PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PLEKHF2 FBXO28 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G ZWINT FBXO28 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SPAG5 FBXO28 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G FBXO28 CLEC11A 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G DCTN2 FBXO28 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GOLGA2 FBXO28 25416956,21516116 biogrid,mint,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GK FBXO28 21988832 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G NEDD1 FBXO28 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NLRP3 FBXO28 26496610 biogrid,intact exp G G HSP90AB1 FBXO28 22939624 intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LDHD FBXO28 26496610 biogrid,intact exp G G G G G PAK2 FBXO28 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EGFL8 FBXO28 26186194 biogrid exp BRAP FBXO28 25820252 intact exp G G G G G G G G G G G PSMB1 FBXO28 22939629 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TRAF2 FBXO28 16189514 hprd,biogrid,mint,intact exp G G PSMC3 FBXO28 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HOMER1 FBXO28 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G FBXO28 NUP50 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PAK1 FBXO28 23455922,20007894 biogrid,i2d,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HSP90AA1 FBXO28 22939624 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G LYN FBXO28 23503679 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G SMEK1 FBXO28 26496610 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SDCBP2 FBXO28 25416956 biogrid,intact exp LURAP1L FBXO28 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G SKP1 FBXO28 25416956,20596027,22632967, 25402006 biogrid,intact,dip exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FOXP3 FBXO28 ortho G G G G G G BIRC2 FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G COPS5 FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TANK FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G DNAJA1 FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G TNFRSF12A FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G ERN1 FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MARCH7 FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SLC25A5 FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G PARP1 FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SEC24B FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2N FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO28 TAB2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G HIVEP3 FBXO28 25402006 pred G G G G G G G G G G G G G NT5DC2 FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G EDARADD FBXO28 25402006 pred G G G G G G G G TIFA FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO28 G3BP2 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G VPS26A FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EFR3A FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G FBXO28 RNF6 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G GCKR FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G FBXO28 MAP4K5 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MYLK2 FBXO28 25402006 pred G G G G ACBD3 FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UFL1 FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MORC3 FBXO28 25402006 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B GOLGA2 FBXO28 MI:0018(two hybrid) 21516116 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_114407 prey bait LYN FBXO28 MI:0004(affinity chromatography technology) 23503679 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_279570 bait prey HSP90AA1 FBXO28 MI:0004(affinity chromatography technology) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_255414 bait prey PSMB1 FBXO28 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_242759 prey bait GK FBXO28 MI:0004(affinity