PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MARCH6 KIF22 26496610 biogrid,intact exp GP G G G G GP G G GP G GP G GP G G GP GP G GP G G G GP G GP G GP GP G MARCH6 GLRA2 26186194 biogrid exp G G G G G G P G G G G G G G G G G MARCH6 ZDHHC7 26186194 biogrid exp GP G G G G GP G G GP G GP G GP G G GP GP G GP G G G GP G GP G GP GP G MARCH6 SHC1 20936779 i2d exp GP G G G G GP G G GP G GP G GP G G GP GP G GP G G G GP G GP G GP GP G MARCH6 MARCH6 17848550 biogrid exp GP G G G G GP G G GP G GP G GP G G GP GP G GP G G G GP G GP G GP GP G MARCH6 PPARG 20195357 intact exp GP P GP P GP G GP P G G P P GP P MARCH6 SQLE 24449766,24840124 biogrid,intact exp GP G G G G GP G G GP G GP G GP G G GP GP G GP G G G GP G GP G GP GP G MARCH6 ELAVL1 19322201 biogrid exp GP G G G G GP G G GP G GP G GP G G GP GP G GP G G G GP G GP G GP GP G MARCH6 SHFM1 24811749 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G MARCH6 DIO2 25074266,19651899 biogrid exp G G G G G GP G G G GP GP G G G GP G G G G G GP G G GP GP G MARCH6 TXNDC15 26186194 biogrid exp GP G G G G GP G G GP G GP G GP G G GP GP G GP G G G GP G GP G GP GP G MARCH6 UBE2D2 17848550 biogrid exp GP G G G G GP G G GP G GP G GP G G G GP G GP G G G G G G G GP GP G MARCH6 UBE2G1 15673284 biogrid exp GP G G G G GP G G GP G GP G GP G G GP GP G GP G G G GP G GP G GP GP G MARCH6 UBC 15673284 biogrid exp GP G G G G GP G G GP G GP G GP G G GP GP G GP G G G GP G GP G GP GP G RIOK3 MARCH6 21836163 pred GP G G G G GP G G GP G GP G GP G G GP GP G GP G G G GP G GP G GP GP G MARCH6 UBE2G2 25402006 pred GP G G G G GP G G GP G GP G GP G G GP GP G GP G G G G G GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q14534 O60337 affinity chromatography technology 24449766 physical association X 2 Q14534 O60337 affinity chromatography technology 24840124 physical association X 2 O60337 Q9HCP7 fluorescent resonance energy transfer 25074266 direct interaction X 2 O60337 Q9HCP7 affinity chromatography technology 19651899 physical association X 2 P0CG48 O60337 affinity chromatography technology 22505724 physical association X 2 P0CG48 O60337 affinity chromatography technology 21963094 physical association X 2 P0CG48 O60337 affinity chromatography technology 23000965 physical association X 2 P0CG48 O60337 enzymatic study 15673284 direct interaction X 2 P0CG48 O60337 affinity chromatography technology 25088257 physical association X 2 P0CG48 O60337 affinity chromatography technology 16196087 physical association X 2 P0CG48 O60337 affinity chromatography technology 21987572 physical association X 2 P0CG48 O60337 affinity chromatography technology 21139048 physical association X 2 P0CG48 O60337 affinity chromatography technology 21890473 physical association X 2 P0CG48 O60337 affinity chromatography technology 21906983 physical association X 2 P60605 O60337 pull down 19103148 direct interaction X 2 P60896 O60337 affinity chromatography technology 24811749 physical association X 2 O60337 P62837 pull down 17848550 direct interaction X 2 O60337 O60337 enzymatic study 17848550 direct interaction X 2 P62253 O60337 pull down 15673284 direct interaction X 2 Q3UJD6-2 O60337 affinity chromatography technology 25088257 physical association X 2 O60337 anti tag coimmunoprecipitation 24811749 association C 66 P37231 O60337 display technology 20195357 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B MARCH6 PPARG MI:0034(display technology) 20195357 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_104723 prey bait MARCH6 DIO2 MI:0004(affinity chromatography technology) 19651899 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_153174 bait prey MARCH6 ELAVL1 MI:0096(pull down) 19322201 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_187265 prey bait MARCH6 SQLE MI:0004(affinity chromatography technology) 24449766 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_309841 bait prey MARCH6 UBC MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0415(enzymatic study)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 16196087,21139048,21890473,21906983,21963094,21987572,22505724,23000965 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid)|(biogrid) BIOGRID_223262|BIOGRID_179610|BIOGRID_175028|BIOGRID_142988|BIOGRID_268631|BIOGRID_162975|BIOGRID_264865|BIOGRID_170373 prey|prey|prey|prey|prey|prey|prey|prey bait|bait|bait|bait|bait|bait|bait|bait

