PTM - CPLM Gene Name UniProt ID Type Position Code EML3 Q32P44 Ubiquitination 577 K

PTM - dbPAF Gene Name UniProt ID Position Type Species EML3 Q32P44 129 S Homo sapiens(Human) EML3 Q32P44 133 S Homo sapiens(Human) EML3 Q32P44 156 S Homo sapiens(Human) EML3 Q32P44 158 S Homo sapiens(Human) EML3 Q32P44 159 S Homo sapiens(Human) EML3 Q32P44 160 S Homo sapiens(Human) EML3 Q32P44 161 S Homo sapiens(Human) EML3 Q32P44 163 S Homo sapiens(Human) EML3 Q32P44 176 S Homo sapiens(Human) EML3 Q32P44 177 S Homo sapiens(Human) EML3 Q32P44 186 S Homo sapiens(Human) EML3 Q32P44 187 T Homo sapiens(Human) EML3 Q32P44 197 S Homo sapiens(Human) EML3 Q32P44 198 S Homo sapiens(Human) EML3 Q32P44 204 S Homo sapiens(Human) EML3 Q32P44 207 S Homo sapiens(Human) EML3 Q32P44 445 T Homo sapiens(Human) EML3 Q32P44 447 T Homo sapiens(Human) EML3 Q32P44 456 Y Homo sapiens(Human) EML3 Q32P44 490 S Homo sapiens(Human) EML3 Q32P44 492 S Homo sapiens(Human) EML3 Q32P44 494 T Homo sapiens(Human) EML3 Q32P44 840 S Homo sapiens(Human) EML3 Q32P44 843 T Homo sapiens(Human) EML3 Q32P44 844 S Homo sapiens(Human) EML3 Q32P44 881 T Homo sapiens(Human) EML3 Q32P44 883 S Homo sapiens(Human) EML3 Q32P44 885 T Homo sapiens(Human) EML3 Q32P44 887 S Homo sapiens(Human) EML3 Q32P44 889 S Homo sapiens(Human) EML3 Q32P44 892 S Homo sapiens(Human) EML3 Q32P44 893 S Homo sapiens(Human)

PTM - PhosphositePlus UniProt ID MOD_RSD Type SITE_+/-7_AA Q32P44 K173-ac Acetylation PRQKLSRkAIssANL Q32P44 R13-m1 Methylation GPGDGPArEALQSLS Q32P44 R190-m1 Methylation RSGSTESrGGKDPLs Q32P44 S129-p Phosphorylation EGGGSSSsGAGsPGP Q32P44 S133-p Phosphorylation SSSsGAGsPGPPGIL Q32P44 S156-p Phosphorylation ADTPRRNsSSSSSPS Q32P44 S176-p Phosphorylation KLSRkAIssANLLVR Q32P44 S177-p Phosphorylation LSRkAIssANLLVRS Q32P44 S197-p Phosphorylation rGGKDPLssPGGPGs Q32P44 S198-p Phosphorylation GGKDPLssPGGPGsR Q32P44 S204-p Phosphorylation ssPGGPGsRRsNYNL Q32P44 S207-p Phosphorylation GGPGsRRsNYNLEGI Q32P44 T445-p Phosphorylation VGVPGNGtLtRKQGV Q32P44 T447-p Phosphorylation VPGNGtLtRKQGVFG Q32P44 Y456-p Phosphorylation KQGVFGKyKKPKFIP Q32P44 S490-p Phosphorylation LTWGRSPsDsKtPGR Q32P44 S492-p Phosphorylation WGRSPsDsKtPGRGG Q32P44 T494-p Phosphorylation RSPsDsKtPGRGGAK Q32P44 S840-p Phosphorylation RMYGGHGsHVtsVRF Q32P44 T843-p Phosphorylation GGHGsHVtsVRFTHD Q32P44 S844-p Phosphorylation GHGsHVtsVRFTHDD Q32P44 T881-p Phosphorylation GAGPAPAtPsRtPsL Q32P44 S883-p Phosphorylation GPAPAtPsRtPsLsP Q32P44 T885-p Phosphorylation APAtPsRtPsLsPAs Q32P44 S887-p Phosphorylation AtPsRtPsLsPAssL Q32P44 S889-p Phosphorylation PsRtPsLsPAssLDV Q32P44 S892-p Phosphorylation tPsLsPAssLDV___ Q32P44 S893-p Phosphorylation PsLsPAssLDV____ Q32P44 K577-ub Ubiquitination ELLVGTTkNALLRGD Q32P44 K817-ub Ubiquitination AVADDFCkVHLFQYP

