsNPNHRtP P29590 T196-p Phosphorylation CsNPNHRtPTLTSIY P29590 Y309-p Phosphorylation DARYQRDyEEMASRL P29590 Y339-p Phosphorylation LVQRMKCyAsDQEVL P29590 S341-p Phosphorylation QRMKCyAsDQEVLDM P29590 S399-p Phosphorylation QGkDAAVskkAsPEA P29590 S403-p Phosphorylation AAVskkAsPEAAstP P29590 S408-p Phosphorylation kAsPEAAstPRDPID P29590 T409-p Phosphorylation AsPEAAstPRDPIDV P29590 S463-p Phosphorylation AFSIKGPsYGEDVsN P29590 S469-p Phosphorylation PsYGEDVsNTTTAQk P29590 S480-p Phosphorylation TAQkRKCsQtQCPRk P29590 T482-p Phosphorylation QkRKCsQtQCPRkVI P29590 S493-p Phosphorylation RkVIkMEsEEGkEAR P29590 S504-p Phosphorylation kEARLARssPEQPRP P29590 S505-p Phosphorylation EARLARssPEQPRPs P29590 S512-p Phosphorylation sPEQPRPsTSkAVsP P29590 S518-p Phosphorylation PsTSkAVsPPHLDGP P29590 S527-p Phosphorylation PHLDGPPsPRsPVIG P29590 S530-p Phosphorylation DGPPsPRsPVIGsEV P29590 S535-p Phosphorylation PRsPVIGsEVFLPNs P29590 S542-p Phosphorylation sEVFLPNsNHVASGA P29590 S560-p Phosphorylation EERVVVIsssEDsDA P29590 S561-p Phosphorylation ERVVVIsssEDsDAE P29590 S562-p Phosphorylation RVVVIsssEDsDAEN P29590 S565-p Phosphorylation VIsssEDsDAENSSS P29590 S578-p Phosphorylation SSRELDDsSsESsDL P29590 S580-p Phosphorylation RELDDsSsESsDLQL P29590 S583-p Phosphorylation DDsSsESsDLQLEGP P29590 S625-p Phosphorylation DNETQkIsQLAAVNR P29590 S804-p Phosphorylation LLALHNVsFMELLSA P29590 S828-p Phosphorylation KKYSRYLsLQTTTLP P29590 T867-p Phosphorylation ARAEGVStPLAGrGL P29590 S879-p Phosphorylation rGLAERAsQQs____ P29590 S882-p Phosphorylation AERAsQQs_______ P29590 K65-sm Sumoylation QQCQAEAkCPKLLPC P29590 K160-sm Sumoylation EAHQWFLkHEARPLA P29590 K380-sm Sumoylation TDGFDEFkVRLQDLS P29590 K400-sm Sumoylation GkDAAVskkAsPEAA P29590 K487-sm Sumoylation sQtQCPRkVIkMEsE P29590 K490-sm Sumoylation QCPRkVIkMEsEEGk P29590 K497-sm Sumoylation kMEsEEGkEARLARs P29590 K616-sm Sumoylation PLVFFDLkIDNETQk P29590 K183-ub Ubiquitination EFLDGTRktNNIFCs P29590 K380-ub Ubiquitination TDGFDEFkVRLQDLS P29590 K394-ub Ubiquitination SSCITQGkDAAVskk P29590 K400-ub Ubiquitination GkDAAVskkAsPEAA P29590 K401-ub Ubiquitination kDAAVskkAsPEAAs P29590 K476-ub Ubiquitination sNTTTAQkRKCsQtQ P29590 K497-ub Ubiquitination kMEsEEGkEARLARs P29590 K623-ub Ubiquitination kIDNETQkIsQLAAV

PTM - dbPTM UniProt ID Position Code Type Resources References P29590 8 S Phosphorylation Swiss-Prot 1010711 17081983;19015637 P29590 38 S Phosphorylation Swiss-Prot 1010711 19015637 P29590 65 K Sumoylation Swiss-Prot 1010711 9756909 P29590 117 S Phosphorylation Swiss-Prot 1010711 12402044 P29590 160 K Sumoylation Swiss-Prot 1010711 9756909 P29590 380 K Ubiquitylation Swiss-Prot 1010711 18408734 P29590 400 K Ubiquitylation Swiss-Prot 1010711 18408734 P29590 401 K Ubiquitylation Swiss-Prot 1010711 18408734 P29590 403 S Phosphorylation Swiss-Prot 1010711 17081983;18669648;19007248 P29590 409 T Phosphorylation Swiss-Prot 1010711 18669648 P29590 476 K Ubiquitylation Swiss-Prot 1010711 18408734 P29590 490 K Sumoylation Swiss-Prot 1010711 9756909 P29590 504 S Phosphorylation Swiss-Prot 1010711 19007248 P29590 505 S Phosphorylation