PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MARK4 USP21 19615732 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G G GP GP G GP G GP GP G UBA52 USP21 23201676 dip exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G SENP3 USP21 22626734 biogrid exp GP GP G G G GP G GP GP G GP GP G G G GP GP G GP G GP G GP G GP G GP GP G ANKRD28 USP21 19615732 biogrid,intact exp G GP G G G GP G G GP G G G GP G G G GP G G G GP G G G G G GP GP G TRIM5 USP21 23105109 biogrid exp GP GP G G P G GP GP GP GP GP G G GP P G GP G GP GP GP GP G GP P G USP4 USP21 22626734 biogrid exp G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP G GP G GP GP G CKAP5 USP21 22298430 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G FUCA1 USP21 19615732 biogrid,intact exp GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G G GP GP G GP G GP GP G ACVR1 USP21 15761153 i2d exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP G G GP G GP GP G RNF185 USP21 23105109 biogrid exp G G G G G GP G G GP G G G G G G G GP G G G G G G G G G GP GP G BHLHE40 USP21 25202122 biogrid exp G GP G G G GP G GP GP G GP GP G G G G GP G GP G GP GP GP G G G GP GP G USP21 TRAF6 20622874 biogrid exp GP GP G G G G G GP GP G GP GP GP G G GP G G G G GP GP GP G GP G GP GP G PCGF6 USP21 23105109 biogrid exp G G G G G G G G G G GP GP G G G G G G G G G G G G G G G G G KRT40 USP21 25416956 biogrid,intact exp P P P P P P P P P P P P P P P P P MARK1 USP21 22298430,19615732 biogrid,intact exp GP GP G G G GP G GP GP G GP P GP G G GP GP G GP G GP GP GP G GP G GP GP G MARK3 USP21 22298430,19615732 biogrid,intact exp GP GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G TRIM9 USP21 23105109 biogrid exp G G G G G G G G G G G UCHL3 USP21 22626734 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G TRIM23 USP21 23105109 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G OTUB1 USP21 22626734 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G UTRN USP21 19615732 biogrid,intact exp GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G TRIM54 USP21 22626734 biogrid exp P P GP P P P P G P G GP P P BEND3 USP21 19615732 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G HECW2 USP21 24163370 biogrid exp GP GP G G G GP G GP GP G GP G GP G G P GP GP G GP GP GP G GP G GP GP XPO1 USP21 21888622 biogrid exp GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G MAP4 USP21 22298430 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G UBC USP21 25527291,22626734,22195557,23287719,22298430,21399617,20622874 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G MARK2 USP21 22298430,19615732 biogrid,intact exp P P G G G GP GP GP G P P G GP GP P G GP GP GP P G GP P PPIB USP21 19615732 biogrid,intact exp GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G UBE2S USP21 20622874 biogrid exp G G G G G G G G GP G G G G G G G G G G G G G G G GP G JOSD1 USP21 22626734 biogrid exp GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP G G IFIH1 USP21 24493797 biogrid exp GP GP P G GP GP GP GP G G GP P G P G GP GP GP GP G GP P DTX3 USP21 23105109 biogrid exp GP GP G G G GP G GP GP G GP GP G G G GP GP G P G G G GP G GP G GP GP G RBCK1 USP21 23105109 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G LRSAM1 USP21 23105109 biogrid exp P GP G GP G P GP G GP GP P G P GP G GP G P GP P P G P P G RNF144A USP21 23105109 biogrid exp G GP G G G GP G GP GP G GP P GP G G GP GP G GP G P G GP G GP G GP P G STAMBP USP21 22626734 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP21 USP20 22626734,19615732 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G TGFBR1 USP21 15761153 i2d exp GP G G G G GP G GP GP G GP GP GP G G GP GP G G G G G G G GP G GP G G DDX58 USP21 24493797 biogrid exp GP GP G G G GP G G GP G GP GP GP G G GP GP G P G GP GP GP G GP G GP GP G RBM45 USP21 19615732 biogrid,intact exp G GP G G G GP G GP GP G GP GP G G G GP GP G P G P GP GP G GP G GP GP G UPF3B USP21 19615732 biogrid,intact exp GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G ARHGEF2 USP21 22298430 biogrid exp GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G EXOSC10 USP21 15231747 hprd,biogrid,i2d,intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G RIPK1 USP21 19910467 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP21 RBM8A 19615732 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRIM63 USP21 22626734 biogrid exp G G G G TRIM8 USP21 23105109 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP28 USP21 22626734 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G CBL USP21 23105109 biogrid exp G GP G G G GP G G GP G GP G GP G G G GP G G G G G G G G G G GP G SENP8 USP21 22626734 biogrid exp P P G GP G GP P G GP P P P P G P G P GP P G GP P GP DHX58 USP21 24493797 biogrid exp P P P P P P P P P P P P P UCHL1 USP21 22626734,19615732 biogrid,intact exp G G G G G GP G G GP G GP G G G G G GP G GP G G G G G G G G GP G IL33 USP21 25197364 biogrid exp GP G G P G GP GP G G G G G G P G P G G GP G G GP G ISG15 USP21 21399617 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP21 CBLC 23105109 biogrid exp P P P P P P GP P P P P P P P P HIST2H2AA3, HIST2H2AA4 USP21 21179169 biogrid exp P P G G P P GP P P P G P P GP P GP P GP G GP GP GATA3 USP21 23395819 biogrid exp G GP G G G G G G GP G GP GP GP G G GP G G G G GP G G G GP G GP GP G PPP6R3 USP21 19615732 biogrid,intact exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G ESPL1 USP21 22626734 biogrid exp GP GP G G G GP GP GP