PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ELAVL1 KLHL8 19322201 biogrid exp GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP G G ATXN1 KLHL8 16713569 hprd,biogrid,mint,intact exp GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP G G COPS5 KLHL8 21145461 biogrid exp GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP G G COIL KLHL8 16713569 hprd,biogrid,mint,intact exp GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP G GP GP G GP G G BMI1 KLHL8 24457600 biogrid exp P P P P P P P P P P P P P P P P P DCUN1D1 KLHL8 21145461 biogrid exp P G G G GP G P G P P P P GP G GP G GP GP P GP GP P G G COPS6 KLHL8 19615732,21145461 biogrid,intact exp GP GP G G G GP G G GP G GP G GP G G GP GP GP GP G GP GP GP G GP G GP G G USP7 KLHL8 16713569 hprd,biogrid,mint,intact exp GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP G G CUL3 KLHL8 21145461 innatedb,biogrid exp GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP G G MAPK14 KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP G GP GP GP G GP G G NUDT21 KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP G G RAPSN KLHL8 ortho P P P P P P P P P P P P GP GP P OSTF1 KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP G GP GP G GP G G RAN KLHL8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MAPK1 KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP G G PSMA7 KLHL8 ortho G GP G G G GP G G GP G GP GP G G G GP GP G GP G GP G G G GP G GP G G PSMA2 KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP G G ACOT13 KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP G G MAD2L1 KLHL8 ortho P G G P GP P P P G G GP P G P P GP P GP G GP G UBA52 KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP G G KLHL8 UFC1 ortho GP GP G G G GP G G GP G GP G GP G G GP GP G GP G GP GP GP GP GP G GP G G PSMA5 KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP G G CDC37 KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP G G ITSN1 KLHL8 ortho G GP G G G GP G G GP G GP GP GP G G GP GP G G G GP G GP GP GP G GP G G POLR2H KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP G G TDO2 KLHL8 ortho P GP G G GP G GP P GP P G GP GP G GP G P P GP GP GP G GP G G KCTD2 KLHL8 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ARF1 KLHL8 ortho GP GP G G G GP G GP G GP GP GP G G GP GP G P G GP GP GP P P G GP G G FAM213A KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP G G U2AF2 KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP G G KLHL8 TBL2 ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G ATP5B KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP G G PSMA3 KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP G G MAP2K7 KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP G GP G GP G G PSMA1 KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP G G SNUPN KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP GP GP G GP G G PSMB1 KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP G GP G G TRAPPC3 KLHL8 ortho GP GP G G G GP G G GP G GP GP GP G G GP GP G GP G GP GP GP G GP G GP G G SKP2 KLHL8 23023127 pred GP GP G G G GP G G GP G G GP GP G G GP GP G GP G GP G G GP GP G GP G G SOCS3 KLHL8 23023127 pred GP GP G G G GP G G GP G GP GP GP G G GP GP GP GP G GP G GP GP GP G GP G G UBE2M KLHL8 21836163 pred GP GP G G G GP G G GP G GP G GP G G GP GP GP GP G GP G GP GP GP G GP G G SOCS4 KLHL8 23023127 pred GP GP G G G GP G G GP G GP G GP G G GP GP G G G GP GP GP GP GP G GP G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9P2G9 Q93009 two hybrid 16713569 direct interaction X 2 Q9P2G9 P35226 affinity chromatography technology 24457600 physical association X 2 Q9P2G9 A0A024R475 affinity chromatography technology 21145461 physical association X 2 Q9P2G9 A0A024R7W9 affinity chromatography technology 21145461 physical association X 2 Q9P2G9 Q7L5N1 affinity chromatography technology 21145461 physical association X 2 Q9P2G9 Q96GG9 affinity chromatography technology 21145461 physical association X 2 Q9P2G9 Q96FF1 two hybrid 16713569 direct interaction X 2 Q9P2G9 P38432 two hybrid 16713569 direct interaction X 2 Q9P2G9 P0CG48 affinity chromatography technology 22505724 physical association X 2 Q9P2G9 P0CG48 affinity chromatography technology 25147182 physical association X 2 Q9P2G9 Q7L5N1 affinity chromatography technology 19615732 physical association X 2 Q9P2G9 P0CG48 affinity chromatography technology 21890473 physical association X 2 Q9P2G9 P0CG48 affinity chromatography technology 21906983 physical association X 2 Q9P2G9 Q93009 two hybrid 16713569 - X 2 Q9P2G9 Q93009 two hybrid 16713569 - X 2 Q9P2G9 P38432 two hybrid 16713569 - X 2 Q9P2G9 P54253 two hybrid 16713569 - X 2 Q9P2G9 P54253 two hybrid 16713569 - X 2 Q9P2G9 P38432 two hybrid 16713569 - X 2 Q9P2G9 Q93009 two hybrid 16713569 physical association X 2 Q9P2G9 anti tag coimmunoprecipitation 19615732 physical association C 55 Q9P2G9 P54253 two hybrid 16713569 physical association X 2 Q9P2G9 P38432 two hybrid 16713569 physical association X 2

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9P2G9 Q13702 KLHL8 RAPSN 0.454 19158078 Q9P2G9 Q9JLV5 KLHL8 CUL3 0.236 26496610 Q9P2G9 Q8NBR0 KLHL8 TP53I13 0.236 unassigned1304 Q9P2G9 P11086 KLHL8 PNMT 0.236 unassigned1304 Q9P2G9 P12271 KLHL8 RLBP1 0.236 unassigned1304 Q9P2G9 Q9BY14 KLHL8 TEX101 0.236 unassigned1304 Q9P2G9 Q62376 KLHL8 SNRNP70 0.236 26496610 Q9P2G9 P97801 KLHL8 SMN1 0.236 26496610 Q9P2G9 Q6IPC0 KLHL8 PPM1F {ECO:0000313|EMBL:AAH71989.1} 0.236 unassigned1304 Q9P2G9 O00204 KLHL8 SULT2B1 0.236 unassigned1304 Q9P2G9 P45984 KLHL8 MAPK9 0.236 unassigned1304 Q9P2G9 P35219 KLHL8 CA8 0.236 unassigned1304 Q9P2G9 Q7Z3E5 KLHL8 ARMC9 0.236 unassigned1304 Q9P2G9 Q7L5N1 KLHL8 COPS6 0.332 19615732,21145461 Q9P2G9 Q92905 KLHL8 COPS5 0.126 21145461 Q9P2G9 Q96GG9 KLHL8 DCUN1D1 0.126 21145461 Q9P2G9 Q13618 KLHL8 CUL3 0.309 19158078,21145461 Q9P2G9 P54253 KLHL8 ATXN1 0.454 16713569 Q9P2G9 P38432 KLHL8 COIL 0.454 16713569 Q9P2G9 Q93009 KLHL8 USP7 0.454 16713569 Q9P2G9 Q15717 KLHL8 ELAVL1 0.126 19322201