PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus UBC CBLC 14661060 biogrid exp P P P P P P GP P P P P P P P P P TGFB1I1 CBLC 23145173,24831009 biogrid exp P P P P P P GP P P P P P P P P OTUD6A CBLC 23105109 biogrid exp P P P P P P P P P P P P P P P P BIRC2 CBLC 22493164 biogrid,intact exp P P P P P P GP P P P P P P P P SH3GL3 CBLC 21900206 biogrid,mint,intact exp P G P P P P NACAD CBLC 21900206 biogrid,mint,intact exp P P P P P P P P UBE2H CBLC 19549727 biogrid,intact exp P P P P P P GP P P P P P P P P P USP2 CBLC 23105109 biogrid exp P P P P P P P P P P P P P P P UBE2R2 CBLC 19549727 biogrid,intact exp G P CBLC CD2AP 18753381 biogrid exp P P P P P GP P P P P P P P P UBE2D2 CBLC 14661060,20525694 biogrid exp P P P P G P P P P P P P ABI1 CBLC 20598684 mint,intact exp P P P P P P GP P P P P P P P P P TRIM46 CBLC 22493164 biogrid,intact exp P P P P P GP P P P P P P P P UBE2D3 CBLC 14661060 biogrid exp P P P P G P P P P P P P UBE2K CBLC 19549727 biogrid,intact exp P P P P P P GP P P P P P P P P P CHFR CBLC 22493164 biogrid,intact exp G CKM CBLC 20525694 biogrid exp P G P P TRAF4 CBLC 22493164 biogrid,intact exp P P P P P GP P P P P P P P P OXA1L CBLC 21988832 biogrid,intact exp P P P P GP P P P P P P P UBE2L6 CBLC 19549727 biogrid,intact exp P P P P P GP P P P P P P P P USP21 CBLC 23105109 biogrid exp P P P P P P GP P P P P P P P P UBE2L3 CBLC 19549727 biogrid,intact exp P P P P GP P P P P P P P TRIP6 CBLC 23145173 biogrid exp P P P P P P GP P P P P P P P P P UBE2D1 CBLC 14661060 biogrid exp P P P P G P P P P P P P UBE2I CBLC 19549727 biogrid,intact exp P P P P P GP P P P P P P P P PDLIM7 CBLC 24466333 biogrid exp P P P P G P P P P P MET CBLC 22888118, 25402006 biogrid exp, ortho, pred P P P P P P GP P P P P P P P P P SHC1 CBLC 21900206, 25402006 biogrid,mint,intact exp, pred P P P P P P GP P P P P P P P P P CRK CBLC 25814554,10571044,10362357, 25402006 hprd,biogrid,intact exp, pred P P P P GP P P P P P P P SPRY2 CBLC 12234920, 21836163 hprd exp, pred P P P P P P GP P P P P P P P P P SRC CBLC 14661060,20525694,22888118,9988270, 25402006 hprd,biogrid exp, pred P P P P P GP P P P P P P EGFR CBLC 22888118,10571044,10362357, 25402006, 21836163 hprd,biogrid exp, pred P P P P P GP P P P P P P P GRB2 CBLC 10086340, 25402006, 21836163 hprd exp, pred P P P P P GP P P P P P P P P P LYN CBLC 10362357, 25402006 hprd,biogrid exp, pred P P GP P P P P P P P ZAP70 CBLC 22888118, 25402006 biogrid exp, pred G ITCH CBLC 12226085, 25402006 hprd,biogrid,mint,intact exp, pred P P P P P P GP P P P P P P P P P RET CBLC 24466333,18753381, 25402006 biogrid exp, pred P P P P P GP P P P P P P P P P FYN CBLC 10571044, 25402006 biogrid exp, pred P P P P G P SH2B2 CBLC ortho P P P P P GP P P P P P P P P CBLB CBLC 25402006 ortho, pred P P P P P GP P P P P P P P IL6ST CBLC 21836163 pred P P P P P P GP P P P P P P P P P ARRB2 CBLC 25402006 pred G CSK CBLC 25402006 pred P GP P P P P P P AP2M1 CBLC 25402006 pred P P P P P P GP P P P P P P TAX1BP1 CBLC 25402006 pred P P P P P G P P P P P P LCK CBLC 25402006 pred G DOK2 CBLC 25402006 pred G SHC2 CBLC 25402006 pred P P P P P P GP P P P P P P P P P CBLC SH2B3 25402006 pred P P P P P GP P P P P P P P P P PIK3CG CBLC 21836163 pred G CLNK CBLC 25402006 pred P P P P P GP P P P P P P P PTPN21 CBLC 25402006 pred P P P P P P GP P P P P P P P P P DDR2 CBLC 25402006 pred G NCK2 CBLC 25402006 pred P P P P P GP P P P P P P P P P EPS15 CBLC 25402006 pred P P P P P P GP P P P P P P P P P PXN CBLC 25402006 pred P P P P GP P P P P P P P GRB7 CBLC 25402006 pred P P P P P P GP P P P P P P P P P SOS2 CBLC 25402006 pred P P P P P GP P P P P P P P P P AREG, AREGB CBLC 25402006 pred P P P P P P GP P P P P P P P P P PTK2 CBLC 