PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus PNMA1 FEM1C 25416956 biogrid,intact exp G G G G G GP G G G G G G G G G G GP G G G G G G G G GP G GP G FEM1C RPGRIP1 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G P GP G GP G GP GP GP G P GP GP G BCL2L11 FEM1C 21988832 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G FEM1C LZTS2 25416956 biogrid,intact exp GP GP G G G GP G G GP G GP G G G G GP GP G GP G GP GP GP G GP G GP GP G ELAVL1 FEM1C 19322201 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP G GP GP G TCEAL1 FEM1C 19615732 biogrid,intact exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G COPS5 FEM1C 21145461 biogrid exp GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G CUL2 FEM1C 21145461, 25402006 biogrid exp, ortho, pred GP GP G G G GP G G GP G GP G GP GP G G GP G GP G GP GP GP G G G GP GP G TCEB1 FEM1C ortho G G G G G G G G G G G G G G G G G G G G G G G G G G G G G NPHP4 FEM1C ortho GP G G G G GP G P G G GP G GP G G G GP G G G G GP G G G G G SSTR2 FEM1C ortho GP GP G G G GP G GP GP G GP G P G P GP G GP G P GP G P G GP GP FEM1C PARD6G ortho G G G G G G G G G G GP G GP G G G G G G G G G GP G G G G GP G NOTCH2 FEM1C 23023127 pred G GP G G G G G G GP G G G G G G G G G G G G G G G G G GP G G ILK FEM1C 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G RFXANK FEM1C 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP P G FEM1C BARD1 23023127 pred P G GP P P GP P P GP G GP P G P P GP P G P GP GP GP G NOTCH1 FEM1C 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G CASP6 FEM1C 23023127 pred GP G G GP G G GP GP G G GP G GP G GP P GP GP GP G GP G GABPA FEM1C 23023127 pred GP GP G G GP GP G G G G GP G GP GP G GP GP G P G GP GP GP G GP GP GP GP FEM1C NOTCH3 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G TRIM21 FEM1C 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G LIMS1 FEM1C 23023127 pred GP GP G G G GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G ZDHHC17 FEM1C 23023127 pred G GP G G GP GP G G GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G FEM1C FEM1B 23023127 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP G GP GP G GABPB1 FEM1C 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G GP GP GP G GP GP GP GP G MAML1 FEM1C 23023127 pred GP GP G G GP GP G GP GP G GP G GP G G GP GP G GP G GP GP GP G GP GP GP GP G PLK1 FEM1C 23023127 pred P P G G GP P G GP GP P P GP GP GP G GP G GP P GP G GP P P GP CDKN2C FEM1C 23023127 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP G GP G P GP GP G GP GP GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q96JP0 Q13617 affinity chromatography technology 21145461 physical association X 2 Q96JP0 A0A024R7W9 affinity chromatography technology 21145461 physical association X 2 Q96JP0 Q96KN7 two hybrid 25416956 direct interaction X 2 Q96JP0 Q9BRK4 two hybrid 25416956 direct interaction X 2 Q96JP0 Q15170 affinity chromatography technology 19615732 physical association X 2 Q8ND90 Q96JP0 two hybrid 25416956 direct interaction X 2 Q96JP0 two hybrid 21988832 direct interaction X 2 Q96JP0 P0CG48 affinity chromatography technology 21139048 physical association X 2 Q96JP0 P0CG48 affinity chromatography technology 21890473 physical association X 2 Q96JP0 P0CG48 affinity chromatography technology 21906983 physical association X 2 Q96JP0 Q96KN7 two hybrid prey pooling approach 25416956 physical association X 2 Q96JP0 Q9BRK4 two hybrid prey pooling approach 25416956 physical association X 2 Q96JP0 Q96KN7 two hybrid array 25416956 physical association X 2 Q96JP0 Q9BRK4 two hybrid array 25416956 physical association X 2 Q96JP0 Q96KN7 validated two hybrid 25416956 physical association X 2 Q96JP0 Q9BRK4 validated two hybrid 25416956 physical association X 2 Q96JP0 anti tag coimmunoprecipitation 19615732 physical association C 15 Q8ND90 Q96JP0 two hybrid prey pooling approach 25416956 physical association X 2 Q8ND90 Q96JP0 two hybrid array 25416956 physical association X 2 Q8ND90 Q96JP0 validated two hybrid 25416956 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality CUL2 FEM1C 21145461 0004 HT TCEAL1 FEM1C 19615732,19615732 0004,0007 HT COPS5 FEM1C 21145461 0004 HT CUL2 FEM1C 21145461 0004 HT TCEAL1 FEM1C 19615732,19615732 0004,0007 HT COPS5 FEM1C 21145461 0004 HT BCL2L11 FEM1C 21988832 0018 HT PNMA1 FEM1C 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT FEM1C RPGRIP1 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT FEM1C LZTS2 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9UJA3 Q96JP0 MCM8 FEM1C 0.236 unassigned1304 Q96JP0 Q8ND90 FEM1C PNMA1 0.454 25416956 Q96MT8 Q96JP0 CEP63 FEM1C 0.236 unassigned1304 Q9UDY8 Q96JP0 MALT1 FEM1C 0.236 unassigned1304 Q96JP0 Q15170 FEM1C TCEAL1 0.236 19615732 Q96JP0 O43521 FEM1C BCL2L11 0.332 21988832 Q9BRK4 Q96JP0 LZTS2 FEM1C 0.454 25416956 Q96JP0 Q92905 FEM1C COPS5 0.126 21145461 Q96KN7 Q96JP0 RPGRIP1 FEM1C 0.454 25416956 Q96JP0 Q13617 FEM1C CUL2 0.126 21145461 Q96JP0 Q15717 FEM1C ELAVL1 0.126 19322201

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 BCL2L11 FEM1C MI:0045 experimental interaction detection MI:0461 interaction database NPHP4 FEM1C MI:0362 inference MI:0461 interaction database UBC FEM1C MI:0045 experimental interaction detection MI:0461 interaction database SSTR2 FEM1C MI:0362 inference MI:0461 interaction database CUL2 FEM1C MI:0045 experimental interaction detection MI:0461 interaction database TCEAL1 FEM1C MI:0045 experimental interaction detection MI:0461 interaction database TCEB1 FEM1C MI:0362 inference MI:0461 interaction database ELAVL1 FEM1C MI:0045 experimental interaction detection MI:0461 interaction database PNMA1 FEM1C MI:0045 experimental interaction detection MI:0461 interaction database COPS5 FEM1C MI:0045 experimental interaction detection MI:0461 interaction database FBXW7 FEM1C MI:0362 inference MI:0461 interaction database FEM1C RPGRIP1 MI:0045 experimental interaction detection MI:0461 interaction database FEM1C LZTS2 MI:0045 experimental interaction detection MI:0461 interaction database FEM1C PARD6G MI:0362 inference MI:0461 interaction database FEM1C PARD6A MI:0362 inference MI:0461 interaction database