PTM - CPLM Gene Name UniProt ID Type Position Code HERC4; KIAA1593 Q5GLZ8 Ubiquitination 469 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 488 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 493 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 890 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 365 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 34 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 218 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 572 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 606 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 165 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 397 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 769 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 70 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 177 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 27 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 336 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 243 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 237 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 959 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 1003 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 1006 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 835 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 1033 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 342 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 828 K HERC4; KIAA1593 Q5GLZ8 Ubiquitination 922 K

PTM - dbPAF Gene Name UniProt ID Position Type Species HERC4; KIAA1593 Q5GLZ8 1004 S Homo sapiens(Human) HERC4; KIAA1593 Q5GLZ8 1018 Y Homo sapiens(Human) HERC4; KIAA1593 Q5GLZ8 1024 T Homo sapiens(Human) HERC4; KIAA1593 Q5GLZ8 1055 S Homo sapiens(Human) HERC4; KIAA1593 Q5GLZ8 146 Y Homo sapiens(Human) HERC4; KIAA1593 Q5GLZ8 147 Y Homo sapiens(Human) HERC4; KIAA1593 Q5GLZ8 180 S Homo sapiens(Human) HERC4; KIAA1593 Q5GLZ8 246 Y Homo sapiens(Human) HERC4; KIAA1593 Q5GLZ8 379 S Homo sapiens(Human) HERC4; KIAA1593 Q5GLZ8 380 S Homo sapiens(Human) HERC4; KIAA1593 Q5GLZ8 830 S Homo sapiens(Human) HERC4; KIAA1593 Q5GLZ8 867 T Homo sapiens(Human) HERC4; KIAA1593 Q5GLZ8 874 T Homo sapiens(Human) HERC4; KIAA1593 Q5GLZ8 886 T Homo sapiens(Human) HERC4; KIAA1593 Q5GLZ8 992 T Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q5GLZ8 Y146-p Phosphorylation IVQVACGyyHSLALS Q5GLZ8 Y147-p Phosphorylation VQVACGyyHSLALSK Q5GLZ8 S180-p Phosphorylation TDCKkQTsPQLLKSL Q5GLZ8 Y246-p Phosphorylation LRSQKIVyICCGEDH Q5GLZ8 S830-p Phosphorylation KLLKKKPsLDDLKEL Q5GLZ8 T886-p Phosphorylation LVLNGADtAVNkQNR Q5GLZ8 T992-p Phosphorylation KQFLLFLtGSDRIPI Q5GLZ8 S1004-p Phosphorylation IPILGMKsLKLVIQS Q5GLZ8 Y1018-p Phosphorylation STGGGEEyLPVSHtC Q5GLZ8 T1024-p Phosphorylation EyLPVSHtCFNLLDL Q5GLZ8 S1055-p Phosphorylation IDHNEGFsLI_____ Q5GLZ8 K34-ub Ubiquitination KSDFFINkRVRDVGC Q5GLZ8 K177-ub Ubiquitination GLGTDCKkQTsPQLL Q5GLZ8 K218-ub Ubiquitination IFGWGRNkFGQLGLN Q5GLZ8 K409-ub Ubiquitination VNEALIQkWLSYPSG Q5GLZ8 K469-ub Ubiquitination AARLLFHkLIQPDHP Q5GLZ8 K488-ub Ubiquitination QVAASLEkNLIPkLT Q5GLZ8 K493-ub Ubiquitination LEkNLIPkLTSSLPD Q5GLZ8 K572-ub Ubiquitination EVVVHLLkLYKIGIP Q5GLZ8 K606-ub Ubiquitination ILHRVNEkMGQIIQY Q5GLZ8 K890-ub Ubiquitination GADtAVNkQNRQEFV Q5GLZ8 K922-ub Ubiquitination AFHAGFHkVCGGKVL

