PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus USP4 TRIM55 22626734 biogrid exp P P GP P P GP P P P P P P GP GP P GP MRPL19 TRIM55 18157088 biogrid exp P P GP P P GP P P P P P P GP GP P GP PIAS1 TRIM55 18157088 biogrid exp P P GP P P GP P P P P P P GP GP P GP YOD1 TRIM55 22626734 biogrid exp P P GP P P GP P P P P P P GP GP P GP SAP18 TRIM55 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP GFM1 TRIM55 18157088 biogrid,mint,intact exp P P GP P P GP P P P P P P GP GP P GP ATP5B TRIM55 18157088 biogrid exp P P GP P P GP P P P P P P GP GP P GP USP8 TRIM55 22626734 biogrid exp P P G P P G P P P P P GP GP P GP FLNA TRIM55 18157088 biogrid exp P G P P GP P P P P G G P GP USP28 TRIM55 22626734 biogrid exp P P GP P P GP P P P P P P GP GP P GP SEPT2 TRIM55 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP NFIA TRIM55 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP NOMO1 TRIM55 18157088 biogrid exp P P P P P P P P P P P P P EIF3E TRIM55 18157088 biogrid exp P P GP P P GP P P P P P P G GP P GP NEBL TRIM55 18157088 biogrid exp P GP P P GP P P P G GP P G TRIM55 PRPF19 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP UCHL3 TRIM55 22626734 biogrid exp P P GP P P GP P P P P P P GP GP P GP UBE2I TRIM55 15802564,11927605 biogrid exp P P GP P P G P P P P P P G GP P GP SAFB TRIM55 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP TRIM23 TRIM55 22493164 intact exp P P GP P P GP P P P P P P GP GP P GP FLNB TRIM55 18157088 biogrid exp P P G P P GP P P P P P P GP GP P GP TRIM55 MYOZ1 18157088 biogrid exp G G GP G G TNNI1 TRIM55 18157088 biogrid exp P GP G DHX9 TRIM55 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP TRIM55 RNF114 22493164 biogrid,intact exp P P GP P P GP P P P P P P GP GP P GP TRIM54 TRIM55 11243782 hprd exp P GP P P P P P GP GP P P CDC5L TRIM55 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP MDM4 TRIM55 22493164 biogrid,intact exp P P GP P P GP P P P P P P GP GP P GP SRSF10 TRIM55 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP TNNI2 TRIM55 18157088 biogrid exp GP G TNNI3 TRIM55 18157088 biogrid exp GP P G GP GP TRIM55 UXT 18157088 biogrid exp P P GP P P GP P P P P P P GP GP P GP STAM TRIM55 22626734 biogrid exp P P GP P P GP P P P P P P G GP P GP USP7 TRIM55 22626734 biogrid exp P P GP P P GP P P P P P P GP GP P GP EEF1G TRIM55 18157088 biogrid,mint,intact exp P P P P P P P P P P P P ESPL1 TRIM55 22626734 biogrid exp P P GP P P GP P P P P P P GP GP P GP S100A9 TRIM55 22939629 biogrid exp G G P G G TTN TRIM55 18157088 biogrid exp P P GP P P G P P P GP GP G TRIM55 SF3B6 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP ATXN3 TRIM55 22626734 biogrid exp P P GP P P G P P P P P P GP GP P GP SRSF1 TRIM55 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP BRAP TRIM55 22493164 biogrid,intact exp P P GP P P P P P P P P P GP GP P GP MYBPC1 TRIM55 18157088 biogrid exp G GP G G PYGM TRIM55 23414517 intact exp P G P P P P P GP G GP HNRNPU TRIM55 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP NHP2L1 TRIM55 22939629 biogrid exp P P GP P P GP P P P P P G GP P GP MRPL41 TRIM55 18157088 biogrid exp P P GP P P GP P P P P P P GP GP P GP TRIM55 GMEB1 18157088 biogrid exp P P P P P P P P P P P P GP P GP CCAR1 TRIM55 18157088 mint,intact exp P P GP P P GP P P P P P P GP GP P GP UBE2D2 TRIM55 19549727 biogrid,intact exp P G P P GP P P P P GP G P GP NCSTN TRIM55 22939629 biogrid exp P P GP P P G P P P P P P G GP P GP EHHADH TRIM55 18157088 biogrid exp P P GP P P GP P P P P P P P GP P P MYBPC3 TRIM55 18157088 biogrid exp GP G