25402006 pred P P P P P P GP P P P P P P P P P DOK6 CBLC 25402006 pred P P P P P P P P P P NEDD9 CBLC 25402006 pred P P P P P P GP P P P P P P P P P PAK2 CBLC 25402006 pred P P P P P GP P P P P P P NUDT21 CBLC 25402006 pred P P P P P P GP P P P P P P P P P SHC3 CBLC 25402006 pred P P P P P P P P P P P P P P P P SH3KBP1 CBLC 25402006, 21836163 pred P G P P ESR1 CBLC 25402006 pred P G STAT5B CBLC 25402006 pred P P P P P P GP P P P P P P P SPG20 CBLC 25402006 pred P P P P P P GP P P P P P P P P P IGF1R CBLC 25402006 pred P P P P P GP P P P P P P P CAV1 CBLC 25402006 pred P P P P P G P P P STAT1 CBLC 25402006 pred P P GP P P P P P P ERBB2 CBLC 25402006 pred P P GP P P P WAS CBLC 25402006 pred P P P G P P P P P P VAV3 CBLC 25402006 pred P P P P P P GP P P P P P P P P P LNX1 CBLC 25402006 pred P P P P P GP P P P P P P P P MLANA CBLC 25402006 pred CRKL CBLC 25402006, 21836163 pred P P GP P P P P P P APBB2 CBLC 25402006 pred P P P P P P GP P P P P P P P P P YWHAZ CBLC 25402006 pred P P P P P P GP P P P P P P P P P PDGFRA CBLC 25402006 pred P P G P P P SYK CBLC 25402006 pred P P P GP P P P P P STAT3 CBLC 25402006 pred P P P P P P GP P P P P P P P P P ASAP2 CBLC 25402006 pred P P P P P GP P P P P P P P P GRB10 CBLC 25402006 pred P P P P P P GP P P P P P P P P P MMD CBLC 21836163 pred G ASAP1 CBLC 25402006 pred P P P P P P GP P P P P P P P P IL4R CBLC 21836163 pred P P P P P GP P P P P P P P P EPHB2 CBLC 25402006 pred P P P P P P GP P P P P P P P P P PRLR CBLC 21836163 pred G TYK2 CBLC 21836163 pred P P P P P P GP P P P P P P P P P GAB1 CBLC 25402006 pred G INSRR CBLC 25402006 pred P P P P P P P P P P P P P P P P PIK3CB CBLC 21836163 pred P P P P P P GP P P P P P P P P P BCAR3 CBLC 25402006 pred P P P P P P GP P P P P P P P P P MPZL1 CBLC 25402006 pred P P P P P P GP P P P P P P P P P PIK3CA CBLC 21836163 pred P P P P P P P P P P P P P P P P USP9X CBLC 25402006 pred P P P P P GP P P P P P P P P P IL2RA CBLC 21836163 pred G STAM2 CBLC 25402006 pred P P P P P P GP P P P P P P P P P CBLC RNF11 25402006 pred P P P P P P GP P P P P P P P P P IRS4 CBLC 25402006 pred P P P P P P GP P P P P P P P P P PTPN2 CBLC 25402006 pred P P P P P P GP P P P P P P P P P BLK CBLC 25402006 pred P P P P P P P P P P P P TGFA CBLC 25402006 pred P P P P P P GP P P P P P P P P P PDGFRB CBLC 25402006 pred P P G P P P P P YWHAE CBLC 25402006 pred P P P P P P GP P P P P P P P P P BCAR1 CBLC 25402006 pred P P P P P P GP P P P P P P P P P MST1R CBLC 25402006 pred P P P P P P GP P P P P P P P P P CBLC MAP4K5 25402006 pred P P P G P P P P P INPPL1 CBLC 25402006 pred P P P P P P GP P P P P P P P P P PLCG1 CBLC 25402006 pred P P P P P P GP P P P P P P P P P SOCS5 CBLC 25402006 pred P P P P P P GP P P P P P P P P P MAP4K1 CBLC 25402006 pred G P HGS CBLC 25402006 pred P P P P P GP P P P P P P P P P ABL2 CBLC 25402006 pred P P P P P P GP P P P P P P P P P SGK3 CBLC 25402006 pred P P P P P P P P P P P P P P P P PIK3R1 CBLC 25402006, 21836163 pred P P P P P P GP P P P P P P P P P PRKCD CBLC 25402006 pred P P P P P P GP P P P P P P P P P PDCD6IP CBLC 25402006 pred P P P P P GP P P P P P P P P P PIK3R3 CBLC 25402006, 21836163 pred P P P P P GP P P P P P P P DTX1 CBLC 25402006 pred P P P P GP P P P P P P P P SFN CBLC 25402006 pred P G P PIK3C2B CBLC 25402006 pred P P P GP P P P P P P SNX3 CBLC 25402006 pred P P P P P GP P P P P P P P P P PTPN1 CBLC 25402006 pred P P P P GP P P P P P P P RAPGEF1 CBLC 25402006, 21836163 pred P P P GP P P P P P P P P EPOR CBLC 21836163 pred G MUC1 CBLC 25402006 pred P P P P GP P P P P P P P IL2RB CBLC 21836163 pred G SRCIN1 CBLC 25402006 pred ERBB4 CBLC 25402006 pred P P P P P P GP P P P P P P P P P FRK CBLC 25402006 pred P P P P P P P P P P P P P