PPI - HINT Gene A Gene B PMID Method Quality MARCH6 GLRA2 26186194 0004 HT MARCH6 KIF22 26496610,26496610 0007,0004 HT MARCH6 TXNDC15 26186194 0004 HT MARCH6 ZDHHC7 26186194 0004 HT MARCH6 ERG1 24449766,24840124 0004,0004 LC MARCH6 GLRA2 26186194 0004 HT MARCH6 KIF22 26496610,26496610 0007,0004 HT MARCH6 TXNDC15 26186194 0004 HT MARCH6 ZDHHC7 26186194 0004 HT MARCH6 ERG1 24449766,24840124 0004,0004 LC MARCH6 MARCH6 17848550 0415 LC MARCH6 UBC 15673284 0415 LC MARCH6 PPARG 20195357 0034 LC MARCH6 MTNR1B 26514267 0018 LC MARCH6 Q9HCP7 25074266 0055 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID P23416 O60337 GLRA2 MARCH6 0.126 26186194 O60337 O60337 MARCH6 MARCH6 0.332 17848550 P0CG48 O60337 UBC MARCH6 0.309 15673284 P49286 O60337 MTNR1B MARCH6 0.183 26514267 P60605 O60337 UBE2G2 MARCH6 0.309 19103148 P62253 O60337 UBE2G1 MARCH6 0.309 15673284 P62837 O60337 UBE2D2 MARCH6 0.309 17848550 Q9NXF8 O60337 ZDHHC7 MARCH6 0.126 26186194 Q9QYM8 O60337 CENPH {ECO:0000312|MGI:MGI:1349448} MARCH6 0.236 26496610 Q8R034 O60337 ANAPC13 MARCH6 0.236 26496610 Q99JP4 O60337 CDC26 MARCH6 0.236 26496610 P60896 O60337 SHFM1 MARCH6 0.236 24811749 Q14534 O60337 SQLE MARCH6 0.507 24449766,24840124 Q92813 O60337 DIO2 MARCH6 0.454 19651899,25074266 P37231 O60337 PPARG MARCH6 0.126 20195357 Q96J42 O60337 TXNDC15 MARCH6 0.126 26186194 Q14807 O60337 KIF22 MARCH6 0.126 26496610 Q15717 O60337 ELAVL1 MARCH6 0.126 19322201 Q3UJD6 O60337 USP19 MARCH6 0.21 25088257

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 LSM1 MARCH6 MI:0362 inference MI:0461 interaction database MARCH6 CDC40 MI:0362 inference MI:0461 interaction database MARCH6 DNAJA2 MI:0362 inference MI:0461 interaction database MARCH6 WDR1 MI:0362 inference MI:0461 interaction database MARCH6 WDHD1 MI:0362 inference MI:0461 interaction database MARCH6 IDH1 MI:0362 inference MI:0461 interaction database MARCH6 USP19 MI:0362 inference MI:0461 interaction database MARCH6 PGLS MI:0362 inference MI:0461 interaction database MARCH6 HSPA4L MI:0362 inference MI:0461 interaction database MARCH6 GOT2 MI:0362 inference MI:0461 interaction database MARCH6 ENO1 MI:0362 inference MI:0461 interaction database MARCH6 PYGL MI:0362 inference MI:0461 interaction database MARCH6 P4HB MI:0362 inference MI:0461 interaction database MARCH6 ABCB1 MI:0362 inference MI:0461 interaction database MARCH6 PFKM MI:0362 inference MI:0461 interaction database MARCH6 HSP90AB1 MI:0362 inference MI:0461 interaction database MARCH6 ENO2 MI:0362 inference MI:0461 interaction database MARCH6 LTA4H MI:0362 inference MI:0461 interaction database MARCH6 UBB MI:0362 inference MI:1106 pathways database MARCH6 UBC MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database MARCH6 HSPA1A MI:0362 inference MI:0461 interaction database MARCH6 HSPA1B MI:0362 inference MI:0461 interaction database MARCH6 HSPA8 MI:0362 inference MI:0461 interaction database MARCH6 PYGB MI:0362 inference MI:0461 interaction database MARCH6 PYGM MI:0362 inference MI:0461 interaction database MARCH6 PC MI:0362 inference MI:0461 interaction database MARCH6 PDIA4 MI:0362 inference MI:0461 interaction database MARCH6 ENO3 MI:0362 inference MI:0461 interaction database MARCH6 FDPS MI:0362 inference MI:0461 interaction database MARCH6 GLUL MI:0362 inference MI:0461 interaction database MARCH6 HSPA6 MI:0362 inference MI:0461 interaction database MARCH6 GOT1 MI:0362 inference MI:0461 interaction database MARCH6 PFKL MI:0362 inference MI:0461 interaction database MARCH6 RAB6A MI:0362 inference MI:0461 interaction database MARCH6 AMPD1 MI:0362 inference MI:0461 interaction database MARCH6 GLRA2 MI:0045 experimental interaction detection MI:0461 interaction database MARCH6 RRM1 MI:0362 inference MI:0461 interaction database MARCH6 MPST MI:0362 inference MI:0461 interaction database MARCH6 PDIA3 MI:0362 inference MI:0461 interaction database MARCH6 ADSS MI:0362 inference MI:0461 