PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CCT5 WRAP53 26496610,25467444 biogrid,intact exp G GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PTGES3 WRAP53 22939629 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CCT8 WRAP53 26496610,25467444 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G FAM43A WRAP53 26186194 biogrid exp G GP G G GP G G GP G G GP G G G G G G G GP G GP G G GP G G G G G PTPN1 WRAP53 26496610 biogrid,intact exp GP GP G G GP G G G GP G GP GP GP GP G GP G GP GP G GP GP GP G GP GP GP GP G CCT4 WRAP53 26496610,25467444 biogrid,intact exp GP GP G G G GP G G GP G GP G G GP G G GP GP G G GP G G G G G GP GP G KPNB1 WRAP53 21072240 dip exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CCT3 WRAP53 26496610,25467444 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZFHX3 WRAP53 26496610 biogrid,intact exp GP GP G G G GP G GP GP G GP G G GP G GP GP GP G G GP G GP GP GP G GP GP G RBBP7 WRAP53 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DKC1 WRAP53 26496610,25467444,19179534 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P P WRAP53 DDX20 21072240 dip exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G USP11 WRAP53 22939629 biogrid exp G GP G G G GP G G GP G GP G G G G G GP G G G G G G G G G G GP G SNRPC WRAP53 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G PRPF38B WRAP53 26496610 biogrid,intact exp GP G G G GP GP G GP GP G G G GP GP G GP GP G G G G G GP G GP GP GP G G WAPAL WRAP53 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G H2AFX WRAP53 25512560 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MDC1 WRAP53 25512560 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MYBPH WRAP53 26496610 biogrid,intact exp G PRPF4 WRAP53 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WRAP53 WRAP53 21072240,25467444,19179534 intact,dip exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WRAP53 POLG2 26496610 biogrid,intact exp GP GP G G GP GP G G GP G GP GP GP G G GP GP GP GP G P GP GP GP GP G GP GP G CCT2 WRAP53 26496610,25467444 biogrid,intact exp GP GP G G GP GP G GP GP G G GP GP GP G GP GP G GP G GP GP G G GP GP GP GP G MRPL14 WRAP53 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP G GP GP GP GP GP GP G RNF8 WRAP53 25512560 biogrid exp GP GP G G G GP G GP GP G GP G G G G GP GP G GP G G G GP G GP G GP GP G SMN1, SMN2 WRAP53 21072240 dip exp P P P P P P P P P P P P P P P P P P P P RXRB WRAP53 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TNPO1 WRAP53 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WRAP53 GAR1 26186194,26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TERT WRAP53 19179534 intact exp G G G G G G G HNRNPU WRAP53 26344197 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G WRAP53 STK24 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TCP1 WRAP53 26496610,25467444 biogrid,intact exp P P P P P P P P P P P P P P P P P P P P P P NDUFV3 WRAP53 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G COIL WRAP53 21072240 dip exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP G GP GP G GP GP G CCT7 WRAP53 26496610,25467444 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CNTROB WRAP53 26496610 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CCT6A WRAP53 26496610,25467444 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G XPC WRAP53 22939629 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RAP1B WRAP53 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WRAP53 INO80 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PIGS WRAP53 ortho G GP G G GP GP G GP G G GP GP GP G G G GP GP GP G GP GP G G G GP GP GP G ATP1B2 WRAP53 21836163 