PTM - CPLM Gene Name UniProt ID Type Position Code SH3KBP1; CIN85 Q96B97 Sumoylation 598 K

PTM - dbPAF Gene Name UniProt ID Position Type Species SH3KBP1; CIN85 Q96B97 108 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 109 Y Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 156 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 165 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 171 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 178 T Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 179 T Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 181 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 183 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 188 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 193 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 230 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 252 T Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 254 T Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 344 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 354 T Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 355 T Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 408 T Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 410 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 412 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 436 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 444 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 445 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 447 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 471 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 472 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 473 T Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 482 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 493 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 495 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 498 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 500 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 502 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 503 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 509 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 511 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 521 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 536 T Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 538 T Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 540 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 572 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 577 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 580 T Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 587 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 589 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 593 T Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 621 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 79 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 82 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 85 S Homo sapiens(Human) SH3KBP1; CIN85 Q96B97 86 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q96B97 K57-ac Acetylation DNFVREIkkEMkkDP Q96B97 K58-ac Acetylation NFVREIkkEMkkDPL Q96B97 K61-ac Acetylation REIkkEMkkDPLTNK Q96B97 K62-ac Acetylation EIkkEMkkDPLTNKA Q96B97 K401-ac Acetylation SVPAIPPkKPRPPKt Q96B97 K535-ac Acetylation DASKKTSktVtIsQV Q96B97 K546-ac Acetylation IsQVSDNkASLPPKP Q96B97 K349-m1 Methylation PPsAPVIkQGAGttE Q96B97 S79-p Phosphorylation KPLHEVPsGNsLLsS Q96B97 S82-p Phosphorylation HEVPsGNsLLsSETI Q96B97 S85-p Phosphorylation PsGNsLLsSETILRT Q96B97 S108-p Phosphorylation RRCQVAFsyLPQNDD Q96B97 Y109-p Phosphorylation RCQVAFsyLPQNDDE Q96B97 S156-p Phosphorylation SNFIKELsGEsDELG Q96B97 S159-p Phosphorylation IKELsGEsDELGIsQ Q96B97 S165-p Phosphorylation EsDELGIsQDEQLsk Q96B97 S171-p Phosphorylation IsQDEQLskSSLRET Q96B97 T179-p Phosphorylation kSSLRETtGsEsDGG Q96B97 S181-p Phosphorylation SLRETtGsEsDGGDS Q96B97 S183-p Phosphorylation RETtGsEsDGGDSSS Q96B97 S193-p Phosphorylation GDSSSTKsEGANGtV Q96B97 T199-p Phosphorylation KsEGANGtVATAAIQ Q96B97 S230-p Phosphorylation PIKLRPRsIEVENDF Q96B97 T252-p Phosphorylation GKKLPATtAtPDSSK Q96B97 T254-p Phosphorylation KLPATtAtPDSSKTE Q96B97 S344-p Phosphorylation PKKPPPPsAPVIkQG Q96B97 T354-p Phosphorylation VIkQGAGttERKHEI Q96B97 T355-p