interaction database MARCH6 ALDH3A1 MI:0362 inference MI:0461 interaction database MARCH6 DNAJA1 MI:0362 inference MI:0461 interaction database MARCH6 ATIC MI:0362 inference MI:0461 interaction database MARCH6 HSPA1L MI:0362 inference MI:0461 interaction database MARCH6 HSPA4 MI:0362 inference MI:0461 interaction database MARCH6 PSMC2 MI:0362 inference MI:0461 interaction database MARCH6 PPARG MI:0045 experimental interaction detection MI:0461 interaction database MARCH6 RGS2 MI:0362 inference MI:0461 interaction database MARCH6 ALDH3B2 MI:0362 inference MI:0461 interaction database MARCH6 IDH2 MI:0362 inference MI:0461 interaction database MARCH6 MTNR1B MI:0045 experimental interaction detection MI:0461 interaction database MARCH6 AARS MI:0362 inference MI:0461 interaction database MARCH6 ALDH3A2 MI:0362 inference MI:0461 interaction database MARCH6 PGD MI:0362 inference MI:0461 interaction database MARCH6 HSPA2 MI:0362 inference MI:0461 interaction database MARCH6 VCP MI:0362 inference MI:0461 interaction database MARCH6 SEC13 MI:0362 inference MI:0461 interaction database MARCH6 UBE2G2 MI:0362 inference MI:0461 interaction database MARCH6 SHFM1 MI:0045 experimental interaction detection MI:0461 interaction database MARCH6 SEC61A1 MI:0362 inference MI:0461 interaction database MARCH6 UBE2G1 MI:0045 experimental interaction detection MI:0461 interaction database MARCH6 RPL7A MI:0362 inference MI:0461 interaction database MARCH6 RAN MI:0362 inference MI:0461 interaction database MARCH6 UBE2D2 MI:0045 experimental interaction detection MI:0461 interaction database MARCH6 RPS27A MI:0362 inference MI:1106 pathways database MARCH6 UBA52 MI:0362 inference MI:1106 pathways database MARCH6 AMPD3 MI:0362 inference MI:0461 interaction database MARCH6 AMPD2 MI:0362 inference MI:0461 interaction database MARCH6 PFKP MI:0362 inference MI:0461 interaction database MARCH6 CSTF3 MI:0362 inference MI:0461 interaction database MARCH6 EIF3I MI:0362 inference MI:0461 interaction database MARCH6 OS9 MI:0362 inference MI:1106 pathways database MARCH6 SQLE MI:0045 experimental interaction detection MI:0461 interaction database MARCH6 KIF22 MI:0045 experimental interaction detection MI:0461 interaction database MARCH6 PPA1 MI:0362 inference MI:0461 interaction database MARCH6 ELAVL1 MI:0045 experimental interaction detection MI:0461 interaction database MARCH6 KYNU MI:0362 inference MI:0461 interaction database MARCH6 TST MI:0362 inference MI:0461 interaction database MARCH6 RAB41 MI:0362 inference MI:0461 interaction database MARCH6 THNSL2 MI:0362 inference MI:0461 interaction database MARCH6 SLC9A9 MI:0362 inference MI:0461 interaction database MARCH6 ADSSL1 MI:0362 inference MI:0461 interaction database MARCH6 UBE2J2 MI:0362 inference MI:0461 interaction database MARCH6 CDC26 MI:0362 inference MI:0461 interaction database MARCH6 NPLOC4 MI:0362 inference MI:0461 interaction database MARCH6 DNAJA4 MI:0362 inference MI:0461 interaction database MARCH6 SLC9A6 MI:0362 inference MI:0461 interaction database MARCH6 HSPH1 MI:0362 inference MI:0461 interaction database MARCH6 DIO2 MI:0045 experimental interaction detection MI:0461 interaction database MARCH6 UFD1L MI:0362 inference MI:0461 interaction database MARCH6 USP7 MI:0362 inference MI:0461 interaction database MARCH6 TXNDC15 MI:0045 experimental interaction detection MI:0461 interaction database MARCH6 ANAPC13 MI:0362 inference MI:0461 interaction database MARCH6 DERL2 MI:0362 inference MI:1106 pathways database MARCH6 RAB6C MI:0362 inference MI:0461 interaction database MARCH6 PPA2 MI:0362 inference MI:0461 interaction database MARCH6 CENPH MI:0362 inference MI:0461 interaction database MARCH6 TPK1 MI:0362 inference MI:0461 interaction database MARCH6 SEC61A2 MI:0362 inference MI:0461 interaction database MARCH6 RAB6B MI:0362 inference MI:0461 interaction database MARCH6 ZDHHC7 MI:0045 experimental interaction detection MI:0461 interaction database MARCH6 SEL1L MI:0362 inference MI:1106 pathways database MARCH6 NOB1 MI:0362 inference MI:0461 interaction database MARCH6 SNX8 MI:0362 inference MI:0461 interaction database