PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus AK4 WDR45B 26186194 biogrid exp P P P P P P P P P P RCN1 WDR45B 26186194 biogrid exp GP GP G G G GP G G GP G GP G GP G G G GP GP G G GP GP G G G G G GP G APP WDR45B 21832049 biogrid exp G GP G G GP GP G G GP G G G G G G G GP G G G GP GP G G G G G GP G SPA17 WDR45B 26186194 biogrid exp GP G G G G GP G G GP G GP G G G GP GP G G G G G G G GP G WDR45B TXNDC17 22939629 biogrid exp GP GP G G G GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G JUN WDR45B 25609649 intact exp GP GP G G G GP G G GP G GP G GP G G G GP G G G GP G G G G G G G G WDR45B ARRDC1 26186194 biogrid exp G GP G G G GP G G GP G GP G G G G G GP G G G GP G G G G G G GP G UROD WDR45B 26186194 biogrid exp GP GP G G G G G G GP G GP G GP G G G G G G G GP GP G G G G G G G WDR45B GAS2L1 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDR45B GABARAPL1 20562859 intact exp GP GP G G GP GP G G GP G GP G GP G G G GP G G G GP G G G G G G GP G WDR45B PMF1 26186194 biogrid exp G GP G G G GP G G GP G GP G GP G G G GP G G G G GP G G G G G GP G UPP1 WDR45B 22939629 biogrid exp GP G G G G G G G G G G G G G G G G G G G G G G G G RAB3A WDR45B 26186194 biogrid exp GP G G G GP G G G G G G G GP G G G G G G G G G ELAVL1 WDR45B 19322201 biogrid exp GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G G G GP G TYMS WDR45B 22939629 biogrid exp GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G DBI WDR45B 21836163 pred GP GP G G G GP G G GP G GP G GP G G G GP GP G G G GP G G G G G GP G SKP1 WDR45B 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G EIF3H WDR45B 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G ATG2A WDR45B 16082366 pred G G G G GP GP G G G G G G GP G G G GP G G G GP G G G G GP G G G WDR45B AP3S1 21836163 pred GP G G G G GP G G G G GP G GP G G G GP G G G G G G G G G G GP G GNB2L1 WDR45B 23023127 pred P P P P P P P P P P P P PPP1CC WDR45B 21836163 pred GP GP G G G GP G G GP G GP G GP G G G GP G G G GP GP G G G GP G GP G WDR45B TOMM7 21836163 pred GNA13 WDR45B 23023127 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G STAU1 WDR45B 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G ATF4 WDR45B 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G CAP1 WDR45B 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G WDR45B GNB4 23023127 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G WDR45B WDR82 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HERPUD1 WDR45B 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G RGS9 WDR45B 23023127 pred G G G G G G G G DNAJA1 WDR45B 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G RPN2 WDR45B 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G LAMTOR5 WDR45B 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G UBC WDR45B 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G NDUFS2 WDR45B 21836163 pred G GP G G G GP G G GP G GP G G G G G GP G G G GP G G G G G G GP G RAP1B WDR45B 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ADRBK1 WDR45B 23023127 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G SET WDR45B 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G WDR45B FAM32A 21836163 pred GP GP G G GP G G G GP G GP G G G G G G GP G G G G G G G GP G GP G SEC13 WDR45B 23023127 pred GP GP G G GP GP G G GP G G G G G G G GP G G G GP GP G G G GP G G G WDR46 WDR45B 23023127 pred P P P P P P G G P G P GP G G GP GP PTTG1IP WDR45B 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP G G G GP GP G G G GP G GP G WDR45B TSG101 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G WDR45B NIPA2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DHX15 WDR45B 21836163 pred G GP G G G GP G G GP G GP G G G G G GP GP G G GP G G G G G G GP G GNAT1 