DOCK1 CBLC 25402006 pred P P P P P GP P P P P P P P P ERBB3 CBLC 25402006 pred P P P P P P GP P P P P P P P P P FGR CBLC 25402006 pred P P P P P P GP P P P P P P P P FRS2 CBLC 25402006 pred P G P P CTNND1 CBLC 25402006 pred P P P P P P P P P P P P P P P P PTK6 CBLC 25402006 pred P P P P P P GP P P P P P P P P P RASA1 CBLC 25402006 pred P P G P P P PTPN11 CBLC 25402006 pred P P P P P GP P P P P P P P P YWHAG CBLC 25402006 pred P P P P P P GP P P P P P P P P P ARF4 CBLC 25402006 pred G JAK2 CBLC 21836163 pred P P P P P P P P P P P P P NEDD4 CBLC 25402006 pred P P P P P GP P P P P P P P P P PIK3R2 CBLC 25402006, 21836163 pred G VAV2 CBLC 25402006 pred P P P P P GP P P P P P P P P SOS1 CBLC 25402006 pred P P P GP P P P P P P P CLTA CBLC 25402006 pred P P P P P GP P P P P P P P P KIT CBLC 25402006 pred P G P PTK2B CBLC 25402006 pred P P P P P GP P P P P P P P CPSF6 CBLC 25402006 pred P P P P P P GP P P P P P P P P P UBASH3B CBLC 25402006 pred P P P P P P P P P P P P P P P P ABL1 CBLC 25402006, 21836163 pred P P P P P P GP P P P P P P P P P DOCK3 CBLC 25402006 pred P P P P P P P P P P P P P P P NFE2 CBLC 25402006 pred P P P P P P P P P P P P P P P P OGN CBLC 25402006 pred P P P P P GP P P P P P P VAV1 CBLC 25402006 pred P P P P P P GP P P P P P P P P LCP2 CBLC 25402006 pred G PIK3CD CBLC 21836163 pred G P P P INSR CBLC 25402006 pred P P P P P P GP P P P P P P P P P ADRBK1 CBLC 25402006 pred P P P P P P GP P P P P P P P P P SH2D3A CBLC 25402006 pred P P P P P P GP P P P P P P P P P KHDRBS1 CBLC 25402006 pred P P P P P P GP P P P P P P P P P NTRK1 CBLC 25402006 pred P P P P P P P P P P P P P P P P EPS8 CBLC 25402006 pred P P P P P P GP P P P P P P P P P MTR CBLC 21836163 pred P P P P P GP P P P P P P P P P TXK CBLC 25402006 pred P P PTPN6 CBLC 25402006 pred G P PTPRJ CBLC 25402006 pred P P P P P P GP P P P P P P P P P RAF1 CBLC 25402006 pred P P P P P P GP P P P P P P P P P RGS16 CBLC 25402006 pred P P P P P GP P P P P P P P P CBL CBLC 25402006 pred P P P G P P YES1 CBLC 25402006 pred P P P P P P GP P P P P P P P P P IFNAR2 CBLC 21836163 pred P P P G P P P P P

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A8K379 Q9ULV8 pull down 10362357 direct interaction X 2 P12931 Q9ULV8 affinity chromatography technology 20525694 physical association X 2 P12931 Q9ULV8 unspecified method 22888118 direct interaction X 2 P12931 Q9ULV8 affinity chromatography technology 22888118 physical association X 2 P12931 Q9ULV8 x-ray crystallography 22888118 association X 2 P12931 Q9ULV8 pull down 14661060 direct interaction X 2 P12931 Q9ULV8 enzymatic study 14661060 direct interaction X 2 A0A087WW00 Q9ULV8 pull down 14661060 direct interaction X 2 Q96J02-2 Q9ULV8 two hybrid 12226085 direct interaction X 2 Q96J02-2 Q9ULV8 pull down 12226085 direct interaction X 2 Q96J02-2 Q9ULV8 affinity chromatography technology 12226085 physical association X 2 Q96J02-2 Q9ULV8 affinity chromatography technology 12226085 physical association X 2 L7RT18 Q9ULV8 pull down 10362357 direct interaction X 2 A0A024R1A4 Q9ULV8 two hybrid 19549727 direct interaction X 2 Q7L8S5 Q9ULV8 two hybrid 23105109 direct interaction X 2 P61086 Q9ULV8 two hybrid 19549727 direct interaction X 2 Q9Y5K6 Q9ULV8 affinity chromatography technology 18753381 physical association X 2 Q9Y5K6 Q9ULV8 affinity chromatography technology 18753381 physical association X 2 A0A024QZ59 Q9ULV8 two hybrid 22493164 direct interaction X 2 P06241-3 Q9ULV8 affinity chromatography technology 10571044 physical association X 2 P06241-3 Q9ULV8 pull down 10571044 direct interaction X 2 Q9ULV8 P62837 pull down 20525694 direct interaction X 2 Q9ULV8 Q9UK80 two hybrid 23105109 direct interaction X 2 Q9ULV8 Q96EP1-4 two