PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus SHPRH LPP 16169070 hprd,i2d,mint,intact exp GP G G G G GP G GP GP G GP G G G G GP GP GP G G GP G G GP GP G GP G G FDFT1 SHPRH 16169070 hprd,biogrid,i2d,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP G G GP GP G G G GP G GP GP GP G GP GP G SHPRH RBBP7 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SHPRH FBXW7 16169070 hprd,biogrid,i2d,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G P GP GP GP GP GP GP GP HLTF SHPRH 21396873,18719106 biogrid,dip exp GP GP G G GP GP G G GP G G G G G G G GP G G G GP G G G G G GP GP G SHPRH DTL 23555860 biogrid exp P P G GP P G P P P G P GP P P P P G G G GP SHPRH RAD18 25023518,21396873,17108083 biogrid exp P P P P GP P P G P P GP P SHPRH USP36 19615732 biogrid,intact exp G G G G G GP G G GP G GP GP G GP G G GP G G G G GP G GP G G G G G YWHAG SHPRH 15324660 hprd exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J SHPRH 25281560 biogrid exp P GP G GP P GP P P P P P P P P P P GP GP GP P GP P P SHPRH EDARADD 25416956 biogrid,intact exp P P G GP P GP P P P P GP P P GP G GP P P P P GP P SHPRH C17orf59 25416956 biogrid,intact exp P P P P G P P P P P GP P P P P P GP G P P P UBE2A SHPRH 17108083 biogrid exp G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SHPRH USP49 19615732 biogrid,intact exp, ortho GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G P G GP GP GP GP GP GP GP GP G SHPRH UBE2V2 17108083, 21836163 biogrid exp, pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G UBE2N SHPRH 17108083, 21836163 biogrid exp, pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G PCNA SHPRH 17108083, 21836163 biogrid exp, pred GP GP G G GP G G G GP G GP G G GP G GP G G GP G GP GP GP G GP GP GP GP G KIN SHPRH 23023127 pred GP GP G G GP GP G GP GP GP P GP GP G GP GP G P G GP GP GP GP GP GP GP GP G BRD1 SHPRH 23023127 pred G G G G G GP G G G G G G G G G G GP G G G G G G G G G G GP G SHPRH POLI 21836163 pred G GP G G GP GP G GP GP G GP GP G G G G GP GP GP G G G G P G G GP GP G CBX1 SHPRH 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SHPRH POLH 21836163 pred GP G G G GP GP G GP GP G GP P P P G GP GP GP G GP P GP GP GP GP GP GP SHPRH REV1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RAD21 SHPRH 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G NTHL1 SHPRH 16082366 pred GP GP G P GP G GP GP G GP GP GP GP G GP GP GP P G P GP GP GP GP GP GP GP G CTCF SHPRH 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G H1F0 SHPRH 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SSBP1 SHPRH 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G PEX10 SHPRH 16082366 pred G G G G G GP G G GP G GP G G G G G GP G G G G G G G G G GP G SHPRH TAB2 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SHPRH KAT6A 23023127 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SHPRH MYSM1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RPA4 SHPRH 21836163 pred G G G G G G G G SHPRH SMARCC1 23023127 pred GP G G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP G G GP GP GP GP G ARID4A SHPRH 23023127 pred G P G GP G P G P GP G G P GP G P G P G G GP GP G G P G ERCC1 SHPRH 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SHPRH FOXA2 23023127 pred P GP G GP GP GP P GP GP G FEN1 SHPRH 21836163 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G SHPRH TAB1 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP P G GP GP GP GP GP GP GP GP G DMC1 SHPRH 16082366 pred G G G G G G G G G G G G G G G G G G G GP G FUS SHPRH 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RFC1 SHPRH 21836163 pred GP GP G G GP GP G GP GP G GP G GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SHPRH HESX1 21836163 pred P P P P P P P P P P P P P P P P P P P P HDAC1 SHPRH 25402006 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G FOXO4 SHPRH 23023127 pred G G G G G G GP G G G G G G GP G G GP G GP G G GP GP G G GP G SHPRH ABI1 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RAD51 SHPRH 16082366 pred P P G GP P G P GP P GP P P GP GP GP GP GP P P P GP P GP GP BRD4 SHPRH 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G FOXA1 SHPRH 23023127 pred GP G G G GP G GP G GP GP G RPA2 SHPRH 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G DBT SHPRH 21836163 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP G GP GP G SHPRH NFE2 21836163 pred P P G GP P P P P P P P P P P P P P P P P G P P