G G G OTUB1 TRIM55 22626734 biogrid exp P P GP P P GP P P P P P P GP GP P GP OTUB2 TRIM55 22626734 biogrid exp P P P P P GP THOC6 TRIM55 22939629 biogrid exp P P P P P GP P P P P P P P GP P P BUD31 TRIM55 22939629 biogrid exp P GP P P GP P P P P P P GP GP P GP CKM TRIM55 18157088 biogrid exp GP GP G P G PRPF8 TRIM55 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP NDUFA1 TRIM55 18157088 biogrid exp P P GP P P GP P P P P P GP GP P GP SF3A1 TRIM55 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP ANKRD1 TRIM55 18157088 biogrid exp GP G P FLNC TRIM55 18157088 biogrid exp P P GP P P G P P P P P P GP GP P GP FHL2 TRIM55 18157088 biogrid exp P P GP P P GP P P P P GP GP P GP SF3B3 TRIM55 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP SRSF11 TRIM55 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP TRIM55 TRIM55 22493164 biogrid,intact exp P P GP P P GP P P P P P P GP GP P GP TCAP TRIM55 18157088 biogrid exp GP GP G G TRIM55 LMCD1 18157088 biogrid exp P G P P GP P P P P P P GP GP P GP TRIM55 ATXN3L 22626734 biogrid exp P P P P P P P P P P P GP P P GP PCGF1 TRIM55 22493164 biogrid,intact exp P P GP P P P P P P P P GP GP P GP SEPT7 TRIM55 22939629 biogrid exp P P G P P GP P P P P P P G GP P GP NEB TRIM55 18157088 biogrid exp G P GP G G ACTA1 TRIM55 18157088 biogrid exp GP GP G G DES TRIM55 18157088 biogrid exp GP G GP G G HNRNPC TRIM55 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP RANBP2 TRIM55 22939629 biogrid exp P P GP P P GP P P P P P P GP GP P GP DCAF6 TRIM55 18157088 biogrid exp G G G G G PHGDH TRIM55 22939629 biogrid exp P G P P GP P P P P P P G GP P GP SRSF7 TRIM55 22939629 biogrid exp P GP P GP P P P P P P G GP P GP TRIM55 MYOT 18157088 biogrid exp G GP G USP39 TRIM55 22939629 biogrid exp G G G G TRIM27 TRIM55 22493164 biogrid,intact exp P P GP P P GP P P P P P P GP GP P GP TRIM55 PIAS3 18157088 biogrid exp G G G G G PIAS2 TRIM55 18157088 biogrid exp G G G G G USP5 TRIM55 22626734 biogrid exp, ortho P P GP P P GP P P P P P GP GP P GP SQSTM1 TRIM55 15802564,18157088 biogrid exp, ortho P G P P GP P P P P P GP GP P GP USP13 TRIM55 11927605 hprd,biogrid exp, ortho P P GP P P GP P P P P P P GP GP P GP TRIM55 UCHL5 22626734 biogrid exp, ortho P P GP P P GP P P P P P P GP GP P GP UBE2D3 TRIM55 19549727,22626734, 23023127 biogrid,intact exp, pred P G P P GP P P P P GP G P GP UBE2D1 TRIM55 19549727, 23023127 biogrid,intact exp, pred P G P P GP P P P P GP G P GP TRIM63 TRIM55 11243782,23414517,18157088, 21836163 hprd,biogrid,intact exp, pred G G G NBR1 TRIM55 ortho P P GP P P GP P P P P P P GP GP P GP TRIM55 MAP1LC3A ortho P P G P GP P P P G GP GP TRIM65 TRIM55 23023127 pred P P GP P P GP P P P P P P G GP P GP S100A5 TRIM55 23023127 pred G TRIM40 TRIM55 23023127 pred P P P P P P P P P P P P P P P TRIM67 TRIM55 23023127 pred P P P P P P P P P P P P P P P P MIA2 TRIM55 23023127 pred P P P P P GP P P P P GP P P P TRIM28 TRIM55 23023127 pred P P GP P P GP P P P P P P GP GP P GP TRIM55 MID2 23023127 pred P P GP P P GP P P P P P P GP GP P GP TRIM55 RHBDD3 23023127 pred P P GP P P G P P P P P P G GP P GP TRIM55 TRIM33 23023127 pred P P GP P P G P P P P P P G GP P GP