G GP GP GP G G GP GP G GP G GP P GP G GP G GP GP G USP21 USP21 22626734 biogrid exp GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G OTUB2 USP21 22626734 biogrid exp P P P P P P GP ATXN3 USP21 22626734 biogrid exp GP GP G G G GP G GP GP G GP G GP G G P GP G P G GP GP GP G GP G GP GP G NKD1 USP21 19888210 i2d exp G G G G G P G G G G GP USP33 USP21 22626734, 23023127 biogrid exp, ortho, pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP8 USP21 22626734, 23023127 biogrid exp, ortho, pred G GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP14 USP21 22626734, 23023127 biogrid exp, ortho, pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP51 USP21 22626734, 23023127 biogrid exp, ortho, pred GP GP G G G GP G GP P G GP P G G P GP G GP G GP GP P P G P GP YOD1 USP21 22626734, 23023127 biogrid exp, pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G P G GP GP GP G GP G GP GP G BAP1 USP21 22626734, 23023127 biogrid exp, pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP7 USP21 22626734, 23023127 biogrid exp, pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP48 USP21 19615732, 23023127 biogrid,intact exp, pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP2 USP21 22626734, 23023127 biogrid exp, pred GP G GP G GP P G GP GP GP G P GP G GP G GP P GP G GP P GP G PRKCI USP21 19615732, 23023127 biogrid,intact exp, pred GP GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP G G GP G GP GP G USP21 USP15 22626734, 23023127 biogrid exp, pred G GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G EED USP21 ortho GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP G GP G GP GP G UHRF2 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G UBXN10 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP GP G GP G GP GP GP G GP G GP GP G SQSTM1 USP21 23023127 pred GP GP G G G G G G GP G GP GP GP G G GP G G GP G GP GP GP G GP G GP GP G UBXN11 USP21 23023127 pred G GP G G G GP G GP P G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G DVL3 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G SUMO4 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G G GP G GP G GP GP GP G G G GP GP G USP12 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP9Y USP21 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G RAD23B USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G UBXN1 USP21 23023127 pred GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP G G GP G GP GP G UFM1 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G DDI2 USP21 23023127 pred P P P P P P P P P P P USP21 UBQLN1 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G RGS14 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP44 USP21 23023127 pred P P P P P P P P P P GP G P P P P P GP UBTD1 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G G GP G GP G P G G G G G GP G CIDEA USP21 23023127 pred G G G G G G G G UBFD1 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G RAD23A USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP21 USP3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MYO7B USP21 23023127 pred P P G G G P P P GP G GP G G G G P GP G GP G P G UBXN7 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G RASSF1 USP21 23023127 pred GP GP G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G UBTD2 USP21 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G RBBP6 USP21 23023127 pred GP G G G G GP G GP GP G GP GP GP G G GP GP G G G GP G GP G GP G GP GP G DDI1 USP21 23023127 pred P P P G GP GP P G P GP FRMD5 USP21 23023127 pred P GP G GP G GP P G P P P P GP G P G P P P P P P PARK2 USP21 23023127 pred P GP G GP G GP GP G GP P P G P GP G P G P GP G GP P GP G ARAF USP21 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBXN2B USP21 23023127 pred G GP G G G G G G GP G GP G GP G G GP G G G G G GP G G GP G GP GP G NBR1 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP46 USP21 23023127 pred GP GP G GP G GP GP G GP P GP G GP GP G GP G GP GP GP G GP G GP GP G BAG6 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G SF3A1 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G UBQLN2 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G MYLIP USP21 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TCEB2 USP21 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP54 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G PIK3CA USP21 23023127 pred GP GP G GP G GP GP G GP GP GP G G P GP G GP G P GP GP G GP G GP GP UBXN2A USP21 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP9X USP21 23023127 pred GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G UBQLNL USP21 23023127 pred P P P P P P G P P P P GP UBL4B USP21 23023127 pred P P P P P P P P P P P P P P P P AXIN1 USP21 23023127 pred GP GP G G GP G P GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G SUMO1 USP21 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G USP10 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP21 USP18 23023127 pred GP P G G GP G G G G G P GP G G G GP G TMUB1 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G TRIM21 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G RAF1 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP50 USP21 23023127 pred P P P P P P P P P P P P P P P P P VPS72 USP21 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G USP34 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G G G GP GP GP G GP G GP GP G USP47 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G UBA3 