PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus MORF4L2 KLHL3 25416956 biogrid,intact exp G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G KLHL12 KLHL3 25416956 biogrid,intact exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G WNK1 KLHL3 23838290,23576762,23387299 biogrid exp G GP G G G GP G GP GP G GP GP GP G G G GP G GP G G G G GP G G G GP G GNAI1 KLHL3 11259487 hprd exp G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G OPRD1 KLHL3 11259487 hprd exp P P P P P P P G P P P RBX1 KLHL3 23387299 biogrid exp G G G G G GP G GP G G G G GP G G G GP G GP G GP G G G G G G GP G SYT2 KLHL3 10734137 hprd exp GP G G G GP G GP GP G GP GP GP G GP G GP G GP GP GP P GP G ELAVL1 KLHL3 19322201 biogrid exp G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G WNK4 KLHL3 23665031,23838290,23576762,23962426,25313067,24641320,23453970 biogrid,intact exp P P P GP GP P G GP P P G P G P P GP P P KEAP1 KLHL3 25416956 biogrid,intact exp G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G KLHL3 WNK2 23838290,23387299 biogrid exp P G GP G GP G P P P G P GP GP G P G GP GP GP P P SYNCRIP KLHL3 10734137 hprd exp G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G WNK3 KLHL3 23838290,23387299,24641320 biogrid exp G G GP G P P G GP GP G GP GP G G G GP P GP P G SLC12A3 KLHL3 22406640 biogrid exp G G G G G G G G G GP G G G G G G G G G G G G G G C6orf165 KLHL3 25416956 biogrid,intact exp P P P P P P P P P P P P GP GNAO1 KLHL3 11259487 hprd exp GP G GP G G GP G G G G G GP GP G G G G G G G G CLDN8 KLHL3 25831548 biogrid exp P GP P P G P P GP G GP P P P CUL3 KLHL3 25416956,25250572,23665031,23576762,23838290,23573258,23387299,23453970 biogrid,intact exp, ortho G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G KLHL3 KLHL3 25416956,23387299 biogrid,intact exp, ortho G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G CXXC1 KLHL3 ortho G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G KPNA6 KLHL3 ortho G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G KBTBD7 KLHL3 23023127 pred G G G G G GP G GP GP G GP GP GP G G GP GP G GP G G G G G GP G GP GP G KLHL3 BTBD3 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP G GP G GP GP G KCNA2 KLHL3 23023127 pred G G GP G G P G P P P G GP GP P G P P G P GP P KLHL3 BTRC 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G SOCS7 KLHL3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KLHL3 UBQLN2 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G KLHL18 KLHL3 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G G GP GP GP G GP GP G KLHL1 KLHL3 23023127 pred P G P G P P G P P P P P KCNA1 KLHL3 23023127 pred G GP G G G GP G GP GP G P GP P G GP GP G GP G GP GP GP GP GP GP G BTBD6 KLHL3 23023127 pred G G G G G G G G GP G G G G G G GP G G G G G G G GP GP G G G G KLHL26 KLHL3 23023127 pred G P G GP G P GP G GP P P G G GP GP GP G P G GP GP GP GP GP G KBTBD11 KLHL3 23023127 pred G GP G G G GP G P GP G GP GP GP G G GP GP P G P G P GP GP G P P G SPOP KLHL3 23023127 pred G GP G G G GP G G GP G GP GP GP G G G GP G GP G GP G GP G G G GP GP G FBXW7 KLHL3 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G P G GP GP GP G GP GP KBTBD6 KLHL3 23023127 pred G GP G G G GP G GP GP G GP GP GP G G G GP G G G G G GP G G G G G G BTBD1 KLHL3 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G G G GP G GP GP GP G GP GP G ZBTB18 KLHL3 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G KLHL3 FBXL2 23023127 pred G G G G G G G G G G G G G G G G G G G G G SOCS3 KLHL3 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G KLHL2 KLHL3 23023127 pred G G G G G G G G G G GP GP G G G GP G G G G G G G G GP G G GP G ZBTB44 KLHL3 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G LRP2 KLHL3 23023127 pred G G G G G G G G GP G G G G G G BTBD9 KLHL3 23023127 pred G G G G GP G G GP G G G GP G G G GP GP G G GP G G G GP GP G SOCS5 KLHL3 23023127 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G GP G GP G GP GP GP G GP GP G KLHL32 KLHL3 23023127 pred P G GP P G P P GP P P ENC1 KLHL3 23023127 pred G GP G G G GP G GP GP G GP G GP G G GP GP G GP G GP G GP