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants Q9BYV6 Q8IX12 pull down 18157088 physical association X 2 Q9BYV6 E5KND5 pull down 18157088 physical association X 2 Q9BYV6 P62837 two hybrid array 19549727 physical association X 2 Q9BYV6 A0A024R990 two hybrid array 22493164 physical association X 2 Q9BYV6 P14373 two hybrid array 22493164 physical association X 2 Q9BYV6 Q9BSM1 two hybrid array 22493164 physical association X 2 Q9BYV6 P36406 anti tag coimmunoprecipitation 22493164 physical association X 2 Q9BYV6 Q9BYV6 anti tag coimmunoprecipitation 22493164 physical association X 2 Q9BYV6 Q9BYV6 two hybrid array 22493164 physical association X 2 Q9BYV6 Q969Q1 two hybrid fragment pooling approach 23414517 physical association X 2 A0A024QZJ2 Q9BYV6 two hybrid array 19549727 physical association X 2 Q9BYV6 P26641 pull down 18157088 physical association X 2 Q9BYV6 A0A024RDH2 two hybrid array 19549727 physical association X 2 Q9BYV6 Q7Z569 two hybrid array 22493164 physical association X 2 Q9BYV6 Q9Y508 two hybrid array 22493164 physical association X 2 P11217 Q9BYV6 two hybrid fragment pooling approach 23414517 physical association X 2

PPI - PINA Gene A Gene B Method Publications Species A Species B Interaction Type Source Database Interaction Identidiers Experimental Role(s) Interactor A Experimental Role(s) Interactor B CDC5L TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_240213 bait prey TRIM55 PRPF19 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237715 prey bait TRIM54 TRIM55 MI:0493(in vivo) 11243782 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) - MI:0468(hprd) HPRD_27511 - - STAM TRIM55 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223033 prey bait SEPT2 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237573 bait prey THOC6 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238094 bait prey UBE2D3 TRIM55 MI:0018(two hybrid)|MI:0415(enzymatic study)|MI:0018(two hybrid) 19549727,22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|MI:0407(direct interaction) (intact)|(biogrid)|(biogrid) UniProt_101290|BIOGRID_223061|BIOGRID_124447 bait|prey|bait prey|bait|prey GFM1 TRIM55 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18157088 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact) MINT_64153|MINT_35151|UniProt_94284 bait|bait|bait prey|prey|prey USP8 TRIM55 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223027 prey bait YOD1 TRIM55 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223034 prey bait ATXN3 TRIM55 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223023 prey bait USP5 TRIM55 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223022 prey bait USP39 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237843 bait prey BUD31 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238155 bait prey NCSTN TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236494 bait prey TRIM23 TRIM55 MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_122639 bait prey ESPL1 TRIM55 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223032 prey bait HNRNPC TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236118 bait prey MDM4 TRIM55 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122592|BIOGRID_284088 prey|prey bait|bait TRIM63 TRIM55 MI:0663(confocal microscopy)|MI:0018(two hybrid)|MI:0493(in vivo) 11243782,23414517 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction)|- (intact)|(biogrid)|MI:0468(hprd) UniProt_127460|BIOGRID_110035|HPRD_13886 bait|bait|- prey|prey|- SRSF10 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236317 bait prey TRIM27 TRIM55 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122593|BIOGRID_284169 prey|prey bait|bait USP28 TRIM55 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223031 prey bait UCHL3 TRIM55 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223026 prey bait UBE2I TRIM55 MI:0018(two hybrid)|MI:0018(two hybrid) 