pred G G G G G GP G GP G G G GP G G G G GP G G G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9BUR4 O43172-2 biochemical 22939629 colocalization X 2 Q9BUR4 A0A024RB32 biochemical 22939629 colocalization X 2 Q9BUR4 P09234 biochemical 22939629 colocalization X 2 Q9BUR4 P51784 biochemical 22939629 colocalization X 2 Q9BUR4 Q92973-2 biochemical 22939629 colocalization X 2 Q9BUR4 P0CG48 affinity chromatography technology 21963094 physical association X 2 Q9BUR4 P0CG48 affinity chromatography technology 25147182 physical association X 2 Q9BUR4 Q9D0T1 affinity chromatography technology 20360068 physical association X 2 Q9BUR4 Q01831-3 biochemical 22939629 colocalization X 2 Q9BUR4 Q7Z5K2 biochemical 22939629 colocalization X 2 Q9BUR4 Q16576 biochemical 22939629 colocalization X 2 Q9BUR4 anti bait coimmunoprecipitation 21072240 - C 3 Q9BUR4 anti bait coimmunoprecipitation 21072240 - C 3 Q9BUR4 Q9BUR4 anti tag coimmunoprecipitation 21072240 physical association Y 1 Q9BUR4 Q9BUR4 anti tag coimmunoprecipitation 21072240 physical association Y 1 Q9BUR4 Q9BUR4 anti tag coimmunoprecipitation 21072240 physical association Y 1 Q9BUR4 P38432 anti bait coimmunoprecipitation 21072240 physical association X 2 Q9BUR4 P38432 anti bait coimmunoprecipitation 21072240 physical association X 2 Q9BUR4 P38432 anti bait coimmunoprecipitation 21072240 physical association X 2 Q9BUR4 P38432 anti tag coimmunoprecipitation 21072240 physical association X 2 Q9BUR4 Q9UHI6 anti bait coimmunoprecipitation 21072240 physical association X 2 Q9BUR4 Q14974 anti bait coimmunoprecipitation 21072240 physical association X 2 Q9BUR4 Q14974 anti bait coimmunoprecipitation 21072240 physical association X 2 Q9BUR4 anti bait coimmunoprecipitation 21072240 - C 3 Q9BUR4 anti tag coimmunoprecipitation 21072240 - C 3 Q9BUR4 Q16637 anti tag coimmunoprecipitation 21072240 physical association X 2 Q9BUR4 Q16637 anti bait coimmunoprecipitation 21072240 physical association X 2 Q9BUR4 Q16637 anti bait coimmunoprecipitation 21072240 physical association X 2 Q9BUR4 Q16637 anti bait coimmunoprecipitation 21072240 physical association X 2 Q9BUR4 Q16637 anti bait coimmunoprecipitation 21072240 physical association X 2 Q9BUR4 tandem affinity purification 19179534 association C 9 Q9BUR4 anti tag coimmunoprecipitation 19179534 association C 5

PPI - HINT Gene A Gene B PMID Method Quality PRPF4 WRAP53 22939629 0401 HT DKC1 WRAP53 25416818,26496610,25467444,26496610,19179534,25416818,19179534,19179534 0004,0004,0007,0007,0676,0090,0006,0007 LC,HT RNF8 WRAP53 26734725,26734725,25512560 0428,0004,0004 LC SNRPC WRAP53 22939629 0401 HT H2AFX WRAP53 26734725,26734725,25512560 0428,0004,0004 LC TCP1 WRAP53 26496610,25467444,26496610,25467444 0007,0006,0004,0007 HT,LC PTPN1 WRAP53 26496610,26496610 0007,0004 HT RXRB WRAP53 26496610,26496610 0007,0004 HT CCT6A WRAP53 26496610,26496610,25467444 0007,0004,0007 HT,LC CCT5 WRAP53 26496610,25467444 0007,0007 HT,LC CCT3 WRAP53 26496610,25467444,25467444 0007,0006,0007 HT,LC CCT8 WRAP53 26496610,26496610,25467444 0007,0004,0007 HT,LC CCT4 WRAP53 26496610,26496610,25467444 0007,0004,0007 HT,LC USP11 WRAP53 22939629 0401 HT NDUFV3 WRAP53 26496610,26496610 0007,0004 HT RAP1B WRAP53 26496610,26496610 0007,0004 HT CCT2 WRAP53 26496610,25467444,25467444 0007,0006,0007 HT,LC XPC WRAP53 22939629 0401 HT MYBPH WRAP53 26496610,26496610 0007,0004 HT MDC1 WRAP53 26734725,26734725,25512560 0428,0004,0004 LC PTGES3 WRAP53 22939629 0401 HT ZFHX3 WRAP53 26496610,26496610 0007,0004 HT RBBP7 WRAP53 22939629 0401 HT Q59H77 WRAP53 26496610 0004 HT PRPF38B WRAP53 26496610 0007 HT DKFZP434O1172 WRAP53 