G GP G GP GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants F8W9F9 Q9UH77 affinity chromatography technology 23387299 physical association X 2 F8W9F9 Q9UH77 affinity chromatography technology 23387299 physical association X 2 F8W9F9 Q9UH77 affinity chromatography technology 23838290 physical association X 2 A0A024R7C0 Q9UH77 two hybrid 25416956 direct interaction X 2 Q9UH77 P55017-2 affinity chromatography technology 22406640 physical association X 2 Q9UH77 affinity chromatography technology 23387299 physical association X 2 Q9UH77 Q9BYP7-4 affinity chromatography technology 23387299 physical association X 2 Q9UH77 A0A024R475 affinity chromatography technology 23387299 physical association X 2 Q9UH77 Q9UH77 affinity chromatography technology 23387299 physical association X 2 Q9UH77 P62877 affinity chromatography technology 23387299 physical association X 2 Q9UH77 affinity chromatography technology 23387299 physical association X 2 Q9UH77 Q9BYP7-4 affinity chromatography technology 23387299 physical association X 2 Q9UH77 A0A024R475 affinity chromatography technology 23387299 physical association X 2 Q9UH77 Q9UH77 affinity chromatography technology 23387299 physical association X 2 Q9UH77 affinity chromatography technology 23387299 physical association X 2 Q9UH77 A0A024R475 affinity chromatography technology 23453970 physical association X 2 Q9UH77 A0A024R475 x-ray crystallography 23573258 association X 2 Q9UH77 A0A024R475 affinity chromatography technology 23576762 physical association X 2 Q9UH77 affinity chromatography technology 23576762 physical association X 2 Q9UH77 A0A024R475 affinity chromatography technology 23576762 physical association X 2 Q9UH77 A0A024R475 affinity chromatography technology 23838290 physical association X 2 Q9UH77 affinity chromatography technology 23838290 physical association X 2 Q9UH77 Q9BYP7-4 affinity chromatography technology 23838290 physical association X 2 Q9UH77 Q9BYP7-4 unspecified method 24641320 direct interaction X 2 Q9UH77 A0A024R475 affinity chromatography technology 25250572 physical association X 2 Q9UH77 P0CG48 affinity chromatography technology 25250572 physical association X 2 Q9UH77 A0A024R475 two hybrid 25416956 direct interaction X 2 Q9UH77 Q9UH77 two hybrid 25416956 direct interaction X 2 Q9UH77 Q96J92 affinity chromatography technology 23453970 physical association X 2 Q9UH77 Q96J92 enzymatic study 23453970 direct interaction X 2 Q9UH77 Q96J92 affinity chromatography technology 23576762 physical association X 2 Q9UH77 Q96J92 affinity chromatography technology 23576762 physical association X 2 Q9UH77 Q96J92 affinity chromatography technology 23838290 physical association X 2 Q9UH77 Q96J92 enzymatic study 23962426 direct interaction X 2 Q9UH77 Q96J92 unspecified method 24641320 direct interaction X 2 Q9UH77 Q96J92 x-ray crystallography 24641320 association X 2 Q9UH77 Q96J92 pull down 25313067 direct interaction X 2 Q9UH77 Q96J92 affinity chromatography technology 25313067 physical association X 2 Q9UH77 Q15014 two hybrid 25416956 direct interaction X 2 Q9UH77 Q53G59 two hybrid 25416956 direct interaction X 2 Q9UH77 Q8IYR0 two hybrid 25416956 direct interaction X 2 Q9UH77 in vivo 11259487 - X 2 Q9UH77 in vivo 11259487 - X 2 O60506 Q9UH77 in vitro 10734137 - X 2 O60506 Q9UH77 in vitro 10734137 - X 2 P41143 Q9UH77 in vivo 11259487 - X 2 P41143 Q9UH77 in vivo 11259487 - X 2 Q9UH77 P09471 in vivo 11259487 - X 2 Q9UH77 A0A024R9B3 in vitro 10734137 - X 2 Q9UH77 A0A024R9B3 in vitro 10734137 - X 2 Q9UH77 P09471 in vivo 11259487 - X 2 Q9UH77 A0A024R475 pull down 23665031 physical association X 2 Q9UH77 Q96J92 pull down 23665031 physical association X 2