11927605,15802564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(biogrid) BIOGRID_102440|BIOGRID_198771 bait|prey prey|bait OTUB1 TRIM55 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223025 prey bait DHX9 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_242738 bait prey HNRNPU TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236659 bait prey SQSTM1 TRIM55 MI:0018(two hybrid) 15802564 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (biogrid) BIOGRID_198772 prey bait NHP2L1 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237137 bait prey PRPF8 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237005 bait prey EEF1G TRIM55 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18157088 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact) MINT_64154|MINT_35152|UniProt_94285 bait|bait|bait prey|prey|prey E2F4 TRIM55 MI:0428(imaging technique) 15782160 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_190078 bait prey SEPT7 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236281 bait prey SRSF11 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236120 bait prey CCAR1 TRIM55 MI:0096(pull down)|MI:0096(pull down)|MI:0096(pull down) 18157088 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0915(physical association)|MI:0915(physical association) MI:0471(mint)|MI:0471(mint)|(intact) MINT_64152|MINT_35150|UniProt_94283 bait|bait|bait prey|prey|prey SF3A1 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237551 bait prey PYGM TRIM55 MI:0663(confocal microscopy) 23414517 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association) (intact) UniProt_127333 bait prey USP13 TRIM55 MI:0493(in vivo)|MI:0018(two hybrid) 11927605 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) -|MI:0407(direct interaction) MI:0468(hprd)|(biogrid) HPRD_12534|BIOGRID_102444 -|bait -|prey TRIM55 ATXN3L MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223030 bait prey RANBP2 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241448 bait prey SRSF7 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236240 bait prey OTUB2 TRIM55 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223029 prey bait UBE2D1 TRIM55 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101242|BIOGRID_124445 bait|bait prey|prey SAFB TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_236119 bait prey TRIM55 SF3B14 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_239204 prey bait S100A9 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238427 bait prey BRAP TRIM55 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122508|BIOGRID_284038 prey|bait bait|prey USP7 TRIM55 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223024 prey bait PHGDH TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_238194 bait prey UBE2D2 TRIM55 MI:0018(two hybrid)|MI:0018(two hybrid) 19549727 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_101266|BIOGRID_124446 bait|bait prey|prey SF3B3 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_242749 bait prey PCGF1 TRIM55 MI:0415(enzymatic study)|MI:0397(two hybrid array) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction)|MI:0915(physical association) (biogrid)|(intact) BIOGRID_284101|UniProt_122596 bait|bait prey|prey SAP18 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_237357 bait prey SRSF1 TRIM55 MI:0401(biochemical) 22939629 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0403(colocalization) (biogrid) BIOGRID_241236 bait prey TRIM55 UCHL5 MI:0415(enzymatic study) 22626734 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0407(direct interaction) (biogrid) BIOGRID_223028 bait prey TRIM55 RNF114 MI:0397(two hybrid array)|MI:0415(enzymatic study) 22493164 taxid:9606(Homo sapiens) taxid:9606(Homo sapiens) MI:0915(physical association)|MI:0407(direct interaction) (intact)|(biogrid) UniProt_122569|BIOGRID_284104 bait|prey prey|bait