Phosphorylation IkQGAGttERKHEIK Q96B97 T408-p Phosphorylation kKPRPPKtNsLsRPG Q96B97 S410-p Phosphorylation PRPPKtNsLsRPGAL Q96B97 S412-p Phosphorylation PPKtNsLsRPGALPP Q96B97 S436-p Phosphorylation LTHTRGDsPKIDLAG Q96B97 S445-p Phosphorylation KIDLAGSsLsGILDK Q96B97 S447-p Phosphorylation DLAGSsLsGILDKDL Q96B97 S472-p Phosphorylation GFDSVVSstEKLSHP Q96B97 T473-p Phosphorylation FDSVVSstEKLSHPT Q96B97 S493-p Phosphorylation ATGRRPPsQsLTsSs Q96B97 S495-p Phosphorylation GRRPPsQsLTsSsLs Q96B97 S498-p Phosphorylation PPsQsLTsSsLssPD Q96B97 S500-p Phosphorylation sQsLTsSsLssPDIF Q96B97 S502-p Phosphorylation sLTsSsLssPDIFds Q96B97 S503-p Phosphorylation LTsSsLssPDIFdsP Q96B97 S509-p Phosphorylation ssPDIFdsPsPEEDK Q96B97 S511-p Phosphorylation PDIFdsPsPEEDKEE Q96B97 S521-p Phosphorylation EDKEEHIsLAHRGVD Q96B97 T536-p Phosphorylation ASKKTSktVtIsQVS Q96B97 T538-p Phosphorylation KKTSktVtIsQVSDN Q96B97 S540-p Phosphorylation TSktVtIsQVSDNkA Q96B97 S572-p Phosphorylation PLSSAAPsPLSSsLG Q96B97 S577-p Phosphorylation APsPLSSsLGtAGHR Q96B97 T580-p Phosphorylation PLSSsLGtAGHRANs Q96B97 S587-p Phosphorylation tAGHRANsPsLFGtE Q96B97 S589-p Phosphorylation GHRANsPsLFGtEGK Q96B97 T593-p Phosphorylation NsPsLFGtEGKPkME Q96B97 S621-p Phosphorylation TQVRELRsIIETMKD Q96B97 S639-p Phosphorylation REIKQLLsELDEEKK Q96B97 K598-sm Sumoylation FGtEGKPkMEPAASS Q96B97 K172-ub Ubiquitination sQDEQLskSSLRETt

PTM - dbPTM UniProt ID Position Code Type Resources References Q96B97 230 S Phosphorylation Swiss-Prot 1010711 17081983;18669648;19367720 Q96B97 254 T Phosphorylation Swiss-Prot 1010711 18669648 Q96B97 436 S Phosphorylation Swiss-Prot 1010711 18669648 Q96B97 509 S Phosphorylation Swiss-Prot 1010711 17081983;18669648 Q96B97 511 S Phosphorylation Swiss-Prot 1010711 17081983;18669648 Q96B97 521 S Phosphorylation Swiss-Prot 1010711 18669648 Q96B97 587 S Phosphorylation Swiss-Prot 1010711 16083285;18669648 Q96B97 230 S Phosphorylation PhosphoELM.10011 18669648;17081983 Q96B97 436 S Phosphorylation PhosphoELM.10011 18669648 Q96B97 447 S Phosphorylation PhosphoELM.10011 18669648 Q96B97 509 S Phosphorylation PhosphoELM.10011 18669648 Q96B97 511 S Phosphorylation PhosphoELM.10011 18669648 Q96B97 521 S Phosphorylation PhosphoELM.10011 18669648 Q96B97 587 S Phosphorylation PhosphoELM.10011 18669648;16083285 Q96B97 254 T Phosphorylation PhosphoELM.10011 18669648 Q96B97 473 T Phosphorylation PhosphoELM.10011 18669648 Q96B97 508 D Caspase Phosphositeplus.1010730 18724940 Q96B97 598 K Sumoylation Phosphositeplus.1010730 22203040 Q96B97 156 S Phosphorylation Phosphositeplus.1010730 20164059 Q96B97 165 S Phosphorylation Phosphositeplus.1010730 20164059 Q96B97 183 S Phosphorylation Phosphositeplus.1010730 20562096;22115753 Q96B97 230 S Phosphorylation Phosphositeplus.1010730 17081983;18669648;19362540;19367720;19415658;19664994;19690332;20058876;20068231;20164059;20562096;20815410;21406692;22067460;22115753 Q96B97 436 S Phosphorylation Phosphositeplus.1010730 18669648;20068231;22067460 Q96B97 502 S Phosphorylation Phosphositeplus.1010730 22067460 Q96B97 503 S Phosphorylation Phosphositeplus.1010730 22067460 Q96B97 509 S Phosphorylation Phosphositeplus.1010730 18669648;20363803 Q96B97 511 S Phosphorylation Phosphositeplus.1010730 18669648;20363803;22067460 Q96B97 521 S Phosphorylation Phosphositeplus.1010730 18669648 Q96B97 540 S Phosphorylation Phosphositeplus.1010730 18077418 Q96B97 572 S Phosphorylation Phosphositeplus.1010730 22067460 Q96B97 587 S Phosphorylation Phosphositeplus.1010730 16083285;18669648;19276368;19415658;19664994;20058876;20068231;20164059;20815410;22067460 Q96B97 79 S Phosphorylation Phosphositeplus.1010730 20166139 Q96B97 82 S Phosphorylation Phosphositeplus.1010730 19367720;20166139 Q96B97 254 T Phosphorylation Phosphositeplus.1010730 17446864;18669648;22067460 Q96B97 536 T Phosphorylation Phosphositeplus.1010730 18077418 Q96B97 538 T Phosphorylation Phosphositeplus.1010730 18077418 Q96B97 580 T Phosphorylation Phosphositeplus.1010730 22067460 Q96B97 79 S Phosphorylation HPRD 9.0 20166139 Q96B97 82 S Phosphorylation HPRD 9.0 20166139 Q96B97 193 S Phosphorylation HPRD 9.0 15144186,18669648,19651622,19664994,18452278,20068231,20058876 Q96B97 230 S Phosphorylation HPRD 9.0 15144186,18669648,19651622,19664994,18452278,20068231,20058876 Q96B97 410 S Phosphorylation HPRD 9.0 18669648 Q96B97 436 S