PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus WDTC1 NUDC 25036637 intact exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G CUL3 WDTC1 25011449 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G BCKDK WDTC1 26186194 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP G GP G GP GP GP G GP G GP GP G WDTC1 MED23 12421765 hprd,i2d,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MRPS11 WDTC1 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G XPO1 WDTC1 26673895 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G WDTC1 FBXW11 25515538 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDTC1 MED4 12421765 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G TADA2A WDTC1 20508642 biogrid exp G G G G G G G G G G G G G G G G G G G G WDTC1 USP3 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G VCL WDTC1 i2d exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G WDTC1 SLC25A22 26186194 biogrid exp GP GP G G G GP G G GP G GP GP GP GP G GP GP G GP G GP GP G GP GP G GP GP G CUL4A WDTC1 16949367,21145461,16964240, 25402006 innatedb,biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DDB1 WDTC1 19966799,16949367,16964240, 25402006 hprd,biogrid,dip exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G WDTC1 DDA1 19295130,20562859, 25402006 biogrid,intact exp, pred GP GP G G GP GP G GP GP G GP GP GP G GP GP GP P G GP GP GP GP GP G GP GP G HIST1H2BJ WDTC1 ortho P P P P P P P P P P P P P P P P P P P P P WDTC1 TRPM7 ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP HDAC3 WDTC1 ortho GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, HIST1H4E, HIST1H4F, HIST1H4H, HIST1H4I, HIST1H4J, HIST1H4K, HIST1H4L, HIST2H4A, HIST2H4B, HIST4H4 WDTC1 ortho P P P P P P P P P P P P P P P P P P P P P DCAF6 WDTC1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DCAF10 WDTC1 25402006 pred G G G G G GP G GP G G G G GP G G G GP G G G G G G GP G G GP G G MAP3K1 WDTC1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G WDTC1 RFWD2 25402006 pred G G G G G GP G G GP G G G G G G G GP G G G GP G G G G G GP G G WDTC1 AMBRA1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP G P G GP GP GP GP GP G GP GP G WDTC1 IKBKG 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G APBB1 WDTC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP G G G GP G GP G GP GP GP GP G G GP GP G WDTC1 DCAF5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G COPS6 WDTC1 25402006 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP G GP G GP GP G LRP2 WDTC1 23023127 pred G G G G G G G G GP G G G G G G WDTC1 DDIT4 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G DCAF8 WDTC1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G CUL4B WDTC1 25402006 pred GP GP G G GP GP G GP GP G GP GP G GP G GP GP G GP G GP GP GP GP GP G GP GP G WDTC1 COPS3 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G SOCS7 WDTC1 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PRKAA1 WDTC1 23023127 pred GP GP G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP WDTC1 DTL 25402006 pred P P G GP P G P P P G P GP P P P P G G G GP GNB1 WDTC1 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP GP GP G G G GP G GP G GP GP G WDTC1 COPS7B 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G MEF2C WDTC1 23023127 pred G GP G G GP GP G GP GP G GP G GP GP G G GP GP G G G G GP G G G GP G GNG2 WDTC1 23023127 pred G G G G G GP G G GP G GP G G GP G G GP GP GP G GP G GP G G G GP GP G WDTC1 VPRBP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G WDTC1 TRPC4AP 25402006 pred GP GP G G GP GP G GP GP G GP GP GP G G GP GP GP GP G GP G GP G GP G GP GP G TLE2 WDTC1 25402006 pred G GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP G GP GP G GP GP G WDTC1 PHIP 25402006 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G DCAF12 WDTC1 25402006 pred G G G G GP GP G G GP G G G GP GP G GP GP GP GP G G G GP GP GP G GP G G DET1 WDTC1 25402006 pred G G G G GP GP G G G G G GP GP GP G GP GP G GP G GP G G GP GP G GP G G CIDEA WDTC1 23023127 pred G G G G G G G G WDTC1 PLEKHA1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G WDTC1 