Swiss-Prot 1010711 17287340 P29590 512 S Phosphorylation Swiss-Prot 1010711 17287340 P29590 518 S Phosphorylation Swiss-Prot 1010711 17081983;18669648 P29590 527 S Phosphorylation Swiss-Prot 1010711 17081983;18669648 P29590 530 S Phosphorylation Swiss-Prot 1010711 17081983;18669648;19690332 P29590 535 S Phosphorylation Swiss-Prot 1010711 17081983 P29590 560 S Phosphorylation Swiss-Prot 1010711 17081983 P29590 561 S Phosphorylation Swiss-Prot 1010711 17081983 P29590 562 S Phosphorylation Swiss-Prot 1010711 17081983 P29590 565 S Phosphorylation Swiss-Prot 1010711 17081983 P29590 867 T Phosphorylation Swiss-Prot 1010711 19690332 P29590 403 S Phosphorylation PhosphoELM.10011 18669648 P29590 505 S Phosphorylation PhosphoELM.10011 17287340 P29590 512 S Phosphorylation PhosphoELM.10011 17287340 P29590 518 S Phosphorylation PhosphoELM.10011 18669648 P29590 527 S Phosphorylation PhosphoELM.10011 18669648 P29590 530 S Phosphorylation PhosphoELM.10011 18669648;17081983 P29590 535 S Phosphorylation PhosphoELM.10011 18669648 P29590 578 S Phosphorylation PhosphoELM.10011 17081983 P29590 579 S Phosphorylation PhosphoELM.10011 17081983 P29590 580 S Phosphorylation PhosphoELM.10011 17081983 P29590 38 S Phosphorylation PhosphoELM.10011 19015637 P29590 409 T Phosphorylation PhosphoELM.10011 18669648 P29590 160 K Sumoylation Phosphositeplus.1010730 11413191;12759344;12885887;15710327;16608850;17989716;18408733;19106612;19380586;20205709;9756909 P29590 380 K Sumoylation Phosphositeplus.1010730 21098080 P29590 400 K Sumoylation Phosphositeplus.1010730 21098080 P29590 487 K Sumoylation Phosphositeplus.1010730 9885291 P29590 490 K Sumoylation Phosphositeplus.1010730 12759344;16608850;17989716;18408733;19106612;19380586;20205709;20797634;21098080;9756909;9885291 P29590 497 K Sumoylation Phosphositeplus.1010730 21098080 P29590 65 K Sumoylation Phosphositeplus.1010730 12759344;16608850;17989716;18408733;19106612;19380586;9756909 P29590 380 K Ubiquitylation Phosphositeplus.1010730 21906983 P29590 394 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P29590 400 K Ubiquitylation Phosphositeplus.1010730 21906983 P29590 401 K Ubiquitylation Phosphositeplus.1010730 18408733;21906983 P29590 476 K Ubiquitylation Phosphositeplus.1010730 21906983 P29590 497 K Ubiquitylation Phosphositeplus.1010730 21906983 P29590 623 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 P29590 487 K Acetylation Phosphositeplus.1010730 18621739 P29590 515 K Acetylation Phosphositeplus.1010730 18621739 P29590 36 S Phosphorylation Phosphositeplus.1010730 19015637;19664995;20164059;20363803;21659604 P29590 38 S Phosphorylation Phosphositeplus.1010730 19015637;19664995;21659604 P29590 40 S Phosphorylation Phosphositeplus.1010730 21659604 P29590 403 S Phosphorylation Phosphositeplus.1010730 18669648;18707149;20068231;20164059;20166139;20832753;22115753 P29590 504 S Phosphorylation Phosphositeplus.1010730 20164059;20363803 P29590 505 S Phosphorylation Phosphositeplus.1010730 17287340;17989716;18707149;20363803 P29590 512 S Phosphorylation Phosphositeplus.1010730 17287340 P29590 518 S Phosphorylation Phosphositeplus.1010730 