OGG1 SHPRH 16082366 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CBX5 SHPRH 16082366 pred GP GP G G GP GP G G GP G GP G GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G PDC SHPRH 21836163 pred P P P P P P P P P P P P P P P P P P SHPRH RAD9A 21836163 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP G GP GP GP GP G CBX3 SHPRH 16082366 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MAFK SHPRH 21836163 pred G G G G GP G G GP GP G G G G G G GP G G GP G GP G G G GP G GP G G PEX2 SHPRH 16082366 pred GP GP G G G GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOP3A SHPRH 16082366 pred GP G G G GP GP G G GP G GP G GP GP G G GP GP GP G GP GP GP GP G GP GP GP G UBE2B SHPRH 21836163 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G SHPRH H1FOO 23023127 pred P P P P P P P P P P P P P P P P P P P P P SHPRH SMARCC2 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G SHPRH MUS81 16082366 pred GP GP G G GP GP G GP GP G GP G G G G GP GP G GP G GP G G GP GP G G GP G SHPRH UNK 21836163 pred G GP G G G GP G GP GP G GP GP GP G G GP GP G G G G G GP GP GP G GP GP G POLB SHPRH 16082366 pred GP GP G G GP GP G G GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TERF1 SHPRH 23023127 pred G G G G G G G G G G G G G G G G G G G G G G G G G G G G G EP300 SHPRH 23023127 pred GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G TOP3B SHPRH 16082366 pred G G G G G G G G G G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q149N8 Q14527 anti tag coimmunoprecipitation 18719106 physical association X 2 Q8WWZ3 Q149N8 two hybrid prey pooling approach 25416956 physical association X 2 Q8WWZ3 Q149N8 two hybrid array 25416956 physical association X 2 Q8WWZ3 Q149N8 validated two hybrid 25416956 physical association X 2 Q93052 Q149N8 two hybrid pooling approach 16169070 physical association X 2 Q149N8 anti tag coimmunoprecipitation 19615732 physical association C 33 Q149N8 anti tag coimmunoprecipitation 19615732 physical association C 23 Q149N8 Q969H0 two hybrid pooling approach 16169070 physical association X 2 Q149N8 Q96GS4 two hybrid prey pooling approach 25416956 physical association X 2 Q149N8 Q96GS4 two hybrid array 25416956 physical association X 2 Q149N8 Q96GS4 validated two hybrid 25416956 physical association X 2 P37268 Q149N8 two hybrid pooling approach 16169070 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B SHPRH FBXW7 MI:0018(two hybrid)|MI:0007(anti tag coimmunoprecipitation)|MI:0492(in vitro)|MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint) BIOGRID_95384|UniProt_154914|HPRD_22681|MINT_63706|MINT_34736 bait|bait|-|bait|bait prey|prey|-|prey|prey SHPRH NRF1 MI:0428(imaging technique) 24250222 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_296772 prey bait UBE2N SHPRH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17108083 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_194183|BIOGRID_225678 prey|prey bait|bait HLTF SHPRH MI:0004(affinity chromatography technology)|MI:0006(anti bait coimmunoprecipitation) 18719106,21396873 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|MI:0465(dip) BIOGRID_164056|DIP_54416 bait|- prey|- SHPRH USP36 MI:0007(anti tag coimmunoprecipitation)|MI:0004(affinity chromatography technology) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid) UniProt_100672|BIOGRID_120860 prey|prey bait|bait SHPRH UBE2V2 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17108083 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_194182|BIOGRID_225679 bait|bait prey|prey YWHAG SHPRH MI:0493(in vivo) 15324660 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_26146 - - UBE2A SHPRH MI:0004(affinity chromatography technology) 17108083 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_194184 prey bait SHPRH LPP MI:0018(two hybrid)|MI:0492(in vitro)|MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|-|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0468(hprd)|(intact)|MI:0471(mint) MINT_34735|HPRD_28743|UniProt_157170|MINT_63705 bait|-|bait|bait prey|-|prey|prey PCNA SHPRH MI:0004(affinity chromatography technology) 17108083 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_225676 prey bait SHPRH RAD18 MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 17108083,21396873 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_164058|BIOGRID_164041|BIOGRID_194185 bait|prey|bait prey|bait|prey SHPRH DTL