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G MAP3K3 USP21 23023127 pred G G G G G GP G GP G G GP G GP G G GP GP G G G GP G G G GP G GP G G TMUB2 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP36 USP21 23023127 pred G G G G G GP G G GP G GP GP G G G G GP G G G G GP G G G G G G G USP17L4 USP21 23023127 pred SUMO3 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP40 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G G G GP G GP GP G UBL7 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP21 NSFL1C 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G NFATC2IP USP21 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G BRD1 USP21 23023127 pred G G G G G GP G G G G G G G G G G GP G G G G G G G G G G GP G UBC USP21 23023127 pred UBL4A USP21 23023127 pred GP GP G G G GP G G GP G GP G G G G G GP G GP G GP G G G G G GP P G USP17L5 USP21 23023127 pred P P P P P P P P P P P P P P P P DVL2 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP39 USP21 23023127 pred G G G G G G G G G G G G G G G G G G G G G G USP21 USP22 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G CYLD USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G P G GP GP GP G GP G GP GP USP17L7 USP21 23023127 pred SUMO2 USP21 23023127 pred GP GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP GP G USP21 FAF1 23023127 pred GP GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G USP17L2 USP21 23023127 pred P P P P P P P P P P P P P P P P UBLCP1 USP21 23023127 pred GP GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G USP17L8 USP21 23023127 pred MIDN USP21 23023127 pred GP GP G G G GP G GP GP G GP G G G G GP GP G G G GP GP GP G GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9UK80 affinity chromatography technology 22298430 physical association X 2 Q9Y2K6 Q9UK80 enzymatic study 22626734 direct interaction X 2 Q9Y2K6 Q9UK80 affinity chromatography technology 19615732 physical association X 2 Q9BYX4 Q9UK80 affinity chromatography technology 24493797 physical association X 2 Q93009 Q9UK80 enzymatic study 22626734 direct interaction X 2 Q6FI13 Q9UK80 enzymatic study 21179169 direct interaction X 2 A0A024R1Y5 Q9UK80 affinity chromatography technology 24493797 physical association X 2 Q9BZR9 Q9UK80 two hybrid 23105109 direct interaction X 2 A0A023T787 Q9UK80 affinity chromatography technology 19615732 physical association X 2 O14503 Q9UK80 affinity chromatography technology 25202122 physical association X 2 Q70EK9 Q9UK80 enzymatic study 22626734 direct interaction X 2 Q969Q1 Q9UK80 enzymatic study 22626734 direct interaction X 2 Q14008-3 Q9UK80 affinity chromatography technology 22298430 physical association X 2 Q16763 Q9UK80 enzymatic study 20622874 direct interaction X 2 Q9Y4K3 Q9UK80 enzymatic study 20622874 direct interaction X 2 P36406 Q9UK80 two hybrid 23105109 direct interaction X 2 A0A024QZU0 Q9UK80 affinity chromatography technology 19910467 physical association X 2 A0A024QZU0 Q9UK80 affinity chromatography technology 19910467 physical association X 2 A0A024R305 Q9UK80 enzymatic study 22626734 direct interaction X 2 P54578-3 Q9UK80 enzymatic study 22626734 direct interaction X 2 Q9BZI7-2 Q9UK80 affinity chromatography technology 19615732 physical association X 2 Q9ULV8 Q9UK80 two hybrid 23105109 direct interaction X 2 Q9UK80 P27448-4 affinity chromatography technology 22298430 physical association X 2 Q9UK80 Q9UK80 enzymatic study 22626734 direct interaction X 2 Q9UK80 Q8TEY7 enzymatic study 22626734 direct interaction X 2 Q9UK80 Q9Y4E8-2 enzymatic study 22626734 direct interaction X 2 Q9UK80 Q9Y4E8-2 enzymatic study 22626734 direct interaction X 2 Q9UK80 two hybrid 23105109 direct interaction X 2 Q9UK80 P27448-4 affinity chromatography technology 19615732 physical association X 2 Q9UK80 Q5H9R7-5 affinity chromatography technology 19615732 physical association X 2 Q9UK80 affinity chromatography technology 19615732 physical association X 2 Q15040 Q9UK80 enzymatic study 22626734 direct interaction X 2 Q9BYE7 Q9UK80 two hybrid 23105109 direct interaction X 2 P41743 Q9UK80 affinity chromatography technology 19615732 physical association X 2 A8K8D3 Q9UK80 enzymatic study 22626734 direct interaction X 2 O95630 Q9UK80 enzymatic study 22626734 direct interaction X 2 A0A024RB96 Q9UK80 two hybrid 23105109 direct interaction X 2 P15374 Q9UK80 enzymatic study 22626734 direct interaction X 2 C9JQV6 Q9UK80 enzymatic study 22626734 direct interaction X 2 P46939 Q9UK80 affinity chromatography technology 19615732 physical association X 2 Q9UK80 affinity chromatography technology 22298430 physical association X 2 Q96DC9 Q9UK80 enzymatic study 22626734 direct interaction X 2 O95760-3 Q9UK80 affinity chromatography technology 25197364 physical association X 2 O95760-3 Q9UK80 affinity chromatography technology 25197364 physical association X 2 Q9BYV2 Q9UK80 enzymatic study 22626734 direct interaction X 2 Q6A162 Q9UK80 two hybrid 25416956 direct interaction X 2 Q14674 Q9UK80 enzymatic study 22626734 direct interaction X 2 A0A024R870 Q9UK80 two hybrid 23105109 direct interaction X 2 Q96FW1 Q9UK80 enzymatic study 22626734 direct interaction X 2 P23771 Q9UK80 affinity chromatography technology 23395819 physical association X 2 P23771 Q9UK80 affinity chromatography technology 23395819 physical association X 2 Q9P2P5 Q9UK80 affinity chromatography technology 24163370 physical association X 2 P22681 Q9UK80 two hybrid 23105109 direct