hybrid 22493164 direct interaction X 2 Q9ULV8 Q9NR12-6 two hybrid 24466333 direct interaction X 2 Q9ULV8 Q9NR12-6 affinity chromatography technology 24466333 physical association X 2 Q9ULV8 Q9NR12-6 affinity chromatography technology 24466333 physical association X 2 Q9ULV8 P62837 pull down 14661060 direct interaction X 2 Q9ULV8 two hybrid 19549727 direct interaction X 2 P0CG48 Q9ULV8 enzymatic study 23145173 direct interaction X 2 P0CG48 Q9ULV8 enzymatic study 14661060 direct interaction X 2 P0CG48 Q9ULV8 affinity chromatography technology 21906983 physical association X 2 Q99963 Q9ULV8 two hybrid 21900206 direct interaction X 2 Q15654 Q9ULV8 two hybrid 23145173 direct interaction X 2 P00533 Q9ULV8 unspecified method 22888118 direct interaction X 2 P00533 Q9ULV8 affinity chromatography technology 22888118 physical association X 2 P00533 Q9ULV8 x-ray crystallography 22888118 association X 2 P00533 Q9ULV8 affinity chromatography technology 10571044 physical association X 2 P00533 Q9ULV8 pull down 10362357 direct interaction X 2 P00533 Q9ULV8 affinity chromatography technology 10362357 physical association X 2 P61077-3 Q9ULV8 pull down 14661060 direct interaction X 2 Q13490 Q9ULV8 two hybrid 22493164 direct interaction X 2 O15069 Q9ULV8 two hybrid 21900206 direct interaction X 2 Q7Z4K8 Q9ULV8 two hybrid 22493164 direct interaction X 2 Q9ULV8 two hybrid 21988832 direct interaction X 2 B4DLF5 Q9ULV8 affinity chromatography technology 22888118 physical association X 2 Q712K3 Q9ULV8 two hybrid 19549727 direct interaction X 2 Q9ULV8 A0A024R7T2 affinity chromatography technology 18753381 physical association X 2 Q9ULV8 A0A024R7T2 affinity chromatography technology 18753381 physical association X 2 Q9ULV8 P06732 enzymatic study 20525694 direct interaction X 2 Q9ULV8 unspecified method 22888118 direct interaction X 2 Q9ULV8 O75604-2 two hybrid 23105109 direct interaction X 2 Q9ULV8 A0A024R7T2 affinity chromatography technology 24466333 physical association X 2 Q9ULV8 A0A024R7T2 affinity chromatography technology 24466333 physical association X 2 Q9ULV8 P29353-5 two hybrid 21900206 direct interaction X 2 O14933-2 Q9ULV8 two hybrid 19549727 direct interaction X 2 P63279 Q9ULV8 two hybrid 19549727 direct interaction X 2 O43294 Q9ULV8 affinity chromatography technology 23145173 physical association X 2 O43294 Q9ULV8 two hybrid 23145173 direct interaction X 2 O43294 Q9ULV8 affinity chromatography technology 24831009 physical association X 2 Q8IZP0 Q9ULV8 array technology 20598684 direct interaction X 2 Q96J02 Q9ULV8 two hybrid 12226085 physical association X 2 Q96J02 Q9ULV8 fluorescence microscopy 12226085 colocalization X 2 Q96J02 Q9ULV8 pull down 12226085 physical association X 2 Q96J02 Q9ULV8 pull down 12226085 physical association X 2 Q96J02 Q9ULV8 anti tag coimmunoprecipitation 12226085 physical association X 2 A0A024R1A4 Q9ULV8 two hybrid array 19549727 physical association X 2 A0A024QZ59 Q9ULV8 two hybrid array 22493164 physical association X 2 Q99963 Q9ULV8 two hybrid 21900206 physical association X 2 O14933 Q9ULV8 two hybrid array 19549727 physical association X 2 A4D1L5 Q9ULV8 two hybrid array 19549727 physical association X 2 P29353 Q9ULV8 two hybrid 21900206 physical association X 2 Q13490 Q9ULV8 two hybrid array 22493164 physical association X 2 Q8CZZ7 Q9ULV8 two hybrid pooling approach 20711500 physical association X 2 O15069 Q9ULV8 two hybrid 21900206 physical association X 2 Q7Z4K8 Q9ULV8 two hybrid array 22493164 physical association X 2 Q95XU3 Q9ULV8 two hybrid 12226085 physical association X 2 Q96EP1 Q9ULV8 two hybrid array 22493164 physical association X 2 Q15070 Q9ULV8 two hybrid array 21988832 physical association X 2 