17081983;17989716;18669648;19690332;20058876;20068231;20164059;20166139;20363803;21406692;21659604;21840486;22115753 P29590 527 S Phosphorylation Phosphositeplus.1010730 17081983;17989716;18669648;19690332;20058876;20068231;20164059;20166139;20363803;21406692;21659604;22115753 P29590 530 S Phosphorylation Phosphositeplus.1010730 17989716;18669648;19690332;20166139;21406692 P29590 560 S Phosphorylation Phosphositeplus.1010730 19217413;19380586;20363803;21406692 P29590 561 S Phosphorylation Phosphositeplus.1010730 19217413;19380586;20363803;21406692 P29590 562 S Phosphorylation Phosphositeplus.1010730 19217413;19380586;20363803;21406692 P29590 565 S Phosphorylation Phosphositeplus.1010730 16873060;19217413;19380586;20164059;20363803;21406692;22115753 P29590 578 S Phosphorylation Phosphositeplus.1010730 22115753 P29590 580 S Phosphorylation Phosphositeplus.1010730 22115753 P29590 583 S Phosphorylation Phosphositeplus.1010730 22115753 P29590 625 S Phosphorylation Phosphositeplus.1010730 20068231 P29590 8 S Phosphorylation Phosphositeplus.1010730 17081983;19015637;21406692 P29590 409 T Phosphorylation Phosphositeplus.1010730 20832753 P29590 867 T Phosphorylation Phosphositeplus.1010730 19690332;22115753 P29590 36 S Phosphorylation HPRD 9.0 19664995,19651622,20068231 P29590 38 S Phosphorylation HPRD 9.0 19664995 P29590 40 S Phosphorylation HPRD 9.0 19651622,20068231 P29590 117 S Phosphorylation HPRD 9.0 20068231 P29590 403 S Phosphorylation HPRD 9.0 17081983,18669648,19007248,19651622,18707149,20166139,20068231 P29590 403 S Phosphorylation HPRD 9.0 19007248,19651622,18707149,20166139 P29590 504 S Phosphorylation HPRD 9.0 19007248,19651622 P29590 505 S Phosphorylation HPRD 9.0 17081983,17287340 P29590 512 S Phosphorylation HPRD 9.0 17081983,19651622 P29590 512 S Phosphorylation HPRD 9.0 17287340,20068231 P29590 514 S Phosphorylation HPRD 9.0 17081983,19651622 P29590 518 S Phosphorylation HPRD 9.0 17081983,18669648,19651622,20166139,20068231,20058876 P29590 527 S Phosphorylation HPRD 9.0 17081983,18669648,19651622,20166139,20068231,20058876 P29590 530 S Phosphorylation HPRD 9.0 17081983 P29590 530 S Phosphorylation HPRD 9.0 17081983,18212344 P29590 530 S Phosphorylation HPRD 9.0 17081983,18669648,19651622,18452278,20166139,20068231 P29590 535 S Phosphorylation HPRD 9.0 17081983 P29590 535 S Phosphorylation HPRD 9.0 18669648,18452278 P29590 560 S Phosphorylation HPRD 9.0 17081983,19651622 P29590 560 S Phosphorylation HPRD 9.0 19651622 P29590 561 S Phosphorylation HPRD 9.0 17081983,19651622 P29590 561 S Phosphorylation HPRD 9.0 19651622 P29590 562 S Phosphorylation HPRD 9.0 17081983,19651622 P29590 562 S Phosphorylation HPRD 9.0 19651622 P29590 565 S Phosphorylation HPRD 9.0 17081983,19651622 P29590 565 S Phosphorylation HPRD 9.0 19651622 P29590 578 S Phosphorylation HPRD 9.0 17081983 P29590 579 S Phosphorylation HPRD 9.0 17081983 P29590 580 S Phosphorylation HPRD 9.0 17081983 P29590 582 S Phosphorylation HPRD 9.0 17081983 P29590 583 S Phosphorylation HPRD 9.0 17081983 P29590 625 S Phosphorylation HPRD 9.0 20068231 P29590 409 T Phosphorylation HPRD 9.0 18669648 P29590 513 T Phosphorylation