interaction X 2 Q5T5X7 Q9UK80 affinity chromatography technology 19615732 physical association X 2 P04066 Q9UK80 affinity chromatography technology 19615732 physical association X 2 Q9H4L4 Q9UK80 enzymatic study 22626734 direct interaction X 2 O95786 Q9UK80 affinity chromatography technology 24493797 physical association X 2 O95786 Q9UK80 affinity chromatography technology 24493797 physical association X 2 O95786 Q9UK80 imaging technique 24493797 colocalization X 2 Q96RU2 Q9UK80 enzymatic study 22626734 direct interaction X 2 Q96RU2 Q9UK80 enzymatic study 22626734 direct interaction X 2 Q9UK80 two hybrid 23105109 direct interaction X 2 P50876 Q9UK80 two hybrid 23105109 direct interaction X 2 P09936 Q9UK80 enzymatic study 22626734 direct interaction X 2 P09936 Q9UK80 affinity chromatography technology 19615732 physical association X 2 Q5VVQ6 Q9UK80 enzymatic study 22626734 direct interaction X 2 P0CG48 Q9UK80 enzymatic study 22195557 direct interaction X 2 P0CG48 Q9UK80 x-ray crystallography 21399617 association X 2 P0CG48 Q9UK80 pull down 21399617 direct interaction X 2 P0CG48 Q9UK80 enzymatic study 22298430 direct interaction X 2 P0CG48 Q9UK80 enzymatic study 22626734 direct interaction X 2 P0CG48 Q9UK80 unspecified method 23287719 direct interaction X 2 P0CG48 Q9UK80 affinity chromatography technology 23287719 physical association X 2 P0CG48 Q9UK80 affinity chromatography technology 23287719 physical association X 2 P0CG48 Q9UK80 enzymatic study 21399617 direct interaction X 2 P0CG48 Q9UK80 affinity chromatography technology 22118674 physical association X 2 P0CG48 Q9UK80 enzymatic study 20622874 direct interaction X 2 P0CG48 Q9UK80 affinity chromatography technology 21906983 physical association X 2 Q9UK80 O14980 imaging technique 21888622 colocalization X 2 Q9UK80 Q7KZI7 affinity chromatography technology 22298430 physical association X 2 Q9UK80 Q7KZI7 affinity chromatography technology 22298430 physical association X 2 Q9UK80 enzymatic study 22626734 direct interaction X 2 Q9UK80 O75604-2 enzymatic study 22626734 direct interaction X 2 Q9UK80 Q13107-3 enzymatic study 22626734 direct interaction X 2 Q9UK80 unspecified method 20467438 direct interaction X 2 Q9UK80 Q7KZI7 affinity chromatography technology 19615732 physical association X 2 Q9UK80 affinity chromatography technology 19615732 physical association X 2 Q9C035 Q9UK80 two hybrid 23105109 direct interaction X 2 Q96L34-2 Q9UK80 affinity chromatography technology 19615732 physical association X 2 P23284 Q9UK80 affinity chromatography technology 19615732 physical association X 2 Q9UK80 two hybrid 15231747 direct interaction X 2 Q9UK80 affinity chromatography technology 19615732 physical association X 2 P05161 Q9UK80 enzymatic study 21399617 direct interaction X 2 A0A024R1F5 Q9UK80 two hybrid 23105109 direct interaction X 2 Q9P0L2 Q9UK80 affinity chromatography technology 22298430 physical association X 2 Q9P0L2 Q9UK80 affinity chromatography technology 19615732 physical association X 2 Q9UK80 P62987 fluorescent resonance energy transfer 23201676 direct interaction X 2 Q9UK80 P62987 fluorescent resonance energy transfer 23201676 direct interaction X 2 Q01780-2 Q9UK80 two hybrid 15231747 - X 2 Q01780-2 Q9UK80 two hybrid 15231747 - X 2 Q9UK80 anti tag coimmunoprecipitation 19615732 physical association C 18 Q6A162 Q9UK80 two hybrid prey pooling approach 25416956 physical association X 2 Q6A162 Q9UK80 two hybrid array 25416956 physical association X 2 Q6A162 Q9UK80 validated two hybrid 25416956 physical association X 2 Q01780 Q9UK80 two hybrid 15231747 physical association X 2 P31016 Q9UK80 peptide array 20467438 direct interaction X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B LRSAM1 USP21 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248214 prey bait TRIM5 USP21 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248218 prey bait RNF144A USP21 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248213 prey bait USP2 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223085 prey bait PPP6R3 USP21 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120524|UniProt_100667 prey|prey bait|bait USP33 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223079 prey bait TRIM54 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223056 bait prey TRIM8 USP21 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248216 prey bait USP8 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223076 prey bait SENP3 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223090 prey bait YOD1 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223087 prey bait UCHL3 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223075 prey bait PPIB USP21 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100667|BIOGRID_119667 prey|prey bait|bait ISG15 USP21 MI:0114(x-ray crystallography) 21399617 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_200405 prey bait MARK1 USP21 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732,22298430 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_119576|BIOGRID_209022|UniProt_100667 prey|prey|prey bait|bait|bait RNF185 USP21 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248219 prey bait RBCK1 USP21 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248215 prey bait UCHL1 USP21 MI:0007(anti tag coimmunoprecipitation)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology) 