26496610 0004 HT MRPL14 WRAP53 26496610,26496610 0007,0004 HT WAPL WRAP53 22939629 0401 HT CNTROB WRAP53 26496610,26496610 0007,0004 HT FAM43A WRAP53 26186194 0004 HT TNPO1 WRAP53 22939629 0401 HT Q96BA7 WRAP53 26344197 0401 HT CCT7 WRAP53 26496610,26496610,25467444 0007,0004,0007 HT,LC WRAP53 GAR1 26496610,26186194,26496610 0007,0004,0004 HT WRAP53 POLG2 26496610,26496610 0007,0004 HT WRAP53 STK24 26496610,26496610 0007,0004 HT WRAP53 HEL-S-69 26496610 0004 HT WRAP53 HEL-S-100N 26496610 0004 HT PRPF4 WRAP53 22939629 0401 HT DKC1 WRAP53 26496610,26496610 0004,0007 HT SNRPC WRAP53 22939629 0401 HT TCP1 WRAP53 26496610,26496610 0007,0004 HT PTPN1 WRAP53 26496610,26496610 0007,0004 HT RXRB WRAP53 26496610,26496610 0007,0004 HT CCT6A WRAP53 26496610,26496610 0007,0004 HT CCT5 WRAP53 26496610 0007 HT CCT3 WRAP53 26496610 0007 HT CCT8 WRAP53 26496610,26496610 0007,0004 HT CCT4 WRAP53 26496610,26496610 0007,0004 HT USP11 WRAP53 22939629 0401 HT NDUFV3 WRAP53 26496610,26496610 0007,0004 HT RAP1B WRAP53 26496610,26496610 0007,0004 HT CCT2 WRAP53 26496610 0007 HT XPC WRAP53 22939629 0401 HT MYBPH WRAP53 26496610,26496610 0007,0004 HT PTGES3 WRAP53 22939629 0401 HT ZFHX3 WRAP53 26496610,26496610 0007,0004 HT RBBP7 WRAP53 22939629 0401 HT Q59H77 WRAP53 26496610 0004 HT PRPF38B WRAP53 26496610 0007 HT DKFZP434O1172 WRAP53 26496610 0004 HT MRPL14 WRAP53 26496610,26496610 0007,0004 HT WAPL WRAP53 22939629 0401 HT CNTROB WRAP53 26496610,26496610 0007,0004 HT FAM43A WRAP53 26186194 0004 HT TNPO1 WRAP53 22939629 0401 HT Q96BA7 WRAP53 26344197 0401 HT CCT7 WRAP53 26496610,26496610 0007,0004 HT WRAP53 GAR1 26496610,26186194,26496610 0007,0004,0004 HT WRAP53 POLG2 26496610,26496610 0007,0004 HT WRAP53 STK24 26496610,26496610 0007,0004 HT WRAP53 HEL-S-69 26496610 0004 HT WRAP53 HEL-S-100N 26496610 0004 HT DKC1 WRAP53 25416818,25467444,19179534,25416818,19179534,19179534 0004,0007,0676,0090,0006,0007 LC RNF8 WRAP53 26734725,26734725,25512560 0428,0004,0004 LC H2AFX WRAP53 26734725,26734725,25512560 0428,0004,0004 LC TCP1 WRAP53 25467444,25467444 0006,0007 LC CCT6A WRAP53 25467444 0007 LC CCT5 WRAP53 25467444 0007 LC CCT3 WRAP53 25467444,25467444 0006,0007 LC CCT8 WRAP53 25467444 0007 LC CCT4 WRAP53 25467444 0007 LC CCT2 WRAP53 25467444,25467444 0006,0007 LC MDC1 WRAP53 26734725,26734725,25512560 0428,0004,0004 LC CCT7 WRAP53 25467444 0007 LC PRPF4 WRAP53 22939629 0401 LC DKC1 WRAP53 25416818,25416818 0004,0090 LC SNRPC WRAP53 22939629 0401 LC USP11 WRAP53 22939629 0401 LC XPC WRAP53 22939629 0401 LC PTGES3 WRAP53 22939629 0401 LC RBBP7 WRAP53 22939629 0401 LC WAPL WRAP53 22939629 0401 LC TNPO1 WRAP53 22939629 0401 LC Q96BA7 WRAP53 26344197 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9BUR4 O43172 WRAP53 PRPF4 0.081 22939629 Q9BUR4 P61224 WRAP53 RAP1B 0.126 26496610 Q9BUR4 Q8N137 WRAP53 CNTROB 0.126 26496610 Q9BUR4 Q8N2R8 WRAP53 FAM43A 0.126 26186194 Q9BUR4 P16104 WRAP53 H2AFX 0.569 25512560,26734725 Q9BUR4 O60832 WRAP53 DKC1 0.623 25467444,25416818,26496610 Q9BUR4 O76064 WRAP53 RNF8 0.569 25512560,26734725 Q9BUR4 P09234 WRAP53 SNRPC 0.081 22939629 Q9NY12 Q9BUR4 GAR1 WRAP53 0.416 26496610,26186194 Q9BUR4 P0C0A3 WRAP53 CHMP6 0.236 26496610 Q9BUR4 O77622 WRAP53 CCT6 0.376 25467444 Q9BUR4 P40227 WRAP53 CCT6A 0.309 26496610,25467444 Q9BUR4 Q15911 WRAP53 ZFHX3 0.236 26496610 Q9BUR4 Q6P1L8 WRAP53 MRPL14 0.236 26496610 Q9D0T1 Q9BUR4 NHP2L1 WRAP53 0.236 20360068 Q9BUR4 Q08AM6 WRAP53 VAC14 0.236 unassigned1304 Q9BUR4 P48643 WRAP53 CCT5 0.396 26496610,25467444 Q9BUR4 P50991 WRAP53 CCT4 0.396 26496610,25467444 Q9BUR4 P50990 WRAP53 CCT8 0.396 26496610,25467444 Q9BUR4 Q14676 WRAP53 