PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SKI RNF165 23610558 dip exp P P G P GP P P G P G P P GP P G P GP P G P GP P P SMAD7 RNF165 23610558 dip exp P P G P GP P P G P GP P P P GP P G P GP P G P GP P P SMAD6 RNF165 23610558 dip exp G G G G G G G SKIL RNF165 23610558 dip exp P P G P GP P G P GP P P GP G P GP P G P G P P RNF165 UBE2W 19690564 biogrid,intact exp P P G P GP P P G P GP P P P GP P G P GP P G P GP P P UBE2E1 RNF165 19690564, 23023127 biogrid,intact exp, pred P P G GP P G P G P P GP G P G G P G P P UBE2D3 RNF165 19690564, 23023127 biogrid,intact exp, pred P G P GP P G P GP P P GP P G P GP G GP P P UBE2D2 RNF165 19690564, 23023127 biogrid,intact exp, pred P G P GP P G P GP P P GP P G P GP G GP P P RNF165 UBE2E3 19690564, 23023127 biogrid,intact exp, pred P P G GP P G P G P P GP G P G G P G P P UBE2D1 RNF165 19690564, 23023127 biogrid,intact exp, pred P G P GP P G P GP P P GP P G P GP G GP P P RNF165 UBE2D4 19690564, 23023127 biogrid,intact exp, pred P G P GP P G P GP P P GP P G P GP G GP P P UBE2N RNF165 19690564, 23023127 biogrid,intact exp, pred P P G P GP P P G P GP P P P GP P G P GP P G P GP P P RNF165 STUB1 23023127 pred P P G P GP P P G P GP P P P GP P G P GP P G P GP P P UBE2G2 RNF165 23023127 pred P P G P GP P G P GP P P P GP P G P GP G P GP P P RNF165 UBE2R2 23023127 pred G P G G G P G G G G GP P BMI1 RNF165 23023127 pred P P P P P P P P P P P P P P P P P P P P CUL4A RNF165 23023127 pred G G G G G G G G G UBE2I RNF165 23023127 pred P P G P GP P P G P G P P P GP P G P GP P G P GP P P UBE2M RNF165 23023127 pred P P G P GP P P G P G P P P GP P G P G P G P GP P P RNF165 UBE2E2 23023127 pred P P G P GP P P G P GP P P P GP P G P GP P G P GP P P RNF144A RNF165 23023127 pred P G P GP P P G P P P P P GP P G P G P G P GP P P UBE2L3 RNF165 23023127 pred P G GP P P G P G P GP P G G P G P G P P GSTA4 RNF165 23023127 pred P P G P GP P P G P GP P P GP P G G P G P G P P RNF165 RNF150 23023127 pred P P G GP P P G P P P P P GP P G P GP P G P GP P P UBE2NL RNF165 23023127 pred G G G G G G G G G UBE2K RNF165 23023127 pred P P G P GP P P G P GP P P P GP P G P GP P G P GP P P TTC3 RNF165 23023127 pred P P P P P CALM1, CALM2, CALM3 RNF165 23023127 pred P P G P GP P P G P GP P P P GP P G P GP P G P GP P P RNF165 CALN1 23023127 pred P P G P GP P P G P P P GP P P P P P P RNF165 PTCD3 23023127 pred P P G P GP P P G P GP P P P GP P G P GP P G P GP P P UBE2C RNF165 23023127 pred P P G P GP P P G P GP P P P GP P G P GP P G P GP P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q6ZSG1 A0A087WW00 two hybrid 19690564 direct interaction X 2 Q6ZSG1 P62837 two hybrid 19690564 direct interaction X 2 Q6ZSG1 P61077-3 two hybrid 19690564 direct interaction X 2 Q6ZSG1 P61088 two hybrid 19690564 direct interaction X 2 Q969T4 Q6ZSG1 two hybrid 19690564 direct interaction X 2 Q6ZSG1 A0A024RA90 two hybrid 19690564 direct interaction X 2 Q6ZSG1 A0A024R2K3 two hybrid 19690564 direct interaction X 2 Q6ZSG1 Q96FI0 two hybrid 19690564 direct interaction X 2 Q6ZSG1 anti tag coimmunoprecipitation 23610558 - C 3 P12755 Q6ZSG1 anti tag coimmunoprecipitation 23610558 physical association X 2 P12755 Q6ZSG1 anti tag coimmunoprecipitation 23610558 physical association X 2 Q6ZSG1 anti tag coimmunoprecipitation 23610558 physical association X 2 Q6ZSG1 O43541 anti tag coimmunoprecipitation 23610558 physical association X 2 O15105 Q6ZSG1 anti tag coimmunoprecipitation 23610558 physical association X 2 Q6ZSG1 A0A024RDH2 two hybrid array 19690564 physical association X 2 Q6ZSG1 P61088 two hybrid array 19690564 physical association X 2 Q6ZSG1 P62837 two hybrid array 19690564 physical