Q712K3 Q9ULV8 two hybrid array 19549727 physical association X 2 B3KSH4 Q9ULV8 two hybrid array 19549727 physical association X 2 P63279 Q9ULV8 two hybrid array 19549727 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SH3GL3 CBLC MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_178726|BIOGRID_156304|UniProt_158128 prey|prey|prey bait|bait|bait USP2 CBLC MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248184 bait prey FYN CBLC MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 10571044 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_98688|BIOGRID_98687 bait|prey prey|bait GRB2 CBLC MI:0493(in vivo) 10086340 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_4653 - - UBE2I CBLC MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101367|BIOGRID_124381 bait|bait prey|prey TRIP6 CBLC MI:0004(affinity chromatography technology) 23145173 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248356 prey bait UBC CBLC MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21906983,23145173 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_248359|BIOGRID_181132 prey|bait bait|prey OXA1L CBLC MI:0397(two hybrid array)|MI:0004(affinity chromatography technology) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_117837|BIOGRID_288232 unspecified role|prey unspecified role|bait ABI1 CBLC MI:0008(array technology)|MI:0008(array technology)|MI:0008(array technology)|MI:0008(array technology)|MI:0008(array technology) 20598684 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction)|MI:0407(direct interaction) MI:0471(mint)|(intact)|MI:0471(mint)|(intact)|(intact) MINT_77037|UniProt_109616|MINT_46332|UniProt_185970|UniProt_173618 bait|bait|bait|bait|bait prey|prey|prey|prey|prey SPRY2 CBLC MI:0493(in vivo) 12234920 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_10891 - - NACAD CBLC MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(intact) UniProt_178725|BIOGRID_156302|UniProt_158127 prey|prey|prey bait|bait|bait UBE2H CBLC MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124380|UniProt_101344 bait|bait prey|prey UBE2D2 CBLC MI:0415(enzymatic study) 20525694 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225686 prey bait LYN CBLC MI:0492(in vitro)|MI:0096(pull down) 10362357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_264|BIOGRID_112580 -|prey -|bait CRK CBLC MI:0096(pull down)|MI:0492(in vitro) 10362357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|- (biogrid)|MI:0468(hprd) BIOGRID_112581|HPRD_38996 prey|- bait|- SRC CBLC MI:0686(unspecified method)|MI:0493(in vivo)|MI:0686(unspecified method)|MI:0415(enzymatic study)|MI:0686(unspecified method) 20525694,22888118,9988270 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0914(association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid) BIOGRID_208371|HPRD_4150|BIOGRID_208375|BIOGRID_195486|BIOGRID_208368 bait|-|prey|prey|prey prey|-|bait|bait|bait RET CBLC MI:0004(affinity chromatography technology)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0004(affinity chromatography technology) 18753381,24466333 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_195025|BIOGRID_307825|BIOGRID_307831|BIOGRID_195026 bait|prey|bait|prey prey|bait|prey|bait SHC1 CBLC MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 21900206 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (intact)|(intact)|(biogrid) UniProt_178727|UniProt_158129|BIOGRID_156303 prey|prey|prey bait|bait|bait ITCH CBLC MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0492(in vitro)|MI:0018(two hybrid) 12226085 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|-|MI:0915(physical