Disease associated variation - GWASdb Chr Pos SNP ID(dbSNP 142) Ref Alt Ori SNP ID P-value Drug Name Drug Anno GWAS Trait HPO ID DO ID AA Type Trait or Drug 17 46233490 rs11079811 G A rs11079811 9.98E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 G intron GWASdb_drug 17 46259254 rs12948653 C A rs12948653 1.41E-04 NICOTINE|BUPROPION NICOTINIC AGONISTS|ANTIDEPRESSIVE AGENTS, SECOND-GENERATION Smoking cessation HPOID:0000707 DOID:0050742 C intron GWASdb_drug 17 46260674 rs10514935 T C rs10514935 1.51E-04 NICOTINE|BUPROPION NICOTINIC AGONISTS|ANTIDEPRESSIVE AGENTS, SECOND-GENERATION Smoking cessation HPOID:0000707 DOID:0050742 T intron GWASdb_drug 17 46260674 rs10514935 T C rs10514935 1.52E-04 NICOTINE|BUPROPION NICOTINIC AGONISTS|ANTIDEPRESSIVE AGENTS, SECOND-GENERATION Smoking cessation HPOID:0000707 DOID:0050742 T intron GWASdb_drug 17 46319852 rs2938484 C T rs2938484 4.53E-04 ALDOSTERONE BIOLOGICAL MARKERS|NATRIURETIC PEPTIDE, BRAIN|RENIN Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 C intron GWASdb_drug 17 46356364 rs9905961 T A rs9905961 4.62E-05 NICOTINE|BUPROPION NICOTINIC AGONISTS|ANTIDEPRESSIVE AGENTS, SECOND-GENERATION Smoking cessation HPOID:0000707 DOID:0050742 T intron GWASdb_drug 17 46356364 rs9905961 T A rs9905961 4.82E-04 NICOTINE|BUPROPION NICOTINIC AGONISTS|ANTIDEPRESSIVE AGENTS, SECOND-GENERATION Smoking cessation HPOID:0000707 DOID:0050742 T intron GWASdb_drug 17 46373671 rs7221510 C T rs7221510 8.59E-05 METHOTREXATE POLYGLUTAMIC ACID|ANTIMETABOLITES, ANTINEOPLASTIC|DOPA DECARBOXYLASE|MKL1 PROTEIN, HUMAN|IKAROS TRANSCRIPTION FACTOR|ARID5B PROTEIN, HUMAN|TRANSCRIPTION FACTORS|IKZF1 PROTEIN, HUMAN|ONCOGENE PROTEINS, FUSION|DNA-BINDING PROTEINS Acute lymphoblastic leukemia (childhood) HPOID:0006721 DOID:9952|DOID:12603 T intron GWASdb_drug 17 46217457 rs8071879 G A rs8071879 3.22E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 A intron GWASdb_trait 17 46218545 rs2325804 G A rs2325804 3.21E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 A intron GWASdb_trait 17 46229691 rs208009 C T rs208009 3.07E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 A intron GWASdb_trait 17 46230838 rs208008 C T rs208008 5.30E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 A intron GWASdb_trait 17 46239985 rs208005 A G rs208005 3.05E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 C intron GWASdb_trait 17 46246894 rs3805366 C T rs3805366 7.09E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 C intron GWASdb_trait 17 46248994 rs12603115 C T rs12603115 4.18E-04 Lung function (forced expiratory flow between 25% and 75% of forced vital capacity) HPOID:0002088 DOID:850 C intron GWASdb_trait 17 46253263 rs3805368 G A rs3805368 2.23E-04 Suicide attempts in bipolar disorder HPOID:0007302 DOID:3312 G intron GWASdb_trait 17 46259254 rs12948653 C A rs12948653 1.41E-04 Smoking cessation HPOID:0000707 DOID:0050742 C intron GWASdb_trait 17 46260674 rs10514935 T C rs10514935 1.51E-04 Smoking cessation HPOID:0000707 DOID:0050742 T intron GWASdb_trait 17 46260674 rs10514935 T C rs10514935 1.52E-04 Smoking cessation HPOID:0000707 DOID:0050742 T intron GWASdb_trait 17 46293386 rs1452663 C G rs1452663 5.65E-04 Type 2 diabetes HPOID:0005978 DOID:9352 C intron GWASdb_trait 17 46293386 rs1452663 C G rs1452663 2.44E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 C intron GWASdb_trait 17 46296204 rs16953941 C A rs16953941 5.65E-04 Type 2 diabetes HPOID:0005978 DOID:9352 C intron GWASdb_trait 17 46296204 rs16953941 