PPI - IID Symbol 1 Symbol 2 PMID DBs Evidence Type Adipose Tissue Adrenal Gland Amygdala Bone Bone Marrow Brain Dorsal Root Ganglia Eye Heart Hindgut Hypothalamus Kidney Liver Lung Lymph Nodes Mammary Gland Midgut Neurons Ovary Pancreas Pituitary Gland Placenta Prostate Salivary Gland Skeletal Muscle Small Intestine Spleen Stomach Testes Uterus CD19 FAM188A 26186194 biogrid exp G G G GP P GP G G GP GP G P P GP G G GP GP GP G ZNF644 FAM188A 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G FAM188A LANCL2 26186194 biogrid exp G G G G G GP G GP G G G G GP G G G GP G GP G G G G G G G GP GP G UBB FAM188A 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RNF25 FAM188A 26186194 biogrid exp P G P P P P P P P P P P P P P GP P P LIN7A FAM188A 26186194 biogrid exp G G G G G G G G G G G G G G G G G G G MCM3 FAM188A 26186194 biogrid exp GP G G G GP G G G GP G G G G GP G GP G G G G GP G G G GP G GP GP G RPUSD3 FAM188A 26186194 biogrid exp G G G G GP GP G GP G G G GP GP G G GP GP G G G GP G G G GP GP GP G G KIFC1 FAM188A 26186194 biogrid exp P P G GP P P GP P P P GP P P P P P P GP P P GP UBA1 FAM188A 25260751 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G CSK FAM188A 26186194 biogrid exp G G G G GP GP G G GP G G G GP GP G GP GP G GP G GP G G G GP GP GP GP G UBE2V1 FAM188A 25260751 intact exp ZC3HC1 FAM188A 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G COPS5 FAM188A 21499297 biogrid,i2d,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G FAM188A SCAF8 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G RPL8 FAM188A 16169070 hprd,i2d,mint,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G MCM5 FAM188A 26186194 biogrid exp GP P G GP G GP G G GP GP G GP G GP G G GP GP G GP G MAP3K1 FAM188A 25260751 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G UBE2N FAM188A 25260751 intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP G GP G GP GP GP GP GP GP GP GP G RAD23A FAM188A 25416956 biogrid,intact exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G HNRNPLL FAM188A 26186194 biogrid exp GP GP G G GP GP G GP GP G GP GP GP GP G GP GP GP GP G GP GP GP GP GP GP GP GP G IBA57 FAM188A 26186194 biogrid exp GP GP G G GP G G G GP GP G GP GP G GP G G GP G G P GP G GP GP GP GP PKP2 FAM188A 26186194 biogrid exp G P G G P G GP GP GP G P G GP P G GP G GP G GP GP GP GP GP FAM188A MPP6 26186194 biogrid exp P P G P P P P P GP P P P P GP MYBPC3 FAM188A 21836163 pred G G G G G GP G G G G G G G G G G G G G G G G G G ITGA8 FAM188A 21836163 pred G G G G G G G G G G GP G G G G G G G G G G G G G G G GP G

