PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus ZBTB18 FBXL17 24035498 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G CUL1 FBXL17 24035498,21145461 biogrid exp GP G G G G GP G GP GP G GP GP GP G G GP GP GP GP G GP GP GP GP GP GP GP GP G KLHL14 FBXL17 26186194 biogrid exp P P G GP P P P GP P P GP P P P P P P P P P GP P P CUL3 FBXL17 21145461 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G FBXL17 KLHL20 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G FBXL17 SUFU 24035498 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G P GP GP GP G GP GP GP GP GP G GP GP G SKP1 FBXL17 24035498 biogrid exp GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G ZBTB10 FBXL17 24035498 biogrid exp GP GP G P GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G ZBTB46 FBXL17 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP P GP GP GP GP GP P G BACH1 FBXL17 24035498 biogrid exp GP GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CUL1 FBXL17 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21145461,24035498 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_289824|BIOGRID_204608 prey|bait bait|prey SIRT1 FBXL17 MI:0004(affinity chromatography technology) 22318606 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0799(additive genetic interaction defined by inequality) (biogrid) BIOGRID_193211 bait prey ZBTB10 FBXL17 MI:0004(affinity chromatography technology) 24035498 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_289813 prey bait FBXL17 SUFU MI:0004(affinity chromatography technology) 24035498 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_289812 bait prey ZNF238 FBXL17 MI:0004(affinity chromatography technology) 24035498 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_289811 prey bait SKP1 FBXL17 MI:0004(affinity chromatography technology) 24035498 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_289823 prey bait BACH1 FBXL17 MI:0004(affinity chromatography technology) 24035498 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_289814 prey bait

PPI - HINT Gene A Gene B PMID Method Quality BACH1 FBXL17 24035498,27234298 0004,0004 LC SKP1 FBXL17 24035498,27234298 0004,0004 LC CUL1 FBXL17 21145461,24035498,27234298 0004,0004,0004 HT,LC CUL3 FBXL17 21145461 0004 HT ZBTB46 FBXL17 26186194 0004 HT Q9H9H3 FBXL17 24035498,27234298 0004,0004 LC KLHL14 FBXL17 26186194 0004 HT FBXL17 SUFU 27234298,24035498,27234298,27234298 0096,0004,0004,0415 LC FBXL17 KLHL20 26186194 0004 HT CUL1 FBXL17 21145461 0004 HT CUL3 FBXL17 21145461 0004 HT ZBTB46 FBXL17 26186194 0004 HT KLHL14 FBXL17 26186194 0004 HT FBXL17 KLHL20 26186194 0004 HT BACH1 FBXL17 24035498,27234298 0004,0004 LC SKP1 FBXL17 24035498,27234298 0004,0004 LC CUL1 FBXL17 24035498,27234298 0004,0004 LC Q9H9H3 FBXL17 24035498,27234298 0004,0004 LC FBXL17 SUFU 27234298,24035498,27234298,27234298 0096,0004,0004,0415 LC FBXL17 SUFU 27234298,27234298,27234298 0096,0004,0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9Y2M5 Q9UF56 KLHL20 FBXL17 0.126 26186194 Q9UF56 Q86UZ6 FBXL17 ZBTB46 0.126 26186194 Q9UF56 O14867 FBXL17 BACH1 0.376 24035498,27234298 Q9UF56 Q96DT7 FBXL17 ZBTB10 0.376 24035498,27234298 Q9UF56 Q9P2G3 FBXL17 KLHL14 0.126 26186194 Q9UF56 O14641 FBXL17 DVL2 0.21 27234298 Q9UF56 O15355 FBXL17 PPM1G 0.21 27234298 Q9UF56 O43164 FBXL17 PJA2 0.21 27234298 Q9UF56 O43318 FBXL17 MAP3K7 0.21 27234298 Q9UF56 P08151 FBXL17 GLI1 0.21 27234298 Q9UF56 Q04721 FBXL17 NOTCH2 0.21 27234298 Q9UF56 Q86T24 FBXL17 ZBTB33 0.21 27234298 Q9UF56 Q99592 FBXL17 ZBTB18 0.21 24035498 Q9UF56 Q9BXU1 FBXL17 STK31 0.21 27234298 Q9UF56 Q9BY89 FBXL17 KIAA1671 0.21 27234298 Q9UMX1 Q9UF56 SUFU FBXL17 0.765 27234298,24035498 Q9UF56 Q13616 FBXL17 CUL1 0.454 27234298,21145461,24035498 Q9UF56 Q13618 FBXL17 CUL3 0.126 21145461 Q9UF56 P63208 FBXL17 SKP1 0.454 27705803,27234298,24035498

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 DVL2 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database BACH1 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database PPM1G FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database PJA2 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database MAP3K7 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database GLI1 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database UBC FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database NOVA1 FBXL17 MI:0362 inference MI:0461 interaction database SKP1 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database NOTCH2 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database CUL1 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB33 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB46 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB10 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database ZBTB18 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database STK31 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database KIAA1671 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database KLHL14 FBXL17 MI:0045 experimental interaction detection MI:0461 interaction database FBXL17 SUFU MI:0045 experimental interaction detection MI:0461 interaction database FBXL17 NOVA2 MI:0362 inference MI:0461 interaction database FBXL17 KLHL20 MI:0045 experimental interaction detection MI:0461 interaction database