HPRD 9.0 17081983,20068231 P29590 226 K Sumoylation HPRD 9.0 17000644 P29590 490 K Sumoylation HPRD 9.0 17000644 P29590 616 K Sumoylation HPRD 9.0 17000644 P29590 65 K Sumoylation HPRD 9.0 9756909 P29590 160 K Sumoylation HPRD 9.0 9756909 P29590 490 K Sumoylation HPRD 9.0 9756909,17000644 P29590 403 S Phosphorylation SysPTM 1.1 17081983;18669648;18707149 P29590 505 S Phosphorylation SysPTM 1.1 17287340;18707149 P29590 512 S Phosphorylation SysPTM 1.1 17287340 P29590 518 S Phosphorylation SysPTM 1.1 18669648 P29590 527 S Phosphorylation SysPTM 1.1 18669648 P29590 530 S Phosphorylation SysPTM 1.1 18669648 P29590 409 T Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References PML 117 S Phosphorylation 20068231 PML 160 K Sumoylation 9756909 PML 226 K Sumoylation 17000644 PML 36 S Phosphorylation 19664995,19651622,20068231 PML 38 S Phosphorylation 19664995 PML 40 S Phosphorylation 19651622,20068231 PML 403 S Phosphorylation 17081983,18669648,19007248,19651622,18707149,20166139,20068231 PML 403 S Phosphorylation 19007248,19651622,18707149,20166139 PML 409 T Phosphorylation 18669648 PML 442 K Sumoylation 9756909,17000644 PML 456 S Phosphorylation 19007248,19651622 PML 457 S Phosphorylation 17081983,17287340 PML 464 S Phosphorylation 17287340,20068231 PML 465 T Phosphorylation 17081983,20068231 PML 470 S Phosphorylation 17081983,18669648,19651622,20166139,20068231,20058876 PML 479 S Phosphorylation 17081983,18669648,19651622,20166139,20068231,20058876 PML 482 S Phosphorylation 17081983,18669648,19651622,18452278,20166139,20068231 PML 487 S Phosphorylation 18669648,18452278 PML 490 K Sumoylation 17000644 PML 490 K Sumoylation 9756909,17000644 PML 504 S Phosphorylation 19007248,19651622 PML 505 S Phosphorylation 17081983,17287340 PML 512 S Phosphorylation 17081983,19651622 PML 512 S Phosphorylation 17287340,20068231 PML 513 S Phosphorylation 17081983,19651622 PML 513 T Phosphorylation 17081983,20068231 PML 514 S Phosphorylation 17081983,19651622 PML 517 S Phosphorylation 17081983,19651622 PML 518 S Phosphorylation 17081983,18669648,19651622,20166139,20068231,20058876 PML 527 S Phosphorylation 17081983,18669648,19651622,20166139,20068231,20058876 PML 530 S Phosphorylation 17081983 PML 530 S Phosphorylation 17081983,18212344 PML 530 S Phosphorylation 17081983,18669648,19651622,18452278,20166139,20068231 PML 531 S Phosphorylation 17081983 PML 532 S Phosphorylation 17081983 PML 534 S Phosphorylation 17081983 PML 535 S Phosphorylation 17081983 PML 535 S Phosphorylation 18669648,18452278 PML 560 S Phosphorylation 17081983,19651622 PML 560 S Phosphorylation 19651622 PML 561 S Phosphorylation 17081983,19651622 PML 561 S Phosphorylation 19651622 PML 562 S Phosphorylation 17081983,19651622 PML 562 S Phosphorylation 19651622 PML 565 S Phosphorylation 17081983,19651622 PML 565 S Phosphorylation 19651622 PML 568 K Sumoylation 17000644 PML 578 S Phosphorylation 17081983 PML 579 S Phosphorylation 17081983 PML 580 S Phosphorylation 17081983 PML 582 S Phosphorylation 17081983 PML 583 S Phosphorylation 17081983 PML 616 K Sumoylation 17000644 PML 625 S Phosphorylation 20068231 PML 65 K Sumoylation 9756909