MI:0004(affinity chromatography technology) 23555860 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_272775 prey bait FDFT1 SHPRH MI:0007(anti tag coimmunoprecipitation)|MI:0018(two hybrid)|MI:0492(in vitro)|MI:0018(two hybrid)|MI:0018(two hybrid) 16169070 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|-|MI:0915(physical association)|MI:0915(physical association) (intact)|(biogrid)|MI:0468(hprd)|MI:0471(mint)|MI:0471(mint) UniProt_155742|BIOGRID_94800|HPRD_28467|MINT_34734|MINT_63704 prey|prey|-|prey|prey bait|bait|-|bait|bait UBC SHPRH MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology)|MI:0004(affinity chromatography technology) 21139048,21890473,21963094 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) (biogrid)|(biogrid)|(biogrid) BIOGRID_265758|BIOGRID_168320|BIOGRID_175828 bait|bait|bait prey|prey|prey SHPRH USP49 MI:0004(affinity chromatography technology)|MI:0007(anti tag coimmunoprecipitation) 19615732 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_120861|UniProt_100679 prey|prey bait|bait

PPI - HINT Gene A Gene B PMID Method Quality HLTF SHPRH 21396873,18719106 0004,0007 LC SHPRH RBBP7 26186194 0004 HT SHPRH USP49 19615732,19615732 0004,0007 HT SHPRH RAD18 25023518,17108083,21396873,25023518,17108083 0096,0004,0004,0004,0096 LC SHPRH USP36 19615732,19615732 0004,0007 HT SHPRH RBBP7 26186194 0004 HT SHPRH USP49 19615732,19615732 0004,0007 HT SHPRH USP36 19615732,19615732 0004,0007 HT HLTF SHPRH 21396873,18719106 0004,0007 LC SHPRH RAD18 25023518,17108083,21396873,25023518,17108083 0096,0004,0004,0004,0096 LC PCNA SHPRH 17108083 0415 LC FDFT1 SHPRH 16169070,16169070 0018,0398 HT SHPRH EDARADD 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT SHPRH LPP 16169070,16169070 0018,0398 HT SHPRH FBXW7 16169070,16169070 0018,0398 HT SHPRH C17ORF59 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9NZJ0 Q149N8 DTL SHPRH 0.21 23555860 Q9P275 Q149N8 USP36 SHPRH 0.236 19615732 Q15819 Q149N8 UBE2V2 SHPRH 0.454 17108083 Q149N8 P61088 SHPRH UBE2N 0.454 17108083 Q70CQ1 Q149N8 USP49 SHPRH 0.236 19615732 Q9NS91 Q149N8 RAD18 SHPRH 0.814 25023518,21396873,17108083 Q93052 Q149N8 LPP SHPRH 0.126 16169070 Q149N8 P37268 SHPRH FDFT1 0.286 16169070 Q969H0 Q149N8 FBXW7 SHPRH 0.286 16169070 Q149N8 Q14527 SHPRH HLTF 0.376 21396873,18719106 Q149N8 P12004 SHPRH PCNA 0.309 17108083 Q149N8 P49459 SHPRH UBE2A 0.21 17108083 Q8WWZ3 Q149N8 EDARADD SHPRH 0.454 25416956 Q96GS4 Q149N8 C17ORF59 SHPRH 0.454 25416956 Q149N8 P68431 SHPRH HIST1H3J 0.126 25281560 Q16576 Q149N8 RBBP7 SHPRH 0.126 26186194 Q149N8 P21272 SHPRH CEBPB 0.126 22242598

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBC SHPRH MI:0045 experimental interaction detection MI:0461 interaction database PCNA SHPRH MI:0045 experimental interaction detection MI:0461 interaction database CEBPB SHPRH MI:0362 inference MI:0461 interaction database FDFT1 SHPRH MI:0045 experimental interaction detection MI:0461 interaction database UBE2A SHPRH MI:0045 experimental interaction detection MI:0461 interaction database UBE2N SHPRH MI:0045 experimental interaction detection MI:0461 interaction database UBE2B SHPRH MI:0362 inference MI:0461 interaction database HIST1H3A SHPRH MI:0045 experimental interaction detection MI:0461 interaction database HLTF SHPRH MI:0045 experimental interaction detection MI:0461 interaction database SHPRH UBE2V2 MI:0045 experimental interaction detection MI:0461 interaction database SHPRH RBBP7 MI:0045 experimental interaction detection MI:0461 interaction database SHPRH USP49 MI:0045 experimental interaction detection MI:0461 interaction database SHPRH EDARADD MI:0045 experimental interaction detection MI:0461 interaction database SHPRH LPP MI:0045 experimental interaction detection MI:0461 interaction database SHPRH FBXW7 MI:0045 experimental interaction detection MI:0461 interaction database SHPRH C17orf59 MI:0045 experimental interaction detection MI:0461 interaction database SHPRH RAD18 MI:0045 experimental interaction detection MI:0461 interaction database SHPRH DTL MI:0045 experimental interaction detection MI:0461 interaction database SHPRH USP36 MI:0045 experimental interaction detection MI:0461 interaction database SHPRH POLK MI:0362 inference MI:0461 interaction database SHPRH RAB22A MI:0362 inference MI:0461 interaction database SHPRH POLH MI:0362 inference MI:0461 interaction database