MDC1 0.454 25512560,26734725 Q9BUR4 Q99832 WRAP53 CCT7 0.396 26496610,25467444 Q9BUR4 P17987 WRAP53 TCP1 0.523 26496610,25467444 Q9BUR4 P78371 WRAP53 CCT2 0.523 26496610,25467444 Q9BUR4 P49368 WRAP53 CCT3 0.523 26496610,25467444 Q9BUR4 Q92973 WRAP53 TNPO1 0.081 22939629 Q9BUR4 P28702 WRAP53 RXRB 0.126 26496610 Q9BUR4 B4DR80 WRAP53 STK24 {ECO:0000313|ENSEMBL:ENSP00000380651} 0.126 26496610 Q9BUR4 P56181 WRAP53 NDUFV3 0.126 26496610 Q9BUR4 Q00839 WRAP53 HNRNPU 0.081 26344197 Q9BUR4 Q01831 WRAP53 XPC 0.081 22939629 Q9BUR4 Q13203 WRAP53 MYBPH 0.126 26496610 Q9BUR4 Q5VTL8 WRAP53 PRPF38B 0.126 26496610 Q9BUR4 Q7Z5K2 WRAP53 WAPAL 0.081 22939629 Q9Y6E0 Q9BUR4 STK24 WRAP53 0.126 26496610 Q9UHN1 Q9BUR4 POLG2 WRAP53 0.126 26496610 Q9BUR4 P18031 WRAP53 PTPN1 0.126 26496610 Q9BUR4 E0CXD4 WRAP53 E0CXD4 0.126 26496610 Q9BUR4 Q15185 WRAP53 PTGES3 0.081 22939629 Q9BUR4 P51784 WRAP53 USP11 0.081 22939629 Q9BUR4 Q16576 WRAP53 RBBP7 0.081 22939629

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 TERT WRAP53 MI:0045 experimental interaction detection MI:0461 interaction database DKC1 WRAP53 MI:0045 experimental interaction detection MI:0461 interaction database RNF8 WRAP53 MI:0045 experimental interaction detection MI:0461 interaction database UBC WRAP53 MI:0045 experimental interaction detection MI:0461 interaction database H2AFX WRAP53 MI:0045 experimental interaction detection MI:0461 interaction database TCP1 WRAP53 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PTPN1 WRAP53 MI:0045 experimental interaction detection MI:0461 interaction database RXRB WRAP53 MI:0045 experimental interaction detection MI:0461 interaction database COIL WRAP53 MI:0362 inference MI:0461 interaction database CCT6A WRAP53 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CCT5 WRAP53 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CCT3 WRAP53 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CCT8 WRAP53 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CCT4 WRAP53 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SNU13 WRAP53 MI:0362 inference MI:0461 interaction database NDUFV3 WRAP53 MI:0045 experimental interaction detection MI:0461 interaction database RAP1B WRAP53 MI:0045 experimental interaction detection MI:0461 interaction database CCT2 WRAP53 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database PCDH1 WRAP53 MI:0362 inference MI:0461 interaction database MYBPH WRAP53 MI:0045 experimental interaction detection MI:0461 interaction database MDC1 WRAP53 MI:0045 experimental interaction detection MI:0461 interaction database KPNB1 WRAP53 MI:0362 inference MI:0461 interaction database ZFHX3 WRAP53 MI:0045 experimental interaction detection MI:0461 interaction database SMN1 WRAP53 MI:0362 inference MI:0461 interaction database PRPF38B WRAP53 MI:0045 experimental interaction detection MI:0461 interaction database MRPL14 WRAP53 MI:0045 experimental interaction detection MI:0461 interaction database CNTROB WRAP53 MI:0045 experimental interaction detection MI:0461 interaction database FAM43A WRAP53 MI:0045 experimental interaction detection MI:0461 interaction database CCT6B WRAP53 MI:0362 inference MI:0461 interaction database CHMP6 WRAP53 MI:0362 inference MI:0461 interaction database CCT7 WRAP53 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database WRAP53 GAR1 MI:0045 experimental interaction detection MI:0461 interaction database WRAP53 DDX20 MI:0362 inference MI:0461 interaction database WRAP53 POLG2 MI:0045 experimental interaction detection MI:0461 interaction database WRAP53 STK24 MI:0045 experimental interaction detection MI:0461 interaction database