association) (intact)|MI:0471(mint)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(intact)|(biogrid)|(biogrid)|(intact)|(intact)|(intact)|(biogrid)|(intact)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|MI:0471(mint)|(biogrid)|MI:0471(mint)|MI:0468(hprd)|MI:0471(mint) 215022|MINT_59608|UniProt_71059|MINT_59607|MINT_59604|MINT_59603|UniProt_71060|BIOGRID_134355|BIOGRID_134356|UniProt_71061|UniProt_71062|UniProt_1301|BIOGRID_134354|UniProt_71064|MINT_59573|MINT_31059|MINT_31058|MINT_31046|BIOGRID_134357|MINT_31055|HPRD_26013|MINT_31056 prey|bait|prey|unspecified role|bait|prey|unspecified role|prey|prey|bait|prey|prey|prey|bait|prey|bait|unspecified role|prey|bait|prey|-|bait bait|prey|bait|unspecified role|prey|bait|unspecified role|bait|bait|prey|bait|bait|bait|prey|bait|prey|unspecified role|bait|prey|bait|-|prey UBE2L6 CBLC MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124383|UniProt_101418 bait|bait prey|prey CHFR CBLC MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284160|UniProt_122542 prey|bait bait|prey EGFR CBLC MI:0686(unspecified method)|MI:0492(in vitro)|MI:0686(unspecified method)|MI:0686(unspecified method)|MI:0004(affinity chromatography technology)|MI:0096(pull down)|MI:0096(pull down) 10362357,10571044,22888118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0914(association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|MI:0468(hprd)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_208367|HPRD_33666|BIOGRID_208374|BIOGRID_208370|BIOGRID_98686|BIOGRID_112583|BIOGRID_112582 prey|-|prey|prey|prey|prey|prey bait|-|bait|bait|bait|bait|bait UBE2R2 CBLC MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124385|UniProt_101469 bait|bait prey|prey TGFB1I1 CBLC MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23145173 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_248355|BIOGRID_248354 prey|prey bait|bait BIRC2 CBLC MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284110|UniProt_122458 bait|bait prey|prey TRAF4 CBLC MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122515|BIOGRID_284157 bait|bait prey|prey UBE2K CBLC MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_124384 bait prey ZAP70 CBLC MI:0686(unspecified method) 22888118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_208369 prey bait CBLC HIP2 MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_101202 prey bait UBE2L3 CBLC MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_124382|UniProt_101381 bait|bait prey|prey OTUD6A CBLC MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248251 bait prey USP21 CBLC MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248210 bait prey CBLC CD2AP MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 18753381 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_195028|BIOGRID_195027 bait|prey prey|bait CKM CBLC MI:0415(enzymatic study) 20525694 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_195485 prey bait MET CBLC MI:0686(unspecified method) 22888118 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_208372 bait prey PDLIM7 CBLC MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 24466333 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_307823|BIOGRID_307824|BIOGRID_307822 prey|bait|prey bait|prey|bait TRIM46 CBLC MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284177|UniProt_122579 bait|bait prey|prey