chromatography technology)|MI:0397(two hybrid array) 21988832 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_288206|UniProt_119655 prey|unspecified role bait|unspecified role HSP90AB1 FBXO28 MI:0729(luminescence based mammalian interactome mapping) 22939624 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_124995 prey bait SKP1 FBXO28 MI:0096(pull down) 22632967 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_122755 prey bait TRAF2 FBXO28 MI:0018(two hybrid)|MI:0018(two hybrid)|MI:0096(pull down) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|-|MI:0915(physical association) (biogrid)|MI:0468(hprd)|(intact) BIOGRID_78635|HPRD_21864|UniProt_151493 bait|-|unspecified role prey|-|unspecified role FBXO28 TRAF2 MI:0018(two hybrid)|MI:0018(two hybrid) 16189514 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint) MINT_65816|MINT_36664 prey|prey bait|bait PAK1 FBXO28 MI:0004(affinity chromatography technology)|MI:0676(tandem affinity purification) 23455922 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0914(association) (biogrid)|(intact) BIOGRID_278013|UniProt_127608 bait|bait prey|prey UBC FBXO28 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21890473,21906983,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_270454|BIOGRID_177634|BIOGRID_175665 bait|bait|bait prey|prey|prey

PPI - HINT Gene A Gene B PMID Method Quality ZWINT FBXO28 26186194 0004 HT PSMC3 FBXO28 26186194 0004 HT PSMB1 FBXO28 22939629 0401 HT MCM2 FBXO28 25963833 0004 HT SKP1 FBXO28 20596027,22632967 0007,0007 LC PAK1 FBXO28 23455922,23455922 0004,0676 HT PAK2 FBXO28 26496610,26496610 0007,0004 HT PPP4R3A FBXO28 26496610 0007 HT LDHD FBXO28 26496610,26496610 0007,0004 HT HOMER1 FBXO28 26186194 0004 HT LURAP1L FBXO28 26186194 0004 HT SMEK1 FBXO28 26496610 0004 HT NEDD1 FBXO28 26496610,26496610 0007,0004 HT NLRP3 FBXO28 26496610,26496610 0007,0004 HT EGFL8 FBXO28 26186194 0004 HT FBXO28 NUP50 26186194 0004 HT FBXO28 CLEC11A 26186194 0004 HT FBXO28 HEL-S-77 26186194 0004 HT ZWINT FBXO28 26186194 0004 HT PSMC3 FBXO28 26186194 0004 HT PSMB1 FBXO28 22939629 0401 HT MCM2 FBXO28 25963833 0004 HT PAK1 FBXO28 23455922,23455922 0004,0676 HT PAK2 FBXO28 26496610,26496610 0007,0004 HT PPP4R3A FBXO28 26496610 0007 HT LDHD FBXO28 26496610,26496610 0007,0004 HT HOMER1 FBXO28 26186194 0004 HT LURAP1L FBXO28 26186194 0004 HT SMEK1 FBXO28 26496610 0004 HT NEDD1 FBXO28 26496610,26496610 0007,0004 HT NLRP3 FBXO28 26496610,26496610 0007,0004 HT EGFL8 FBXO28 26186194 0004 HT FBXO28 NUP50 26186194 0004 HT FBXO28 CLEC11A 26186194 0004 HT FBXO28 HEL-S-77 26186194 0004 HT SKP1 FBXO28 20596027,22632967 0007,0007 LC HSP90AB1 FBXO28 22939624 0729 HT PSMB1 FBXO28 22939629 0401 LC GK FBXO28 21988832 0018 HT SKP1 FBXO28 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT GOLGA2 FBXO28 25416956,25416956,25416956,21516116,25416956 1112,0397,0018,0018,1356 HT TRAF2 FBXO28 16189514,16189514 0398,0018 HT BRAP FBXO28 25820252 0018 LC SPAG5 FBXO28 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SDCBP2 FBXO28 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT PLEKHF2 FBXO28 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NVF7 Q9H8W4 FBXO28 PLEKHF2 0.454 25416956 Q9NVF7 P08238 FBXO28 HSP90AB1 0.126 22939624 Q9NVF7 P20618 FBXO28 PSMB1 0.081 22939629 Q9NVF7 Q12933 FBXO28 TRAF2 0.454 16189514,unassigned1304 Q9NVF7 Q7Z569 FBXO28 BRAP 0.183 25820252 Q9NVF7 Q8IV03 FBXO28 LURAP1L 0.126 26186194 Q9NVF7 P07900 FBXO28 HSP90AA1 0.126 22939624 Q9NVF7 P07948 FBXO28 LYN 0.126 23503679 Q9Y240 Q9NVF7 CLEC11A FBXO28 0.126 26186194 Q9NVF7 Q86YM7 FBXO28 HOMER1 0.126 26186194 Q9NVF7 O95229 FBXO28 ZWINT 0.126 26186194 Q9NVF7 O00463 FBXO28 TRAF5 0.236 unassigned1304 Q9NVF7 A6NEM1 FBXO28 GOLGA6L9 {ECO:0000312|HGNC:HGNC:37229} 0.236 unassigned1304 Q9NVF7 A0A0C4DGS5 FBXO28 A0A0C4DGS5 0.236 unassigned1304 Q9NVF7 Q96CN9 FBXO28 GCC1 0.236 unassigned1304 Q9NVF7 Q6NZI2 FBXO28 PTRF 0.236 unassigned1304 Q9NVF7 Q8N302 FBXO28 AGGF1 