PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus TRIM50 UBE2D4 21143188 biogrid exp P P P P GP P P P P GP P P P GP GP UBE2D2 TRIM50 21143188 biogrid exp P P P P GP P P P P GP P P P GP GP TRIM50 TRIM50 22829933 intact exp P P P P P GP P P P P P GP P P P P P GP GP SQSTM1 TRIM50 22792322 biogrid exp P P P P GP P P P P GP P P P P P GP GP UBE2D1 TRIM50 21143188 biogrid exp P P P P GP P P P P GP P P P GP GP TRIM50 HDAC6 24308962,22792322 biogrid exp P P P P P GP P P P P GP P P P P P GP GP UBE2D3 TRIM50 21143188 biogrid exp P P P P GP P P P P GP P P P GP GP TRIM50 UBE2E3 21143188 biogrid exp P P P P GP P P P P G P P GP GP UBE2N TRIM50 21143188 biogrid exp P P P P P GP P P P P GP P P P P P GP GP UBE2E1 TRIM50 21143188 biogrid exp P P P P GP P P P P G P P GP GP TRIM50 NOD2 22829933 intact exp P P P P P P P P P P P P P P P TRIM50 UBE2E2 21143188 biogrid exp P P P P P GP P P P P P GP P P P P P GP GP TNK2 TRIM50 24308962 biogrid exp P P P P P GP P P P P P GP P P P P P GP GP TRIM50 TRIM52 23023127 pred P P P P GP P P P P G P P P P GP GP TRIM50 TRIM36 23023127 pred P P P P P P P P GP BSPRY TRIM50 23023127 pred P P P G P P G P P G GP MEFV TRIM50 23023127 pred G G G TRIM26 TRIM50 23023127 pred P P P P P GP P P P P P GP P P P P P GP GP TRIM50 TRIM4 23023127 pred P P P P P GP P P P P P GP P P P P P GP GP TRIM50 TRIM22 23023127 pred P P P P P GP P P P P P GP P P P P P GP GP TRIM71 TRIM50 23023127 pred P P P P P P P P P P P P P P P TRIM50 TRIM10 23023127 pred G P P G P GP GP TRIM75P TRIM50 23023127 pred TRIM50 MID2 23023127 pred P P P P GP P P P P GP P P P GP GP RFPL4A TRIM50 23023127 pred P P P P P P P P P P P P P P P P P P P TRIM21 TRIM50 23023127 pred P P P P P GP P P P P P GP P P P P P GP GP TRIM38 TRIM50 23023127 pred P P P P P GP P P P P P GP P P P P P GP P TRIM50 TRIM54 23023127 pred P P P P P P P P P P TRIM65 TRIM50 23023127 pred P P P P P GP P P P P P GP P P P P P GP GP TRIM50 RNF39 23023127 pred P P P P GP P P P P GP P P GP GP TRIM50 RNF39 23023127 pred P P P P GP P P P P GP P P GP GP TRIM50 TRIM31 23023127 pred P P P P P P P P P P P P P P P P P GP P TRIM50 TRIM31 23023127 pred P P P P P P P P P P P P P P P P P GP P TRIM50 TRIM63 23023127 pred

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q86XT4 Q9HC29 two hybrid 22829933 physical association X 2 Q86XT4 Q86XT4 two hybrid 22829933 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B TRIM50 HDAC6 MI:0004(affinity chromatography technology) 22792322 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_201605 bait prey UBE2N TRIM50 MI:0018(two hybrid)|MI:0018(two hybrid) 21143188 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_194272|BIOGRID_194265 bait|prey prey|bait TRIM50 UBE2E2 MI:0018(two hybrid)|MI:0018(two hybrid) 21143188 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_194270|BIOGRID_194263 prey|bait bait|prey TRIM50 UBE2D4 MI:0018(two hybrid) 21143188 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_194313 bait prey UBE2D1 TRIM50 MI:0018(two hybrid)|MI:0018(two hybrid) 21143188 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_194259|BIOGRID_194266 prey|bait bait|prey UBE2E1 TRIM50 MI:0018(two hybrid)|MI:0018(two hybrid) 21143188 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_194262|BIOGRID_194269 prey|bait bait|prey TRIM50 UBE2E3 MI:0018(two hybrid)|MI:0018(two hybrid) 21143188 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_194271|BIOGRID_194264 prey|bait bait|prey UBE2D2 TRIM50 MI:0018(two hybrid)|MI:0018(two hybrid) 21143188 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_194260|BIOGRID_194267 prey|bait bait|prey UBE2D3 TRIM50 MI:0018(two hybrid)|MI:0018(two hybrid) 21143188 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0407(direct interaction) (biogrid)|(biogrid) BIOGRID_194261|BIOGRID_194268 prey|bait bait|prey SQSTM1 TRIM50 MI:0004(affinity chromatography technology) 22792322 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_201606 prey bait UBC TRIM50 MI:0004(affinity chromatography technology) 22792322 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_201607 prey bait