PTM - dbPTM UniProt ID Position Code Type Resources References Q32P44 176 S Phosphorylation Swiss-Prot 1010711 16964243;18669648;19690332 Q32P44 881 T Phosphorylation Swiss-Prot 1010711 16964243;18220336;18669648 Q32P44 176 S Phosphorylation PhosphoELM.10011 18669648;16964243 Q32P44 889 S Phosphorylation PhosphoELM.10011 18669648 Q32P44 881 T Phosphorylation PhosphoELM.10011 18669648;18220336;16964243 Q32P44 885 T Phosphorylation PhosphoELM.10011 18669648 Q32P44 577 K Ubiquitylation Phosphositeplus.1010730 21890473;21906983 Q32P44 176 S Phosphorylation Phosphositeplus.1010730 16964243;18669648;19276368;19690332;20068231;20166139;20363803;20815410;21406692;22067460;22115753 Q32P44 177 S Phosphorylation Phosphositeplus.1010730 19690332 Q32P44 198 S Phosphorylation Phosphositeplus.1010730 19276368;19691289;20363803;22067460 Q32P44 207 S Phosphorylation Phosphositeplus.1010730 19691289 Q32P44 490 S Phosphorylation Phosphositeplus.1010730 20068231 Q32P44 492 S Phosphorylation Phosphositeplus.1010730 20068231 Q32P44 883 S Phosphorylation Phosphositeplus.1010730 18847512 Q32P44 887 S Phosphorylation Phosphositeplus.1010730 22115753 Q32P44 889 S Phosphorylation Phosphositeplus.1010730 22067460;22115753 Q32P44 893 S Phosphorylation Phosphositeplus.1010730 22115753 Q32P44 494 T Phosphorylation Phosphositeplus.1010730 20068231 Q32P44 881 T Phosphorylation Phosphositeplus.1010730 16964243;17446864;18220336;18669648;18847512;19276368;21659604;22067460 Q32P44 885 T Phosphorylation Phosphositeplus.1010730 18669648 Q32P44 176 S Phosphorylation HPRD 9.0 18669648,18212344,19651622,18767875,16964243,20166139,20068231 Q32P44 177 S Phosphorylation HPRD 9.0 20068231 Q32P44 198 S Phosphorylation HPRD 9.0 19691289 Q32P44 207 S Phosphorylation HPRD 9.0 19691289 Q32P44 490 S Phosphorylation HPRD 9.0 20068231 Q32P44 492 S Phosphorylation HPRD 9.0 20068231 Q32P44 889 S Phosphorylation HPRD 9.0 18669648 Q32P44 494 T Phosphorylation HPRD 9.0 20068231 Q32P44 881 T Phosphorylation HPRD 9.0 18669648,19691289,16964243,20068231 Q32P44 885 T Phosphorylation HPRD 9.0 18669648 Q32P44 176 S Phosphorylation SysPTM 1.1 18669648;18212344 Q32P44 881 T Phosphorylation SysPTM 1.1 18669648

PTM - HPRD Symbol Position Code Type References EML3 176 S Phosphorylation 18669648,18212344,19651622,18767875,16964243,20166139,20068231 EML3 177 S Phosphorylation 20068231 EML3 198 S Phosphorylation 19691289 EML3 207 S Phosphorylation 19691289 EML3 490 S Phosphorylation 20068231 EML3 492 S Phosphorylation 20068231 EML3 494 T Phosphorylation 20068231 EML3 881 T Phosphorylation 18669648,19691289,16964243,20068231 EML3 885 T Phosphorylation 18669648 EML3 889 S Phosphorylation 18669648

PTM - Phospho.ELM UniProt Position Code PMIDs Kinase Source Type Q32P44 881 T 18669648 HTP Phosphorylation Q32P44 881 T 18220336 HTP Phosphorylation Q32P44 881 T 16964243 HTP Phosphorylation Q32P44 889 S 18669648 HTP Phosphorylation Q32P44 885 T 18669648 HTP Phosphorylation Q32P44 176 S 18669648 HTP Phosphorylation Q32P44 176 S 16964243 HTP Phosphorylation

PTM - UniProt UniProt ID Position Type PMIDs Q32P44 1 N-acetylmethionine 22814378 Q32P44 176 Phosphoserine 16964243;18669648;19690332;20068231;21406692;23186163 Q32P44 198 Phosphoserine 23186163 Q32P44 204 Phosphoserine 23186163 Q32P44 881 Phosphothreonine 16964243 Q32P44 883 Phosphoserine 23186163;24275569

PTM - PHOSIDA Symbol Accession Code Position Surrounding Sequence Type EML3 IPI00167909 S 176 LSRKAIpSSANLLV phosphorylation EML3 IPI00167909 S 177 SRKAISpSANLLVR phosphorylation EML3 IPI00167909 S 490 TWGRSPpSDSKTPG phosphorylation EML3 IPI00167909 S 492 GRSPSDpSKTPGRG phosphorylation EML3 IPI00167909 T 494 SPSDSKpTPGRGGA phosphorylation

PTM - BioGRID Entrez Gene BioGRID ID Position Code Type PMIDs 256364 129161 - K Ubiquitination 21987572 256364 129161 - K Ubiquitination 21139048 256364 129161 - K Ubiquitination 21890473 256364 129161 - K Ubiquitination 21906983 256364 129161 - K Ubiquitination 22053931 256364 129161 - K Ubiquitination 22505724 256364 129161 - K Ubiquitination 21963094 256364 129161 - K Ubiquitination 23000965 256364 129161 - K Ubiquitination 24816145 256364 129161 - K Ubiquitination 25015289 256364 129161 - K Ubiquitination 25147182

PTM - mUbiSiDa Gene Name Species Ubiquitination Site Ubiquitination Sequence Evidence PMID EML3 Homo sapiens (Human) 577 "577,LLVGTTKNALLRG" 577:21890473 EML3 Homo sapiens (Human) 578 "578,LLVGTTKNALLRG" "578:21906983,21890473" EML3 Homo sapiens (Human) 577 "577,LLVGTTKNALLRG" "577:21139048,22053931" EML3 Homo sapiens (Human) 577 "577,LLVGTTKNALLRG" "577:21906983,21890473" EML3 Homo sapiens (Human) 577 "577,LLVGTTKNALLRG" "577:21906983,21890473" EML3 Homo sapiens (Human) 462 "462,LLVGTTKNALLRG" "462:21906983,21890473" EML3 Homo sapiens (Human) 549 "549,LLVGTTKNALLRG" 549:21906983