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type P29590 512 S 17287340 HTP Phosphorylation P29590 409 T 18669648 HTP Phosphorylation P29590 535 S 18669648 HTP Phosphorylation P29590 403 S 18669648 HTP Phosphorylation P29590 580 S 17081983 HTP Phosphorylation P29590 579 S 17081983 HTP Phosphorylation P29590 578 S 17081983 HTP Phosphorylation P29590 38 S 19015637 HIPK2 LTP Phosphorylation P29590 530 S 18669648 HTP Phosphorylation P29590 530 S 17081983 HTP Phosphorylation P29590 527 S 18669648 HTP Phosphorylation P29590 518 S 18669648 HTP Phosphorylation P29590 505 S 17287340 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs P29590 8 Phosphoserine; by HIPK2 24275569;19015637 P29590 28 Phosphothreonine; by MAPK1 15195100 P29590 36 Phosphoserine; by HIPK2 and MAPK1 23186163;24275569;15195100 P29590 38 Phosphoserine; by HIPK2 and MAPK1 23186163;19015637 P29590 40 Phosphoserine; by MAPK1 15195100 P29590 42 Phosphothreonine 15195100 P29590 48 Phosphoserine 23186163 P29590 117 Phosphoserine; by CHEK2 12402044 P29590 403 Phosphoserine; by MAPK1 and MAPK7 17081983;18669648;23186163;24275569;22033920 P29590 409 Phosphothreonine; by MAPK7 15195100 P29590 487 N6-acetyllysine; alternate 18621739;22274616 P29590 505 Phosphoserine; by MAPK1 23186163;22033920 P29590 512 Phosphoserine 23186163 P29590 515 N6-acetyllysine 18621739 P29590 518 Phosphoserine; by CDK1 and CDK2 17081983;18669648;20068231;21406692;23186163;24275569;21840486;22033920 P29590 527 Phosphoserine; by MAPK1 17081983;18669648;20068231;21406692;23186163;24275569;22033920 P29590 530 Phosphoserine; by MAPK1 17081983;18669648;19690332;21406692;23186163;24275569 P29590 535 Phosphoserine 15195100 P29590 565 Phosphoserine; by CK2 22406621 P29590 867 Phosphothreonine 23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type PML IPI00022348 S 36 SEGRQPpSPSPSPT phosphorylation PML IPI00022348 S 38 GRQPSPpSPSPTER phosphorylation PML IPI00022348 S 40 QPSPSPpSPTERAP phosphorylation PML IPI00022348 S 403 AVSKKApSPEAAST phosphorylation PML IPI00022348 S 518 STSKAVpSPPHLDG phosphorylation PML IPI00022348 S 527 HLDGPPpSPRSPVI phosphorylation PML IPI00022348 S 530 GPPSPRpSPVIGSE phosphorylation PML IPI00022348 S 542 EVFLPNpSNHVASG phosphorylation PML IPI00022348 S 547 NSNHVApSGAGEAE phosphorylation PML IPI00022348 S 560 ERVVVIpSSSEDSD phosphorylation PML IPI00022348 S 561 RVVVISpSSEDSDA phosphorylation PML IPI00022348 S 562 VVVISSpSEDSDAE phosphorylation PML IPI00022348 S 565 ISSSEDpSDAENSS phosphorylation PML IPI00022348 S 578 SRELDDpSSSESSD phosphorylation PML IPI00022348 S 579 RELDDSpSSESSDL phosphorylation PML IPI00022348 S 580 ELDDSSpSESSDLQ phosphorylation PML IPI00022348 S 625 NETQKIpSQLAAVN phosphorylation PML IPI00022348 S 8 EPAPARpSPRPQQD phosphorylation PML IPI00181058 S 403 AVSKKApSPEAAST phosphorylation PML IPI00303999 S 560 ERVVVIpSSSEDSD phosphorylation PML IPI00303999 S 561 RVVVISpSSEDSDA phosphorylation PML IPI00303999 S 562 VVVISSpSEDSDAE phosphorylation PML IPI00303999 S 565 ISSSEDpSDAENSV phosphorylation PML IPI00337754 S 530 GPPSPRpSPVIGSE phosphorylation PML IPI00337754 S 535 RSPVIGpSEVFLPN phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 5371 111384 - K Sumoylation 9452416 5371 111384 - K Ubiquitination 18708055 5371 111384 - K Sumoylation 18625722 5371 111384 - K Ubiquitination 19325566 5371 111384 - K Sumoylation 21779164 5371 111384 - K Sumoylation 20972456 5371 111384 - K Sumoylation 21057547 5371 111384 - K Sumoylation 21693764 5371 111384 - K Ubiquitination 21139048 5371 111384 - K Ubiquitination 21890473 5371 111384 - K Ubiquitination 21906983 5371 111384 - K Sumoylation 19471022 5371 111384 - K Sumoylation 21252943 5371 111384 - K Sumoylation 9427741 5371 111384 - K Sumoylation 22406621 5371 111384 - K Ubiquitination 22406621 5371 111384 - K Sumoylation 19553342 5371 111384 - K Ubiquitination 19553342 5371 111384 - K Sumoylation 17081986 5371 111384 - K Sumoylation 19380586 5371 111384 - K Ubiquitination 21900687 5371 111384 - K Sumoylation 20797634 5371 111384 - K Sumoylation 17000875 5371 111384 - K Sumoylation 22155184 5371 111384 - K Ubiquitination 21305000 5371 111384 - K Sumoylation 21305000 5371 111384 - K Sumoylation 11160742 5371 111384 - K Sumoylation 16501610 5371 111384 - K Sumoylation 20826694 5371 111384 - K Sumoylation 20188669 5371 111384 - K Sumoylation 15940266 5371 111384 - K Sumoylation 17027752 5371 111384 - K Sumoylation 19015637 5371 111384 - K Sumoylation 15017387 5371 111384 - K Sumoylation 15576338 5371 111384 - K Sumoylation 23028697 5371 111384 - K Ubiquitination 22505724 5371 111384 - K Sumoylation 17000644 5371 111384 - K Sumoylation 17036045 5371 111384 - K Ubiquitination 21840486 5371 111384 - K Ubiquitination 16873060 5371 111384 - K Ubiquitination 21963094 5371 111384 - K Ubiquitination 23000965 5371 111384 - K Sumoylation 23543742 5371 111384 - K Sumoylation 23604351 5371 111384 - K Sumoylation 23830076 5371 111384 - K Sumoylation 24654937 5371 111384 - K Ubiquitination 24816145 5371 111384 - K Ubiquitination 24637324 5371 111384 - K Sumoylation 25027693 5371 111384 - K Ubiquitination 25015289 5371 111384 - K Ubiquitination 25147182 5371 111384 - K Sumoylation 21148299 5371 111384 - K Sumoylation 16608850 5371 111384 - K Sumoylation 25391492 5371 111384 - K Sumoylation 25410875 5371 111384 - K Sumoylation 18474224 5371 111384 - K Sumoylation 18708055 5371 111384 - K Sumoylation 9412458 5371 111384 - K Ubiquitination 24190887 5371 111384 - K Sumoylation 24190887 5371 111384 - K Sumoylation 22578841 5371 111384 - K Sumoylation 21098080

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID PML Homo sapiens (Human) 394; 90 "394,SCITQGKDAAVSK; 90,SCITQGKDAAVSK" "394:21906983,21890473; 428:21906983; 380:21906983; 400:21906983; 401:21906983; 449:21906983" PML Homo sapiens (Human) 394 "394,SCITQGKDAAVSK" 394:21890473 PML Homo sapiens (Human) 394 "394,SCITQGKDAAVSK" 394:21890473 PML Homo sapiens (Human) 394 "394,SCITQGKDAAVSK" 394:21890473 PML Homo sapiens (Human) 394; 380; 400; 497 "394,SCITQGKDAAVSK; 380,DGFDEFKVRLQDL; 400,KDAAVSKKASPEA; 497,MESEEGKEARLAR" "394:21906983,21890473; 380:21906983; 400:21906983; 497:21906983" PML Homo sapiens (Human) 394 "394,SCITQGKDAAVSK" 394:21890473 PML Homo sapiens (Human) 