19615732,22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0915(physical association) (intact)|(biogrid)|(biogrid) UniProt_100667|BIOGRID_223088|BIOGRID_119837 prey|prey|prey bait|bait|bait USP51 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223069 prey bait UTRN USP21 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119851|UniProt_100667 prey|prey bait|bait MARK4 USP21 MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_120614 prey bait UPF3B USP21 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100667|BIOGRID_120653 prey|prey bait|bait TRIM23 USP21 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248212 prey bait PCGF6 USP21 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248217 prey bait OTUB1 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223073 prey bait TRIM63 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223005 bait prey CKAP5 USP21 MI:0004(affinity chromatography technology) 22298430 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_208663 prey bait HECW2 USP21 MI:0004(affinity chromatography technology) 24163370 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_294071 bait prey UBE2S USP21 MI:0415(enzymatic study) 20622874 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_165032 prey bait USP14 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223084 prey bait IFIH1 USP21 MI:0004(affinity chromatography technology) 24493797 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_307968 prey bait DDX58 USP21 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 24493797 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0403(colocalization) (biogrid)|(biogrid)|(biogrid) BIOGRID_307963|BIOGRID_307964|BIOGRID_307965 prey|bait|prey bait|prey|bait USP21 USP20 MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732,22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_223068|BIOGRID_120204|UniProt_100667 bait|bait|bait prey|prey|prey MARK3 USP21 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732,22298430 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(intact) BIOGRID_208664|BIOGRID_119578|UniProt_100667 prey|prey|prey bait|bait|bait DHX58 USP21 MI:0004(affinity chromatography technology) 24493797 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_307969 prey bait MARK2 USP21 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19615732,22298430 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|(biogrid)|(biogrid) UniProt_100667|BIOGRID_119464|BIOGRID_208660|BIOGRID_209023 prey|prey|prey|prey bait|bait|bait|bait MAP4 USP21 MI:0004(affinity chromatography technology) 22298430 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_208661 prey bait BAP1 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223086 prey bait PRKCI USP21 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_119683|UniProt_100667 prey|prey bait|bait SENP8 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223083 prey bait ANKRD28 USP21 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120298|UniProt_100667 prey|prey bait|bait ATXN3 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223070 prey bait RBM45 USP21 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120807|UniProt_100667 prey|prey bait|bait BEND3 USP21 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100667|BIOGRID_120612 prey|prey bait|bait EXOSC10 USP21 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0018(two hybrid) 15231747 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0915(physical association)|MI:0407(direct interaction) MI:0468(hprd)|(intact)|(biogrid) HPRD_18330|UniProt_76772|BIOGRID_290025 -|bait|bait -|prey|prey CBL USP21 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248211 prey bait USP4 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223091 prey bait USP21 RBM8A MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120112|UniProt_100667 bait|bait prey|prey XPO1 USP21 MI:0428(imaging technique) 21888622 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_198012 prey bait USP21 USP15 MI:0415(enzymatic study)|MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_223099|BIOGRID_223080 prey|bait bait|prey USP21 TRAF6 MI:0415(enzymatic study) 20622874 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_165049 bait prey JOSD1 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223074 prey bait USP48 USP21 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100667|BIOGRID_120727 prey|prey bait|bait OTUB2 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223078 prey bait GATA3 USP21 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 23395819 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_273051|BIOGRID_273052 prey|bait bait|prey NRF1 USP21 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_295951 bait prey USP21 CBLC MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248210 bait prey ARHGEF2 USP21 MI:0004(affinity chromatography technology) 22298430 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_208662 prey bait DTX3 USP21 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248221 prey bait USP7 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223071 prey bait STAMBP USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223072 prey bait RIPK1 USP21 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 19910467 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_134377|BIOGRID_134376 bait|prey prey|bait ESPL1 USP21 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223082 prey bait USP28 USP21 MI:0415(enzymatic study)|MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_223081|BIOGRID_223131 prey|bait bait|prey FUCA1 USP21 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100667|BIOGRID_119488 prey|prey bait|bait TRIM9 USP21 MI:0018(two hybrid) 23105109 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_248220 prey bait