association X 2 Q969T4 Q6ZSG1 two hybrid array 19690564 physical association X 2 A0A024QZJ2 Q6ZSG1 two hybrid array 19690564 physical association X 2 Q6ZSG1 A0A024RA90 two hybrid array 19690564 physical association X 2 Q6ZSG1 A0A024R2K3 two hybrid array 19690564 physical association X 2 Q6ZSG1 Q96B02 two hybrid array 19690564 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B RNF165 UBE2D4 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123525|UniProt_102513 prey|prey bait|bait UBE2D1 RNF165 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123429|UniProt_102418 bait|bait prey|prey UBE2D3 RNF165 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123492|UniProt_102480 bait|bait prey|prey UBE2D2 RNF165 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102448|BIOGRID_123458 bait|bait prey|prey UBE2E1 RNF165 MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123549|UniProt_102538 bait|bait prey|prey RNF165 UBE2E3 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102556|BIOGRID_123567 prey|prey bait|bait RNF165 UBE2W MI:0018(two hybrid)|MI:0397(two hybrid array) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_123704|UniProt_102693 prey|prey bait|bait UBE2N RNF165 MI:0397(two hybrid array)|MI:0018(two hybrid) 19690564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_102611|BIOGRID_123622 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality UBE2D2 RNF165 26656854,26656854 0114,0096 LC UBE2D2 RNF165 26656854,26656854 0114,0096 LC UBB RNF165 26656854 0114 LC UBC RNF165 26656854,26656854,26656854 0114,0415,0096 LC UBE2D1 RNF165 19690564,19690564 0397,0018 HT UBE2E1 RNF165 19690564,19690564 0397,0018 HT UBE2D3 RNF165 19690564,19690564 0397,0018 HT UBE2N RNF165 19690564,19690564 0397,0018 HT UBE2D2 RNF165 19690564,26656854,26656854,19690564 0397,0114,0096,0018 HT,LC RNF165 RNF165 26656854 0114 LC RNF165 UBE2E3 19690564,19690564 0397,0018 HT RNF165 UBE2W 19690564,19690564 0397,0018 HT RNF165 UBE2D4 19690564,19690564 0397,0018 HT RNF165 HEL-S-71 19690564 0018 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Y2X8 Q6ZSG1 UBE2D4 RNF165 0.286 19690564 Q6ZSG1 P61077 RNF165 UBE2D3 0.376 19690564 Q6ZSG1 P61088 RNF165 UBE2N 0.507 19690564,26656854 Q969T4 Q6ZSG1 UBE2E3 RNF165 0.286 19690564 Q96B02 Q6ZSG1 UBE2W RNF165 0.286 19690564 Q6ZSG1 P51965 RNF165 UBE2E1 0.286 19690564 Q6ZSG1 P62837 RNF165 UBE2D2 0.702 19690564,26656854 Q6ZSG1 P0CG48 RNF165 UBC 0.671 26656854 Q6ZSG1 P51668 RNF165 UBE2D1 0.286 19690564

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SMAD7 RNF165 MI:0362 inference MI:0461 interaction database SMAD6 RNF165 MI:0362 inference MI:0461 interaction database UBB RNF165 MI:0362 inference MI:0461 interaction database UBC RNF165 MI:0045 experimental interaction detection MI:0461 interaction database SKI RNF165 MI:0362 inference MI:0461 interaction database SKIL RNF165 MI:0362 inference MI:0461 interaction database UBE2D1 RNF165 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 RNF165 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 RNF165 MI:0045 experimental interaction detection MI:0461 interaction database UBE2N RNF165 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 RNF165 MI:0045 experimental interaction detection MI:0461 interaction database RPS27A RNF165 MI:0362 inference MI:0461 interaction database UBA52 RNF165 MI:0362 inference MI:0461 interaction database RNF165 UBE2E3 MI:0045 experimental interaction detection MI:0461 interaction database RNF165 UBE2W MI:0045 experimental interaction detection MI:0461 interaction database RNF165 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database