PPI - HINT Gene A Gene B PMID Method Quality CUL3 KLHL3 25250572,23387299,26286618,23838290,26100637,23576762,26286618,23453970,23665031 0004,0004,0096,0004,0004,0004,0004,0004,0096 LC WNK4 KLHL3 26435498,25313067,26349538,23838290,23576762,25313067,23453970,23453970,23665031 0004,0004,0004,0004,0004,0096,0004,0415,0096 LC WNK3 KLHL3 23838290,23387299 0004,0004 LC WNK1 KLHL3 23838290,23576762,23387299,23387299 0004,0004,0004,0415 LC KLHL3 KLHL3 23387299 0004 LC KLHL3 WNK2 23838290,23387299 0004,0004 LC CUL3 KLHL3 25250572,23387299,26286618,23838290,26100637,23576762,26286618,23453970,23665031 0004,0004,0096,0004,0004,0004,0004,0004,0096 LC WNK4 KLHL3 26435498,25313067,26349538,23838290,23576762,25313067,23453970,23453970,23665031 0004,0004,0004,0004,0004,0096,0004,0415,0096 LC WNK3 KLHL3 23838290,23387299 0004,0004 LC WNK1 KLHL3 23838290,23576762,23387299,23387299 0004,0004,0004,0415 LC KLHL3 KLHL3 23387299 0004 LC KLHL3 WNK2 23838290,23387299 0004,0004 LC PRKACA KLHL3 26435498 0415 LC AKT1 KLHL3 26435498 0415 LC CUL3 KLHL3 25416956,25416956,25416956,23573258,25416956,PDB_4HXI 1112,0397,0018,0114,1356,0114 HT,LC KEAP1 KLHL3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT MORF4L2 KLHL3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT KLHL12 KLHL3 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT C6ORF165 KLHL3 25416956,25416956,25416956 1112,0397,1356 HT Q8N771 KLHL3 25416956 0018 HT WNK4 KLHL3 24641320,23962426,26286618,23453970,23453970 0114,0415,0415,0004,0415 LC WNK1 KLHL3 26286618,23387299,23387299 0415,0004,0415 LC KLHL3 KLHL3 25416956,25416956,24641320 0397,0018,0114 HT,LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9UH77 Q9H4A3 KLHL3 WNK1 0.814 26286618,23576762,23838290,23387299 Q9UH77 O14787 KLHL3 TNPO2 0.236 unassigned1304 Q9UH77 O95198 KLHL3 KLHL2 0.236 unassigned1304 Q9UH77 Q9UH77 KLHL3 KLHL3 0.396 25416956,23387299 Q9Y3S1 Q9UH77 WNK2 KLHL3 0.376 23387299,23838290 Q9UH77 Q96J92 KLHL3 WNK4 0.984 26286618,23453970,23838290,24641320,23962426,26349538,25313067,23665031,23576762,26435498 Q9UH77 Q9BYP7 KLHL3 WNK3 0.569 23387299,24641320,23838290 Q9UH77 Q53G59 KLHL3 KLHL12 0.376 unassigned1304,25416956 Q9UH77 Q08273 KLHL3 HRT1 0.416 27107014 Q9UH77 Q13618 KLHL3 CUL3 0.955 26286618,25416956,23453970,23573258,23838290,23387299,25250572,unassigned1304,26100637,23665031,23576762 Q9UH77 P31749 KLHL3 AKT1 0.309 26435498 Q9UH77 P56748 KLHL3 CLDN8 0.376 25831548 Q9UH77 P62877 KLHL3 RBX1 0.21 23387299 Q9UH77 Q13501 KLHL3 SQSTM1 0.376 26349538 Q9UH77 Q8IYR0 KLHL3 C6ORF165 0.183 25416956 Q9UH77 P17612 KLHL3 PRKACA 0.309 26435498 Q9UH77 Q14145 KLHL3 KEAP1 0.376 unassigned1304,25416956 Q9UH77 Q15014 KLHL3 MORF4L2 0.183 25416956 Q9UH77 Q15717 KLHL3 ELAVL1 0.126 19322201 Q9UH77 P55017 KLHL3 SLC12A3 0.21 22406640

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 KPNA6 KLHL3 MI:0362 inference MI:0461 interaction database UBC KLHL3 MI:0045 experimental interaction detection MI:0461 interaction database PRKACA KLHL3 MI:0045 experimental interaction detection MI:0461 interaction database AKT1 KLHL3 MI:0045 experimental interaction detection MI:0461 interaction database KPNA1 KLHL3 MI:0362 inference MI:0461 interaction database SLC12A3 KLHL3 MI:0045 experimental interaction detection MI:0461 interaction database CLDN8 KLHL3 MI:0045 experimental interaction detection MI:0461 interaction database RBX1 KLHL3 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database SQSTM1 KLHL3 MI:0045 experimental interaction detection MI:0461 interaction database CUL3 KLHL3 MI:0045 experimental interaction detection MI:0461,MI:1106 interaction database,pathways database KEAP1 KLHL3 MI:0045 experimental interaction detection MI:0461 interaction database MORF4L2 KLHL3 MI:0045 experimental interaction detection MI:0461 interaction database ELAVL1 KLHL3 MI:0045 experimental interaction detection MI:0461 interaction database KLHL12 KLHL3 MI:0045 experimental interaction detection MI:0461 interaction database C6orf165 KLHL3 MI:0045 experimental interaction detection MI:0461 interaction database WNK4 KLHL3 MI:0045 experimental interaction detection MI:0461 interaction database WNK3 KLHL3 MI:0045 experimental interaction detection MI:0461 interaction database WNK1 KLHL3 MI:0045 experimental interaction detection MI:0461 interaction database CXXC1 KLHL3 MI:0362 inference MI:0461 interaction database KLHL3 WNK2 MI:0045 experimental interaction detection MI:0461 interaction database