394 "394,SCITQGKDAAVSK" 394:21890473 PML Homo sapiens (Human) 394; 623 "394,SCITQGKDAAVSK; 623,IDNETQKISQLAA" 394:21890473; 623:21890473 PML Homo sapiens (Human) 394 "394,SCITQGKDAAVSK" 394:21890473 PML Homo sapiens (Human) 394; 560 "394,SCITQGKDAAVSK; 560,IDNETQKISQLAA" 394:21890473; 560:21890473 PML Homo sapiens (Human) 394 "394,SCITQGKDAAVSK" 394:21890473 PML Homo sapiens (Human) 152; 172; 166 "152,DGFDEFKVRLQDL; 172,KDAAVSKKASPEA; 166,SCITQGKDAAVSK" 152:21906983; 172:21906983; 166:21906983 PML Homo sapiens (Human) 394; 476; 380; 400; 401; 497 "394,SCITQGKDAAVSK; 476,NTTTAQKRKCSQT; 380,DGFDEFKVRLQDL; 400,KDAAVSKKASPEA; 401,DAAVSKKASPEAA; 497,MESEEGKEARLAR" "394:21890473,21906983; 476:21906983; 380:21906983; 400:21906983; 401:21906983; 497:21906983" PML Homo sapiens (Human) 394; 476; 380; 400; 401; 497 "394,SCITQGKDAAVSK; 476,NTTTAQKRKCSQT; 380,DGFDEFKVRLQDL; 400,KDAAVSKKASPEA; 401,DAAVSKKASPEAA; 497,MESEEGKEARLAR" "394:21890473,21906983; 476:21906983; 380:21906983; 400:21906983; 401:21906983; 497:21906983" PML Homo sapiens (Human) 394; 476; 380; 400; 401; 497; 623 "394,SCITQGKDAAVSK; 476,NTTTAQKRKCSQT; 380,DGFDEFKVRLQDL; 400,KDAAVSKKASPEA; 401,DAAVSKKASPEAA; 497,MESEEGKEARLAR; 623,IDNETQKISQLAA" "394:21890473,21906983; 476:21906983; 380:21906983; 400:21906983; 401:21906983; 497:21906983; 623:21890473,21906983" PML Homo sapiens (Human) 394; 560; 380; 400; 434 "394,SCITQGKDAAVSK; 560,IDNETQKISQLAA; 380,DGFDEFKVRLQDL; 400,KDAAVSKKASDVS; 434,MESEEGKEARLAR" "394:21890473,21906983; 560:21890473,21906983; 380:21906983; 400:21906983; 434:21906983" PML Homo sapiens (Human) 394; 476; 380; 400; 401; 497; 623 "394,SCITQGKDAAVSK; 476,NTTTAQKRKCSQT; 380,DGFDEFKVRLQDL; 400,KDAAVSKKASPEA; 401,DAAVSKKASPEAA; 497,MESEEGKEARLAR; 623,IDNETQKISQLAA" "394:21890473,21906983; 476:21906983; 380:21906983; 400:21906983; 401:21906983; 497:21906983; 623:21890473,21906983" PML Homo sapiens (Human) 394; 476; 380; 400; 401; 497 "394,SCITQGKDAAVSK; 476,NTTTAQKRKCSQT; 380,DGFDEFKVRLQDL; 400,KDAAVSKKASPEA; 401,DAAVSKKASPEAA; 497,MESEEGKEARLAR" "394:21890473,21906983; 476:21906983; 380:21906983; 400:21906983; 401:21906983; 497:21906983" PML Homo sapiens (Human) 394; 476; 380; 400; 401; 497 "394,SCITQGKDAAVSK; 476,NTTTAQKRKCSQT; 380,DGFDEFKVRLQDL; 400,KDAAVSKKASPEA; 401,DAAVSKKASPEAA; 497,MESEEGKEARLAR" "394:21890473,21906983; 476:21906983; 380:21906983; 400:21906983; 401:21906983; 497:21906983" PML Homo sapiens (Human) 394; 623 "394,SCITQGKDAAVSK; 623,IDNETQKISQLAA" 394:21890473; 623:21890473 PML Homo sapiens (Human) 394 "394,SCITQGKDAAVSK" 394:21890473 PML Homo sapiens (Human) 394 "394,SCITQGKDAAVSK" 394:21890473 PML Homo sapiens (Human) 394; 560 "394,SCITQGKDAAVSK; 560,IDNETQKISQLAA" 394:21890473; 560:21890473 PML Homo sapiens (Human) 394; 350; 330; 344 "394,SCITQGKDAAVSK; 350,KDAAVSKKASPEA; 330,DGFDEFKVRLQDL; 344,SCITQGKDAAVSK" 394:21890473; 350:21906983; 330:21906983; 344:21906983 PML Homo sapiens (Human) 394 "394,SCITQGKDAAVSK" 394:21890473 PML Homo sapiens (Human) 394; 560 "394,SCITQGKDAAVSK; 560,IDNETQKISQLAA" 394:21890473; 560:21890473 PML Homo sapiens (Human) 394 "394,SCITQGKDAAVSK" 394:21890473