PPI - HINT Gene A Gene B PMID Method Quality ANKRD28 USP21 19615732,19615732 0004,0007 HT O75271 USP21 19615732 0007 HT FUCA1 USP21 19615732,19615732 0004,0007 HT UCHL1 USP21 19615732,19615732 0004,0007 HT UBC USP21 21399617,21399617,21399617,22118674 0096,0415,0114,0004 LC PPIB USP21 19615732,19615732 0004,0007 HT MARK3 USP21 19615732 0007 HT PRKCI USP21 19615732,19615732 0004,0007 HT UTRN USP21 19615732,19615732 0004,0007 HT PPP6R3 USP21 19615732,19615732 0004,0007 HT BEND3 USP21 19615732,26100909,19615732 0004,0004,0007 HT,LC Q6LBS5 USP21 19615732 0004 HT MARK2 USP21 19615732,19615732,22298430 0004,0007,0004 HT,LC Q86U11 USP21 19615732,22298430 0004,0004 HT,LC USP48 USP21 19615732,19615732 0004,0007 HT RBM45 USP21 19615732,19615732 0004,0007 HT MARK4 USP21 19615732 0004 HT UPF3B USP21 19615732,19615732 0004,0007 HT MARK1 USP21 19615732,19615732,22298430 0004,0007,0004 HT,LC USP21 USP20 19615732,19615732 0004,0007 HT USP21 RBM8A 19615732,19615732 0004,0007 HT USP21 HEL-117 19615732 0004 HT ANKRD28 USP21 19615732,19615732 0004,0007 HT O75271 USP21 19615732 0007 HT FUCA1 USP21 19615732,19615732 0004,0007 HT UCHL1 USP21 19615732,19615732 0004,0007 HT PPIB USP21 19615732,19615732 0004,0007 HT MARK3 USP21 19615732 0007 HT PRKCI USP21 19615732,19615732 0004,0007 HT UTRN USP21 19615732,19615732 0004,0007 HT PPP6R3 USP21 19615732,19615732 0004,0007 HT BEND3 USP21 19615732,19615732 0004,0007 HT Q6LBS5 USP21 19615732 0004 HT MARK2 USP21 19615732,19615732 0004,0007 HT Q86U11 USP21 19615732 0004 HT USP48 USP21 19615732,19615732 0004,0007 HT RBM45 USP21 19615732,19615732 0004,0007 HT MARK4 USP21 19615732 0004 HT UPF3B USP21 19615732,19615732 0004,0007 HT MARK1 USP21 19615732,19615732 0004,0007 HT USP21 USP20 19615732,19615732 0004,0007 HT USP21 RBM8A 19615732,19615732 0004,0007 HT USP21 HEL-117 19615732 0004 HT UBC USP21 21399617,21399617,21399617,22118674 0096,0415,0114,0004 LC BEND3 USP21 26100909 0004 LC MARK2 USP21 22298430 0004 LC Q86U11 USP21 22298430 0004 LC MARK1 USP21 22298430 0004 LC AURKA USP21 26446837 0415 LC USP2 USP21 22626734 0415 HT STAMBP USP21 22626734 0415 HT ISG15 USP21 21399617 0415 LC UBB USP21 21399617 0114 LC UBC USP21 22298430,25527291,22626734,21399617,23287719,20622874,23201676,21399617,22195557,21399617 0415,0415,0415,0096,0114,0415,0055,0415,0415,0114 LC,HT UCHL3 USP21 22626734 0415 HT CBL USP21 23105109 0018 LC TRIM23 USP21 23105109 0018 LC TGFBR1 USP21 15761153 0019 HT USP8 USP21 22626734 0415 HT RNF144A USP21 23105109 0018 LC ATXN3 USP21 22626734 0415 HT USP14 USP21 22626734 0415 HT EXOSC10 USP21 15231747 0018 HT ACVR1 USP21 15761153 0019 HT USP4 USP21 22626734 0415 HT ESPL1 USP21 22626734 0415 HT JOSD1 USP21 22626734 0415 HT UBE2S USP21 20622874 0415 LC YOD1 USP21 22626734 0415 HT KRT40 USP21 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT HIST2H2AA3|HIST2H2AA4 USP21 21179169 0415 LC LRSAM1 USP21 23105109 0018 LC USP51 USP21 22626734 0415 HT DTX3 USP21 23105109 0018 LC USP33 USP21 22626734 0415 HT BAP1 USP21 22626734 0415 HT USP7 USP21 22626734 0415 HT TRIM63 USP21 22626734 0415 HT OTUB2 USP21 22626734 0415 HT OTUB1 USP21 22626734 0415 HT RNF185 USP21 23105109 0018 LC SENP8 USP21 22626734 0415 HT USP28 USP21 22626734 0415 HT PCGF6 USP21 23105109 0018 LC RBCK1 USP21 23105109 0018 LC TRIM54 USP21 22626734 0415 HT TRIM8 USP21 23105109 0018 LC TRIM9 USP21 23105109 0018 LC TRIM5 USP21 23105109 0018 LC SENP3 USP21 22626734 0415 HT USP21 USP21 22626734,21399617,23287719 0415,0114,0114 HT,LC USP21 CBLC 23105109 0018 LC USP21 USP20 22626734 0415 HT USP21 USP15 22626734 0415 HT USP21 TRAF6 20622874 0415 LC USP21 HEL-117 22626734 0415 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9UK80 Q5T5X7 USP21 BEND3 0.396 19615732,26100909 Q9UK80 O15075 USP21 DCLK1 0.126 unassigned1312 Q9UK80 O43896 USP21 KIF1C 0.126 unassigned1312 Q9UK80 O43166 USP21 SIPA1L1 0.126 unassigned1312 Q9UK80 Q9NQT8 USP21 KIF13B 0.126 unassigned1312 Q9UK80 Q8TC76 USP21 FAM110B 0.126 unassigned1312 Q9UK80 O75420 USP21 GIGYF1 0.126 unassigned1312 Q9Y3M2 Q9UK80 CBY1 USP21 0.126 unassigned1312 Q9UK80 Q6ZW31 USP21 SYDE1 0.126 unassigned1312 Q9UK80 Q6IQ23 USP21 PLEKHA7 0.126 unassigned1312 Q9UK80 O95544 USP21 NADK 0.126 unassigned1312 Q9UK80 O95786 USP21 DDX58 0.454 24493797 Q9UK80 P04066 USP21 FUCA1 0.236 19615732 Q9UK80 O95967 USP21 EFEMP2 0.236 unassigned1304 Q9UK80 O15084 USP21 ANKRD28 0.236 19615732 Q9UK80 Q9BZI7 USP21 UPF3B 0.236 19615732 Q9UK80 Q16630 USP21 CPSF6 0.236 unassigned1304 Q9UK80 P23284 USP21 PPIB 0.236 19615732 Q9UK80 P46939 USP21 UTRN 0.236 19615732 Q9UK80 P41743 USP21 PRKCI 0.236 19615732 Q9UK80 Q8IUH3 USP21 RBM45 0.236 19615732 Q9UK80 Q6A162 USP21 KRT40 0.454 25416956 Q9UK80 Q5H9R7 USP21 PPP6R3 0.236 19615732 Q9UK80 Q86UV5 USP21 USP48 0.236 19615732 Q9UK80 Q7L273 USP21 KCTD9 0.236 unassigned1304 Q9UK80 Q9NYD6 USP21 HOXC10 0.236 unassigned1304 Q9Y5S9 Q9UK80 RBM8A USP21 0.236 19615732 Q9UK80 Q6UY14 USP21 ADAMTSL4 0.236 unassigned1304 Q9UK80 P09936 USP21 UCHL1 0.376 19615732,22626734 Q9UK80 P27448 USP21 MARK3 0.396 19615732,22298430 