PPI - HINT Gene A Gene B PMID Method Quality SAP18 TRIM55 22939629 0401 HT PHGDH TRIM55 22939629 0401 HT SRSF10 TRIM55 22939629 0401 HT S100A9 TRIM55 22939629 0401 HT HNRNPC TRIM55 22939629 0401 HT BUD31 TRIM55 22939629 0401 HT RANBP2 TRIM55 22939629 0401 HT SRSF11 TRIM55 22939629 0401 HT DHX9 TRIM55 22939629 0401 HT NFIA TRIM55 22939629 0401 HT SEPT2 TRIM55 22939629 0401 HT SF3B3 TRIM55 22939629 0401 HT SAFB TRIM55 22939629 0401 HT SF3A1 TRIM55 22939629 0401 HT SEPT7 TRIM55 22939629 0401 HT SRSF7 TRIM55 22939629 0401 HT USP39 TRIM55 22939629 0401 HT Q59FA2 TRIM55 22939629 0401 HT NHP2L1 TRIM55 22939629 0401 HT PRPF8 TRIM55 22939629 0401 HT THOC6 TRIM55 22939629 0401 HT NCSTN TRIM55 22939629 0401 HT Q96BA7 TRIM55 22939629 0401 HT CDC5L TRIM55 22939629 0401 HT TRIM55 PRPF19 22939629 0401 HT TRIM55 SF3B6 22939629 0401 HT SAP18 TRIM55 22939629 0401 HT PHGDH TRIM55 22939629 0401 HT SRSF10 TRIM55 22939629 0401 HT S100A9 TRIM55 22939629 0401 HT HNRNPC TRIM55 22939629 0401 HT BUD31 TRIM55 22939629 0401 HT RANBP2 TRIM55 22939629 0401 HT SRSF11 TRIM55 22939629 0401 HT DHX9 TRIM55 22939629 0401 HT NFIA TRIM55 22939629 0401 HT SEPT2 TRIM55 22939629 0401 HT SF3B3 TRIM55 22939629 0401 HT SAFB TRIM55 22939629 0401 HT SF3A1 TRIM55 22939629 0401 HT SEPT7 TRIM55 22939629 0401 HT SRSF7 TRIM55 22939629 0401 HT USP39 TRIM55 22939629 0401 HT Q59FA2 TRIM55 22939629 0401 HT NHP2L1 TRIM55 22939629 0401 HT PRPF8 TRIM55 22939629 0401 HT THOC6 TRIM55 22939629 0401 HT NCSTN TRIM55 22939629 0401 HT Q96BA7 TRIM55 22939629 0401 HT CDC5L TRIM55 22939629 0401 HT TRIM55 PRPF19 22939629 0401 HT TRIM55 SF3B6 22939629 0401 HT SAP18 TRIM55 22939629 0401 LC MDM4 TRIM55 22493164,22493164 0018,0397 HT TCAP TRIM55 18157088,15967462 0018,0018 LC PHGDH TRIM55 22939629 0401 LC FLNB TRIM55 18157088 0018 LC SRSF10 TRIM55 22939629 0401 LC PIAS1 TRIM55 18157088 0018 LC PIAS2 TRIM55 18157088 0018 LC S100A9 TRIM55 22939629 0401 LC CKM TRIM55 18157088 0018 LC HNRNPC TRIM55 22939629 0401 LC MYL2 TRIM55 15967462 0018 LC PYGM TRIM55 23414517 0399 HT TRIM27 TRIM55 22493164,22493164 0018,0397 HT UCHL3 TRIM55 22626734 0415 HT TNNI1 TRIM55 18157088 0018 LC TNNI3 TRIM55 18157088 0018 LC FLNA TRIM55 18157088 0018 LC EEF1G TRIM55 18157088,18157088 0096,0018 LC USP8 TRIM55 22626734 0415 HT BUD31 TRIM55 22939629 0401 LC USP5 TRIM55 22626734 0415 HT TNNI2 TRIM55 18157088,15967462 0018,0018 LC MRPL19 TRIM55 18157088 0018 LC RANBP2 TRIM55 22939629 0401 LC UBE2D1 TRIM55 19549727,19549727 0397,0018 HT ATXN3 TRIM55 22626734 0415 HT EIF3E TRIM55 18157088 0018 LC UBE2D3 TRIM55 19549727,19549727 0397,0018 HT UBE2D2 TRIM55 19549727,19549727 0397,0018 HT UBE2I TRIM55 11927605 0018 LC ACTA1 TRIM55 18157088 0018 LC SRSF11 TRIM55 22939629 0401 LC DHX9 TRIM55 22939629 0401 LC NFIA TRIM55 22939629 0401 LC USP4 TRIM55 22626734 0415 HT SQSTM1 TRIM55 18157088 0018 LC FHL2 TRIM55 18157088 0018 LC ESPL1 TRIM55 22626734 0415 HT MYBPC3 TRIM55 18157088 0018 LC SEPT2 TRIM55 22939629 0401 LC NOMO1 TRIM55 18157088 0018 LC ANKRD1 TRIM55 18157088,18157088 0096,0018 LC SF3B3 TRIM55 22939629 0401 LC SAFB TRIM55 22939629 0401 LC SF3A1 TRIM55 22939629 0401 LC SEPT7 TRIM55 22939629 0401 LC SRSF7 TRIM55 22939629 0401 LC USP39 