PPI - iRefIndex UniProt A UniProt B Method PMID Interaction Type Edge type Num Participants A0A024R7W9 Q9H8M7 affinity chromatography technology 21499297 physical association X 2 P0CG48 Q9H8M7 affinity chromatography technology 21963094 physical association X 2 P0CG48 Q9H8M7 affinity chromatography technology 23000965 physical association X 2 P0CG48 Q9H8M7 affinity chromatography technology 21139048 physical association X 2 P0CG48 Q9H8M7 affinity chromatography technology 21890473 physical association X 2 P0CG48 Q9H8M7 affinity chromatography technology 21906983 physical association X 2 Q9H8M7 A0A024R7G8 two hybrid 25416956 direct interaction X 2 P62917 Q9H8M7 two hybrid 16169070 - X 2 P62917 Q9H8M7 two hybrid 16169070 - X 2 P62917 Q9H8M7 two hybrid pooling approach 16169070 physical association X 2 A0A024R7W9 Q9H8M7 anti tag coimmunoprecipitation 21499297 physical association X 2 A0A024R7W9 Q9H8M7 confocal microscopy 21499297 colocalization X 2 A0A024R7W9 Q9H8M7 two hybrid 21499297 physical association X 2 Q9H8M7 A0A024R7G8 two hybrid prey pooling approach 25416956 physical association X 2 Q9H8M7 A0A024R7G8 two hybrid array 25416956 physical association X 2 Q9H8M7 A0A024R7G8 validated two hybrid 25416956 physical association X 2 Q9H8M7 ubiquitinase assay 25260751 ubiquitination reaction C 5

PPI - HINT Gene A Gene B PMID Method Quality LIN7A FAM188A 26186194 0004 HT UBB FAM188A 26186194 0004 HT CD19 FAM188A 26186194 0004 HT MCM3 FAM188A 26186194 0004 HT MCM5 FAM188A 26186194 0004 HT CSK FAM188A 26186194 0004 HT IBA57 FAM188A 26186194 0004 HT RPUSD3 FAM188A 26186194 0004 HT ZC3HC1 FAM188A 26186194 0004 HT HNRNPLL FAM188A 26186194 0004 HT RNF25 FAM188A 26186194 0004 HT PKP2 FAM188A 26186194 0004 HT KIFC1 FAM188A 26186194 0004 HT ZNF644 FAM188A 26186194 0004 HT FAM188A LANCL2 26186194 0004 HT FAM188A MPP6 26186194 0004 HT FAM188A SCAF8 26186194 0004 HT LIN7A FAM188A 26186194 0004 HT UBB FAM188A 26186194 0004 HT CD19 FAM188A 26186194 0004 HT MCM3 FAM188A 26186194 0004 HT MCM5 FAM188A 26186194 0004 HT CSK FAM188A 26186194 0004 HT IBA57 FAM188A 26186194 0004 HT RPUSD3 FAM188A 26186194 0004 HT ZC3HC1 FAM188A 26186194 0004 HT HNRNPLL FAM188A 26186194 0004 HT RNF25 FAM188A 26186194 0004 HT PKP2 FAM188A 26186194 0004 HT KIFC1 FAM188A 26186194 0004 HT ZNF644 FAM188A 26186194 0004 HT FAM188A LANCL2 26186194 0004 HT FAM188A MPP6 26186194 0004 HT FAM188A SCAF8 26186194 0004 HT UBA1 FAM188A 25260751 0997 LC RAD23A FAM188A 25416956,25416956,25416956,25416956 1112,0397,0018,1356 HT UBE2N FAM188A 25260751 0997 LC RPL8 FAM188A 16169070,16169070 0018,0398 HT MAP3K1 FAM188A 25260751 0415 LC UBE2V1 FAM188A 25260751 0997 LC COPS5 FAM188A 21499297,21499297,21499297,21499297 0007,0018,0004,0663 LC FAM188A SMURF1 20804422 0415 LC

PPI - Mentha Protein A Protein B Gene A Gene B Score PMID Q9H8M7 O14910 FAM188A LIN7A 0.126 26186194 Q9H8M7 P0CG47 FAM188A UBB 0.126 26186194 Q9H8M7 P22314 FAM188A UBA1 0.033 25260751 Q9H8M7 P25205 FAM188A MCM3 0.126 26186194 Q9H8M7 P33992 FAM188A MCM5 0.126 26186194 Q9H8M7 P41240 FAM188A CSK 0.126 26186194 Q9H8M7 P61088 FAM188A UBE2N 0.033 25260751 Q9H8M7 Q13404 FAM188A UBE2V1 0.033 25260751 Q9H8M7 Q5T440 FAM188A IBA57 0.126 26186194 Q9H8M7 Q62925 FAM188A MAP3K1 0.033 25260751 Q9H8M7 Q6P087 FAM188A RPUSD3 0.126 26186194 Q9H8M7 Q86WB0 FAM188A ZC3HC1 0.126 26186194 Q9H8M7 Q8WVV9 FAM188A HNRNPLL 0.126 26186194 Q9H8M7 Q96BH1 FAM188A RNF25 0.126 26186194 