PTM - dbPTM UniProt ID Position Code Type Resources References Q5GLZ8 830 S Phosphorylation Swiss-Prot 1010711 17287340 Q5GLZ8 830 S Phosphorylation PhosphoELM.10011 17287340 Q5GLZ8 218 K Ubiquitylation Phosphositeplus.1010730 21906983 Q5GLZ8 469 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q5GLZ8 488 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q5GLZ8 493 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q5GLZ8 890 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q5GLZ8 830 S Phosphorylation Phosphositeplus.1010730 17287340 Q5GLZ8 830 S Phosphorylation HPRD 9.0 17287340 Q5GLZ8 830 S Phosphorylation SysPTM 1.1 17287340

PTM - HPRD Symbol Position Code Type References HERC4 822 S Phosphorylation 17287340 HERC4 830 S Phosphorylation 17287340

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q5GLZ8 830 S 17287340 HTP Phosphorylation

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type HERC4 IPI00333067 T 867 CLNFTIpTVENFGA phosphorylation HERC4 IPI00333067 T 874 VENFGApTEVKELV phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 26091 117542 - K Ubiquitination 18781797 26091 117542 - K Ubiquitination 21987572 26091 117542 - K Ubiquitination 21139048 26091 117542 - K Ubiquitination 21890473 26091 117542 - K Ubiquitination 21906983 26091 117542 - K Ubiquitination 22505724 26091 117542 - K Ubiquitination 21963094 26091 117542 - K Ubiquitination 23000965 26091 117542 - K Sumoylation 25027693 26091 117542 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID HERC4 Homo sapiens (Human) 359; 383; 780; 378 "359,ARLLFHKLIQPDH; 383,EKNLIPKLTSSLP; 780,ADTAVNKQNRQEF; 378,VAASLEKNLIPKL" 359:21890473; 383:21890473; 780:21890473; 378:21890473 HERC4 Homo sapiens (Human) 493; 882; 488; 469 "493,EKNLIPKLTSSLP; 882,ADTAVNKQNRQEF; 488,VAASLEKNLIPKL; 469,ARLLFHKLIQPDH" 493:21890473; 882:21890473; 488:21890473; 469:21890473 HERC4 Homo sapiens (Human) 359; 108; 383; 780; 378 "359,ARLLFHKLIQPDH; 108,FGWGRNKFGQLGL; 383,EKNLIPKLTSSLP; 780,ADTAVNKQNRQEF; 378,VAASLEKNLIPKL" "359:21890473,21906983; 108:21906983; 383:21890473,21906983; 780:21890473,21906983; 378:21890473,21906983" HERC4 Homo sapiens (Human) 493; 882; 488; 218; 469 "493,EKNLIPKLTSSLP; 882,ADTAVNKQNRQEF; 488,VAASLEKNLIPKL; 218,FGWGRNKFGQLGL; 469,ARLLFHKLIQPDH" "493:21890473,21906983; 882:21890473,21906983; 488:21890473,21906983; 218:21906983; 469:21890473,21906983" HERC4 Homo sapiens (Human) 493; 488; 218; 812; 469 "493,EKNLIPKLTSSLP; 488,VAASLEKNLIPKL; 218,FGWGRNKFGQLGL; 812,ADTAVNKQNRQEF; 469,ARLLFHKLIQPDH" "493:21890473,21906983; 488:21890473,21906983; 218:21906983; 812:21890473,21906983; 469:21890473,21906983" HERC4 Homo sapiens (Human) 493; 488; 218; 469; 890 "493,EKNLIPKLTSSLP; 488,VAASLEKNLIPKL; 218,FGWGRNKFGQLGL; 469,ARLLFHKLIQPDH; 890,ADTAVNKQNRQEF" "493:21890473,21906983; 488:21890473,21906983; 218:21906983; 469:21890473,21906983; 890:21890473,21906983" HERC4 Homo sapiens (Human) 359; 383; 780; 378 "359,ARLLFHKLIQPDH; 383,EKNLIPKLTSSLP; 780,ADTAVNKQNRQEF; 378,VAASLEKNLIPKL" 359:21890473; 383:21890473; 780:21890473; 378:21890473