WDR45B 23023127 pred WDR45B MRPL18 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDR45B ZMAT5 25402006 pred GP P P P P GP P G G P P GP G G G P P GNAI1 WDR45B 23023127 pred GP GP G G GP GP G G GP G GP G GP G G G GP G G G GP GP G G G GP G GP G PITPNB WDR45B 21836163 pred G GP G G GP G G G GP G GP G G G G G G G G G GP G G G G GP G G G ERCC8 WDR45B 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CALM1, CALM2, CALM3 WDR45B 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G GNB2 WDR45B 23023127 pred G GP G G G GP G G GP G GP G GP G G G GP GP G G G G G G G G G GP G EIF3I WDR45B 23023127 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G PDC WDR45B 23023127 pred P P P P P P P P P P P GNG2 WDR45B 23023127 pred G G G G G GP G G GP G GP G G G G G GP GP G G GP G G G G GP G GP G HSPA5 WDR45B 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G GNAI3 WDR45B 23023127 pred G GP G G G GP G G GP G G G GP G G G GP G G G G G G G G G G GP G WDR45B GHITM 21836163 pred GP GP G G G GP G G GP G GP G GP G G G GP G G G GP GP G G G G G GP G WDR45B ATG2B 16082366 pred G G G G G GP G G GP G G G G G G G GP G G G G G G G G GP G G G WDR45B EIF3C 21836163 pred P GP P P GP GP G P G G P GP P GP G GP G GP G RPL24 WDR45B 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G WDR45B GORASP2 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G COPB2 WDR45B 23023127 pred GP GP G G GP GP G G GP G GP G GP G G G GP G G G GP GP G G G G G GP G PSMA6 WDR45B 21836163 pred P P P P P P P P P P P PRDX6 WDR45B 21836163 pred GP GP G G GP GP G G GP G GP G GP G G G GP GP G G GP GP G G G GP G GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q5MNZ6 P05067-7 pull down 21832049 direct interaction X 2 Q9BRA2 Q5MNZ6 biochemical 22939629 colocalization X 2 P04818 Q5MNZ6 biochemical 22939629 colocalization X 2 Q16831 Q5MNZ6 biochemical 22939629 colocalization X 2 P0CG48 Q5MNZ6 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q5MNZ6 affinity chromatography technology 24816145 physical association X 2 P0CG48 Q5MNZ6 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q5MNZ6 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q5MNZ6 affinity chromatography technology 21906983 physical association X 2 Q81VA8 Q5MNZ6 two hybrid pooling approach 20711500 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B ELAVL1 WDR45L MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_186295 bait prey APP WDR45L MI:0096(pull down) 21832049 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_228945 prey bait UBC WDR45L MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21906983,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_178713|BIOGRID_267567|BIOGRID_169394|BIOGRID_173292 bait|bait|bait|bait prey|prey|prey|prey WDR45L TXNDC17 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_243573 prey bait TYMS WDR45L MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241088 bait prey UPP1 WDR45L MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239777 bait prey

PPI - HINT Gene A Gene B PMID Method Quality TYMS WDR45B 22939629 0401 HT JUN WDR45B 25609649 0006 HT UROD WDR45B 26186194 0004 HT RAB3A WDR45B 26186194 0004 HT AK4 WDR45B 26186194 0004 HT SPA17 WDR45B 26186194 0004 HT WDR45B PMF1 26186194 0004 HT WDR45B Q86Y75 22939629 0401 HT WDR45B ARRDC1 26186194 0004 HT WDR45B GAS2L1 26186194 0004 HT WDR45B TXNDC17 22939629 0401 HT WDR45B GABARAPL1 20562859 0007 HT WDR45B HEL-S-84 26186194 0004 HT TYMS WDR45B 22939629 0401 HT JUN WDR45B 25609649 0006 HT UROD WDR45B 26186194 0004 HT RAB3A WDR45B 26186194 0004 HT AK4 WDR45B 26186194 0004 HT SPA17 WDR45B 26186194 0004 HT WDR45B PMF1 26186194 0004 HT WDR45B Q86Y75 22939629 0401 HT WDR45B ARRDC1 26186194 0004 HT WDR45B