Q9H8M7 Q99959 FAM188A PKP2 0.126 26186194 Q9H8M7 Q9BW19 FAM188A KIFC1 0.126 26186194 Q9H8M7 Q9H582 FAM188A ZNF644 0.126 26186194 Q9NS86 Q9H8M7 LANCL2 FAM188A 0.126 26186194 Q9NZW5 Q9H8M7 MPP6 FAM188A 0.126 26186194 Q9UPN6 Q9H8M7 SCAF8 FAM188A 0.126 26186194 Q9HCE7 Q9H8M7 SMURF1 FAM188A 0.183 20804422 Q9H8M7 P0CI25 FAM188A TRIM49 0.236 unassigned1304 Q9H8M7 Q15038 FAM188A DAZAP2 0.236 unassigned1304 Q9H8M7 O00560 FAM188A SDCBP 0.236 unassigned1304 Q9H8M7 P54725 FAM188A RAD23A 0.583 25416956,unassigned1304 Q9H8M7 Q92905 FAM188A COPS5 0.21 21499297 Q9H8M7 P62917 FAM188A RPL8 0.126 16169070 Q9H8M7 Q13233 FAM188A MAP3K1 0.183 25260751 Q9H8M7 P15391 FAM188A CD19 0.126 26186194

PPI - InWeb_IM Gene A Gene B MI 1 Interaction 1 MI 2 Interaction 2 LIN7A FAM188A MI:0045 experimental interaction detection MI:0461 interaction database UBB FAM188A MI:0045 experimental interaction detection MI:0461 interaction database UBC FAM188A MI:0045 experimental interaction detection MI:0461 interaction database CD19 FAM188A MI:0045 experimental interaction detection MI:0461 interaction database TAF1 FAM188A MI:0045 experimental interaction detection MI:0461 interaction database UBA1 FAM188A MI:0045 experimental interaction detection MI:0461 interaction database MCM3 FAM188A MI:0045 experimental interaction detection MI:0461 interaction database MCM5 FAM188A MI:0045 experimental interaction detection MI:0461 interaction database CSK FAM188A MI:0045 experimental interaction detection MI:0461 interaction database RAD23A FAM188A MI:0045 experimental interaction detection MI:0461 interaction database UBE2N FAM188A MI:0045 experimental interaction detection MI:0461 interaction database RPL8 FAM188A MI:0045 experimental interaction detection MI:0461 interaction database MAP3K1 FAM188A MI:0045 experimental interaction detection MI:0461 interaction database UBE2V1 FAM188A MI:0045 experimental interaction detection MI:0461 interaction database IBA57 FAM188A MI:0045 experimental interaction detection MI:0461 interaction database RPUSD3 FAM188A MI:0045 experimental interaction detection MI:0461 interaction database ZC3HC1 FAM188A MI:0045 experimental interaction detection MI:0461 interaction database HNRNPLL FAM188A MI:0045 experimental interaction detection MI:0461 interaction database COPS5 FAM188A MI:0045 experimental interaction detection MI:0461 interaction database RNF25 FAM188A MI:0045 experimental interaction detection MI:0461 interaction database PKP2 FAM188A MI:0045 experimental interaction detection MI:0461 interaction database KIFC1 FAM188A MI:0045 experimental interaction detection MI:0461 interaction database ZNF644 FAM188A MI:0045 experimental interaction detection MI:0461 interaction database FAM188A LANCL2 MI:0045 experimental interaction detection MI:0461 interaction database FAM188A MPP6 MI:0045 experimental interaction detection MI:0461 interaction database FAM188A SCAF8 MI:0045 experimental interaction detection MI:0461 interaction database