0.236 unassigned1304 Q9NVF7 Q9NT22 FBXO28 EMILIN3 0.236 unassigned1304 Q9NVF7 Q9NSC5 FBXO28 HOMER3 0.236 unassigned1304 Q9NVF7 Q8NHV4 FBXO28 NEDD1 0.236 26496610 Q9NVF7 Q96P20 FBXO28 NLRP3 0.236 26496610 Q9NVF7 Q9H190 FBXO28 SDCBP2 0.583 25416956,unassigned1304 Q9NVF7 Q13153 FBXO28 PAK1 0.236 23455922 Q9NVF7 Q13177 FBXO28 PAK2 0.236 26496610 Q9NVF7 Q6IN85 FBXO28 SMEK1 0.236 26496610 Q9NVF7 Q86WU2 FBXO28 LDHD 0.236 26496610 Q9NVF7 Q8BT07 FBXO28 CEP55 0.236 20360068 Q9NVF7 Q08379 FBXO28 GOLGA2 0.636 21516116,25416956 Q9NVF7 P63208 FBXO28 SKP1 0.712 25416956,27705803,unassigned1304,22632967 Q9NVF7 Q96R06 FBXO28 SPAG5 0.454 25416956 Q9NVF7 P32189 FBXO28 GK 0.332 21988832 Q9NVF7 Q99944 FBXO28 EGFL8 0.126 26186194 Q9UKX7 Q9NVF7 NUP50 FBXO28 0.126 26186194 Q9NVF7 Q13561 FBXO28 DCTN2 0.126 26186194 Q9NVF7 P17980 FBXO28 PSMC3 0.126 26186194 Q9NVF7 P49736 FBXO28 MCM2 0.126 25963833 Q9NVF7 Q13077 FBXO28 TRAF1 0.21 25996949 Q9NVF7 P52286 FBXO28 SKP1 0.332 27107014

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 SAP18 FBXO28 MI:0362 inference MI:0461 interaction database NCK2 FBXO28 MI:0362 inference MI:0461 interaction database AKR1B10 FBXO28 MI:0362 inference MI:0461 interaction database ZWINT FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database NRAS FBXO28 MI:0362 inference MI:0461 interaction database HRAS FBXO28 MI:0362 inference MI:0461 interaction database KRAS FBXO28 MI:0362 inference MI:0461 interaction database HSP90AA1 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database LYN FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database HSP90AB1 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database UBC FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database AKR1B1 FBXO28 MI:0362 inference MI:0461 interaction database PSMC3 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database GK FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database MCM2 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database CDC42 FBXO28 MI:0362 inference MI:0461 interaction database SKP1 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database GOLGA2 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database TRAF2 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database TRAF1 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database PAK1 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database PAK2 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database DCTN2 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database ARHGEF7 FBXO28 MI:0362 inference MI:0461 interaction database ARHGEF6 FBXO28 MI:0362 inference MI:0461 interaction database CEP55 FBXO28 MI:0362 inference MI:0461 interaction database PPP4R3A FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database LCLAT1 FBXO28 MI:0362 inference MI:0461 interaction database BRAP FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database LDHD FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database HOMER1 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database LURAP1L FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database NAV2 FBXO28 MI:0362 inference MI:0461 interaction database NEDD1 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database NLRP3 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database SPAG5 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database EGFL8 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database FOXP3 FBXO28 MI:0362 inference MI:0461 interaction database SDCBP2 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database PLEKHF2 FBXO28 MI:0045 experimental interaction detection MI:0461 interaction database FBXO28 NUP50 MI:0045 experimental interaction detection MI:0461 interaction database FBXO28 CLEC11A MI:0045 experimental interaction detection MI:0461 interaction database FBXO28 GIT1 MI:0362 inference MI:0461 interaction database FBXO28 PTRH2 MI:0362 inference MI:0461 interaction database