C A rs16953941 2.43E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 C intron GWASdb_trait 17 46309546 rs1979897 C T rs1979897 2.30E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 C intron GWASdb_trait 17 46319546 rs16954268 G A rs16954268 2.25E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 G intron GWASdb_trait 17 46319852 rs2938484 C T rs2938484 4.53E-04 Blood pressure, CVD RF and other traits (body mass index (BMI), waist:hip ratio, renin activity in plasma, aldosterone concentration in plasma, BNP levels in plasma, alcohol consumption) HPOID:0011025 DOID:10763 C intron GWASdb_trait 17 46324584 rs16954324 C T rs16954324 4.83E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 C intron GWASdb_trait 17 46328398 rs17620866 C G rs17620866 2.19E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 C intron GWASdb_trait 17 46328667 rs8081754 G A rs8081754 0.0000117 LDL cholesterol HPOID:0010979 DOID:1936|DOID:3393 G intron GWASdb_trait 17 46334294 rs17694092 A G rs17694092 2.33E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 A intron GWASdb_trait 17 46336112 rs979746 A C rs979746 9.96E-04 Alzheimer's disease HPOID:0002511 DOID:10652 C intron GWASdb_trait 17 46348354 rs17694404 G A rs17694404 2.53E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 G intron GWASdb_trait 17 46356364 rs9905961 T A rs9905961 4.62E-05 Smoking cessation HPOID:0000707 DOID:0050742 T intron GWASdb_trait 17 46356364 rs9905961 T A rs9905961 4.82E-04 Smoking cessation HPOID:0000707 DOID:0050742 T intron GWASdb_trait 17 46357120 rs2084881 G A rs2084881 2.00E-06 Ovarian cancer HPOID:0100615 DOID:2394 G intron GWASdb_trait 17 46358952 rs17621689 T G rs17621689 5.13E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 T intron GWASdb_trait 17 46373671 rs7221510 C T rs7221510 8.59E-05 Acute lymphoblastic leukemia (childhood) HPOID:0006721 DOID:9952|DOID:12603 T intron GWASdb_trait 17 46394050 rs7218167 G A rs7218167 2.00E-05 Asperger disorder HPOID:0000717 DOID:0050432 G intron GWASdb_trait 17 46398352 rs10514944 G A rs10514944 4.30E-04 Type 2 diabetes HPOID:0005978 DOID:9352 G intron GWASdb_trait 17 46398352 rs10514944 G A rs10514944 5.21E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 G intron GWASdb_trait 17 46411500 rs9303542 A G rs9303542 1.00E-06 Ovarian cancer HPOID:0100615 DOID:2394 A intron GWASdb_trait 17 46411500 rs9303542 A G rs9303542 3.00E-10 Ovarian cancer HPOID:0100615 DOID:2394 A intron GWASdb_trait 17 46411500 rs9303542 A G rs9303542 6.00E-09 Ovarian cancer HPOID:0100615 DOID:2394 A intron GWASdb_trait 17 46430565 rs17623416 A C rs17623416 5.17E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 A intron GWASdb_trait 17 46438150 rs17623518 G A rs17623518 1.72E-04 Type 2 diabetes HPOID:0005978 DOID:9352 G intron GWASdb_trait 17 46438150 rs17623518 G A rs17623518 5.55E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 G intron GWASdb_trait 17 46445993 rs16955960 T G rs16955960 1.61E-04 Type 2 diabetes HPOID:0005978 DOID:9352 T intron GWASdb_trait 17 46445993 rs16955960 T G rs16955960 5.40E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 T intron GWASdb_trait 17 46497274 rs16956501 G C rs16956501 3.23E-04 Type 2 diabetes HPOID:0005978 DOID:9352 G intron GWASdb_trait 17 46497274 rs16956501 G C rs16956501 6.23E-04 Depression (quantitative trait) HPOID:0000716 DOID:1596 G intron GWASdb_trait

Disease associated variation - OMIM Ensembl_gene_ID Approved Gene Symbol MIM Number ENSG00000141293.15 SKAP1 604969