Phosphorylation HPRD 9.0 18669648,19651622,20068231 Q96B97 447 S Phosphorylation HPRD 9.0 18669648 Q96B97 472 S Phosphorylation HPRD 9.0 17081983,18669648 Q96B97 472 S Phosphorylation HPRD 9.0 18452278 Q96B97 503 S Phosphorylation HPRD 9.0 18077418 Q96B97 509 S Phosphorylation HPRD 9.0 17081983,18669648 Q96B97 511 S Phosphorylation HPRD 9.0 17081983,18669648,19651622 Q96B97 521 S Phosphorylation HPRD 9.0 18669648 Q96B97 540 S Phosphorylation HPRD 9.0 18077418 Q96B97 587 S Phosphorylation HPRD 9.0 16083285,18669648,19415658,19651622,19664994,18452278,20068231,20058876 Q96B97 589 S Phosphorylation HPRD 9.0 19651622 Q96B97 254 T Phosphorylation HPRD 9.0 18669648 Q96B97 473 T Phosphorylation HPRD 9.0 18669648 Q96B97 536 T Phosphorylation HPRD 9.0 18077418 Q96B97 538 T Phosphorylation HPRD 9.0 18077418 Q96B97 230 S Phosphorylation SysPTM 1.1 18669648 Q96B97 436 S Phosphorylation SysPTM 1.1 18669648 Q96B97 509 S Phosphorylation SysPTM 1.1 18669648 Q96B97 511 S Phosphorylation SysPTM 1.1 18669648 Q96B97 521 S Phosphorylation SysPTM 1.1 18669648 Q96B97 587 S Phosphorylation SysPTM 1.1 18669648 Q96B97 254 T Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References SH3KBP1 193 S Phosphorylation 15144186,18669648,19651622,19664994,18452278,20068231,20058876 SH3KBP1 217 T Phosphorylation 18669648 SH3KBP1 230 S Phosphorylation 15144186,18669648,19651622,19664994,18452278,20068231,20058876 SH3KBP1 254 T Phosphorylation 18669648 SH3KBP1 399 S Phosphorylation 18669648,19651622,20068231 SH3KBP1 410 S Phosphorylation 18669648 SH3KBP1 42 S Phosphorylation 20166139 SH3KBP1 435 S Phosphorylation 18452278 SH3KBP1 436 S Phosphorylation 18669648,19651622,20068231 SH3KBP1 436 T Phosphorylation 18669648 SH3KBP1 447 S Phosphorylation 18669648 SH3KBP1 45 S Phosphorylation 20166139 SH3KBP1 472 S Phosphorylation 17081983,18669648 SH3KBP1 472 S Phosphorylation 18452278 SH3KBP1 473 T Phosphorylation 18669648 SH3KBP1 474 S Phosphorylation 17081983,18669648,19651622 SH3KBP1 484 S Phosphorylation 18669648 SH3KBP1 499 T Phosphorylation 18077418 SH3KBP1 501 T Phosphorylation 18077418 SH3KBP1 503 S Phosphorylation 18077418 SH3KBP1 509 S Phosphorylation 17081983,18669648 SH3KBP1 511 S Phosphorylation 17081983,18669648,19651622 SH3KBP1 521 S Phosphorylation 18669648 SH3KBP1 536 T Phosphorylation 18077418 SH3KBP1 538 T Phosphorylation 18077418 SH3KBP1 540 S Phosphorylation 18077418 SH3KBP1 550 S Phosphorylation 16083285,18669648,19415658,19651622,19664994,18452278,20068231,20058876 SH3KBP1 552 S Phosphorylation 19651622 SH3KBP1 587 S Phosphorylation 16083285,18669648,19415658,19651622,19664994,18452278,20068231,20058876 SH3KBP1 589 S Phosphorylation 19651622 SH3KBP1 79 S Phosphorylation 20166139 SH3KBP1 82 S Phosphorylation 20166139

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q96B97 230 S 18669648 HTP Phosphorylation Q96B97 230 S 17081983 HTP Phosphorylation Q96B97 521 S 18669648 HTP Phosphorylation Q96B97 587 S 18669648 HTP Phosphorylation Q96B97 587 S 16083285 HTP Phosphorylation Q96B97 436 S 18669648 HTP Phosphorylation Q96B97 473 T 18669648 HTP Phosphorylation Q96B97 511 S 18669648 HTP Phosphorylation Q96B97 509 S 18669648 HTP Phosphorylation Q96B97 254 T 18669648 HTP Phosphorylation Q96B97 447 S 18669648 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q96B97 183 Phosphoserine 24275569 Q96B97 230 Phosphoserine 15144186;17081983;19367720;19690332;20068231;21406692;23186163 Q96B97 254 Phosphothreonine 18669648;23186163 Q96B97 436 Phosphoserine 18669648;20068231;23186163 Q96B97 509 Phosphoserine 18669648;24275569 Q96B97 511 Phosphoserine 18669648;24275569 Q96B97 521 Phosphoserine 18669648 Q96B97 587 Phosphoserine 18669648;20068231;23186163

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type SH3KBP1 IPI00294962 S 230 IKLRPRpSIEVEND phosphorylation SH3KBP1 IPI00294962 S 436 THTRGDpSPKIDLA phosphorylation SH3KBP1 IPI00294962 S 509 SPDIFDpSPSPEED phosphorylation SH3KBP1 IPI00294962 S 511 DIFDSPpSPEEDKE phosphorylation SH3KBP1 IPI00294962 S 587 AGHRANpSPSLFGT phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 30011 119029 - K Ubiquitination 15456872 30011 119029 - K Ubiquitination 12135478 30011 119029 - K Ubiquitination 12734385 30011 119029 - K Ubiquitination 20130058 30011 119029 - K Ubiquitination 21139048 30011 119029 - K Sumoylation 22203040 30011 119029 - K Ubiquitination 24816145