PPI - HINT Gene A Gene B PMID Method Quality TGFB1I1 CBLC 24831009,23145173,23145173 0004,0004,0018 LC EGFR CBLC 10362357,22888118,10362357,22888118,10571044 0004,0004,0096,0114,0004 LC RET CBLC 24466333,18753381 0004,0004 LC SRC CBLC 20525694,14661060,14661060,22888118,22888118 0004,0415,0096,0004,0114 LC UBE2D2 CBLC 14661060,20525694 0096,0096 LC TGFB1I1 CBLC 24831009,23145173,23145173 0004,0004,0018 LC EGFR CBLC 10362357,22888118,10362357,22888118,10571044 0004,0004,0096,0114,0004 LC RET CBLC 24466333,18753381 0004,0004 LC SRC CBLC 20525694,14661060,14661060,22888118,22888118 0004,0415,0096,0004,0114 LC UBE2D2 CBLC 14661060,20525694 0096,0096 LC HIP2 CBLC 19549727 0397 HT UBE2L6 CBLC 19549727,19549727 0397,0018 HT NACAD CBLC 21900206 0018 HT TGFB1I1 CBLC 23145173,23145173 0004,0018 LC USP2 CBLC 23105109 0018 LC EGFR CBLC PDB_3OP0,22888118,22888118 0114,0004,0114 LC CKM CBLC 20525694 0415 LC UBC CBLC 14661060 0415 LC SRC CBLC 14661060,14661060,22888118,22888118 0415,0096,0004,0114 LC SHC1 CBLC 21900206 0018 HT CRK CBLC 25814554,25814554,25814554 0397,1356,0018 HT UBE2K CBLC 19549727 0018 HT UBE2H CBLC 19549727,19549727 0397,0018 HT UBE2I CBLC 19549727,19549727 0397,0018 HT UBE2L3 CBLC 19549727,19549727 0397,0018 HT BIRC2 CBLC 22493164,22493164 0018,0397 HT OXA1L CBLC 21988832,21988832 0397,0018 HT TRIP6 CBLC 23145173 0018 LC UBE2R2 CBLC 19549727,19549727 0397,0018 HT OTUD6A CBLC 23105109 0018 LC TRIM46 CBLC 22493164,22493164 0018,0397 HT ABI1 CBLC 20598684 0008 LC BAP1 CBLC 27107012,27107012 1356,2215 HT CHFR CBLC 22493164,22493164 0018,0397 HT ITCH CBLC 12226085,12226085,12226085,12226085,12226085,12226085 0007,0416,0021,0018,0096,0004 LC SH3GL3 CBLC 21900206 0018 HT TRAF4 CBLC 22493164,22493164 0018,0397 HT PDLIM7 CBLC 24466333,24466333 0018,0004 LC USP21 CBLC 23105109 0018 LC CBLC CBLC PDB_3OP0,22888118 0114,0114 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9ULV8 P61086 CBLC UBE2K 0.183 19549727 Q9ULV8 O43294 CBLC TGFB1I1 0.569 23145173,24831009 Q9ULV8 Q8CZZ7 CBLC RECN 0.126 20711500 Q9ULV8 Q9NR12 CBLC PDLIM7 0.569 24466333 Q9ULV8 O75604 CBLC USP2 0.183 23105109 Q9ULV8 Q7L8S5 CBLC OTUD6A 0.183 23105109 Q9ULV8 P08581 CBLC MET 0.21 22888118 Q9ULV8 P07949 CBLC RET 0.61 24466333,18753381 Q9ULV8 Q96EP1 CBLC CHFR 0.286 22493164 Q9ULV8 Q15070 CBLC OXA1L 0.286 21988832 Q9ULV8 P62837 CBLC UBE2D2 0.523 14661060,20525694 Q9ULV8 Q99963 CBLC SH3GL3 0.332 21900206 Q9ULV8 Q92560 CBLC BAP1 0.236 27107012 Q9ULV8 P12931 CBLC SRC 0.858 14661060,22888118,20525694 Q9ULV8 Q9BUZ4 CBLC TRAF4 0.286 22493164 Q9ULV8 Q13490 CBLC BIRC2 0.286 22493164 Q9ULV8 Q712K3 CBLC UBE2R2 0.286 19549727 Q9ULV8 O14933 CBLC UBE2L6 0.286 19549727 Q9ULV8 P62256 CBLC UBE2H 0.286 19549727 Q9ULV8 Q96J02 CBLC ITCH 0.888 12226085 Q9ULV8 P00533 CBLC EGFR 0.837 10362357,22888118,10571044 Q9ULV8 P29353 CBLC SHC1 0.332 21900206 Q9ULV8 Q9UK80 CBLC USP21 0.183 23105109 Q9ULV8 B3KSH4 CBLC HIP2 0.236 19549727 Q9ULV8 O15069 CBLC NACAD 0.332 21900206 Q9ULV8 P06241 CBLC FYN 0.454 10571044 Q9ULV8 P06732 CBLC CKM 0.309 20525694 Q9ULV8 P07948 CBLC LYN 0.309 10362357 Q9ULV8 P0CG48 CBLC UBC 0.309 14661060 Q9ULV8 P43403 CBLC ZAP70 0.309 22888118 Q9ULV8 P51668 CBLC UBE2D1 0.309 14661060 Q9ULV8 P61077 CBLC UBE2D3 0.309 14661060 Q9ULV8 P63279 CBLC UBE2I 0.286 19549727 Q9ULV8 P68036 CBLC UBE2L3 0.286 19549727 Q9ULV8 Q15654 CBLC TRIP6 0.309 23145173 Q9ULV8 Q7Z4K8 CBLC TRIM46 0.286 22493164 Q9ULV8 Q8IZP0 CBLC ABI1 0.309 20598684 Q9ULV8 Q95XU3 CBLC WWP-1 0.309 12226085 Q9Y5K6 Q9ULV8 CD2AP CBLC 0.376 18753381 Q9ULV8 P46108 CBLC CRK 0.569 25814554,10362357