TRIM55 22939629 0401 LC TMP_LOCUS_29 TRIM55 18157088 0018 LC DCAF6 TRIM55 18157088 0018 LC Q59FA2 TRIM55 22939629 0401 LC Q59FZ8 TRIM55 18157088 0018 LC Q59H94 TRIM55 18157088 0018 LC YOD1 TRIM55 22626734 0415 HT NHP2L1 TRIM55 22939629 0401 LC ZNF183 TRIM55 18157088 0018 LC PRPF8 TRIM55 22939629 0401 LC BRAP TRIM55 22493164,22493164 0018,0397 HT DKFZP451M091 TRIM55 18157088 0018 LC THOC6 TRIM55 22939629 0401 LC MRPL41 TRIM55 18157088 0018 LC TTN TRIM55 18157088 0018 LC NCSTN TRIM55 22939629 0401 LC STAM TRIM55 22626734 0415 HT USP13 TRIM55 11927605 0018 LC USP7 TRIM55 22626734 0415 HT TRIM63 TRIM55 18157088,23414517,11243782 0018,0399,0018 LC,HT Q96BA7 TRIM55 22939629 0401 LC OTUB2 TRIM55 22626734 0415 HT OTUB1 TRIM55 22626734 0415 HT Q96MF8 TRIM55 18157088,15967462 0018,0018 LC GFM1 TRIM55 18157088,18157088 0096,0018 LC USP28 TRIM55 22626734 0415 HT CDC5L TRIM55 22939629 0401 LC PCGF1 TRIM55 22493164,22493164 0018,0397 HT TRIM54 TRIM55 11243782 0018 LC TRIM55 TRIM55 22493164,22493164,22493164 0007,0018,0397 HT TRIM55 ATXN3L 22626734 0415 HT TRIM55 MYOZ1 18157088 0018 LC TRIM55 TUBA8 18157088 0018 LC TRIM55 LMCD1 18157088 0018 LC TRIM55 MYOT 18157088,15967462 0018,0018 LC TRIM55 UXT 18157088 0018 LC TRIM55 PRPF19 22939629 0401 LC TRIM55 SF3B6 22939629 0401 LC TRIM55 RNF114 22493164,22493164 0018,0397 HT TRIM55 UCHL5 22626734 0415 HT TRIM55 GMEB1 18157088 0018 LC TRIM55 PIAS3 18157088 0018 LC TRIM55 HEL-S-271 18157088 0018 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9BYV6 Q53GS9 TRIM55 USP39 0.081 22939629 Q9BYV6 P23180 TRIM55 AIM17 0.332 27107014 Q9BYV6 O43175 TRIM55 PHGDH 0.081 22939629 Q9BYV6 P07910 TRIM55 HNRNPC 0.081 22939629 Q9BYV6 O75494 TRIM55 SRSF10 0.081 22939629 Q9Y3B4 Q9BYV6 SF3B6 TRIM55 0.081 22939629 Q9BYV6 Q86W42 TRIM55 THOC6 0.081 22939629 Q9BYV6 Q6P2Q9 TRIM55 PRPF8 0.081 22939629 Q9BYV6 P06702 TRIM55 S100A9 0.081 22939629 Q9BYV6 Q9BSM1 TRIM55 PCGF1 0.286 22493164 Q9BYV6 Q13501 TRIM55 SQSTM1 0.354 18157088,15802564 Q9BYV6 P61077 TRIM55 UBE2D3 0.49 19549727,22626734 Q9BYV6 P14373 TRIM55 TRIM27 0.286 22493164 Q9BYV6 Q13895 TRIM55 BYSL 0.236 unassigned1304 Q9BYV6 P51668 TRIM55 UBE2D1 0.286 19549727 Q9BYV6 P40482 TRIM55 SEC24 0.332 27107014 Q9BYV6 P32464 TRIM55 HYM1 0.332 27107014 Q9BYV6 Q9BYV6 TRIM55 TRIM55 0.436 22493164 Q9BYV6 Q92995 TRIM55 USP13 0.309 11927605 Q9BYV6 Q969Q1 TRIM55 TRIM63 0.507 23414517,11243782,18157088 Q9BYV6 Q92542 TRIM55 NCSTN 0.081 22939629 Q9BYV6 P38340 TRIM55 TAE1 0.332 27107014 Q9BYV6 O15151 TRIM55 MDM4 0.286 22493164 Q9BYV6 O15273 TRIM55 TCAP 0.183 18157088 Q9BYV6 O75369 TRIM55 FLNB 0.183 18157088 Q9BYV6 O76041 TRIM55 NEBL 0.183 18157088 Q9BYV6 P11217 TRIM55 PYGM 0.126 23414517 Q9BYV6 P15374 TRIM55 UCHL3 0.183 22626734 Q9BYV6 P17661 TRIM55 DES 0.183 18157088 Q9BYV6 P19237 TRIM55 TNNI1 0.183 18157088 Q9BYV6 P19429 TRIM55 TNNI3 0.183 18157088 Q9BYV6 P20929 TRIM55 NEB 0.183 18157088 Q9BYV6 P21333 TRIM55 FLNA 0.183 18157088 Q9BYV6 P26641 TRIM55 EEF1G 0.126 18157088 Q9BYV6 P36406 TRIM55 TRIM23 0.126 22493164 Q9BYV6 P40818 TRIM55 USP8 0.183 22626734 Q9BYV6 P45974 TRIM55 USP5 0.183 22626734 Q9BYV6 P48788 TRIM55 TNNI2 0.183 18157088 Q9BYV6 P54252 TRIM55 ATXN3 0.183 22626734 Q9BYV6 P62837 TRIM55 UBE2D2 0.286 19549727 Q9BYV6 P63279 TRIM55 UBE2I 0.454 11927605,15802564 Q9BYV6 P68133 TRIM55 ACTA1 0.183 18157088 Q9BYV6 Q00872 TRIM55 MYBPC1 0.183 18157088 Q9BYV6 Q12100 TRIM55 RTK1 0.332 27107014 Q9BYV6 Q13107 TRIM55 USP4 0.183 22626734 Q9BYV6 Q14192 TRIM55 FHL2 0.183 18157088 Q9BYV6 Q14315 TRIM55 FLNC 0.183 18157088 Q9BYV6 Q14674 TRIM55 