PPI - HINT Gene A Gene B PMID Method Quality TRIM50 HDAC6 24308962,22792322,24308962 0004,0004,0415 LC TRIM50 HDAC6 24308962,22792322,24308962 0004,0004,0415 LC UBE2D1 TRIM50 21143188 0018 LC UBE2E1 TRIM50 21143188 0018 LC UBE2D3 TRIM50 21143188 0018 LC UBE2N TRIM50 21143188 0018 LC UBE2D2 TRIM50 21143188 0018 LC TRIM50 TRIM50 22829933 0018 LC TRIM50 UBE2E3 21143188 0018 LC TRIM50 UBE2E2 21143188 0018 LC TRIM50 NOD2 22829933 0018 LC TRIM50 HDAC6 24308962,24308962 0004,0415 LC TRIM50 UBE2D4 21143188 0018 LC TRIM50 HEL-S-71 21143188 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q86XT4 P61077 TRIM50 UBE2D3 0.332 21143188 Q86XT4 P61088 TRIM50 UBE2N 0.332 21143188 Q9HC29 Q86XT4 NOD2 TRIM50 0.309 22829933 Q86XT4 Q13501 TRIM50 SQSTM1 0.21 22792322 Q9UBN7 Q86XT4 HDAC6 TRIM50 0.569 24308962,22792322 Q8TBB1 Q86XT4 LNX1 TRIM50 0.236 unassigned1304 Q96PN8 Q86XT4 TSSK3 TRIM50 0.236 unassigned1304 Q96CN9 Q86XT4 GCC1 TRIM50 0.236 unassigned1304 Q86XT4 A4D127 TRIM50 MEOX2 {ECO:0000313|EMBL:EAL24289.1} 0.236 unassigned1304 Q86XT4 Q12933 TRIM50 TRAF2 0.236 unassigned1304 Q86XT4 A6H8Z2 TRIM50 FAM221B 0.236 unassigned1304 Q86XT4 P61086 TRIM50 UBE2K 0.236 unassigned1304 Q86XT4 O60733 TRIM50 PLA2G6 0.236 unassigned1304 Q86XT4 P54725 TRIM50 RAD23A 0.236 unassigned1304 Q86XT4 O95198 TRIM50 KLHL2 0.236 unassigned1304 Q86XT4 O75604 TRIM50 USP2 0.236 unassigned1304 Q86XT4 O75928 TRIM50 PIAS2 0.236 unassigned1304 Q86XT4 P14373 TRIM50 TRIM27 0.236 unassigned1304 Q86XT4 P49760 TRIM50 CLK2 0.236 unassigned1304 Q8NA54 Q86XT4 IQUB TRIM50 0.236 unassigned1304 Q86XT4 Q3SY00 TRIM50 TSGA10IP 0.236 unassigned1304 Q86XT4 Q07002 TRIM50 CDK18 0.236 unassigned1304 Q86XT4 Q5JST6 TRIM50 EFHC2 0.236 unassigned1304 Q86XT4 Q7L775 TRIM50 EPM2AIP1 0.236 unassigned1304 Q9UHP6 Q86XT4 RTDR1 TRIM50 0.236 unassigned1304 Q92619 Q86XT4 HMHA1 TRIM50 0.236 unassigned1304 Q969R5 Q86XT4 L3MBTL2 TRIM50 0.236 unassigned1304 Q9NZD8 Q86XT4 SPG21 TRIM50 0.236 unassigned1304 Q9HAC8 Q86XT4 UBTD1 TRIM50 0.236 unassigned1304 Q86XT4 P57075 TRIM50 UBASH3A 0.236 unassigned1304 Q9Y2X8 Q86XT4 UBE2D4 TRIM50 0.376 unassigned1304,21143188 Q86XT4 Q86XT4 TRIM50 TRIM50 0.523 22829933,unassigned1304 Q969T4 Q86XT4 UBE2E3 TRIM50 0.49 unassigned1304,21143188 Q96LR5 Q86XT4 UBE2E2 TRIM50 0.49 unassigned1304,21143188 Q86XT4 P62837 TRIM50 UBE2D2 0.49 unassigned1304,21143188 Q86XT4 P51668 TRIM50 UBE2D1 0.49 unassigned1304,21143188 Q86XT4 P51965 TRIM50 UBE2E1 0.332 21143188 Q86XT4 Q07912 TRIM50 TNK2 0.376 24308962

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 UBC TRIM50 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 TRIM50 MI:0045 experimental interaction detection MI:0461 interaction database UBE2E1 TRIM50 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 TRIM50 MI:0045 experimental interaction detection MI:0461 interaction database UBE2N TRIM50 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 TRIM50 MI:0045 experimental interaction detection MI:0461 interaction database TNK2 TRIM50 MI:0045 experimental interaction detection MI:0461 interaction database SQSTM1 TRIM50 MI:0045 experimental interaction detection MI:0461 interaction database TRIM50 UBE2E3 MI:0045 experimental interaction detection MI:0461 interaction database TRIM50 UBE2E2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM50 NOD2 MI:0045 experimental interaction detection MI:0461 interaction database TRIM50 HDAC6 MI:0045 experimental interaction detection MI:0461 interaction database TRIM50 UBE2D4 MI:0045 experimental interaction detection MI:0461 interaction database