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 LGALS9 CBLC MI:0362 inference MI:0461 interaction database SH2B2 CBLC MI:0362 inference MI:0461 interaction database UBE2L6 CBLC MI:0045 experimental interaction detection MI:0461 interaction database NACAD CBLC MI:0045 experimental interaction detection MI:0461 interaction database PHGDH CBLC MI:0362 inference MI:0461 interaction database TGFB1I1 CBLC MI:0045 experimental interaction detection MI:0461 interaction database SPRY2 CBLC MI:0362 inference MI:1106 pathways database USP2 CBLC MI:0045 experimental interaction detection MI:0461 interaction database ATG7 CBLC MI:0362 inference MI:0461 interaction database HPRT1 CBLC MI:0362 inference MI:0461 interaction database EGFR CBLC MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FYN CBLC MI:0045 experimental interaction detection MI:0461 interaction database CKM CBLC MI:0045 experimental interaction detection MI:0461 interaction database LYN CBLC MI:0045 experimental interaction detection MI:0461 interaction database RET CBLC MI:0045 experimental interaction detection MI:0461 interaction database MET CBLC MI:0045 experimental interaction detection MI:0461 interaction database UBC CBLC MI:0045 experimental interaction detection MI:0461 interaction database SRC CBLC MI:0045 experimental interaction detection MI:0461 interaction database RPL7 CBLC MI:0362 inference MI:0461 interaction database CBL CBLC MI:0362 inference MI:0461 interaction database SHC1 CBLC MI:0045 experimental interaction detection MI:0461 interaction database YWHAB CBLC MI:0362 inference MI:0461 interaction database FRK CBLC MI:0362 inference MI:0461 interaction database ZAP70 CBLC MI:0362 inference MI:0461 interaction database CRK CBLC MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UBE2D1 CBLC MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 CBLC MI:0045 experimental interaction detection MI:0461 interaction database UBE2K CBLC MI:0045 experimental interaction detection MI:0461 interaction database UBE2H CBLC MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 CBLC MI:0045 experimental interaction detection MI:0461 interaction database RPL11 CBLC MI:0362 inference MI:0461 interaction database GRB2 CBLC MI:0362 inference MI:0461,MI:1106 interaction database,pathways database YWHAZ CBLC MI:0362 inference MI:0461 interaction database UBE2I CBLC MI:0045 experimental interaction detection MI:0461 interaction database UBE2L3 CBLC MI:0045 experimental interaction detection MI:0461 interaction database UBXN1 CBLC MI:0362 inference MI:0461 interaction database CBLB CBLC MI:0362 inference MI:0461 interaction database BIRC2 CBLC MI:0045 experimental interaction detection MI:0461 interaction database GRAP CBLC MI:0362 inference MI:0461 interaction database OXA1L CBLC MI:0045 experimental interaction detection MI:0461 interaction database TRIP6 CBLC MI:0045 experimental interaction detection MI:0461 interaction database LGALS9B CBLC MI:0362 inference MI:0461 interaction database UBE2R2 CBLC MI:0045 experimental interaction detection MI:0461 interaction database OTUD6A CBLC MI:0045 experimental interaction detection MI:0461 interaction database TRIM46 CBLC MI:0045 experimental interaction detection MI:0461 interaction database ABI1 CBLC MI:0045 experimental interaction detection MI:0461 interaction database BAP1 CBLC MI:0045 experimental interaction detection MI:0461 interaction database CHFR CBLC MI:0045 experimental interaction detection MI:0461 interaction database ITCH CBLC MI:0045 experimental interaction detection MI:0461 interaction database SH3GL3 CBLC MI:0045 experimental interaction detection MI:0461 interaction database TRAF4 CBLC MI:0045 experimental interaction detection MI:0461 interaction database WWP1 CBLC MI:0362 inference MI:0461 interaction database PDLIM7 CBLC MI:0045 experimental interaction detection MI:0461 interaction database PRTFDC1 CBLC MI:0362 inference MI:0461 interaction database USP21 CBLC MI:0045 experimental interaction detection MI:0461 interaction database CBLC RBM19 MI:0362 inference MI:0461 interaction database CBLC CD2AP MI:0045 experimental interaction detection MI:0461 interaction database