Q9UK80 Q7KZI7 USP21 MARK2 0.396 19615732,22298430 Q9Y2K6 Q9UK80 USP20 USP21 0.376 19615732,22626734 Q9UK80 Q9P0L2 USP21 MARK1 0.396 19615732,22298430 Q9UK80 P0CG48 USP21 UBC 0.939 21399617,25527291,23287719,22195557,22298430,20622874,22626734 Q9UK80 Q969Q1 USP21 TRIM63 0.183 22626734 Q9UK80 Q8WXF0 USP21 SRSF12 0.126 unassigned1312 Q9UK80 Q9BQ89 USP21 FAM110A 0.126 unassigned1312 Q9UK80 Q96QZ7 USP21 MAGI1 0.126 unassigned1312 Q9UK80 Q96RU2 USP21 USP28 0.332 22626734 Q9UK80 Q96S53 USP21 TESK2 0.126 unassigned1312 Q9UK80 Q9BYV2 USP21 TRIM54 0.183 22626734 Q9UK80 Q9P0V3 USP21 SH3BP4 0.126 unassigned1312 Q9UK80 Q9P244 USP21 LRFN1 0.126 unassigned1312 Q9UK80 Q9P2P5 USP21 HECW2 0.126 24163370 Q9UK80 Q9UHB6 USP21 LIMA1 0.126 unassigned1312 Q9UK80 Q9UIF9 USP21 BAZ2A 0.21 26100909 Q9UK80 Q9UJF2 USP21 RASAL2 0.126 unassigned1312 Q9UK80 O14965 USP21 AURKA 0.309 26446837 Q9UK80 O14980 USP21 XPO1 0.126 21888622 Q9UK80 O60307 USP21 MAST3 0.126 unassigned1312 Q9UK80 O60573 USP21 EIF4E2 0.126 unassigned1312 Q9UK80 O75044 USP21 SRGAP2 0.126 unassigned1312 Q9UK80 O75271 USP21 O75271 0.126 19615732 Q9UK80 O75604 USP21 USP2 0.183 22626734 Q9UK80 O95630 USP21 STAMBP 0.183 22626734 Q9UK80 O95760 USP21 IL33 0.376 25197364 Q9UK80 P05161 USP21 ISG15 0.309 21399617 Q9UK80 P15374 USP21 UCHL3 0.183 22626734 Q9UK80 P21359 USP21 NF1 0.126 unassigned1312 Q9UK80 P22681 USP21 CBL 0.183 23105109 Q9UK80 P23771 USP21 GATA3 0.376 23395819 Q9UK80 P27816 USP21 MAP4 0.21 22298430 Q9UK80 P30305 USP21 CDC25B 0.126 unassigned1312 Q9UK80 P31016 USP21 DLG4 0.183 20467438 Q9UK80 P36406 USP21 TRIM23 0.183 23105109 Q9UK80 P40818 USP21 USP8 0.183 22626734 Q9UK80 P50876 USP21 RNF144A 0.183 23105109 Q9UK80 P54252 USP21 ATXN3 0.183 22626734 Q9UK80 P54578 USP21 USP14 0.183 22626734 Q9UK80 Q00536 USP21 CDK16 0.126 unassigned1312 Q9UK80 Q01780 USP21 EXOSC10 0.332 15231747 Q9UK80 Q13009 USP21 TIAM1 0.126 unassigned1312 Q9UK80 Q13107 USP21 USP4 0.183 22626734 Q9UK80 Q13546 USP21 RIPK1 0.376 19910467 Q9UK80 Q14008 USP21 CKAP5 0.21 22298430 Q9UK80 Q14674 USP21 ESPL1 0.183 22626734 Q9UK80 Q14966 USP21 ZNF638 0.126 unassigned1312 Q9UK80 Q15040 USP21 JOSD1 0.183 22626734 Q9UK80 Q16763 USP21 UBE2S 0.309 20622874 Q9UK80 Q5TCX8 USP21 MLK4 0.126 unassigned1312 Q9UK80 Q5TCZ1 USP21 SH3PXD2A 0.126 unassigned1312 Q9UK80 Q5VVQ6 USP21 YOD1 0.183 22626734 Q9UK80 Q5VZ89 USP21 DENND4C 0.126 unassigned1312 Q9UK80 Q69YU3 USP21 ANKRD34A 0.126 unassigned1312 Q9UK80 Q6FI13 USP21 HIST2H2AA4 0.309 21179169 Q9UK80 Q6UWE0 USP21 LRSAM1 0.183 23105109 Q9UK80 Q70EK9 USP21 USP51 0.183 22626734 Q9UK80 Q86SQ0 USP21 PHLDB2 0.126 unassigned1312 Q9UK80 Q8IVT5 USP21 KSR1 0.126 unassigned1312 Q9UK80 Q8N9I9 USP21 DTX3 0.183 23105109 Q9UK80 Q8TEH3 USP21 DENND1A 0.126 unassigned1312 Q9UK80 Q8TEY7 USP21 USP33 0.183 22626734 Q9UK80 Q8WUY9 USP21 DEPDC1B 0.126 unassigned1312 Q9UK80 Q92560 USP21 BAP1 0.183 22626734 Q9UK80 Q92974 USP21 ARHGEF2 0.21 22298430 Q9UK80 Q93009 USP21 USP7 0.183 22626734 Q9UK80 Q96C10 USP21 DHX58 0.21 24493797 Q9UK80 Q96DC9 USP21 OTUB2 0.183 22626734 Q9UK80 Q96FW1 USP21 OTUB1 0.183 22626734 Q9UK80 Q96GF1 USP21 RNF185 0.183 23105109 Q9UK80 Q96L34 USP21 MARK4 0.126 19615732 Q9UK80 Q96LD8 USP21 SENP8 0.183 22626734 Q9UK80 Q96QF0 USP21 RAB3IP 0.126 unassigned1312 Q9UK80 Q9BPZ7 USP21 MAPKAP1 0.126 unassigned1312 Q9UK80 Q9BST9 USP21 RTKN 0.126 unassigned1312 Q9UK80 Q9BYE7 USP21 PCGF6 0.183 23105109 Q9UK80 Q9BYM8 USP21 RBCK1 0.183 23105109 Q9UK80 Q9BYX4 USP21 IFIH1 0.21 24493797 Q9UK80 Q9BZR9 USP21 TRIM8 0.183 23105109 Q9UK80 Q9C026 USP21 TRIM9 0.183 23105109 Q9UK80 Q9C035 USP21 TRIM5 0.183 23105109 Q9UK80 Q9H4L4 USP21 SENP3 0.183 22626734 Q9UK80 Q9NYF3 USP21 FAM53C 0.126 unassigned1312 Q9UK80 Q9UK80 USP21 USP21 0.21 22626734 Q9ULR3 Q9UK80 PPM1H USP21 0.126 unassigned1312 Q9ULV8 Q9UK80 CBLC USP21 0.183 23105109 Q9UQC2 Q9UK80 GAB2 USP21 0.126 unassigned1312 Q9Y4E8 Q9UK80 USP15 USP21 0.332 22626734 Q9Y4K3 Q9UK80 TRAF6 USP21 0.309 20622874 Q9Y597 Q9UK80 KCTD3 USP21 0.126 unassigned1312 Q9ULJ3 Q9UK80 ZBTB21 USP21 0.126 unassigned1312 Q9UPQ3 Q9UK80 AGAP1 USP21 0.126 unassigned1312 Q9UK80 Q14680 USP21 MELK 0.126 unassigned1312 Q9UK80 Q3MII6 USP21 TBC1D25 0.126 unassigned1312 Q9UK80 P55196 USP21 MLLT4 0.126 unassigned1312 Q9UK80 O14503 USP21 BHLHE40 0.21 25202122 Q9UK80 P56524 USP21 HDAC4 0.126 unassigned1312

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 BHLHE40 USP21 MI:0045 experimental interaction detection MI:0461 interaction database AURKA USP21 MI:0045 experimental interaction detection MI:0461 interaction database ANKRD28 USP21 MI:0045 experimental interaction detection MI:0461 interaction database EED USP21 MI:0362 inference MI:0461 interaction database USP2 USP21 MI:0045 experimental interaction detection MI:0461 interaction database STAMBP USP21 MI:0045 experimental interaction detection MI:0461 interaction database IL33 USP21 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database DDX58 USP21 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database FUCA1 USP21 MI:0045 experimental interaction detection MI:0461 interaction database ISG15 USP21 MI:0045 experimental interaction detection MI:0461 interaction database UCHL1 USP21 MI:0045 experimental interaction detection MI:0461 interaction database UBB USP21 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBC USP21 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database UCHL3 USP21 MI:0045 experimental interaction