GAS2L1 26186194 0004 HT WDR45B TXNDC17 22939629 0401 HT WDR45B GABARAPL1 20562859 0007 HT WDR45B HEL-S-84 26186194 0004 HT TYMS WDR45B 22939629 0401 LC WDR45B Q86Y75 22939629 0401 LC WDR45B TXNDC17 22939629 0401 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q5MNZ6 P05067 WDR45B APP 0.183 21832049 Q81VA8 Q5MNZ6 Q81VA8 WDR45B 0.126 20711500 Q8N5I2 Q5MNZ6 ARRDC1 WDR45B 0.126 26186194 Q9H0R8 Q5MNZ6 GABARAPL1 WDR45B 0.126 20562859 Q6P1K2 Q5MNZ6 PMF1 WDR45B 0.126 26186194 Q5MNZ6 P04818 WDR45B TYMS 0.081 22939629 Q5MNZ6 P05412 WDR45B JUN 0.126 25609649 Q5MNZ6 P06132 WDR45B UROD 0.126 26186194 Q96LJ8 Q5MNZ6 UBXN10 WDR45B 0.236 26389662 Q9BRA2 Q5MNZ6 TXNDC17 WDR45B 0.081 22939629 Q5MNZ6 P27144 WDR45B AK4 0.126 26186194 Q99501 Q5MNZ6 GAS2L1 WDR45B 0.126 26186194 Q5MNZ6 Q15293 WDR45B RCN1 0.126 26186194 Q5MNZ6 Q15506 WDR45B SPA17 0.126 26186194 Q5MNZ6 Q15717 WDR45B ELAVL1 0.126 19322201 Q5MNZ6 P20336 WDR45B RAB3A 0.126 26186194 Q5MNZ6 Q16831 WDR45B UPP1 0.081 22939629

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MYO1F WDR45B MI:0362 inference MI:0461 interaction database FBP2 WDR45B MI:0362 inference MI:0461 interaction database XPO1 WDR45B MI:0362 inference MI:0461 interaction database APP WDR45B MI:0045 experimental interaction detection MI:0461 interaction database JUN WDR45B MI:0045 experimental interaction detection MI:0461 interaction database UROD WDR45B MI:0045 experimental interaction detection MI:0461 interaction database FBP1 WDR45B MI:0362 inference MI:0461 interaction database UBC WDR45B MI:0045 experimental interaction detection MI:0461 interaction database PRKACA WDR45B MI:0362 inference MI:0461 interaction database RAB3A WDR45B MI:0045 experimental interaction detection MI:0461 interaction database RAB5A WDR45B MI:0362 inference MI:0461 interaction database PRKACG WDR45B MI:0362 inference MI:0461 interaction database PRKACB WDR45B MI:0362 inference MI:0461 interaction database ACAT1 WDR45B MI:0362 inference MI:0461 interaction database AK4 WDR45B MI:0045 experimental interaction detection MI:0461 interaction database CAPZB WDR45B MI:0362 inference MI:0461 interaction database CSNK1A1 WDR45B MI:0362 inference MI:0461 interaction database CSNK1D WDR45B MI:0362 inference MI:0461 interaction database CSNK1E WDR45B MI:0362 inference MI:0461 interaction database RAB5C WDR45B MI:0362 inference MI:0461 interaction database PRKX WDR45B MI:0362 inference MI:0461 interaction database RAB5B WDR45B MI:0362 inference MI:0461 interaction database TBL3 WDR45B MI:0362 inference MI:0461 interaction database MYO1E WDR45B MI:0362 inference MI:0461 interaction database PWP2 WDR45B MI:0362 inference MI:0461 interaction database RCN1 WDR45B MI:0045 experimental interaction detection MI:0461 interaction database SPA17 WDR45B MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 WDR45B MI:0045 experimental interaction detection MI:0461 interaction database HAGH WDR45B MI:0362 inference MI:0461 interaction database WDR45B PMF1 MI:0045 experimental interaction detection MI:0461 interaction database WDR45B HAGHL MI:0362 inference MI:0461 interaction database WDR45B ARRDC1 MI:0045 experimental interaction detection MI:0461 interaction database WDR45B WDR36 MI:0362 inference MI:0461 interaction database WDR45B UBXN10 MI:0045 experimental interaction detection MI:0461 interaction database WDR45B GAS2L1 MI:0045 experimental interaction detection MI:0461 interaction database WDR45B ACAT2 MI:0362 inference MI:0461 interaction database WDR45B GABARAPL1 MI:0045 experimental interaction detection MI:0461 interaction database WDR45B WDR3 MI:0362 inference MI:0461 interaction database WDR45B UTP18 MI:0362 inference MI:0461 interaction database