STUB1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G WDTC1 DCAF11 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G WDTC1 GFI1 23023127 pred P P G GP P P P P P P P GP P P P P P P P P G P P NF2 WDTC1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G WDTC1 ZNF106 23023127 pred GP GP G G GP GP G GP GP G GP G G GP G GP GP G GP G GP G GP GP GP G GP GP G WDTC1 COPS7A 25402006 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G RBX1 WDTC1 25402006 pred G G G G G GP G GP G G G G GP G G G GP G GP G GP GP G G G G G GP G WDTC1 COPS5 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G PTPRF WDTC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP G GP GP G CDKN1A WDTC1 25402006 pred GP GP G G GP G G G GP G G G GP G G GP G G G G GP G G G GP G G GP G DHH WDTC1 23023127 pred P P P P G P P P P P P P P P G P P P P P P GP NEDD8 WDTC1 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G ERCC8 WDTC1 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WDTC1 DDB2 25402006 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP G GP GP G GP GP G GNAI1 WDTC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G WDTC1 DCAF4 25402006 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP G GP GP G TF WDTC1 21836163 pred G G G GP GP G G G G P GP G G G G GP GP P G P G G G G G GP G PRKCD WDTC1 23023127 pred GP GP G G GP GP G GP GP GP P GP GP G GP GP GP GP GP GP GP P GP G GP GP G SCAP WDTC1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants P18206 Q8N5D0 - 15163412 - X 2 Q8N5D0 x-ray crystallography 19966799 direct interaction X 2 Q8N5D0 pull down 19966799 direct interaction X 2 Q8N5D0 anti tag coimmunoprecipitation 19615732 physical association C 21 Q8N5D0 anti tag coimmunoprecipitation 20562859 physical association C 42 Q9ULK4 Q8N5D0 two hybrid 12421765 physical association X 2 Q8N5D0 tandem affinity purification 20360068 physical association C 32 Q9Y266 Q8N5D0 luminescence based mammalian interactome mapping 25036637 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B WDTC1 DDA1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19295130,20562859 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_221652|BIOGRID_125186 prey|prey bait|bait UBD WDTC1 MI:0004(affinity chromatography technology) 22797925 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_226543 bait prey UBC WDTC1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study) 21139048,21987572,22053931 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_168998|BIOGRID_222183|BIOGRID_163217 bait|bait|bait prey|prey|prey DDB1 WDTC1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0114(x-ray crystallography)|MI:0004(affinity chromatography technology)|MI:0493(in vivo) 16949367,16964240,19966799 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction)|- (biogrid)|(biogrid)|MI:0465(dip)|(biogrid)|MI:0468(hprd) BIOGRID_122503|BIOGRID_122851|DIP_55177|BIOGRID_122879|HPRD_32118 bait|bait|-|prey|- prey|prey|-|bait|- WDTC1 USP3 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120270|UniProt_100675 prey|prey bait|bait WDTC1 MED23 MI:0018(two hybrid)|MI:0018(two hybrid) 12421765 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association) MI:0468(hprd)|(intact) HPRD_13441|UniProt_69967 -|prey -|bait NRF1 WDTC1 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_296579 bait prey WDTC1 MED4 MI:0018(two hybrid) 12421765 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_184106 prey bait CUL4A WDTC1 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16949367,16964240,21145461 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid)|(biogrid) BIOGRID_122530|BIOGRID_202929|BIOGRID_122896 bait|bait|prey prey|prey|bait CUL4B WDTC1 MI:0004(affinity chromatography technology) 16949367 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_122911 prey bait TADA2A WDTC1 MI:0004(affinity chromatography technology) 20508642 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_140263 bait prey