ESPL1 0.183 22626734 Q9BYV6 Q14896 TRIM55 MYBPC3 0.183 18157088 Q9BYV6 Q15327 TRIM55 ANKRD1 0.183 18157088 Q9BYV6 Q5VVQ6 TRIM55 YOD1 0.183 22626734 Q9BYV6 Q7Z569 TRIM55 BRAP 0.286 22493164 Q9BYV6 Q8IX12 TRIM55 CCAR1 0.126 18157088 Q9BYV6 Q8WZ42 TRIM55 TTN 0.183 18157088 Q9BYV6 Q92783 TRIM55 STAM 0.183 22626734 Q9BYV6 Q93009 TRIM55 USP7 0.183 22626734 Q9BYV6 Q96DC9 TRIM55 OTUB2 0.183 22626734 Q9BYV6 Q96FW1 TRIM55 OTUB1 0.183 22626734 Q9BYV6 Q96RP9 TRIM55 GFM1 0.126 18157088 Q9BYV6 Q96RU2 TRIM55 USP28 0.183 22626734 Q9H3M9 Q9BYV6 ATXN3L TRIM55 0.183 22626734 Q9NP98 Q9BYV6 MYOZ1 TRIM55 0.183 18157088 Q9UBF9 Q9BYV6 MYOT TRIM55 0.183 18157088 Q9Y508 Q9BYV6 RNF114 TRIM55 0.286 22493164 Q9Y5K5 Q9BYV6 UCHL5 TRIM55 0.183 22626734 Q9BYV6 P38886 TRIM55 RPN10 0.416 27107014 Q9BYV6 Q99459 TRIM55 CDC5L 0.081 22939629 Q9UMS4 Q9BYV6 PRPF19 TRIM55 0.081 22939629 Q9BYV6 P41223 TRIM55 BUD31 0.081 22939629 Q9BYV6 Q12857 TRIM55 NFIA 0.081 22939629 Q9BYV6 P49792 TRIM55 RANBP2 0.081 22939629 Q9BYV6 Q15019 TRIM55 SEPT2 0.081 22939629 Q9BYV6 Q00839 TRIM55 HNRNPU 0.081 22939629 Q9BYV6 Q15393 TRIM55 SF3B3 0.081 22939629 Q9BYV6 Q15424 TRIM55 SAFB 0.081 22939629 Q9BYV6 Q15459 TRIM55 SF3A1 0.081 22939629 Q9BYV6 Q16181 TRIM55 SEPT7 0.081 22939629 Q9BYV6 O00422 TRIM55 SAP18 0.081 22939629 Q9BYV6 Q05519 TRIM55 SRSF11 0.081 22939629 Q9BYV6 Q16629 TRIM55 SRSF7 0.081 22939629 Q9BYV6 Q07955 TRIM55 SRSF1 0.081 22939629 Q9BYV6 Q08211 TRIM55 DHX9 0.081 22939629 Q9BYV6 P55769 TRIM55 NHP2L1 0.081 22939629 Q9BYV6 O14468 TRIM55 O14468 0.332 27107014

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 MDM4 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database NDUFA1 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database TCAP TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database FLNB TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database PIAS1 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database PIAS2 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database NEBL TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database SEC24D TRIM55 MI:0362 inference MI:0461 interaction database SEC24A TRIM55 MI:0362 inference MI:0461 interaction database SEC24B TRIM55 MI:0362 inference MI:0461 interaction database ATP5B TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database CKM TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database MYL2 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database PYGM TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database TRIM27 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database UCHL3 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database DES TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database TNNI1 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database TNNI3 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database NEB TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database FLNA TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database EEF1G TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database TRIM23 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database USP8 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database HNF4A TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database USP5 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database TNNI2 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database MRPL19 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D1 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database SEC24C