detection MI:0461 interaction database CBL USP21 MI:0045 experimental interaction detection MI:0461 interaction database PPIB USP21 MI:0045 experimental interaction detection MI:0461 interaction database GATA3 USP21 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MARK3 USP21 MI:0045 experimental interaction detection MI:0461 interaction database MAP4 USP21 MI:0045 experimental interaction detection MI:0461 interaction database TRIM23 USP21 MI:0045 experimental interaction detection MI:0461 interaction database TGFBR1 USP21 MI:0045 experimental interaction detection MI:0461 interaction database USP8 USP21 MI:0045 experimental interaction detection MI:0461 interaction database PRKCI USP21 MI:0045 experimental interaction detection MI:0461 interaction database UTRN USP21 MI:0045 experimental interaction detection MI:0461 interaction database RNF144A USP21 MI:0045 experimental interaction detection MI:0461 interaction database ATXN3 USP21 MI:0045 experimental interaction detection MI:0461 interaction database USP14 USP21 MI:0045 experimental interaction detection MI:0461 interaction database RPS27A USP21 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database UBA52 USP21 MI:0362 inference MI:0461,MI:1106 interaction database,pathways database DLG4 USP21 MI:0362 inference MI:0461 interaction database EXOSC10 USP21 MI:0045 experimental interaction detection MI:0461 interaction database ACVR1 USP21 MI:0045 experimental interaction detection MI:0461 interaction database USP4 USP21 MI:0045 experimental interaction detection MI:0461 interaction database RIPK1 USP21 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database CKAP5 USP21 MI:0045 experimental interaction detection MI:0461 interaction database ESPL1 USP21 MI:0045 experimental interaction detection MI:0461 interaction database JOSD1 USP21 MI:0045 experimental interaction detection MI:0461 interaction database UBE2S USP21 MI:0045 experimental interaction detection MI:0461 interaction database PPP6R3 USP21 MI:0045 experimental interaction detection MI:0461 interaction database BEND3 USP21 MI:0045 experimental interaction detection MI:0461 interaction database YOD1 USP21 MI:0045 experimental interaction detection MI:0461 interaction database KRT40 USP21 MI:0045 experimental interaction detection MI:0461 interaction database HIST2H2AA3 USP21 MI:0045 experimental interaction detection MI:0461 interaction database LRSAM1 USP21 MI:0045 experimental interaction detection MI:0461 interaction database USP51 USP21 MI:0045 experimental interaction detection MI:0461 interaction database MARK2 USP21 MI:0045 experimental interaction detection MI:0461 interaction database USP48 USP21 MI:0045 experimental interaction detection MI:0461 interaction database RBM45 USP21 MI:0045 experimental interaction detection MI:0461 interaction database DTX3 USP21 MI:0045 experimental interaction detection MI:0461 interaction database USP33 USP21 MI:0045 experimental interaction detection MI:0461 interaction database BAP1 USP21 MI:0045 experimental interaction detection MI:0461 interaction database ARHGEF2 USP21 MI:0045 experimental interaction detection MI:0461 interaction database USP7 USP21 MI:0045 experimental interaction detection MI:0461 interaction database TRIM63 USP21 MI:0045 experimental interaction detection MI:0461 interaction database DHX58 USP21 MI:0045 experimental interaction detection MI:0461 interaction database OTUB2 USP21 MI:0045 experimental interaction detection MI:0461 interaction database OTUB1 USP21 MI:0045 experimental interaction detection MI:0461 interaction database RNF185 USP21 MI:0045 experimental interaction detection MI:0461 interaction database MARK4 USP21 MI:0045 experimental interaction detection MI:0461 interaction database SENP8 USP21 MI:0045 experimental interaction detection MI:0461 interaction database USP28 USP21 MI:0045 experimental interaction detection MI:0461 interaction database PCGF6 USP21 MI:0045 experimental interaction detection MI:0461 interaction database RBCK1 USP21 MI:0045 experimental interaction detection MI:0461 interaction database TRIM54 USP21 MI:0045 experimental interaction detection MI:0461 interaction database IFIH1 USP21 MI:0045 experimental interaction detection MI:0461 interaction database UPF3B USP21 MI:0045 experimental interaction detection MI:0461 interaction database TRIM8 USP21 MI:0045 experimental interaction detection MI:0461 interaction database TRIM9 USP21 MI:0045 experimental interaction detection MI:0461 interaction database TRIM5 USP21 MI:0045 experimental interaction detection MI:0461 interaction database SENP3 USP21 MI:0045 experimental interaction detection MI:0461 interaction database MARK1 USP21 MI:0045 experimental interaction detection MI:0461 interaction database HECW2 USP21 MI:0045 experimental interaction detection MI:0461 interaction database BAZ2A USP21 MI:0045 experimental interaction detection MI:0461 interaction database USP21 CBLC MI:0045 experimental interaction detection MI:0461 interaction database USP21 USP20 MI:0045 experimental interaction detection MI:0461 interaction database USP21 USP15 MI:0045 experimental interaction detection MI:0461 interaction database USP21 TRAF6 MI:0045 experimental interaction detection MI:0461 interaction database USP21 RBM8A MI:0045 experimental interaction detection MI:0461 interaction database USP21 USP16 MI:0362 inference MI:1106 pathways database