PPI - HINT Gene A Gene B PMID Method Quality BCKDK WDTC1 26186194 0004 HT MRPS11 WDTC1 26186194 0004 HT CUL4A WDTC1 16949367,16964240,21145461,16949367 0004,0004,0004,0096 LC,HT DDB1 WDTC1 16964240,19966799,16949367,16949367,19966799 0004,0114,0096,0004,0096 LC WDTC1 DDA1 20562859,20562859,19295130 0007,0004,0004 HT,LC WDTC1 SLC25A22 26186194 0004 HT WDTC1 USP3 19615732,19615732 0004,0007 HT BCKDK WDTC1 26186194 0004 HT MRPS11 WDTC1 26186194 0004 HT CUL4A WDTC1 21145461 0004 HT WDTC1 DDA1 20562859,20562859 0007,0004 HT WDTC1 SLC25A22 26186194 0004 HT WDTC1 USP3 19615732,19615732 0004,0007 HT CUL4A WDTC1 16949367,16964240,16949367 0004,0004,0096 LC DDB1 WDTC1 16964240,19966799,16949367,16949367,19966799 0004,0114,0096,0004,0096 LC WDTC1 DDA1 19295130 0004 LC VCL WDTC1 15163412 0019 LC DDB1 WDTC1 19966799,19966799 0114,0096 LC WDTC1 MED4 12421765 0018 HT WDTC1 MED23 12421765 0018 HT WDTC1 NUDC 25036637 0729 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q8N5D0 O14874 WDTC1 BCKDK 0.126 26186194 Q8N5D0 O14980 WDTC1 XPO1 0.126 26673895 Q8N5D0 Q13619 WDTC1 CUL4A 0.332 16964240,21145461,16949367 Q9P202 Q8N5D0 DFNB31 WDTC1 0.126 unassigned1312 Q9ULK4 Q8N5D0 MED23 WDTC1 0.183 12421765 Q9Y266 Q8N5D0 NUDC WDTC1 0.126 25036637 Q9H936 Q8N5D0 SLC25A22 WDTC1 0.126 26186194 Q9NPJ6 Q8N5D0 MED4 WDTC1 0.183 12421765 Q8N5D0 O75478 WDTC1 TADA2A 0.126 20508642 Q8N5D0 Q6P5F9 WDTC1 XPO1 0.126 26673895 Q9Y6I4 Q8N5D0 USP3 WDTC1 0.236 19615732 Q8N5D0 Q16531 WDTC1 DDB1 0.681 16964240,19966799,16949367 Q8N5D0 Q3U1J4 WDTC1 DDB1 0.236 20360068 Q9BW61 Q8N5D0 DDA1 WDTC1 0.332 20562859,19295130 Q9UKB1 Q8N5D0 FBXW11 WDTC1 0.126 25515538 Q8N5D0 Q13618 WDTC1 CUL3 0.21 25011449 Q8N5D0 P82912 WDTC1 MRPS11 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 BCKDK WDTC1 MI:0045 experimental interaction detection MI:0461 interaction database XPO1 WDTC1 MI:0045 experimental interaction detection MI:0461 interaction database UBD WDTC1 MI:0045 experimental interaction detection MI:0461 interaction database HDAC3 WDTC1 MI:0362 inference MI:0461 interaction database HIST1H2BK WDTC1 MI:0362 inference MI:0461 interaction database TADA2A WDTC1 MI:0045 experimental interaction detection MI:0461 interaction database HIST1H2BJ WDTC1 MI:0362 inference MI:0461 interaction database UBC WDTC1 MI:0045 experimental interaction detection MI:0461 interaction database VCL WDTC1 MI:0045 experimental interaction detection MI:0461 interaction database HIST1H2BO WDTC1 MI:0362 inference MI:0461 interaction database HIST1H2BB WDTC1 MI:0362 inference MI:0461 interaction database HIST1H2BD WDTC1 MI:0362 inference MI:0461 interaction database HIST1H4A WDTC1 MI:0362 inference MI:0461 interaction database HIST1H2BC WDTC1 MI:0362 inference MI:0461 interaction database MRPS11 WDTC1 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 WDTC1 MI:0045 experimental interaction detection MI:0461 interaction database CUL4A WDTC1 MI:0045 experimental interaction detection MI:0461 interaction database NEDD8 WDTC1 MI:0045 experimental interaction detection MI:0461 interaction database DDB1 WDTC1 MI:0045 experimental interaction detection MI:0461 interaction database HIST2H2BE WDTC1 MI:0362 inference MI:0461 interaction database HIST3H2BB WDTC1 MI:0362 inference MI:0461 interaction database WDTC1 HIST1H2BH MI:0362 inference MI:0461 interaction database WDTC1 HIST1H2BA MI:0362 inference MI:0461 interaction database WDTC1 TRPM7 MI:0362 inference MI:0461 interaction database WDTC1 HIST1H2BN MI:0362 inference MI:0461 interaction database WDTC1 HIST1H2BM MI:0362 inference MI:0461 interaction database WDTC1 HIST1H2BL MI:0362 inference MI:0461 interaction database WDTC1 DDA1 MI:0045 experimental interaction detection MI:0461 interaction database WDTC1 SLC25A22 MI:0045 experimental interaction detection MI:0461 interaction database WDTC1 MED4 MI:0045 experimental interaction detection MI:0461 interaction database WDTC1 FBXW11 MI:0045 experimental interaction detection MI:0461 interaction database WDTC1 MED23 MI:0045 experimental interaction detection MI:0461 interaction database WDTC1 NUDC MI:0045 experimental interaction detection MI:0461 interaction database WDTC1 USP3 MI:0045 experimental interaction detection MI:0461 interaction database