TRIM55 MI:0362 inference MI:0461 interaction database ATXN3 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database PSMD4 TRIM55 MI:0362 inference MI:0461 interaction database EIF3E TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D3 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database UBE2D2 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database UBE2I TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database ACTA1 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database MYBPC1 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database EHHADH TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database USP4 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database SQSTM1 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database FHL2 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database FLNC TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database NBR1 TRIM55 MI:0362 inference MI:0461 interaction database ESPL1 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database MYBPC3 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database NOMO1 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database ANKRD1 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database E2F4 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database DCAF6 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database YOD1 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database BRAP TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database CCAR1 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database MRPL41 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database TTN TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database STAM TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database USP13 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database USP7 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database TRIM63 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database OTUB2 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database OTUB1 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database GFM1 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database USP28 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database PCGF1 TRIM55 MI:0045 experimental interaction detection MI:0461 interaction database NTMT1 TRIM55 MI:0362 inference MI:0461 interaction database MAP1LC3C TRIM55 MI:0362 inference MI:0461 interaction database TRIM55 MAP1LC3B MI:0362 inference MI:0461 interaction database TRIM55 ATXN3L MI:0045 experimental interaction detection MI:0461 interaction database TRIM55 MAP1LC3A MI:0362 inference MI:0461 interaction database TRIM55 CAB39L MI:0362 inference MI:0461 interaction database TRIM55 MYOZ1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM55 TUBA8 MI:0045 experimental interaction detection MI:0461 interaction database TRIM55 LMCD1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM55 MYOT MI:0045 experimental interaction detection MI:0461 interaction database TRIM55 UXT MI:0045 experimental interaction detection MI:0461 interaction database TRIM55 CAB39 MI:0362 inference MI:0461 interaction database TRIM55 RNF114 MI:0045 experimental interaction detection MI:0461 interaction database TRIM55 UCHL5 MI:0045 experimental interaction detection MI:0461 interaction database TRIM55 GMEB1 MI:0045 experimental interaction detection MI:0461 interaction database TRIM55 PIAS3 MI:0045 experimental interaction detection MI:0461 interaction database